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Blood, ISSN 0006-4971, 06/2011, Volume 117, Issue 23, pp. 6287 - 6296
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and... 
B-CELLS | CLL | FLUDARABINE PLUS CYCLOPHOSPHAMIDE | APOPTOTIC CELL-DEATH | RITUXIMAB | SURVIVAL SIGNALS | LYMPHOMA | DRUG-RESISTANCE | INHIBITOR | HEMATOLOGY | EXPRESSION | T-Lymphocytes - enzymology | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cell Survival - genetics | Apoptosis - genetics | Male | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Receptors, Antigen, B-Cell - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Interleukin-6 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation, Leukemic - drug effects | Pyrimidines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | B-Cell Activating Factor - metabolism | CD40 Ligand - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Gene Expression Regulation, Enzymologic - genetics | Cell Line, Tumor | Receptors, Antigen, B-Cell - genetics | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mitogen-Activated Protein Kinase 1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Gene Expression Regulation, Leukemic - genetics | Protein-Tyrosine Kinases - genetics | CD40 Ligand - metabolism | MAP Kinase Signaling System - genetics | Female | Interleukin-4 - genetics | Protein-Tyrosine Kinases - biosynthesis | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Neoplasm Proteins - biosynthesis | Interleukin-4 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Cell Proliferation - drug effects | Lymphoid Neoplasia
Journal Article
Leukemia, ISSN 0887-6924, 2012, Volume 26, Issue 7, pp. 1576 - 1583
Journal Article
Blood, ISSN 0006-4971, 04/2010, Volume 115, Issue 13, pp. 2578 - 2585
Certain malignant B cells rely on B-cell receptor (BCR)-mediated survival signals. Spleen tyrosine kinase (Syk) initiates and amplifies the BCR signal. In in... 
RHEUMATOID-ARTHRITIS | BCR | B-CELL LYMPHOMA | RESPONSE CRITERIA | R-CHOP | THERAPEUTIC TARGET | PHASE-III | TYROSINE KINASE INHIBITOR | FOLLICULAR LYMPHOMA | HEMATOLOGY | EXPRESSION | Humans | Middle Aged | Neoplasm Proteins - physiology | Salvage Therapy | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Lymphoma, Non-Hodgkin - enzymology | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Diarrhea - chemically induced | Protein-Tyrosine Kinases - physiology | Pyridines - adverse effects | Antineoplastic Agents - adverse effects | Hypertension - chemically induced | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacology | Oxazines - administration & dosage | Syk Kinase | Lymphoma, Non-Hodgkin - drug therapy | Oxazines - pharmacology | Pyridines - therapeutic use | Hematologic Diseases - chemically induced | Pyridines - administration & dosage | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Treatment Outcome | Oxazines - adverse effects | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Oxazines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Aged | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Intracellular Signaling Peptides and Proteins - physiology | Cohort Studies | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus | Clinical Trials and Observations
Journal Article
Nature Communications, ISSN 2041-1723, 12/2015, Volume 6, Issue 1, p. 8866
Patients with chromosome 13q deletion or normal cytogenetics represent the majority of chronic lymphocytic leukaemia (CLL) cases, yet have relatively few... 
B-CELLS | MUTATIONAL PROCESSES | SOMATIC HYPERMUTATION | CLUSTERED MUTATIONS | GENE | RNA | DNA | MULTIDISCIPLINARY SCIENCES | AID | CANCER | EXPRESSION
Journal Article
The Lancet Oncology, ISSN 1470-2045, 01/2018, Volume 19, Issue 1, pp. 65 - 75
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 24, pp. 3583 - 3586
Chronic lymphocytic leukemia (CLL) displays constitutive phosphatidylinositol 3-kinase (PI3K) activation resulting from aberrant regulation of B-cell receptor... 
IBRUTINIB | MODELS | INHIBITOR | HEMATOLOGY | THERAPEUTIC TARGET | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | T-Lymphocytes - enzymology | Class Ib Phosphatidylinositol 3-Kinase - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Cell Survival - genetics | Male | Neoplasm Proteins - antagonists & inhibitors | Killer Cells, Natural - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Mutation, Missense | Neoplasm Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Isoquinolines - pharmacology | Female | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Pyrazoles - pharmacology | Cell Survival - drug effects | B-Lymphocytes - enzymology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Signal Transduction - genetics | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Killer Cells, Natural - enzymology | Drug Resistance, Neoplasm - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Lymphoid Neoplasia | Brief Report
Journal Article
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 5, pp. 1029 - 1037
Antigenic stimulation through the B-cell antigen receptor (BCR) is considered to promote the expansion of chronic lymphocytic leukemia (CLL) B cells. The... 
SURFACE IGM | APOPTOSIS | CLL | NURSELIKE CELLS | SYK | CHEMOKINE RECEPTOR | LYMPHOMA | GENE MUTATIONAL STATUS | CD38 EXPRESSION | HEMATOLOGY | MARROW STROMAL CELLS | Chemokine CCL3 - secretion | Chemokine CCL4 - secretion | Cell Adhesion Molecules - genetics | Coculture Techniques | Humans | Middle Aged | Neoplasm Proteins - physiology | Male | Neoplasm Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - physiology | Chemotaxis - physiology | Neoplasm Proteins - secretion | Protein Processing, Post-Translational - drug effects | Receptors, Chemokine - biosynthesis | Aged, 80 and over | Adult | Female | Receptors, Antigen, B-Cell - physiology | Antineoplastic Agents - pharmacology | Receptors, Chemokine - genetics | Syk Kinase | Cell Survival - physiology | Oxazines - pharmacology | Cell Survival - drug effects | Cell Adhesion Molecules - biosynthesis | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Chemotaxis - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Animals | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Aged | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Intracellular Signaling Peptides and Proteins - physiology | Stromal Cells - physiology | Drug Screening Assays, Antitumor | Protein-Tyrosine Kinases - antagonists & inhibitors | Lymphoid Neoplasia
Journal Article
Journal Article
Blood, ISSN 0006-4971, 11/2005, Volume 106, Issue 10, pp. 3377 - 3379
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 38, pp. 13906 - 13911
The Bruton tyrosine kinase inhibitor (BTKi) ibrutinib is a new targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib is given orally... 
Disease resistance | Chronic lymphocytic leukemia | Relapse | Cell growth | B lymphocytes | Mortality | Population size | Genetic mutation | Blood | Tumors | Mathematical models | Stochastic dynamics | Drug resistance | Personalized medicine | Evolutionary dynamics | B-CELL RECEPTOR | MULTIDISCIPLINARY SCIENCES | evolutionary dynamics | mathematical models | TISSUE | PCI-32765 | MECHANISMS | KINASE INHIBITOR IBRUTINIB | TARGETING BTK | CANCER | personalized medicine | stochastic dynamics | THERAPY | IN-VIVO | MUTATION | drug resistance | Prognosis | Protein-Tyrosine Kinases - metabolism | Pyrimidines - administration & dosage | Humans | Neoplasm Proteins - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Neoplasm Proteins - metabolism | Drug Resistance, Neoplasm - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Protein-Tyrosine Kinases - genetics | Pyrazoles - administration & dosage | Models, Biological | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mutation | Neoplasm Proteins - genetics | Drug Resistance, Neoplasm - drug effects | Evolution, Molecular | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Protein-Tyrosine Kinases - antagonists & inhibitors | Pharmaceutical research | Care and treatment | Drug interactions | Oncology, Experimental | Research | Drug therapy | Cancer | Biological Sciences
Journal Article