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1. Full Text Arsenic trioxide and all- trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial
by Burnett, Alan K, Prof and Russell, Nigel H, Prof and Hills, Robert K, DPhil and Bowen, David, Prof and Kell, Jonathan, MD and Knapper, Steve, DM and Morgan, Yvonne G, PhD and Lok, Jennie, MSc and Grech, Angela, BA and Jones, Gail, MD and Khwaja, Asim, Prof and Friis, Lone, PhD and McMullin, Mary Frances, Prof and Hunter, Ann, MD and Clark, Richard E, Prof and Grimwade, David, Prof and UK National Cancer Research Institute Acute Myeloid Leukaemia Working Group and Natl Canc Res Inst Acute Myeloid
The lancet oncology, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. 1295 - 1305
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Young Adult | Arsenicals - therapeutic use | Idarubicin - adverse effects | Time Factors | Adult | Female | Leukocyte Count | Idarubicin - therapeutic use | Real-Time Polymerase Chain Reaction | Arsenicals - adverse effects | Oxides - therapeutic use | Kaplan-Meier Estimate | Treatment Outcome | United Kingdom | Oxides - adverse effects | New Zealand | Tretinoin - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Oncogene Proteins, Fusion - genetics | Adolescent | Intention to Treat Analysis | Leukemia, Promyelocytic, Acute - mortality | Denmark | Quality of Life | Tretinoin - adverse effects | Leukemia, Promyelocytic, Acute - diagnosis | Biomarkers, Tumor - genetics | Leukemia, Promyelocytic, Acute - genetics | Leukemia, Promyelocytic, Acute - drug therapy | Anthracyclines | Product development | Hospitals | Arsenic | Tretinoin | Index Medicus
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2. Acute promyelocytic leukemia : molecular genetics, mouse models and targeted therapy [Current topics in microbiology and immunology, v. 313]
by Vogt, Peter K and Pandolfi, Pier Paolo
2007, Current topics in microbiology and immunology, ISBN 9783540345923, Volume 313, vi, 273
Leukemia | Acute promyelocytic leukemia | Acute myeloid leukemia
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3. Full Text Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
by Gourmel, Bernard and Vitoux, Dominique and Robledo-Sarmiento, Macarena and Guillemin, Marie-Claude and Zhu, Jun and Soilihi, Hassan and Berthier, Caroline and de Thé, Hugues and Rousselot, Philippe and Nasr, Rihab and Pandolfi, Pier Paolo and Rochette-Egly, Cécile and Peres, Laurent and Ferhi, Omar and Lallemand-Breitenbach, Valérie
Nature medicine, ISSN 1078-8956, 12/2008, Volume 14, Issue 12, pp. 1333 - 1342
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Cyclic AMP-Dependent Protein Kinases - metabolism | Oncogene Proteins, Fusion - metabolism | Phosphorylation | Leukemia, Promyelocytic, Acute - pathology | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Serine - genetics | Cell Transformation, Neoplastic - metabolism | Serine - metabolism | Cyclic AMP - pharmacology | Xenograft Model Antitumor Assays | Leukemia, Promyelocytic, Acute - metabolism | Animals | Cell Differentiation - drug effects | Cell Transformation, Neoplastic - genetics | Mice, Nude | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Leukemia, Promyelocytic, Acute - genetics | Cell Transformation, Neoplastic - pathology | Tretinoin - pharmacology | Research | Health aspects | Oncogenes | Tretinoin | Signal transduction | Oncology | Chemotherapy | Cellular biology | Leukemia | Index Medicus | Serine | Cyclic AMP | Life Sciences | Ethics | Oncogene Proteins, Fusion | Cell Transformation, Neoplastic | Leukemia, Promyelocytic, Acute | Cell Differentiation | Cyclic AMP-Dependent Protein Kinases
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4. Full Text Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure
by de Thé, Hugues and Pandolfi, Pier Paolo and Chen, Zhu
Cancer cell, ISSN 1535-6108, 11/2017, Volume 32, Issue 5, pp. 552 - 560
mouse models | targeted therapy | retinoic acid | differentiation | SUMO | RARA | precision medicine | arsenic | PML | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Oncogene Proteins - genetics | Oncogene Proteins, Fusion - metabolism | Tretinoin - administration & dosage | Tumor Suppressor Proteins - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Oncogene Proteins - metabolism | Oncogene Proteins - antagonists & inhibitors | Arsenicals - administration & dosage | Leukemia, Promyelocytic, Acute - metabolism | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Oncogene Proteins, Fusion - genetics | Tumor Suppressor Proteins - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Leukemia, Promyelocytic, Acute - genetics | Leukemia, Promyelocytic, Acute - drug therapy | Medical colleges | Arsenic | Analysis | Tretinoin | Index Medicus
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5. Full Text Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia
by Lo-Coco, Francesco and Avvisati, Giuseppe and Vignetti, Marco and Thiede, Christian and Orlando, Sonia Maria and Iacobelli, Simona and Ferrara, Felicetto and Fazi, Paola and Cicconi, Laura and Di Bona, Eros and Specchia, Giorgina and Sica, Simona and Divona, Mariadomenica and Levis, Alessandro and Fiedler, Walter and Cerqui, Elisa and Breccia, Massimo and Fioritoni, Giuseppe and Salih, Helmut R and Cazzola, Mario and Melillo, Lorella and Carella, Angelo M and Brandts, Christian H and Morra, Enrica and von Lilienfeld-Toal, Marie and Hertenstein, Bernd and Wattad, Mohammed and Lübbert, Michael and Hänel, Matthias and Schmitz, Norbert and Link, Hartmut and Kropp, Maria Grazia and Rambaldi, Alessandro and La Nasa, Giorgio and Luppi, Mario and Ciceri, Fabio and Finizio, Olimpia and Venditti, Adriano and Fabbiano, Francesco and Döhner, Hartmut and Döhner, Konstanze and Sauer, Michaela and Ganser, Arnold and Amadori, Sergio and Mandelli, Franco and Ehninger, Gerhard and Schlenk, Richard F and Platzbecker, Uwe and Study Alliance Leukemia and Grp Italiano Malattie Ematologiche and German-Austrian Acute Myeloid and German-Austrian Acute Myeloid Leukemia Study Group and Gruppo Italiano Malattie Ematologiche dell'Adulto
The New England journal of medicine, ISSN 0028-4793, 07/2013, Volume 369, Issue 2, pp. 111 - 121
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | General aspects | Medical sciences | Oxides - therapeutic use | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Induction Chemotherapy | Male | Consolidation Chemotherapy | Thrombocytopenia - chemically induced | Oxides - adverse effects | Young Adult | Disease-Free Survival | Arsenicals - therapeutic use | Tretinoin - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Tretinoin - adverse effects | Adult | Female | Aged | Maintenance Chemotherapy | Leukemia, Promyelocytic, Acute - genetics | Neutropenia - chemically induced | Arsenicals - adverse effects | Leukemia, Promyelocytic, Acute - drug therapy | Dosage and administration | Drug therapy, Combination | Research | Tretinoin | Arsenic | Toxicity | Leukemia | Arsenic trioxide | Patients | Studies | Promyeloid leukemia | Chemotherapy | Consolidation | Remission | Pharmaceutical industry | Drug therapy | Retinoic acid | Acute promyeloid leukemia | Index Medicus | Abridged Index Medicus
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6. Full Text PML/RARα-regulated miR-181a/b cluster targets the tumor suppressor RASSF1A in acute promyelocytic leukemia
by Bräuer-Hartmann, Daniela and Hartmann, Jens-Uwe and Wurm, Alexander Arthur and Gerloff, Dennis and Katzerke, Christiane and Falzacappa, Maria Vittoria Verga and Pelicci, Pier Giuseppe and Müller-Tidow, Carsten and Tenen, Daniel G and Niederwieser, Dietger and Behre, Gerhard
Cancer research (Chicago, Ill.), ISSN 0008-5472, 08/2015, Volume 75, Issue 16, pp. 3411 - 3424
Life Sciences & Biomedicine | Oncology | Science & Technology | Multigene Family | Oncogene Proteins, Fusion - metabolism | Leukemia, Promyelocytic, Acute - pathology | Apoptosis - drug effects | Humans | Apoptosis - genetics | Immunoblotting | Receptors, Retinoic Acid - genetics | Leukemia, Promyelocytic, Acute - metabolism | Flow Cytometry | U937 Cells | Tumor Suppressor Proteins - genetics | HEK293 Cells | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Tretinoin - pharmacology | Cell Proliferation - genetics | Tumor Suppressor Proteins - metabolism | Mice, Inbred C57BL | Gene Expression Regulation, Leukemic - drug effects | Mice, Transgenic | Nuclear Proteins - metabolism | Receptors, Retinoic Acid - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Transcription Factors - metabolism | Animals | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | HL-60 Cells | Cell Proliferation - drug effects | MicroRNAs - genetics | Leukemia, Promyelocytic, Acute - genetics | Retinoic Acid Receptor alpha | Promyelocytic Leukemia Protein | Index Medicus
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7. Full Text Acute promyelocytic leukemia a review and discussion of variant translocations
by Adams, Julia and Nassiri, Mehdi
Archives of pathology & laboratory medicine (1976), ISSN 0003-9985, 10/2015, Volume 139, Issue 10, pp. 1308 - 1313
Pathology | Life Sciences & Biomedicine | Medical Laboratory Technology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Translocation, Genetic | Diagnosis, Differential | Humans | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Promyelocytic Leukemia Zinc Finger Protein | Receptors, Retinoic Acid - genetics | STAT5 Transcription Factor - genetics | Oncogene Proteins, Fusion - genetics | Leukemia, Promyelocytic, Acute - diagnosis | Leukemia, Promyelocytic, Acute - genetics | Kruppel-Like Transcription Factors - genetics | Retinoic Acid Receptor alpha | Leukemia, Promyelocytic, Acute - drug therapy | Arsenic | Index Medicus | Abridged Index Medicus
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8. Full Text GTF2I‐RARA is a novel fusion transcript in a t(7;17) variant of acute promyelocytic leukaemia with clinical resistance to retinoic acid
by Li, Ji and Zhong, Hai‐Ying and Zhang, Yang and Xiao, Le and Bai, Li‐Hong and Liu, Su‐Fang and Zhou, Guang‐Biao and Zhang, Guang‐Sen
British journal of haematology, ISSN 0007-1048, 03/2015, Volume 168, Issue 6, pp. 904 - 908
t(7; 17) translocation | retinoic acid resistance | variant acute promyelocytic leukaemia | RARA fusion gene | GTF2I | Variant acute promyelocytic leukaemia | T(7; 17) translocation | Retinoic acid resistance | Life Sciences & Biomedicine | Hematology | Science & Technology | Amino Acid Sequence | Translocation, Genetic | Humans | Mutant Chimeric Proteins - genetics | Molecular Sequence Data | Male | Antineoplastic Agents - therapeutic use | Chromosomes, Human, Pair 17 - genetics | Receptors, Retinoic Acid - genetics | Drug Resistance, Neoplasm - genetics | Transcription Factors, TFII - genetics | Tretinoin - therapeutic use | Base Sequence | Fatal Outcome | Adult | Leukemia, Promyelocytic, Acute - genetics | Chromosomes, Human, Pair 7 - genetics | Neoplasm Proteins - genetics | Retinoic Acid Receptor alpha | Karyotype | Tretinoin | Index Medicus
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9. Full Text Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
by Madan, V and Shyamsunder, P and Han, L and Mayakonda, A and Nagata, Y and Sundaresan, J and Kanojia, D and Yoshida, K and Ganesan, S and Hattori, N and Fulton, N and Tan, K.-T and Alpermann, T and Kuo, M.-C and Rostami, S and Matthews, J and Sanada, M and Liu, L.-Z and Shiraishi, Y and Miyano, S and Chendamarai, E and Hou, H.-A and Malnassy, G and Ma, T and Garg, M and Ding, L.-W and Sun, Q.-Y and Chien, W and Ikezoe, T and Lill, M and Biondi, A and Larson, R.A and Powell, B.L and Lübbert, M and Chng, W.J and Tien, H.-F and Heuser, M and Ganser, A and Koren-Michowitz, M and Kornblau, S.M and Kantarjian, H.M and Nowak, D and Hofmann, W.-K and Yang, H and Stock, W and Ghavamzadeh, A and Alimoghaddam, K and Haferlach, T and Ogawa, S and Shih, L.-Y and Mathews, V and Koeffler, H.P
Leukemia, ISSN 0887-6924, 08/2016, Volume 30, Issue 8, pp. 1672 - 1681
Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Recurrence | Exome - genetics | Humans | Cell Differentiation | Gene Expression Profiling | Leukemia, Promyelocytic, Acute - genetics | Transcription Factors - genetics | DNA Mutational Analysis - methods | DNA-Binding Proteins - genetics | Nuclear Proteins - genetics | Relapse | Dosage and administration | Research | Gene expression | Risk factors | Tretinoin | Diseases | Index Medicus | Original
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