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Blood, ISSN 0006-4971, 06/2012, Volume 119, Issue 22, pp. 5133 - 5143
Internal tandem duplication (ITD) of the fms-related tyrosine kinase-3 (FLT3) gene occurs in 30% of acute myeloid leukemias (AMLs) and confers a poor... 
FLT3 TYROSINE KINASE | INTERNAL TANDEM DUPLICATION | ADULT PATIENTS | ACTIVATING MUTATION | INHIBITOR PKC412 | ALDEHYDE DEHYDROGENASE-ACTIVITY | ACUTE MYELOGENOUS LEUKEMIA | TISSUE INHIBITOR | RISK MYELODYSPLASTIC SYNDROME | PROGNOSTIC-SIGNIFICANCE | HEMATOLOGY | Niacinamide - analogs & derivatives | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Neoplasm Transplantation | Humans | Middle Aged | Aldehyde Dehydrogenase - biosynthesis | Matrix Metalloproteinase 15 - genetics | Male | Transplantation, Heterologous | Bone Marrow - enzymology | Gene Expression Profiling | Phenylurea Compounds | Antineoplastic Agents - administration & dosage | Benzenesulfonates - administration & dosage | Benzenesulfonates - adverse effects | Janus Kinase 3 - biosynthesis | fms-Like Tyrosine Kinase 3 - genetics | Leukemia, Myeloid, Acute - enzymology | Pyridines - adverse effects | Time Factors | Antineoplastic Agents - adverse effects | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Protein Structure, Tertiary | Pyridines - administration & dosage | Leukemia, Myeloid, Acute - pathology | Aldehyde Dehydrogenase - genetics | Gene Expression Regulation, Leukemic | Mice, SCID | fms-Like Tyrosine Kinase 3 - metabolism | Matrix Metalloproteinase 15 - biosynthesis | Drug Resistance, Neoplasm - genetics | Animals | Bone Marrow - pathology | Janus Kinase 3 - genetics | Mice, Inbred NOD | Mice | Mutation | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 11/2015, Volume 11, Issue 11, pp. 878 - 886
Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are driver mutations in acute myeloid leukemia (AML) and other cancers. We report the development of... 
ISOCITRATE DEHYDROGENASE 1 | SELECTIVE-INHIBITION | PROGENITOR CELLS | DNA METHYLATION | SMALL-MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLINICAL-IMPLICATIONS | KINASE INHIBITORS | CELL-DIFFERENTIATION | MYELODYSPLASTIC SYNDROMES | ACUTE PROMYELOCYTIC LEUKEMIA | Neoplastic Stem Cells - drug effects | Allosteric Regulation | Humans | Crystallography, X-Ray | Male | Isocitrate Dehydrogenase - antagonists & inhibitors | Dose-Response Relationship, Drug | Leukemia, Myeloid, Acute - enzymology | Pyrazoles - chemistry | Enzyme Inhibitors - pharmacokinetics | Granulocytes - drug effects | Cytosine - metabolism | Dihydropyridines - pharmacokinetics | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Granulocytes - pathology | Pyrazoles - pharmacokinetics | Pyrazoles - pharmacology | Dihydropyridines - chemistry | Leukemia, Myeloid, Acute - pathology | Enzyme Inhibitors - pharmacology | Models, Molecular | Isocitrate Dehydrogenase - genetics | Cytosine - chemistry | Granulocytes - enzymology | Xenograft Model Antitumor Assays | Animals | Cell Differentiation - drug effects | Isocitrate Dehydrogenase - chemistry | Allosteric Site | Cell Line, Tumor | CpG Islands | Dihydropyridines - pharmacology | Protein Binding | Isocitrate Dehydrogenase - metabolism | Mice | Kinetics | Mutation | Primary Cell Culture | DNA Methylation - drug effects | Neoplastic Stem Cells - enzymology | Leukemia, Myeloid, Acute - genetics | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 2013, Volume 122, Issue 22, pp. 3607 - 3615
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2015, Volume 27, Issue 6, pp. 864 - 876
Journal Article
Journal Article
Blood, ISSN 0006-4971, 02/2014, Volume 123, Issue 6, pp. 905 - 913
Journal Article
Leukemia, ISSN 0887-6924, 07/2011, Volume 25, Issue 7, pp. 1153 - 1158
Journal Article
Journal Article