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Nature Genetics, ISSN 1061-4036, 11/2015, Volume 47, Issue 11, pp. 1334 - 1340
Juvenile myelomonocytic leukemia (JMML) is a rare and severe myelodysplastic and myeloproliferative neoplasm of early childhood initiated by germline or... 
LYSINE 27 | COMPLEX | MULTIPLE MECHANISMS | NRAS MUTATION | GENETICS & HEREDITY | MYELOID MALIGNANCIES | RHO-GTPASES | DETECTABLE CLONAL MOSAICISM | CANCER | NERVE SHEATH TUMORS | SOMATIC MUTATIONS | ras Proteins - genetics | Leukemia, Myelomonocytic, Juvenile - metabolism | Polycomb Repressive Complex 2 - genetics | Humans | Leukemia, Myeloid - genetics | Transcriptome | Child, Preschool | ras Proteins - metabolism | Infant | Male | Phosphatidylinositol 3-Kinases - metabolism | Protein Subunits - metabolism | DNA Copy Number Variations | Female | Acetylation | Leukemia, Myelomonocytic, Juvenile - genetics | Child | Protein Subunits - genetics | Acute Disease | Gene Regulatory Networks - genetics | Signal Transduction - genetics | Disease Progression | Phosphatidylinositol 3-Kinases - genetics | Microscopy, Confocal | Leukemia, Myeloid - metabolism | Survival Analysis | Histones - metabolism | Mutation | Methylation | Polycomb Repressive Complex 2 - metabolism | Sequence Analysis, DNA - methods | Gene mutations | Leukemia in children | Development and progression | Genetic aspects | Identification and classification | Health aspects | Myeloproliferative disorders | Laboratories | Colonies & territories | Genomes | Kinases | Patients | Data bases | Proteins | Studies | Archives & records | Acquisitions & mergers | Tumors | Cancer | Life Sciences | Genetics
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2013, Volume 45, Issue 8, pp. 937 - 941
Journal Article
Leukemia, ISSN 0887-6924, 08/2014, Volume 29, Issue 3, pp. 606 - 614
Using serum-containing culture, we examined whether AGM-S3 stromal cells, alone or in combination with hematopoietic growth factor(s), stimulated the... 
CHRONIC MYELOGENOUS LEUKEMIA | PATHOGENESIS | STEM-CELLS | ONCOLOGY | SCID MICE | RAS MUTATIONS | MOUSE | REPOPULATION | IMPROVEMENT | MODEL | THROMBOPOIETIN | HEMATOLOGY | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Embryonic Stem Cells - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Antigens, CD34 - metabolism | Leukemia, Myelomonocytic, Juvenile - metabolism | Stromal Cells - pathology | Coculture Techniques | Humans | Hematopoietic Stem Cells - pathology | ras Proteins - metabolism | Neoplastic Stem Cells - metabolism | Stromal Cells - drug effects | Neoplastic Stem Cells - pathology | Clone Cells | Membrane Proteins - metabolism | Leukemia, Myelomonocytic, Juvenile - genetics | Hematopoietic Stem Cells - drug effects | Proto-Oncogene Proteins - metabolism | ADP-ribosyl Cyclase 1 - genetics | Signal Transduction | Leukemia, Myelomonocytic, Juvenile - pathology | Membrane Proteins - genetics | Stromal Cells - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Proto-Oncogene Proteins - genetics | Hematopoietic Stem Cells - metabolism | Gene Expression Regulation, Leukemic | Mice, SCID | Neoplastic Stem Cells - transplantation | Animals | GTP Phosphohydrolases - metabolism | Embryonic Stem Cells - drug effects | GTP Phosphohydrolases - genetics | Adolescent | Embryonic Stem Cells - pathology | ADP-ribosyl Cyclase 1 - metabolism | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Antigens, CD34 - genetics
Journal Article
Blood, ISSN 0006-4971, 06/2013, Volume 121, Issue 24, pp. 4925 - 4929
Journal Article
Journal Article
Nature, ISSN 0028-0836, 11/2016, Volume 539, Issue 7628, pp. 304 - 308
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 335 - 339
Children with neurofibromatosis type 1 (NF1) are predisposed to juvenile myelomonocytic leukemia (JMML), an aggressive myeloproliferative neoplasm (MPN) that... 
HEMATOPOIETIC-CELLS | INACTIVATION | MEDICINE, RESEARCH & EXPERIMENTAL | PROGENITOR | GENE | RAS | RESISTANCE | Mitogen-Activated Protein Kinase Kinases - genetics | Diphenylamine - pharmacology | Leukemia, Myelomonocytic, Juvenile - metabolism | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Child, Preschool | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Erythropoiesis - drug effects | Hematopoiesis, Extramedullary - genetics | Neurofibromin 1 | Leukemia, Myelomonocytic, Juvenile - etiology | Cell Differentiation - genetics | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Mice, Mutant Strains | Benzamides - pharmacology | Leukemia, Myelomonocytic, Juvenile - genetics | Neurofibromatosis 1 - genetics | Child | Hematopoiesis, Extramedullary - drug effects | Disease Models, Animal | Erythropoiesis - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Animals | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - etiology | Cell Differentiation - drug effects | Neurofibromatosis 1 - drug therapy | Neurofibromatosis 1 - complications | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Cell Proliferation - drug effects | Mice | Leukemia, Myelomonocytic, Juvenile - drug therapy | Gene mutations | Physiological aspects | Genetic aspects | Research | Health aspects | Myeloproliferative disorders | Risk factors | Mitogen-activated protein kinases | Brief Report
Journal Article
Blood, ISSN 0006-4971, 07/2017, Volume 130, Issue 4, pp. 397 - 407
Chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) are myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) overlap... 
HUMAN-DISEASE | COLONY-STIMULATING FACTOR | GM-CSF | IN-VIVO | HEMATOPOIETIC STEM-CELL | MYELOID-LEUKEMIA | MICE | HEMATOLOGY | SRSF2 MUTATIONS | MYELODYSPLASTIC SYNDROMES | CHRONIC MYELOMONOCYTIC LEUKEMIA | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Neoplasm Transplantation | Leukemia, Myelomonocytic, Juvenile - metabolism | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | fms-Like Tyrosine Kinase 3 - genetics | Heterografts | Janus Kinase 2 - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Bridged-Ring Compounds - pharmacology | Female | Leukemia, Myelomonocytic, Juvenile - genetics | Neoplasm Proteins - genetics | Janus Kinase 2 - antagonists & inhibitors | Myelodysplastic Syndromes - drug therapy | Myelodysplastic Syndromes - metabolism | Leukemia, Myelomonocytic, Juvenile - pathology | Janus Kinase 2 - genetics | Pyrimidines - pharmacology | Mice, SCID | fms-Like Tyrosine Kinase 3 - metabolism | Xenograft Model Antitumor Assays | Animals | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice, Inbred NOD | Mice | Leukemia, Myelomonocytic, Juvenile - drug therapy | Myelodysplastic Syndromes - pathology | Plenary Paper
Journal Article
Epigenetics, ISSN 1559-2294, 09/2014, Volume 9, Issue 9, pp. 1252 - 1260
Journal Article