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leucine-trna ligase - metabolism (145) 145
leucine-trna ligase - genetics (141) 141
biochemistry & molecular biology (98) 98
molecular sequence data (79) 79
index medicus (78) 78
mutation (77) 77
leucine-trna ligase - chemistry (74) 74
amino acid sequence (63) 63
humans (60) 60
transfer rna (57) 57
escherichia coli - genetics (55) 55
kinetics (55) 55
escherichia-coli (53) 53
trna (53) 53
animals (50) 50
escherichia coli - enzymology (49) 49
base sequence (43) 43
crystal-structure (43) 43
aminoacylation (42) 42
rna, transfer, leu - metabolism (40) 40
complex (37) 37
leucine - metabolism (36) 36
amino acids (35) 35
amino acyl-trna synthetases - genetics (33) 33
protein structure, tertiary (33) 33
saccharomyces cerevisiae - genetics (30) 30
leucyl-trna synthetase (28) 28
recognition (28) 28
rna editing (28) 28
discrimination (27) 27
models, molecular (27) 27
nucleic acid conformation (27) 27
rna, transfer, leu - genetics (27) 27
aminoacyl-trna synthetases (26) 26
research (26) 26
cell line (25) 25
protein biosynthesis (25) 25
genes (24) 24
substrate specificity (24) 24
amino acyl-trna synthetases - metabolism (23) 23
cricetinae (23) 23
ligases (23) 23
cell biology (22) 22
female (22) 22
mitochondria - enzymology (22) 22
saccharomyces cerevisiae - enzymology (22) 22
sequence homology, amino acid (22) 22
temperature (22) 22
transfer rna aminoacylation (22) 22
enzymes (21) 21
escherichia coli (21) 21
leucine-trna ligase - antagonists & inhibitors (21) 21
acylation (20) 20
cloning, molecular (20) 20
genetic aspects (20) 20
leucine-trna ligase (20) 20
proteins (19) 19
rna, transfer, leu - chemistry (19) 19
structural basis (19) 19
transfer-rna-synthetase (19) 19
protein conformation (18) 18
analysis (17) 17
isoleucine (17) 17
leucine-trna ligase - biosynthesis (17) 17
mutagenesis, site-directed (17) 17
aminoacyl-trna synthetase (16) 16
binding sites (16) 16
leucine (16) 16
leucine-trna ligase - isolation & purification (16) 16
mechanism (16) 16
protein-synthesis (16) 16
amino acids - metabolism (15) 15
article (15) 15
cricetulus (15) 15
crystallography, x-ray (15) 15
genetic-code (15) 15
hydrolysis (15) 15
rna (15) 15
sequence alignment (15) 15
yeast (15) 15
bacteria (14) 14
editing (14) 14
life sciences (14) 14
ovary (14) 14
physiological aspects (14) 14
rna, transfer - metabolism (14) 14
rna, transfer, amino acyl - metabolism (14) 14
bacteria - enzymology (13) 13
biophysics (13) 13
cp1 domain (13) 13
domain (13) 13
escherichia coli - metabolism (13) 13
protein synthesis (13) 13
recombinant proteins - metabolism (13) 13
saccharomyces-cerevisiae (13) 13
sequence (13) 13
evolution (12) 12
microbiology (12) 12
multidisciplinary sciences (12) 12
protein (12) 12
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Journal Article
Science, ISSN 0036-8075, 6/2007, Volume 316, Issue 5832, pp. 1759 - 1761
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2016, Volume 60, Issue 10, pp. 6271 - 6280
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2008, Volume 283, Issue 45, pp. 30482 - 30492
Signaling through mammalian target of rapamycin complex 1 (mTORC1) is stimulated by amino acids and insulin. Insulin inactivates TSC1/2, the GTPase-activator... 
POLYPEPTIDE-CHAIN INITIATION | NUCLEOTIDE-EXCHANGE FACTOR | HAMSTER OVARY CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSFER-RNA-SYNTHETASES | SMALL GTPASE RHEB | BCL-2 REGULATOR FKBP38 | PROTEIN-SYNTHESIS | P70 S6 KINASE | AMINO-ACID AVAILABILITY | TRANSLATIONAL CONTROL | Cricetulus | Hypoglycemic Agents - metabolism | Humans | Multiprotein Complexes - genetics | Ras Homolog Enriched in Brain Protein | Tacrolimus Binding Proteins - metabolism | Amino Acids - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Proteins | Amino Acids - metabolism | Multiprotein Complexes - metabolism | Telomerase - genetics | Leucine-tRNA Ligase - metabolism | Tumor Suppressor Proteins - genetics | Biomarkers, Tumor - metabolism | RNA, Transfer - genetics | Telomerase - metabolism | Neuropeptides - genetics | CHO Cells | Insulin - pharmacology | Cricetinae | Tumor Suppressor Proteins - metabolism | RNA, Transfer - metabolism | Neuropeptides - metabolism | Monomeric GTP-Binding Proteins - genetics | Transcription Factors - genetics | Leucine-tRNA Ligase - genetics | Hypoglycemic Agents - pharmacology | Tacrolimus Binding Proteins - genetics | Transcription Factors - metabolism | Insulin - metabolism | Animals | Monomeric GTP-Binding Proteins - metabolism | Signal Transduction - physiology | Biomarkers, Tumor - genetics | TOR Serine-Threonine Kinases | Mutation | Protein Binding - physiology | Mechanisms of Signal Transduction
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 732 - 15
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 3817 - 3822
Mycoplasma leucyl-tRNA synthetases (LeuRSs) have been identified in which the connective polypeptide 1 (CP1) amino acid editing domain that clears mischarged... 
Enzymes | Pathogens | Active sites | Amino acids | Evolution | Mycoplasma | Codons | Hybridity | Transfer RNA | Crystal structure | Protein evolution | Aminoacylation | Translation | Statistical proteins | Quality control | PATHWAYS | COMPLEX | PRE-TRANSFER | protein evolution | quality control | statistical proteins | YBAK PROTEIN | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | MECHANISMS | EVOLUTION | STRUCTURAL BASIS | translation | CLASS-I | aminoacylation | Codon - metabolism | Leucine-tRNA Ligase - chemistry | Mycoplasma - metabolism | RNA Editing | Mycoplasma - pathogenicity | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Mycoplasma synoviae - enzymology | Recombinant Fusion Proteins - metabolism | RNA, Transfer, Leu - metabolism | Leucine-tRNA Ligase - metabolism | RNA, Bacterial - genetics | Codon - genetics | RNA, Bacterial - metabolism | RNA, Transfer, Leu - genetics | Mycoplasma synoviae - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Bacterial Proteins - genetics | Mycoplasma - genetics | Models, Molecular | Leucine-tRNA Ligase - genetics | Sequence Homology, Amino Acid | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Protein Conformation | Codon | Physiological aspects | Genetic aspects | Aminoacyl-tRNA synthetases | Health aspects | Biological Sciences
Journal Article