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PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e89166 - e89166
The AMPK-Sirt1 pathway is an important regulator of energy metabolism and therefore a potential target for prevention and therapy of metabolic diseases. We... 
SKELETAL-MUSCLE | RESVERATROL | ACTIVATED PROTEIN-KINASE | MITOCHONDRIAL BIOGENESIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NITRIC-OXIDE | AMPK | ENERGY-METABOLISM | SIRT1 ACTIVATION | ADIPOSE-TISSUE | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Leucine - pharmacology | Chlorogenic Acid - pharmacology | Humans | Muscle Cells - drug effects | Polyphenols - pharmacology | Caffeic Acids - pharmacology | Adipocytes - drug effects | Stilbenes - pharmacology | Valerates - pharmacology | Xanthines - pharmacology | Oxidation-Reduction - drug effects | Fatty Acids - metabolism | Ellagic Acid - pharmacology | AMP-Activated Protein Kinases - antagonists & inhibitors | Muscle Cells - metabolism | NAD - pharmacology | Phosphodiesterase Inhibitors - pharmacology | 3T3-L1 Cells | Sirtuin 1 - antagonists & inhibitors | Animals | Adipocytes - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Metabolites | Analysis | Resveratrol | Physiological aspects | Polyphenols | Amino acids | Fatty acids | Energy metabolism | Biosynthesis | Adipocytes | Leucine | Kinases | Synergism | Synergistic effects | Energy | Ellagic acid | Penicillin | Oxidation | Enzymes | Myotubes | Research & development--R&D | Oral administration | Muscles | Bioavailability | Metabolism | Mammals | Insulin | SIRT1 protein | NAD | Studies | Musculoskeletal system | Signaling | Epigallocatechin gallate | Acids | Antibiotics | Diabetes | Kinetics | Metabolic disorders | Index Medicus | Research & development | R&D
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 01/2019, Volume 20, Issue 2, p. 338
Journal Article
PLoS Genetics, ISSN 1553-7390, 01/2013, Volume 9, Issue 1, pp. e1003144 - e1003144
High levels of antibiotic tolerance are a hallmark of bacterial biofilms. In contrast to well-characterized inherited antibiotic resistance, molecular... 
CELLS | BACTERIAL PERSISTENCE | PSEUDOMONAS-AERUGINOSA | ESCHERICHIA-COLI | GENETICS & HEREDITY | GENE-EXPRESSION | RESISTANCE | BETA-LACTAM ANTIBIOTICS | CYSTIC-FIBROSIS | INDUCTION | STRESS | Biofilms - drug effects | Plankton - drug effects | Starvation | Drug Tolerance - genetics | Biofilms - growth & development | Amino Acids - genetics | Ofloxacin - pharmacology | Mutagenesis | Escherichia coli - genetics | Fluoroquinolones - pharmacology | SOS Response (Genetics) | DNA Transposable Elements - genetics | Plankton - genetics | Anti-Bacterial Agents - pharmacology | Drug Resistance, Bacterial - drug effects | Escherichia coli - growth & development | Drug Resistance, Bacterial - genetics | Transposons | Antibiotics | Gene mutations | Physiological aspects | Genetic aspects | Dosage and administration | Research | Drug resistance | Health aspects | Biofilms | Microbiology | E coli | Bacteria | Mutation | Carbon | Index Medicus | Ofloxacin/pharmacology | DNA Transposable Elements/genetics | Bacterial/drug effects/genetics | Anti-Bacterial Agents/pharmacology | Plankton/drug effects/genetics | Escherichia coli/genetics/growth & development | Bacteriology | Fluoroquinolones/pharmacology | Life Sciences | Microbiology and Parasitology | Biofilms/drug effects/growth & development | Drug Tolerance/genetics | Amino Acids/genetics | Drug Resistance
Journal Article
FASEB Journal, ISSN 0892-6638, 12/2012, Volume 26, Issue 12, pp. 5161 - 5171
Inflammatory pain can be controlled by endogenous opioid peptides. Here we blocked the degradation of opioids in peripheral injured tissue to locally augment... 
Immune cells | Analgesia | Ory nerves | DEGRADING ENZYMES | NEUROGENIC INFLAMMATION | SYNOVIAL-FLUID | CATABOLIZING ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | analgesia | immune cells | SPINAL-CORD | BETA-ENDORPHIN | sensory nerves | CELL BIOLOGY | RECEPTORS MEDIATING ANTINOCICEPTION | BIOLOGY | INFLAMMATORY PAIN | RAT-BRAIN | NEUTRAL ENDOPEPTIDASE ENKEPHALINASE | Leucine - pharmacology | Opioid Peptides - pharmacology | Rats, Wistar | Thiorphan - pharmacology | Opioid Peptides - immunology | Male | Enkephalin, Methionine - pharmacology | Leukocytes - enzymology | Enkephalin, Methionine - metabolism | Dose-Response Relationship, Drug | Narcotic Antagonists | Alanine - analogs & derivatives | Enkephalin, Methionine - immunology | Hindlimb - physiopathology | Inflammation - complications | Flow Cytometry | Pain - complications | Pain - enzymology | Enkephalin, Leucine - pharmacology | Antibodies - immunology | Pain Threshold - drug effects | Dynorphins - metabolism | Neurons - drug effects | Leucine - analogs & derivatives | Alanine - pharmacology | Receptors, Opioid - metabolism | Amino Acid Sequence | Enkephalin, Leucine - metabolism | Pain - prevention & control | CD13 Antigens - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Hindlimb - innervation | Enkephalin, Leucine - immunology | Neprilysin - metabolism | CD13 Antigens - metabolism | Opioid Peptides - metabolism | Antibodies - pharmacology | Dynorphins - immunology | Animals | Neurons - enzymology | Phosphinic Acids - pharmacology | Neprilysin - antagonists & inhibitors | Hindlimb - drug effects | Leukocytes - drug effects | Dynorphins - pharmacology | Inflammation - prevention & control | Inflammation - enzymology | Index Medicus
Journal Article
Molecular Reproduction and Development, ISSN 1040-452X, 10/2006, Volume 73, Issue 10, pp. 1277 - 1283
Progesterone receptor (PR) stimulation promotes survival in human and rat periovulatory granulosa cells. PR antagonists, Org 31710 and RU 486, both increase... 
ovary | progesterone receptor | progesterone | ovulation | Ovary | Progesterone | Progesterone receptor | Ovulation | PHOSPHATE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEVELOPMENTAL BIOLOGY | INDUCE APOPTOSIS | LOVASTATIN-INDUCED APOPTOSIS | CELL BIOLOGY | RAB GERANYLGERANYL TRANSFERASE | IN-VITRO | REPRODUCTIVE BIOLOGY | A REDUCTASE INHIBITORS | MESSENGER-RNA | PROGESTERONE-RECEPTOR ANTAGONISTS | MEVALONATE PATHWAY | OVARIAN FOLLICLE ATRESIA | Diterpenes - pharmacology | Protein Prenylation - drug effects | Leucine - pharmacology | Apoptosis - drug effects | Granulosa Cells - physiology | Farnesol - pharmacology | Furans - pharmacology | Humans | Cells, Cultured | Imidazoles - pharmacology | Quinolones - pharmacology | Granulosa Cells - drug effects | Granulosa Cells - metabolism | Receptors, Progesterone - antagonists & inhibitors | Hormone Antagonists - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Estrenes - pharmacology | Female | Farnesyltranstransferase - antagonists & inhibitors | Cholesterol - biosynthesis | Mifepristone - pharmacology | Leucine - analogs & derivatives | Index Medicus | MEDICIN OCH HÄLSOVETENSKAP | Granulosa Cells/drug effects/metabolism/physiology | Receptors | Farnesyltranstransferase/antagonists & inhibitors | Imidazoles/pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology | Progesterone/antagonists & inhibitors | Physiology | Cultured | Estrenes/pharmacology | MEDICAL AND HEALTH SCIENCES | Diterpenes/pharmacology | Farnesol/pharmacology | Hormone Antagonists/pharmacology | Fysiologi | Apoptosis/drug effects | Furans/pharmacology | Cholesterol/biosynthesis | Leucine/analogs & derivatives/pharmacology | Cells | Protein Isoprenylation/drug effects | Mifepristone/pharmacology | Quinolones/pharmacology
Journal Article
Journal of Dental Research, ISSN 0022-0345, 9/2014, Volume 93, Issue 9, pp. 911 - 917
The mechanism of pain in dentine hypersensitivity is poorly understood but proposed to result from the activation of dental sensory neurons in response to... 
orofacial pain | sensation | dentin | signal transduction | transient receptor potential channel | ion channels | HUMAN DENTAL-PULP | CELLS | RAT ODONTOBLASTS | SODIUM-CALCIUM EXCHANGERS | TRANSDUCTION | TOOTH-PULP | IN-VITRO | DENTISTRY, ORAL SURGERY & MEDICINE | ION-CHANNEL | MICE | EXPRESSION | Acrolein - analogs & derivatives | Transient Receptor Potential Channels - antagonists & inhibitors | Leucine - pharmacology | Capsaicin - pharmacology | Humans | Adenosine Triphosphate - secretion | Nociceptors - physiology | Sensory System Agents - pharmacology | Calcium Channels - physiology | Pyrimidinones - pharmacology | Transient Receptor Potential Channels - physiology | Cell Culture Techniques | Leucine - analogs & derivatives | Isothiocyanates - pharmacology | Acrolein - pharmacology | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Acetanilides - pharmacology | Nerve Tissue Proteins - physiology | TRPV Cation Channels - physiology | Purines - pharmacology | Nerve Tissue Proteins - agonists | TRPV Cation Channels - agonists | Dental Pulp - cytology | TRPM Cation Channels - agonists | Sulfonamides - pharmacology | Transient Receptor Potential Channels - agonists | Culture Media, Conditioned | Calcium Signaling - drug effects | Odontoblasts - physiology | Odontoblasts - secretion | TRPA1 Cation Channel | Index Medicus | Dentistry | Research Reports
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 10/2011, Volume 45, Issue 4, pp. 704 - 710
Rho/Ras signaling pathways may play an important role in the mechanism of LPS-induced inflammation and bronchoconstriction. In this study, we investigated the... 
EFS | Rho/Ras signaling pathways | Human bronchi | LPS | Statins | human bronchi | BIOCHEMISTRY & MOLECULAR BIOLOGY | RHO-KINASE INHIBITOR | LUNG INJURY | CONTRACTILE ACTIVITY | CELL BIOLOGY | LIPOPOLYSACCHARIDE EXPOSURE | IN-VITRO | RESPIRATORY SYSTEM | statins | NITRIC-OXIDE | INDUCED AIRWAY HYPERRESPONSIVENESS | INHALED ENDOTOXIN | TRACHEAL SMOOTH-MUSCLE | GERANYLGERANYLTRANSFERASE-I | Leucine - pharmacology | Electric Stimulation | Sesquiterpenes - metabolism | Humans | Middle Aged | Alkyl and Aryl Transferases - metabolism | Alkyl and Aryl Transferases - antagonists & inhibitors | ras Proteins - metabolism | Male | Methionine - pharmacology | Simvastatin - pharmacology | rho-Associated Kinases - antagonists & inhibitors | Bronchi - drug effects | Methionine - analogs & derivatives | Time Factors | rho-Associated Kinases - metabolism | Bronchoconstriction - drug effects | Bronchi - metabolism | Female | Leucine - analogs & derivatives | Amides - pharmacology | Protein Prenylation - drug effects | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Polyisoprenyl Phosphates - metabolism | Naphthalenes - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Signal Transduction - drug effects | rho GTP-Binding Proteins - metabolism | Lipopolysaccharides - pharmacology | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | In Vitro Techniques | Index Medicus
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2010, Volume 161, Issue 3, pp. 571 - 588
BACKGROUND AND PURPOSE Insulin-induced Na+ retention in the distal nephron may contribute to the development of oedema/hypertension in patients with type 2... 
Akti-1/2 | epithelial Na | GSK650394A | PI103 | kinase inhibitors | channel | cortical collecting duct | GDC-0941 | ACTIVATION | SODIUM-TRANSPORT | PHOSPHORYLATION | SERUM | AKT | ENAC | IDENTIFICATION | A6 CELLS | CHANNEL | PHARMACOLOGY & PHARMACY | epithelial Na+ channel | LEUCINE-ZIPPER PROTEIN | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Furans - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Sodium - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinoxalines - pharmacology | Epithelial Cells - physiology | Immediate-Early Proteins - metabolism | Absorption | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Ion Transport - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Kidney Tubules, Collecting - drug effects | Membrane Potentials - drug effects | Insulin - pharmacology | Cells, Cultured | Pyrimidines - pharmacology | Membrane Potentials - physiology | Sulfonamides - pharmacology | Indazoles - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Androstadienes - pharmacology | Benzoates - pharmacology | Mice | Pyridines - pharmacology | Benzylamines - pharmacology | Immediate-Early Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Kinases | Insulin | Index Medicus | Research Papers | 2 | Akti-1
Journal Article
Journal Article