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British Journal of Cancer, ISSN 0007-0920, 09/2017, Volume 117, Issue 7, pp. 938 - 946
Background: We investigated selumetinib (AZD6244, ARRY-142886), an oral, potent, and highly selective, allosteric MEK1/2 inhibitor, plus platinum-doublet... 
non-small cell lung cancer | selumetinib | chemotherapy | MEK1/2 inhibitor | PLUS GEMCITABINE | MULTICENTER | CARBOPLATIN | KRAS MUTATION | RANDOMIZED-TRIAL | OPEN-LABEL | DOCETAXEL | CELL LUNG-CANCER | CLINICAL-PRACTICE GUIDELINES | ONCOLOGY | AZD6244 ARRY-142886 | Lung Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Nausea - chemically induced | Chemotherapy-Induced Febrile Neutropenia - etiology | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Fatigue - chemically induced | Protein Kinase Inhibitors - adverse effects | Diarrhea - chemically induced | Cisplatin - administration & dosage | Benzimidazoles - administration & dosage | Adult | Female | Benzimidazoles - adverse effects | Deoxycytidine - administration & dosage | Anemia - chemically induced | Carboplatin - administration & dosage | Epistaxis - chemically induced | Lethargy - chemically induced | Thrombocytopenia - chemically induced | Protein Kinase Inhibitors - administration & dosage | Vomiting - chemically induced | Pemetrexed - administration & dosage | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Deoxycytidine - analogs & derivatives | Thrombocytopenia | Gemcitabine | Toxicity | Anemia | Lung cancer | Non-small cell lung carcinoma | Diarrhea | Fatigue | Nausea | Patients | Cisplatin | Metastases | Chemotherapy | Allosteric properties | Vomiting | Platinum | Lethargy | Carboplatin | Neutropenia | MEK1 | 2 inhibitor | Clinical Study
Journal Article
Epilepsia, ISSN 0013-9580, 10/2017, Volume 58, Issue 10, pp. 1734 - 1741
Summary Objective Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is a common epilepsy syndrome that is often poorly controlled by... 
Drug response | Efficacy | Adverse drug reactions | Retention | Seizure freedom | CONTROLLED-TRIAL | REFRACTORY EPILEPSY | PROGNOSIS | LOCALIZATION-RELATED EPILEPSY | TOPIRAMATE | RETENTION RATES | NATURAL-HISTORY | CLINICAL NEUROLOGY | THERAPY | LAMOTRIGINE | RESISTANT EPILEPSY | Pregabalin - therapeutic use | Triazines - therapeutic use | Humans | Middle Aged | Epilepsy, Temporal Lobe - drug therapy | Epilepsy, Temporal Lobe - physiopathology | Male | Sclerosis | Young Adult | Amines - therapeutic use | Vision Disorders - chemically induced | Adult | Female | Valproic Acid - therapeutic use | Retrospective Studies | gamma-Aminobutyric Acid - therapeutic use | Epilepsy, Temporal Lobe - pathology | Databases, Factual | Diplopia - chemically induced | Cyclohexanecarboxylic Acids - therapeutic use | Carbamazepine - analogs & derivatives | Vertigo - chemically induced | Dizziness - chemically induced | Anticonvulsants - therapeutic use | Carbamazepine - therapeutic use | Treatment Outcome | Hippocampus - pathology | Lethargy - chemically induced | Fructose - therapeutic use | Fructose - analogs & derivatives | Vigabatrin - therapeutic use | Adolescent | Aged | Ataxia - chemically induced | Benzodiazepines - therapeutic use | Medical research | Care and treatment | Anticonvulsants | Medicine, Experimental | Temporal lobe epilepsy | Seizures (Medicine) | Comparative analysis | Topiramate | Temporal lobe | Gabapentin | Epilepsy | Clinical trials | Valproic acid | Antiepileptic agents | Carbamazepine | Vertigo | Oxcarbazepine | Convulsions & seizures | Drowsiness | Ataxia | Hippocampus | Lamotrigine
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0159607
Acalabrutinib (ACP-196) is a second-generation inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK) with increased target selectivity and potency... 
SURVIVAL | CLL | ACTIVATION | BRUTON TYROSINE KINASE | ONCOLOGY | MULTIDISCIPLINARY SCIENCES | IBRUTINIB | PCI-32765 | CHRONIC LYMPHOCYTIC-LEUKEMIA | GERMINAL CENTER | ANTIGEN | Lethargy - physiopathology | Protein-Tyrosine Kinases - metabolism | Diarrhea - physiopathology | Humans | Pyrazines - administration & dosage | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Weight Loss - drug effects | Diarrhea - chemically induced | Anorexia - physiopathology | Benzamides - administration & dosage | Protein-Tyrosine Kinases - genetics | Antineoplastic Agents - adverse effects | Female | B-Lymphocytes - pathology | Drug Evaluation, Preclinical | Benzamides - adverse effects | Disease Models, Animal | Lymphoma, Large B-Cell, Diffuse - drug therapy | Drug Administration Schedule | Lymphoma, Large B-Cell, Diffuse - enzymology | Lethargy - chemically induced | Lymphoma, Large B-Cell, Diffuse - mortality | B-Lymphocytes - drug effects | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Vomiting - chemically induced | Animals | B-Lymphocytes - immunology | Agammaglobulinaemia Tyrosine Kinase | Dogs | Pyrazines - adverse effects | Cell Line, Tumor | Anorexia - chemically induced | Lymphoma, Large B-Cell, Diffuse - veterinary | Vomiting - physiopathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Antimitotic agents | Care and treatment | Safety and security measures | Dosage and administration | Non-Hodgkin's lymphomas | Research | Antineoplastic agents | Cell proliferation | Cell culture | Flow cytometry | Veterinary colleges | Anorexia | Leukemia | Cytotoxicity | Malignancy | Kinases | Veterinary medicine | Vomiting | Quality | Inhibition | Protein-tyrosine kinase | Tyrosine | Internal medicine | Hematology | Agammaglobulinemia | Diarrhea | Gene expression | Lymphoma | Bruton's tyrosine kinase | Inhibitors | Lymphocytes B | Lethargy | Lymphomas | Cancer | B-cell lymphoma
Journal Article
Lancet, The, ISSN 0140-6736, 2009, Volume 373, Issue 9676, pp. 1681 - 1692
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2011, Volume 31, Issue 31, pp. 11376 - 11386
In response to illness, animals subvert normal homeostasis and divert their energy utilization to fight infection. An important and unexplored feature of this... 
SYSTEM | TUMOR-NECROSIS-FACTOR | MESSENGER-RNA | AROUSAL | PROSTAGLANDIN-E SYNTHASE-1 | FOS EXPRESSION | FOOD-INTAKE | MICE | ANTICIPATORY ACTIVITY | RAT-BRAIN | NEUROSCIENCES | Interleukin-1beta - pharmacology | Lethargy - pathology | Rats, Inbred F344 | Melanocyte-Stimulating Hormones - pharmacology | Male | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Receptors, Interleukin-11 - genetics | Neuropeptides - pharmacology | Receptors, Corticotropin - antagonists & inhibitors | Neurons - metabolism | Disease Models, Animal | Drug Administration Routes | NF-KappaB Inhibitor alpha | Polysaccharides - adverse effects | Rats | Mice, Transgenic | Neuropeptides - metabolism | Lateral Ventricles - drug effects | Rats, Sprague-Dawley | Neurotensin - genetics | Analysis of Variance | Mice | Receptors, OSM-LIF - metabolism | Injections, Intraventricular - methods | Enzyme-Linked Immunosorbent Assay - methods | Inflammation - chemically induced | Intracellular Signaling Peptides and Proteins - pharmacology | Motor Activity - physiology | Lethargy - drug therapy | Motor Activity - drug effects | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Inflammation - complications | Interleukin-6 - blood | Food Deprivation | Neurons - drug effects | Lateral Ventricles - physiology | Orexins | Gene Expression Regulation - genetics | Proto-Oncogene Proteins c-fos - metabolism | Photoperiod | Lethargy - etiology | Gene Expression Regulation - drug effects | Neoplasm Transplantation - methods | Animals | Receptors, OSM-LIF - genetics | Receptors, Interleukin-11 - metabolism | Dark Adaptation - drug effects
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