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1. Acute promyelocytic leukemia
: molecular genetics, mouse models and targeted therapy
by Pandolfi, P. P and Vogt, P. K
2007, Current topics in microbiology and immunology, ISBN 9783540345923, Volume 313., vi, 273
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a... 
Animal models | Treatment | Pathogenesis | Acute myeloid leukemia | Cancer Research | Biomedicine
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2. Full Text Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia
by Lo-Coco, Francesco and Avvisati, Giuseppe and Vignetti, Marco and Thiede, Christian and Orlando, Sonia Maria and Iacobelli, Simona and Ferrara, Felicetto and Fazi, Paola and Cicconi, Laura and Di Bona, Eros and Specchia, Giorgina and Sica, Simona and Divona, Mariadomenica and Levis, Alessandro and Fiedler, Walter and Cerqui, Elisa and Breccia, Massimo and Fioritoni, Giuseppe and Salih, Helmut R and Cazzola, Mario and Melillo, Lorella and Carella, Angelo M and Brandts, Christian H and Morra, Enrica and von Lilienfeld-Toal, Marie and Hertenstein, Bernd and Wattad, Mohammed and LĆ¼bbert, Michael and HƤnel, Matthias and Schmitz, Norbert and Link, Hartmut and Kropp, Maria Grazia and Rambaldi, Alessandro and La Nasa, Giorgio and Luppi, Mario and Ciceri, Fabio and Finizio, Olimpia and Venditti, Adriano and Fabbiano, Francesco and Dƶhner, Hartmut and Dƶhner, Konstanze and Sauer, Michaela and Ganser, Arnold and Amadori, Sergio and Mandelli, Franco and Ehninger, Gerhard and Schlenk, Richard F and Platzbecker, Uwe and Study Alliance Leukemia and Grp Italiano Malattie Ematologiche and German-Austrian Acute Myeloid and German-Austrian Acute Myeloid Leukemia Study Group and Gruppo Italiano Malattie Ematologiche dell'Adulto
The New England Journal of Medicine, ISSN 0028-4793, 07/2013, Volume 369, Issue 2, pp. 111 - 121
All- trans retinoic acid (ATRA) plus arsenic trioxide was found to be noninferior to ATRA plus chemotherapy, and less toxic, in the treatment of acute... 
TRIAL | FRONT-LINE THERAPY | RELAPSE | MEDICINE, GENERAL & INTERNAL | POLYMERASE-CHAIN-REACTION | ANTHRACYCLINE | CONSOLIDATION THERAPY | RISK | FUSION GENE TRANSCRIPTS | MINIMAL-RESIDUAL-DISEASE | CHEMOTHERAPY | Oxides - therapeutic use | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Induction Chemotherapy | Male | Consolidation Chemotherapy | Thrombocytopenia - chemically induced | Oxides - adverse effects | Young Adult | Disease-Free Survival | Arsenicals - therapeutic use | Tretinoin - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Tretinoin - adverse effects | Adult | Female | Aged | Maintenance Chemotherapy | Leukemia, Promyelocytic, Acute - genetics | Neutropenia - chemically induced | Arsenicals - adverse effects | Leukemia, Promyelocytic, Acute - drug therapy | Dosage and administration | Drug therapy, Combination | Research | Tretinoin | Arsenic | Toxicity | Leukemia | Liver | Arsenic trioxide | Patients | Studies | Promyeloid leukemia | Chemotherapy | Consolidation | Remission | Pharmaceutical industry | Drug therapy | Retinoic acid | Acute promyeloid leukemia | Index Medicus | Abridged Index Medicus
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3. Full Text Arsenic trioxide and all- trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial
by Burnett, Alan K, Prof and Russell, Nigel H, Prof and Hills, Robert K, DPhil and Bowen, David, Prof and Kell, Jonathan, MD and Knapper, Steve, DM and Morgan, Yvonne G, PhD and Lok, Jennie, MSc and Grech, Angela, BA and Jones, Gail, MD and Khwaja, Asim, Prof and Friis, Lone, PhD and McMullin, Mary Frances, Prof and Hunter, Ann, MD and Clark, Richard E, Prof and Grimwade, David, Prof and Natl Canc Res Inst Acute Myeloid and UK National Cancer Research Institute Acute Myeloid Leukaemia Working Group
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. 1295 - 1305
Summary Background Acute promyelocytic leukaemia is a chemotherapy-sensitive subgroup of acute myeloid leukaemia characterised by the presence of the PMLā€“RARA... 
Hematology, Oncology and Palliative Medicine | THERAPY | EFFICACY | MYLOTARG | ONCOLOGY | ANTHRACYCLINE | INTERGROUP | OUTCOMES | CHEMOTHERAPY | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Young Adult | Arsenicals - therapeutic use | Idarubicin - adverse effects | Time Factors | Adult | Female | Leukocyte Count | Idarubicin - therapeutic use | Real-Time Polymerase Chain Reaction | Arsenicals - adverse effects | Oxides - therapeutic use | Kaplan-Meier Estimate | Treatment Outcome | United Kingdom | Oxides - adverse effects | New Zealand | Tretinoin - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Oncogene Proteins, Fusion - genetics | Adolescent | Intention to Treat Analysis | Leukemia, Promyelocytic, Acute - mortality | Denmark | Quality of Life | Tretinoin - adverse effects | Leukemia, Promyelocytic, Acute - diagnosis | Biomarkers, Tumor - genetics | Leukemia, Promyelocytic, Acute - genetics | Leukemia, Promyelocytic, Acute - drug therapy | Anthracyclines | Product development | Hospitals | Arsenic | Tretinoin
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4. Full Text Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
by Gourmel, Bernard and Vitoux, Dominique and Robledo-Sarmiento, Macarena and Guillemin, Marie-Claude and Zhu, Jun and Soilihi, Hassan and Berthier, Caroline and de ThƩ, Hugues and Rousselot, Philippe and Nasr, Rihab and Pandolfi, Pier Paolo and Rochette-Egly, CƩcile and Peres, Laurent and Ferhi, Omar and Lallemand-Breitenbach, ValƩrie
Nature Medicine, ISSN 1078-8956, 12/2008, Volume 14, Issue 12, pp. 1333 - 1342
Retinoic acid and arsenic trioxide target the protein stability and transcriptional repression activity of the fusion oncoprotein PML-RARA, resulting in... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARSENIC-TRIOXIDE | TRANS-RETINOIC ACID | RECEPTOR-ALPHA | CELL BIOLOGY | CROSS-TALK | ALPHA FUSION PROTEINS | IN-VIVO | MYELOID-LEUKEMIA | DIFFERENTIATION | Cyclic AMP-Dependent Protein Kinases - metabolism | Oncogene Proteins, Fusion - metabolism | Phosphorylation | Leukemia, Promyelocytic, Acute - pathology | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Serine - genetics | Cell Transformation, Neoplastic - metabolism | Serine - metabolism | Cyclic AMP - pharmacology | Xenograft Model Antitumor Assays | Leukemia, Promyelocytic, Acute - metabolism | Animals | Cell Differentiation - drug effects | Cell Transformation, Neoplastic - genetics | Mice, Nude | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Leukemia, Promyelocytic, Acute - genetics | Cell Transformation, Neoplastic - pathology | Tretinoin - pharmacology | Research | Health aspects | Oncogenes | Tretinoin | Signal transduction | Oncology | Chemotherapy | Cellular biology | Leukemia | Serine | Cyclic AMP | Life Sciences | Ethics | Oncogene Proteins, Fusion | Cell Transformation, Neoplastic | Leukemia, Promyelocytic, Acute | Cell Differentiation | Cyclic AMP-Dependent Protein Kinases
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5. Full Text How I treat acute promyelocytic leukemia
by Tallman, Martin S and Altman, Jessica K
Blood, ISSN 0006-4971, 12/2009, Volume 114, Issue 25, pp. 5126 - 5135
Acute promyelocytic leukemia is the first malignant disease highly curable with targeted therapy directed at a unique molecular abnormality. The characteristic... 
ARSENIC TRIOXIDE THERAPY | SINGLE-CENTER EXPERIENCE | MOLECULAR REMISSION | APL GROUP EXPERIENCE | REMISSION INDUCTION THERAPY | PROGNOSTIC-FACTORS | TRANS-RETINOIC ACID | RAR-ALPHA | HEMATOLOGY | MYELODYSPLASTIC SYNDROME | GEMTUZUMAB-OZOGAMICIN | Oxides - therapeutic use | Tretinoin - administration & dosage | Outcome Assessment (Health Care) | Humans | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Reverse Transcriptase Polymerase Chain Reaction | Bone Marrow Examination | Dose-Response Relationship, Drug | Arsenicals - administration & dosage | Arsenicals - therapeutic use | Tretinoin - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Oncogene Proteins, Fusion - genetics | Leukemia, Promyelocytic, Acute - diagnosis | Leukemia, Promyelocytic, Acute - genetics | Oxides - administration & dosage | Leukemia, Promyelocytic, Acute - drug therapy | Practice Guidelines as Topic
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6. Full Text Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells
by Zeng, Chengwu and Xu, Yan and Xu, Ling and Yu, Xibao and Cheng, Jingjing and Yang, Lijian and Chen, Shaohua and Li, Yangqiu
BMC Cancer, ISSN 1471-2407, 09/2014, Volume 14, Issue 1, pp. 693 - 693
Background: Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15; 17), which fuses PML with retinoic acid receptor alpha... 
CANCER-CELLS | APOPTOSIS | STEM-CELLS | RETINOIC ACID | ONCOLOGY | DEGRADATION | RAR-ALPHA | PROTEINS | EXPRESSION | PU.1 | Oncogene Proteins, Fusion - metabolism | Leukemia, Promyelocytic, Acute - pathology | Humans | Middle Aged | Gene Expression Regulation, Leukemic - drug effects | Male | RNA, Long Noncoding - genetics | Gene Knockdown Techniques | Young Adult | Oncogene Proteins, Fusion - genetics | Adolescent | Cell Line, Tumor | Adult | Female | Leukemia, Promyelocytic, Acute - genetics | Neutrophils - metabolism | Neutrophils - pathology | Tretinoin - pharmacology | Physiological aspects | Research | RNA | Leukemia | Analysis
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7. Full Text Resistance to Arsenic Therapy in Acute Promyelocytic Leukemia
by Zhu, Hong-Hu and Qin, Ya-Zhen and Huang, Xiao-Jun
The New England Journal of Medicine, ISSN 0028-4793, 05/2014, Volume 370, Issue 19, pp. 1864 - 1866
Although resistance to arsenic trioxide in patients with acute promyelocytic leukemia is very rare, mutations in PML at the site of arsenic binding appears to... 
MEDICINE, GENERAL & INTERNAL | PML | TRIOXIDE | Oxides - therapeutic use | Arsenicals - therapeutic use | Drug Resistance, Neoplasm - genetics | Humans | Leukemia, Promyelocytic, Acute - genetics | Mutation | Neoplasm Proteins - genetics | Retinoic Acid Receptor alpha | Receptors, Retinoic Acid - genetics | Leukemia, Promyelocytic, Acute - drug therapy | Promyeloid leukemia | Chemotherapy | Arsenic | Leukemia | Arsenic trioxide | Acute promyeloid leukemia
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8. Full Text Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
by Madan, V and Shyamsunder, P and Han, L and Mayakonda, A and Nagata, Y and Sundaresan, J and Kanojia, D and Yoshida, K and Ganesan, S and Hattori, N and Fulton, N and Tan, K.-T and Alpermann, T and Kuo, M.-C and Rostami, S and Matthews, J and Sanada, M and Liu, L.-Z and Shiraishi, Y and Miyano, S and Chendamarai, E and Hou, H.-A and Malnassy, G and Ma, T and Garg, M and Ding, L.-W and Sun, Q.-Y and Chien, W and Ikezoe, T and Lill, M and Biondi, A and Larson, R.A and Powell, B.L and LĆ¼bbert, M and Chng, W.J and Tien, H.-F and Heuser, M and Ganser, A and Koren-Michowitz, M and Kornblau, S.M and Kantarjian, H.M and Nowak, D and Hofmann, W.-K and Yang, H and Stock, W and Ghavamzadeh, A and Alimoghaddam, K and Haferlach, T and Ogawa, S and Shih, L.-Y and Mathews, V and Koeffler, H.P
Leukemia, ISSN 0887-6924, 08/2016, Volume 30, Issue 8, pp. 1672 - 1681
Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by differentiation block at the promyelocyte stage. Besides the presence of... 
ACID RECEPTOR-ALPHA | INTELLECTUAL DISABILITY | PML-RAR-ALPHA | CHROMATIN-REMODELING COMPLEX | ONCOLOGY | GENOME SEQUENCING DATA | CLONAL EVOLUTION | ACUTE MYELOID-LEUKEMIA | TRANS-RETINOIC ACID | HEMATOLOGY | AGENT ARSENIC TRIOXIDE | MISSENSE MUTATIONS | Recurrence | Exome - genetics | Humans | Cell Differentiation | Gene Expression Profiling | Leukemia, Promyelocytic, Acute - genetics | Transcription Factors - genetics | DNA Mutational Analysis - methods | DNA-Binding Proteins - genetics | Nuclear Proteins - genetics | Relapse | Dosage and administration | Research | Gene expression | Risk factors | Tretinoin | Diseases | Original
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9. Full Text Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure
by de ThƩ, Hugues and Pandolfi, Pier Paolo and Chen, Zhu
Cancer Cell, ISSN 1535-6108, 11/2017, Volume 32, Issue 5, pp. 552 - 560
Recent clinical trials have demonstrated that the immense majority of acute promyelocytic leukemia (APL) patients can be definitively cured by the combination... 
mouse models | targeted therapy | retinoic acid | differentiation | SUMO | RARA | precision medicine | arsenic | PML | PML-RAR-ALPHA | ARSENIC TRIOXIDE AS2O3 | IN-VITRO | ONCOLOGY | FOLLOW-UP | TRANS-RETINOIC ACID | ACUTE MYELOID-LEUKEMIA | T(15-17) TRANSLOCATION | TRANSCRIPTION FACTOR | CELLULAR SENESCENCE | TUMOR-SUPPRESSOR PML | CELL BIOLOGY | Oncogene Proteins - genetics | Oncogene Proteins, Fusion - metabolism | Tretinoin - administration & dosage | Tumor Suppressor Proteins - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Oncogene Proteins - metabolism | Oncogene Proteins - antagonists & inhibitors | Arsenicals - administration & dosage | Leukemia, Promyelocytic, Acute - metabolism | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Oncogene Proteins, Fusion - genetics | Tumor Suppressor Proteins - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Leukemia, Promyelocytic, Acute - genetics | Leukemia, Promyelocytic, Acute - drug therapy | Medical colleges | Arsenic | Analysis | Tretinoin
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10. Acute promyelocytic leukemia
: molecular genetics, mouse models and targeted therapy
by Pandolfi, P. P. (Pier Paolo) and Vogt, P. K. 1932- (Peter K.)
2007, Current topics in microbiology and immunology, ISBN 3540345949, Volume 313
drug therapy | Treatment | Pathogenesis | Leukemia, Promyelocytic, Acute | Antineoplastic Agents | Mice | Acute myeloid leukemia | therapeutic use
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11. Acute promyelocytic leukemia
: molecular genetics, mouse models and targeted therapy
by Pandolfi, P. P. (Pier Paolo) and Vogt, P. K. 1932- (Peter K.)
2007, Current topics in microbiology and immunology, ISBN 9783540345923, Volume 313
drug therapy | Leukemia, Promyelocytic, Acute | Antineoplastic Agents | Mice | therapeutic use
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12. Acute promyelocytic leukemia
: molecular genetics, mouse models and targeted therapy
by Pandolfi, P. P. (Pier Paolo) and Vogt, P. K. 1932- (Peter K.)
2007, Current topics in microbiology and immunology, ISBN 9783540345923, Volume 313
drug therapy | Leukemia, Promyelocytic, Acute | Antineoplastic Agents | Mice | therapeutic use
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13. Full Text Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in acute promyelocytic leukemia
by Tomita, Akihiro and Kiyoi, Hitoshi and Naoe, Tomoki
International Journal of Hematology, ISSN 0925-5710, 6/2013, Volume 97, Issue 6, pp. 717 - 725
Since the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) for the treatment of acute promyelocytic leukemia (APL), the overall... 
PML-RARĪ± | Medicine & Public Health | Hematology | Arsenic trioxide (As 2 O 3 ) | Oncology | ATRA | Drug resistance | APL | Arsenic trioxide (As | TRANSCRIPTION IN-VIVO | PML-RAR alpha | ACUTE MYELOID-LEUKEMIA | T(15-17) TRANSLOCATION | RECEPTOR-ALPHA | PML/RAR-ALPHA | PML-RAR-ALPHA | Arsenic trioxide (As2O3) | REFRACTORY JAPANESE PATIENTS | FUSION PROTEIN | LIGAND-BINDING DOMAIN | HISTONE DEACETYLASE INHIBITORS | HEMATOLOGY | Oxides - therapeutic use | Arsenicals - therapeutic use | Drug Resistance, Neoplasm - genetics | Tretinoin - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Leukemia, Promyelocytic, Acute - genetics | Molecular Targeted Therapy | Leukemia, Promyelocytic, Acute - drug therapy | Medical colleges | Gene mutations | Arsenic | Analysis
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