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1. Full Text B cell receptor signaling in chronic lymphocytic leukemia
by Burger, Jan A and Chiorazzi, Nicholas
Trends in Immunology, ISSN 1471-4906, 2013, Volume 34, Issue 12, pp. 592 - 601
Highlights • In CLL, the BCR is activated by antigens in the tissue microenvironment. • CLL BCRs can recognize autoantigens, microbial antigens, and intrinsic... 
Allergy and Immunology | microenvironment | phosphoinositide 3-kinase δ | chronic lymphocytic leukemia | spleen tyrosine kinase | B cell receptor | Bruton's tyrosine kinase | Chronic lymphocytic leukemia | Spleen tyrosine kinase | Microenvironment | Phosphoinositide 3-kinase δ | BRUTONS TYROSINE KINASE | THERAPEUTIC TARGET | CHEMOKINE RECEPTOR | NON-HODGKIN-LYMPHOMA | ZAP-70 EXPRESSION | KAPPA-B | IMMUNOLOGY | ANTIGEN RECEPTOR | GENE MUTATION STATUS | T-CELLS | DISEASE PROGRESSION | Signal Transduction - immunology | Lymphocyte Activation - immunology | Animals | Humans | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Receptors, Antigen, B-Cell - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Receptors, Antigen, B-Cell - immunology | Autoimmunity | Autoantigens | Antigens | Lymphomas | Mutation | Kinases | Leukemia | BTK | Chronic lymphocytic leukemia (CLL) | SYK | B cell receptor (BCR) | PI3δ
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2. Full Text Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
by Porter, David L and Hwang, Wei-Ting and Frey, Noelle V and Lacey, Simon F and Shaw, Pamela A and Loren, Alison W and Bagg, Adam and Marcucci, Katherine T and Shen, Angela and Gonzalez, Vanessa and Ambrose, David and Grupp, Stephan A and Chew, Anne and Zheng, Zhaohui and Milone, Michael C and Levine, Bruce L and Melenhorst, Jan J and June, Carl H
Science Translational Medicine, ISSN 1946-6234, 09/2015, Volume 7, Issue 303, pp. 303ra139 - 303ra139
Patients with multiply relapsed or refractory chronic lymphocytic leukemia (CLL) have a poor prognosis. Chimeric antigen receptor (CAR)-modified T cells... 
MEDICINE, RESEARCH & EXPERIMENTAL | DIAGNOSIS | GENE | CYTOKINE RELEASE SYNDROME | LENTIVIRAL VECTOR | IN-VIVO | NON-HODGKIN-LYMPHOMA | BLINATUMOMAB | CANCER | ADOPTIVE IMMUNOTHERAPY | TRANSPLANTATION | CELL BIOLOGY | Cytokines - metabolism | Humans | Middle Aged | Male | Remission Induction | Macrophage Activation | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Immunotherapy | Female | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Index Medicus
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3. Full Text B-cell receptor signaling in chronic lymphocytic leukemia
by Stevenson, Freda K and Krysov, Sergey and Davies, Andrew J and Steele, Andrew J and Packham, Graham
Blood, ISSN 0006-4971, 10/2011, Volume 118, Issue 16, pp. 4313 - 4320
The B-cell receptor (BCR) is a key survival molecule for normal B cells and for most B-cell malignancies. Recombinatorial and mutational patterns in the clonal... 
PROMISING THERAPEUTIC TARGET | HUMAN FOLLICULAR LYMPHOMA | TYROSINE KINASE | ANTIGEN-RECEPTOR | FOSTAMATINIB DISODIUM | GENE MUTATIONAL STATUS | CD38 EXPRESSION | ZAP-70 EXPRESSION | HEMATOLOGY | AUTOIMMUNE-DISEASE | LYN-DEFICIENT MICE | Humans | Immunologic Factors - immunology | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Receptors, Antigen, B-Cell - antagonists & inhibitors | Gene Expression Regulation, Leukemic | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Immunologic Factors - genetics | Receptors, Antigen, B-Cell - immunology | Immunologic Factors - antagonists & inhibitors | Signal Transduction - drug effects | Receptors, Antigen, B-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Leukemia, Lymphocytic, Chronic, B-Cell - immunology
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4. Full Text Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia
by Rawstron, Andy C and Bennett, Fiona L and O'Connor, Sheila J.M and Kwok, Marwan and Fenton, James A.L and Plummer, Marieth and de Tute, Ruth and Owen, Roger G and Richards, Stephen J and Jack, Andrew S and Hillmen, Peter
The New England Journal of Medicine, ISSN 0028-4793, 08/2008, Volume 359, Issue 6, pp. 575 - 583
Small numbers of monoclonal B cells with the phenotype of chronic lymphocytic leukemia (CLL) were detected by means of high-sensitivity flow cytometry in about... 
DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | FREQUENT | CLL | EXPANSIONS | GUIDELINES | RECEPTORS | EXPRESSION | GENE MUTATION STATUS | PROGRESSION | BLOOD | Prognosis | Age Factors | Humans | Middle Aged | Male | Reference Values | DNA Mutational Analysis | Aged, 80 and over | Germ-Line Mutation | Female | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Kaplan-Meier Estimate | Genetic Markers | Disease Progression | Genes, Immunoglobulin | Phenotype | B-Lymphocytes - immunology | Lymphocytosis - immunology | Precancerous Conditions - immunology | Lymphocyte Count | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Hemoglobins - analysis | Immunoglobulin Heavy Chains - genetics | Cohort Studies | Causes of | Chronic lymphocytic leukemia | Care and treatment | Diagnosis | Lymphocytosis | Risk factors | Flow cytometry | Genotype & phenotype | Leukemia | Cancer | Teaching hospitals
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5. Chronic lymphocytic leukemia
by Caligaris-Cappio, Federico and Dalla-Favera, R
2005, Current topics in microbiology and immunology, ISBN 3540252797, Volume 294., vi, 189
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of... 
Lymphocytic leukemia | Hematology | Cancer Research | Biomedicine
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6. Full Text Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed After allogeneic stem cell transplant: A phase 1 study
by Cruz, Conrad Russell Y and Micklethwaite, Kenneth P and Savoldo, Barbara and Ramos, Carlos A and Lam, Sharon and Ku, Stephanie and Diouf, Oumar and Liu, Enli and Barrett, A. John and Ito, Sawa and Shpall, Elizabeth J and Krance, Robert A and Kamble, Rammurti T and Carrum, George and Hosing, Chitra M and Gee, Adrian P and Mei, Zhuyong and Grilley, Bambi J and Heslop, Helen E and Rooney, Cliona M and Brenner, Malcolm K and Bollard, Catherine M and Dotti, Gianpietro
Blood, ISSN 0006-4971, 10/2013, Volume 122, Issue 17, pp. 2965 - 2973
Autologous T cells expressing a CD19-specific chimeric antigen receptor (CD19.CAR) are active against B-cellmalignancies, but it is unknown whether allogeneic... 
PERSISTENCE | ACUTE LYMPHOCYTIC-LEUKEMIA | LYMPHOMA | PERIPHERAL-BLOOD | INFECTION | CHIMERIC ANTIGEN RECEPTOR | ANTITUMOR-ACTIVITY | RECIPIENTS | HEMATOLOGY | RECONSTITUTION | ADOPTIVE IMMUNOTHERAPY | Recurrence | Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | Humans | Middle Aged | Male | Antigens, CD19 - genetics | Antineoplastic Agents - therapeutic use | T-Lymphocytes - transplantation | T-Lymphocytes - virology | Transplantation, Homologous | Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy | Protein Engineering | Adult | Female | B-Lymphocytes - pathology | Adenoviridae - immunology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Child | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Antigens, CD19 - immunology | Gene Expression | Herpesvirus 4, Human - immunology | Hematopoietic Stem Cell Transplantation | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Cytomegalovirus - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | B-Lymphocytes - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - virology | T-Lymphocytes - immunology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - virology | Clinical Trials and Observations
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7. Full Text Durable molecular remissions in chronic lymphocytic leukemia treated with CD19-Specific chimeric antigen Receptor-modified T cells after failure of ibrutinib
by Turtle, Cameron J and Hay, Kevin A and Hanafi, Laïla-Aïcha and Li, Daniel and Cherian, Sindhu and Chen, Xueyan and Wood, Brent and Lozanski, Arletta and Byrd, John C and Heimfeld, Shelly and Riddell, Stanley R and Maloney, David G
Journal of Clinical Oncology, ISSN 0732-183X, 09/2017, Volume 35, Issue 26, pp. 3010 - 3020
Purpose We evaluated the safety and feasibility of anti-CD19 chimeric antigen receptor-modified T (CAR-T) cell therapy in patients with chronic lymphocytic... 
LUGANO CLASSIFICATION | SUSTAINED REMISSIONS | TRIAL | THERAPY | B-CELL | RESPONSE CRITERIA | ONCOLOGY | RESISTANCE | LYMPHOMA | OPEN-LABEL | OUTCOMES | Immunotherapy, Adoptive - adverse effects | Immunotherapy, Adoptive - methods | Pyrimidines - administration & dosage | Humans | Middle Aged | Remission Induction | T-Lymphocytes - transplantation | Disease-Free Survival | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Pyrazoles - administration & dosage | Pyrimidines - adverse effects | Adult | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Aged | Leukapheresis - methods | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Lymphocyte Depletion - methods | Antigens, CD19 - immunology | Pyrazoles - adverse effects | Index Medicus | Translational Oncology | ORIGINAL REPORTS | Biological Therapy
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8. Full Text Chronic Lymphocytic Leukemia
by Chiorazzi, Nicholas and Rai, Kanti R and Ferrarini, Manlio
The New England Journal of Medicine, ISSN 0028-4793, 02/2005, Volume 352, Issue 8, pp. 804 - 815
Our concept of the pathogenesis of chronic lymphocytic leukemia has undergone remarkable changes during the past decade. This review addresses the latest ideas... 
T-Lymphocytes - physiology | Prognosis | Signal Transduction | Lymphocyte Activation | Humans | B-Lymphocytes - physiology | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Cell Transformation, Neoplastic | Leukemia, Lymphocytic, Chronic, B-Cell - physiopathology | Receptors, Antigen, B-Cell - chemistry | Mutation | Neoplasm Staging | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Lymphocytic leukemia | Chronic lymphocytic leukemia | Research
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9. Full Text Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
by Minden, Marcus Dühren-Von and Übelhart, Rudolf and Schneider, Dunja and Wossning, Thomas and Bach, Martina P and Buchner, Maike and Hofmann, Daniel and Surova, Elena and Follo, Marie and Köhler, Fabian and Wardemann, Hedda and Zirlik, Katja and Veelken, Hendrik and Jumaa, Hassan
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7415, pp. 309 - 312
B-cell antigen receptor (BCR) expression is an important feature of chronic lymphocytic leukaemia (CLL), one of the most prevalent B-cell neoplasias in Western... 
B-CELLS | INHIBITION | SYK | CLONING | MULTIDISCIPLINARY SCIENCES | FOSTAMATINIB DISODIUM | RECEPTOR | LYMPHOMA | PROLIFERATION | PRECURSORS | EXPRESSION | Autoantigens - metabolism | Signal Transduction | Humans | Epitopes, B-Lymphocyte - immunology | Receptors, Antigen, B-Cell - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Receptors, Antigen, B-Cell - immunology | Amino Acid Motifs | Autoantigens - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Epitopes, B-Lymphocyte - metabolism | Complementarity Determining Regions - immunology | Complementarity Determining Regions - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Calcium Signaling | Leukemia | Research | Antigenic determinants | Ligands | Lymphomas | Kinases | Pathogenesis
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10. Full Text B-Cell Clones as Early Markers for Chronic Lymphocytic Leukemia
by Landgren, Ola and Albitar, Maher and Ma, Wanlong and Abbasi, Fatima and Hayes, Richard B and Ghia, Paolo and Marti, Gerald E and Caporaso, Neil E
The New England Journal of Medicine, ISSN 0028-4793, 02/2009, Volume 360, Issue 7, pp. 659 - 667
Monoclonal B-cell lymphocytosis (MBL), the presence in the blood of monoclonal B cells in numbers below 5000 per cubic millimeter with no other features of a... 
MEDICINE, GENERAL & INTERNAL | CLL | HODGKINS-DISEASE | MBL | IMMUNOGLOBULIN | CLASSIFICATION | RECEPTOR | NATURAL-HISTORY | EXPRESSION | MUTATIONAL STATUS | BLOOD | Immunoglobulin Light Chains - immunology | Humans | Middle Aged | Male | Reverse Transcriptase Polymerase Chain Reaction | Biomarkers, Tumor - blood | B-Lymphocytes - immunology | Flow Cytometry | RNA, Messenger - blood | Gene Rearrangement, B-Lymphocyte, Heavy Chain | Lymphocyte Count | Female | Leukemia, Lymphocytic, Chronic, B-Cell - blood | Aged | Clone Cells | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Immunoglobulin Heavy Chains - genetics | Antigens, CD | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Chronic lymphocytic leukemia | Usage | Monoclonal antibodies | Genetic aspects | Diagnosis | Research | Lymphocytosis | Health aspects | Risk factors | Population | Medical screening | Prostate cancer | Cloning | Mortality | Ovarian cancer
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