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Blood, ISSN 1528-0020, 2013, Volume 122, Issue 20, pp. 3461 - 3472
T cells genetically targeted to the tumor-promoting antigen CD44v6 are effective against AML and MM. CD44v6-targeted T cells do not recognize hematopoietic... 
ADVERSE EVENT | CLINICAL-TRIAL | CHIMERIC-ANTIGEN-RECEPTOR | BONE-MARROW | GENE-THERAPY | HEMATOLOGY | VERSUS-HOST-DISEASE | PHASE-I | ADOPTIVE IMMUNOTHERAPY | DONOR LYMPHOCYTES | SAFETY SWITCH | Graft vs Host Disease - therapy | Recombinant Fusion Proteins - immunology | T-Lymphocyte Subsets - immunology | Neoplasm Transplantation | Humans | Interleukin-7 - pharmacology | Multiple Myeloma - immunology | Cell Line, Tumor - transplantation | Leukemia, Myeloid, Acute - immunology | Molecular Targeted Therapy | Interleukin-15 - immunology | Multiple Myeloma - therapy | Leukemia, Myelomonocytic, Acute - therapy | Leukemia, Myeloid, Acute - therapy | Protein Structure, Tertiary | Antigens, Neoplasm - genetics | Genes, Transgenic, Suicide | Immunotherapy, Adoptive | Antigens, Neoplasm - immunology | Leukemia, Myeloid, Acute - pathology | Lymphocyte Activation | RNA, Small Interfering - pharmacology | CD28 Antigens - immunology | Hyaluronan Receptors - genetics | Xenograft Model Antitumor Assays | Interleukin-15 - pharmacology | Multiple Myeloma - pathology | Animals | Interleukin-7 - immunology | Leukemia, Myelomonocytic, Acute - pathology | Cell Line, Tumor - immunology | CD3 Complex - immunology | Leukemia, Myelomonocytic, Acute - immunology | T-Cell Antigen Receptor Specificity | Hyaluronan Receptors - immunology | Mice | Cytotoxicity, Immunologic | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 31, pp. 13824 - 13829
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 12, p. e0166891
Background Approximately fifty percent of patients with acute myeloid leukemia can be cured with current therapeutic strategies which include, standard dose chemotherapy for patients at standard risk... 
GEMTUZUMAB OZOGAMICIN | PHARMACOKINETICS | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | IMMUNOGLOBULIN | DEATH | ON-TARGET | CASPASE-9 | INDUCED KILLER-CELLS | SAFETY SWITCH | LYMPHOCYTES | Recombinant Fusion Proteins - immunology | Cyclophosphamide - analogs & derivatives | Caspase 9 - genetics | Humans | Sialic Acid Binding Ig-like Lectin 3 - immunology | Leukemia, Myeloid, Acute - immunology | Cellular Reprogramming | Biphenyl Compounds - pharmacology | Lysosomal-Associated Membrane Protein 1 - genetics | Nitrophenols - pharmacology | Myeloid Cells - immunology | T-Lymphocytes - drug effects | Lysosomal-Associated Membrane Protein 1 - immunology | Tumor Necrosis Factor-alpha - immunology | Myeloid Cells - drug effects | Receptors, Antigen, T-Cell - immunology | Leukemia, Myeloid, Acute - therapy | Sialic Acid Binding Ig-like Lectin 3 - genetics | Leukemia, Myeloid, Acute - pathology | Clinical Trials as Topic | Sulfonamides - pharmacology | Piperazines - pharmacology | Caspase 9 - immunology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | T-Lymphocytes - cytology | B7-H1 Antigen - pharmacology | Cyclophosphamide - pharmacology | Interferon-gamma - immunology | Sialic Acid Binding Ig-like Lectin 3 - antagonists & inhibitors | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Cell Engineering | T-Lymphocytes - immunology | Cell Proliferation - drug effects | Receptors, Antigen, T-Cell - genetics | Myeloid Cells - pathology | Primary Cell Culture | Genetic Vectors | Tumor Necrosis Factor-alpha - biosynthesis | Interferon-gamma - biosynthesis | Cytotoxicity, Immunologic | Leukemia, Myeloid, Acute - genetics | Usage | Transplantation | Research | T cells | Immunotherapy | Stem cells | Transplants & implants | Bcl-2 protein | Leukemia | Mental health | Oncology | Standard error | Lymphocytes T | Suicide | Hematopoietic stem cells | Infusion | Immunology | Granulocytes | Lymphocytes | Drug dosages | Genetic modification | Suicide genes | Antigens | Cytokines | Risk groups | Hematology | Myeloid leukemia | Safety measures | Risk reduction | T cell receptors | Tumor necrosis factor-α | Patients | Hemopoiesis | Studies | Chemotherapy | Inhibitors | γ-Interferon | Degranulation | Antitumor activity | Ligands | Interferon | Gene therapy | Acute myeloid leukemia | Cancer | Apoptosis
Journal Article
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2019, Volume 129, Issue 2, pp. 774 - 785
The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the nucleophosmin 1 (NPM1) gene. Mutated NPM1 (Delta NPM1... 
MULTIPLE-MYELOMA | MEDICINE, RESEARCH & EXPERIMENTAL | B-CELL | TUMOR-ANTIGENS | CLASS-II EPITOPES | IMMUNE-RESPONSES | RECEPTOR | MUTATIONS | IDENTIFICATION | T-CELLS | PEPTIDE | HLA-A2 Antigen - genetics | CD8-Positive T-Lymphocytes - pathology | Humans | Neoplasm Proteins - immunology | Peptides - genetics | Male | Adoptive Transfer | Leukemia, Myeloid, Acute - immunology | CD4-Positive T-Lymphocytes - pathology | CD4-Positive T-Lymphocytes - immunology | Female | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Leukemia, Myeloid, Acute - therapy | Transduction, Genetic | HLA-A2 Antigen - immunology | Leukemia, Myeloid, Acute - pathology | Peptides - immunology | Mice, SCID | Nuclear Proteins - immunology | Xenograft Model Antitumor Assays | Animals | Mice, Inbred NOD | Mice | Mutation | CD8-Positive T-Lymphocytes - immunology | Leukemia, Myeloid, Acute - genetics | Usage | Transplantation | Research | Cell differentiation | Immunotherapy | Hematopoietic stem cells | Peptides | CD8 antigen | Leukemia | Multiple myeloma | Lymphocytes T | Genomes | Cancer therapies | Proteins | T-cell receptor | Lymphocytes | Bone marrow | Antigens | Gene transfer | Myeloid leukemia | Immunodeficiency | T cell receptors | Patients | CD4 antigen | Reading | Chemotherapy | Lysis | Antitumor activity | Ligands | Histocompatibility antigen HLA | Gene therapy | Acute myeloid leukemia
Journal Article
Journal Article
Journal Article
Blood, ISSN 1528-0020, 2011, Volume 117, Issue 17, pp. 4501 - 4510
Journal Article
Blood, ISSN 1528-0020, 2017, Volume 129, Issue 17, pp. 2395 - 2407
Depletion of CD123-redirected CAR T cells with monoclonal antibodies preserves leukemia remission in human AML xenograft models. AML CAR T-cell depletion... 
MULTIPLE-MYELOMA | GEMTUZUMAB OZOGAMICIN | THERAPY | B-CELL | SAFETY | ACUTE LYMPHOBLASTIC-LEUKEMIA | INTERNATIONAL EXPERT PANEL | IN-VIVO | HEMATOLOGY | SUICIDE-GENE | GROUP TRIAL AAML0531 | Recombinant Fusion Proteins - immunology | RNA, Messenger - immunology | Humans | Male | Transplantation, Heterologous | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Leukemia, Myeloid, Acute - immunology | Lymphocyte Depletion | T-Lymphocytes - transplantation | Lentivirus - metabolism | CD3 Complex - genetics | T-Lymphocytes - drug effects | Antibodies, Monoclonal, Humanized - pharmacology | Female | Lentivirus - genetics | Receptors, Antigen, T-Cell - immunology | Leukemia, Myeloid, Acute - therapy | Antigens, CD20 - immunology | Gene Expression | Immunotherapy, Adoptive - methods | Genetic Vectors - chemistry | Leukemia, Myeloid, Acute - pathology | RNA, Messenger - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Genetic Vectors - metabolism | Hematopoietic Stem Cell Transplantation | RNA, Antisense - immunology | Treatment Outcome | Alemtuzumab | Remission Induction | Antigens, CD20 - genetics | Rituximab - pharmacology | Xenograft Model Antitumor Assays | Animals | T-Lymphocytes - cytology | Interleukin-3 Receptor alpha Subunit - genetics | Interleukin-3 Receptor alpha Subunit - immunology | CD3 Complex - immunology | Recombinant Fusion Proteins - genetics | Mice, Inbred NOD | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Interleukin-3 Receptor alpha Subunit - antagonists & inhibitors | Leukemia, Myeloid, Acute - genetics | RNA, Antisense - genetics | Immunobiology
Journal Article