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Journal Article
Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7325, pp. 839 - 843
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 138 - 152
Journal Article
Nature: international weekly journal of science, ISSN 0028-0836, 01/2014, Volume 506, Issue 7487, pp. 240 - 244
textabstractCells of the osteoblast lineage affect the homing and the number of long-term repopulating haematopoietic stem cells, haematopoietic stem cell... 
PROGENITOR CELLS | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | BONE-MARROW NICHE | NOTCH ACTIVATION | STEM-CELL NICHE | MYELOID-LEUKEMIA | MICE | DIFFERENTIATION | EXPRESSION | MYELODYSPLASTIC SYNDROMES | Osteoblasts - secretion | Receptors, Notch - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Hematopoietic Stem Cells - pathology | Anemia - pathology | Male | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Membrane Proteins - deficiency | Anemia - genetics | Cell Nucleus - metabolism | Tumor Microenvironment - genetics | Cell Transformation, Neoplastic - genetics | Serrate-Jagged Proteins | Base Sequence | Female | Membrane Proteins - metabolism | Intercellular Signaling Peptides and Proteins - deficiency | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Myelodysplastic Syndromes - metabolism | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Calcium-Binding Proteins - deficiency | Hematopoietic Stem Cells - metabolism | Mutation - genetics | beta Catenin - metabolism | beta Catenin - genetics | Anemia - metabolism | Cell Lineage | Osteoblasts - pathology | Animals | Chromosome Aberrations | Myeloid Cells - metabolism | Ligands | Mice | Myelodysplastic Syndromes - genetics | Myeloid Cells - pathology | Cell Transformation, Neoplastic - pathology | Myelodysplastic Syndromes - pathology | Osteoblasts - metabolism | Calcium-Binding Proteins - genetics | Leukemia, Myeloid, Acute - genetics | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2016, Volume 213, Issue 8, pp. 1513 - 1535
Journal Article
Leukemia, ISSN 0887-6924, 08/2015, Volume 29, Issue 8, pp. 1637 - 1647
Journal Article
British Journal of Haematology, ISSN 0007-1048, 04/2013, Volume 161, Issue 1, pp. 117 - 127
This study explored the anti‐leukaemic efficacy of novel irreversible inhibitors of the major nuclear export receptor, chromosome region maintenance 1 ( CRM 1,... 
all | aml | new drugs for leukaemia | new drugs for lymphoma | Acute leukaemia | All | Aml | New drugs for lymphoma | New drugs for leukaemia | NOTCH1 | SIGNALS | RECEPTOR | RESTORATION | CANCER | TRANSPORT | RESISTANCE | MUTATIONS | PROTEINS | HEMATOLOGY | EXPRESSION | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Cell Nucleus - metabolism | Leukemia, Myeloid, Acute - drug therapy | Female | Antineoplastic Agents - pharmacology | Blood Cells - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Leukemia, Myeloid, Acute - pathology | Nuclear Proteins - metabolism | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Cell Cycle Checkpoints - drug effects | Active Transport, Cell Nucleus - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Mice, Inbred NOD | Mice | Karyopherins - antagonists & inhibitors | Drug Screening Assays, Antitumor | Models | Enzyme inhibitors | T cells | Tumor proteins | Index Medicus | Drugs | Animal models | Transcription factors | Acute lymphatic leukemia | Toxicity | Immunodeficiency | Antagonists | Lymphocytes T | Mutation | Nuclear transport | p53 protein | Apoptosis
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 375 - 388
BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity... 
CELLCYCLE | PROGRAMMED CELL-DEATH | CANCER-CELLS | STEM-CELLS | PROAPOPTOTIC ACTIVITY | ONCOLOGY | X-L | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | MITOCHONDRIAL-MEMBRANE | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | RNA, Small Interfering - genetics | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Nitrophenols - therapeutic use | Hematopoietic Stem Cells - physiology | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | Dimerization | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Cell Line | bcl-2-Associated X Protein - metabolism | Piperazines - therapeutic use | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Proteins | Oncology, Experimental | Lung cancer | Bone marrow | Transplantation | Lymphomas | Research | Hematopoietic stem cells | Cancer | Apoptosis | Index Medicus
Journal Article