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Cancer Cell, ISSN 1535-6108, 2009, Volume 16, Issue 5, pp. 401 - 412
Inhibition of BCR-ABL by imatinib induces durable responses in many patients with chronic myeloid leukemia (CML), but resistance attributable to kinase domain... 
CHEMBIO | HUMDISEASE | CHRONIC MYELOGENOUS LEUKEMIA | DASATINIB BMS-354825 | MESYLATE | CML | ONCOLOGY | KINASE DOMAIN MUTATIONS | AMN107 | IMATINIB RESISTANCE | NILOTINIB | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Imidazoles - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Crystallography, X-Ray | Pyridazines - pharmacology | Protein Kinase Inhibitors - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Antineoplastic Agents - pharmacology | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Proto-Oncogene Proteins c-abl - genetics | Cell Growth Processes - drug effects | Proto-Oncogene Proteins c-abl - chemistry | Models, Molecular | Imidazoles - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Pyridazines - chemistry | Fusion Proteins, bcr-abl - genetics | Animals | Signal Transduction - drug effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-abl - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Fusion Proteins, bcr-abl - metabolism | Chronic myeloid leukemia | BCR protein | Imatinib | Mutagenesis | Abl protein | Mutation | Fusion protein | Tumors | Index Medicus | imatinib resistance | dasatinib | nilotinib | compound mutation
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 396 - 409
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2009, Volume 27, Issue 25, pp. 4204 - 4210
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 14, Issue 3, pp. 238 - 249
Resistance of Bcr-Abl-positive leukemic stem cells (LSCs) to imatinib treatment in patients with chronic myeloid leukemia (CML) can cause relapse of disease... 
STEMCELL | CELLCYCLE | CHRONIC MYELOGENOUS LEUKEMIA | HEMATOPOIETIC-CELLS | MOLECULAR REMISSION | ONCOLOGY | SONIC HEDGEHOG | SIGNALING PATHWAY | PHILADELPHIA-CHROMOSOME | NEURAL-TUBE | IMATINIB MESYLATE DISCONTINUATION | MICE | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | Cell Proliferation | Fetal Stem Cells - cytology | Gene Expression - drug effects | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Fetal Stem Cells - metabolism | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Hedgehog Proteins - physiology | Hematopoiesis - drug effects | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Smoothened Receptor | Bone Marrow Transplantation | Veratrum Alkaloids - pharmacology | Neoplastic Stem Cells - pathology | Bone Marrow Cells - drug effects | Hematopoiesis - physiology | Patched Receptors | Drug Therapy, Combination | Veratrum Alkaloids - therapeutic use | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Receptors, Cell Surface - metabolism | Mice, Transgenic | Pyrimidines - pharmacology | Mice, Knockout | Fusion Proteins, bcr-abl - genetics | Animals | Signal Transduction - drug effects | Pyrimidines - therapeutic use | Survival Analysis | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Signal Transduction - physiology | Fetal Stem Cells - transplantation | Mice | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Bone Marrow Cells - metabolism | Fusion Proteins, bcr-abl - metabolism | Receptors, Cell Surface - genetics | Genetic research | Flexible response (Strategy) | Drug resistance | Deterrence (Strategy) | Leukemia | Stem cells | Index Medicus
Journal Article
Journal Article
Blood, ISSN 0006-4971, 03/2016, Volume 127, Issue 10, pp. 1269 - 1275
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 03/2012, Volume 8, Issue 3, pp. 285 - 293
Journal Article
Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7280, pp. 501 - 506
In an effort to find new pharmacological modalities to overcome resistance to ATP-binding-site inhibitors of Bcr-Abl, we recently reported the discovery of... 
CELL LUNG-CANCER | KINASE-INHIBITOR | SELECTIVE INHIBITOR | C-ABL | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | DYNAMICS | MUTATIONS | LYMPHOBLASTIC-LEUKEMIA | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Male | Transplantation, Heterologous | Piperazines - chemistry | Pyrimidines - chemistry | Pyrimidines - metabolism | Antineoplastic Agents - metabolism | Mass Spectrometry | Bone Marrow Transplantation | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Binding Sites | Disease Models, Animal | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Crystallization | Antineoplastic Combined Chemotherapy Protocols | Models, Molecular | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Mutation - genetics | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - genetics | Animals | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Benzamides | Fusion Proteins, bcr-abl - metabolism | Drug Resistance, Neoplasm - drug effects | Nilotinib | Dasatinib | Drug resistance in microorganisms | Usage | Nuclear magnetic resonance spectroscopy | Research | Chronic myeloid leukemia | X-ray crystallography | Chromosome abnormalities | Gene mutations | Analysis | Genetic aspects | Diagnosis | Binding proteins | Drug therapy | Health aspects | Proteins | Studies | Competition | Enzymes | E coli | Kinases | Drug resistance | Crystal structure | Index Medicus
Journal Article