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Cancer Cell, ISSN 1535-6108, 2009, Volume 16, Issue 5, pp. 401 - 412
Inhibition of BCR-ABL by imatinib induces durable responses in many patients with chronic myeloid leukemia (CML), but resistance attributable to kinase domain... 
CHEMBIO | HUMDISEASE | CHRONIC MYELOGENOUS LEUKEMIA | DASATINIB BMS-354825 | MESYLATE | CML | ONCOLOGY | KINASE DOMAIN MUTATIONS | AMN107 | IMATINIB RESISTANCE | NILOTINIB | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Imidazoles - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Crystallography, X-Ray | Pyridazines - pharmacology | Protein Kinase Inhibitors - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Antineoplastic Agents - pharmacology | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Proto-Oncogene Proteins c-abl - genetics | Cell Growth Processes - drug effects | Proto-Oncogene Proteins c-abl - chemistry | Models, Molecular | Imidazoles - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Pyridazines - chemistry | Fusion Proteins, bcr-abl - genetics | Animals | Signal Transduction - drug effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-abl - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Fusion Proteins, bcr-abl - metabolism | Chronic myeloid leukemia | BCR protein | Imatinib | Mutagenesis | Abl protein | Mutation | Fusion protein | Tumors | Index Medicus | imatinib resistance | dasatinib | nilotinib | compound mutation
Journal Article
Blood, ISSN 0006-4971, 02/2012, Volume 119, Issue 6, pp. 1501 - 1510
Recent evidence suggests chronic myeloid leukemia (CML) stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated... 
CHRONIC MYELOGENOUS LEUKEMIA | SELECTIVE INHIBITOR | POSITIVE CELLS | COLONY-STIMULATING FACTOR | TYROSINE KINASE | PHILADELPHIA-CHROMOSOME | ACUTE LYMPHOBLASTIC-LEUKEMIA | RESIDUAL DISEASE | HEMATOLOGY | HEMATOPOIETIC PROGENITORS | IMATINIB MESYLATE | Antigens, CD34 - metabolism | Apoptosis - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Dose-Response Relationship, Drug | STAT5 Transcription Factor - metabolism | Flow Cytometry | Neoplastic Stem Cells - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | HEK293 Cells | Neoplastic Stem Cells - pathology | Cell Survival - drug effects | Dasatinib | Mice, Transgenic | Nuclear Proteins - metabolism | Gene Expression Regulation, Leukemic | Pyrimidines - pharmacology | Gene Knockout Techniques | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Fusion Proteins, bcr-abl - genetics | Animals | Fusion Proteins, bcr-abl - antagonists & inhibitors | K562 Cells | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Fusion Proteins, bcr-abl - metabolism | Index Medicus | Abridged Index Medicus | Myeloid Neoplasia
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 396 - 409
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 14, Issue 3, pp. 238 - 249
Resistance of Bcr-Abl-positive leukemic stem cells (LSCs) to imatinib treatment in patients with chronic myeloid leukemia (CML) can cause relapse of disease... 
STEMCELL | CELLCYCLE | CHRONIC MYELOGENOUS LEUKEMIA | HEMATOPOIETIC-CELLS | MOLECULAR REMISSION | ONCOLOGY | SONIC HEDGEHOG | SIGNALING PATHWAY | PHILADELPHIA-CHROMOSOME | NEURAL-TUBE | IMATINIB MESYLATE DISCONTINUATION | MICE | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | Cell Proliferation | Fetal Stem Cells - cytology | Gene Expression - drug effects | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Fetal Stem Cells - metabolism | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Hedgehog Proteins - physiology | Hematopoiesis - drug effects | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Smoothened Receptor | Bone Marrow Transplantation | Veratrum Alkaloids - pharmacology | Neoplastic Stem Cells - pathology | Bone Marrow Cells - drug effects | Hematopoiesis - physiology | Patched Receptors | Drug Therapy, Combination | Veratrum Alkaloids - therapeutic use | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Receptors, Cell Surface - metabolism | Mice, Transgenic | Pyrimidines - pharmacology | Mice, Knockout | Fusion Proteins, bcr-abl - genetics | Animals | Signal Transduction - drug effects | Pyrimidines - therapeutic use | Survival Analysis | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Signal Transduction - physiology | Fetal Stem Cells - transplantation | Mice | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Bone Marrow Cells - metabolism | Fusion Proteins, bcr-abl - metabolism | Receptors, Cell Surface - genetics | Genetic research | Flexible response (Strategy) | Drug resistance | Deterrence (Strategy) | Leukemia | Stem cells | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 02/2012, Volume 119, Issue 8, pp. 1904 - 1914
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2001, Volume 344, Issue 14, pp. 1031 - 1037
Chronic myeloid leukemia (CML) is a clonal disorder in which cells of the myeloid lineage undergo massive clonal expansion. The disease progresses through... 
CHRONIC MYELOGENOUS LEUKEMIA | TRANSFORMATION | MEDICINE, GENERAL & INTERNAL | POSITIVE CELLS | PROTEIN | BCR/ABL | GROWTH | NEUTROPHILS | MICE | INDUCTION | CRKL | Piperazines - administration & dosage | Recurrence | Phosphorylation | Protein-Tyrosine Kinases - metabolism | Humans | Middle Aged | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Male | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Enzyme Inhibitors - pharmacokinetics | Antineoplastic Agents - adverse effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Adult | Female | Remission Induction - methods | Antineoplastic Agents - pharmacokinetics | Piperazines - pharmacokinetics | Enzyme Inhibitors - adverse effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood | Pyrimidines - administration & dosage | Interferon-alpha - therapeutic use | Imatinib Mesylate | Piperazines - adverse effects | Blood Cell Count | Fusion Proteins, bcr-abl - antagonists & inhibitors | Pyrimidines - adverse effects | Pyrimidines - pharmacokinetics | Aged | Benzamides | Fusion Proteins, bcr-abl - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Care and treatment | Chronic myeloid leukemia | Proteins | Bone marrow | Interferon | Transplants & implants | Drug therapy | Index Medicus | Abridged Index Medicus
Journal Article