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Immunity, ISSN 1074-7613, 01/2013, Volume 38, Issue 1, pp. 13 - 25
Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response. Discovered as a T cell growth... 
BETA-CHAIN | SEVERE COMBINED IMMUNODEFICIENCY | CYTOKINE RECEPTOR | IN-VIVO | REGULATORY T-CELLS | GENE-EXPRESSION | RECEPTOR-ALPHA-CHAIN | MONOCLONAL-ANTIBODY | IMMUNOLOGY | IL-2 RECEPTOR | GAMMA-CHAIN | T-Lymphocyte Subsets - immunology | Humans | X-Linked Combined Immunodeficiency Diseases - genetics | Interleukin Receptor Common gamma Subunit - metabolism | X-Linked Combined Immunodeficiency Diseases - immunology | Interleukin Receptor Common gamma Subunit - immunology | Leukemia-Lymphoma, Adult T-Cell - immunology | T-Lymphocytes, Regulatory - immunology | Receptors, Interleukin-2 - genetics | Interleukin-2 - physiology | T-Lymphocytes, Helper-Inducer - immunology | Immunotherapy | T-Lymphocytes, Helper-Inducer - cytology | CD8-Positive T-Lymphocytes - metabolism | Leukemia-Lymphoma, Adult T-Cell - therapy | Interleukin-2 - metabolism | Leukemia-Lymphoma, Adult T-Cell - genetics | Immune Tolerance | Receptors, Interleukin-2 - metabolism | X-Linked Combined Immunodeficiency Diseases - therapy | Interleukin Receptor Common gamma Subunit - genetics | Cell Differentiation - immunology | Animals | T-Lymphocyte Subsets - metabolism | Interleukin-15 - metabolism | Immunologic Memory | CD8-Positive T-Lymphocytes - immunology | Interleukins | T cells | Cell growth | T cell receptors | Cytokines | Kinases | Immune system
Journal Article
British Journal of Haematology, ISSN 0007-1048, 05/2015, Volume 169, Issue 3, pp. 356 - 367
Summary Adult T cell leukaemia/lymphoma (ATL) is a human T cell leukaemia virus type‐I (HTLV‐I)‐infected T cell malignancy with poor prognosis. We herein... 
tumour vaccine | human T cell leukaemia virus type‐I | cytotoxic T lymphocyte | adult T cell leukaemia/lymphoma | dendritic cell | Human T cell leukaemia virus type-I | Dendritic cell | Adult T cell leukaemia/lymphoma | Cytotoxic T lymphocyte | Tumour vaccine | human T cell leukaemia virus type-I | LEUKEMIA-LYMPHOMA | adult T cell leukaemia | lymphoma | TRANSPLANTATION | INTERFERON-ALPHA | IMMUNOTHERAPY | VIRUS TYPE-I | PROSTATE-CANCER PATIENTS | DISEASE | LEUKEMIA/LYMPHOMA | HEMATOLOGY | LYMPHOCYTES | ANTIGEN | T-Lymphocytes, Cytotoxic - immunology | Gene Products, tax - immunology | Leukemia-Lymphoma, Adult T-Cell - diagnosis | Cytokines - metabolism | Cancer Vaccines - administration & dosage | Dendritic Cells - immunology | Humans | Middle Aged | Cancer Vaccines - adverse effects | Male | Tomography, X-Ray Computed | Treatment Outcome | Leukemia-Lymphoma, Adult T-Cell - immunology | Cancer Vaccines - immunology | Pilot Projects | T-Lymphocytes, Cytotoxic - metabolism | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Gene Products, tax - chemistry | Immunotherapy | Peptide Fragments - immunology | Female | Aged | Human T-lymphotropic virus 1 - genetics | Leukemia-Lymphoma, Adult T-Cell - therapy | Chemotherapy | Peptides | Dendritic cells | Leukemia | Patient outcomes | Development and progression | Vaccines | Taxation | T cells | Cancer
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 17 - 26
Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency.... 
adoptive T cell therapy | 4-1BB | chimeric antigen receptor | costimulation | T cells | adoptive T cell therapy | ACTIVATION | LIGAND EXPRESSION | CAR | EFFECTOR FUNCTION | GENE-EXPRESSION | FAS | DEATH | ANTITUMOR-ACTIVITY | NF-KAPPA-B | SIGNALING COMPLEX | CELL BIOLOGY | Neoplasm Transplantation | Humans | Mutant Chimeric Proteins - genetics | NF-kappa B - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | T-Lymphocytes - transplantation | Leukemia-Lymphoma, Adult T-Cell - immunology | Lentivirus - metabolism | fas Receptor - immunology | Cell Death | fas Receptor - genetics | Lentivirus - genetics | Receptors, Antigen, T-Cell - immunology | 4-1BB Ligand - immunology | T-Lymphocytes - pathology | 4-1BB Ligand - genetics | Antigens, Neoplasm - genetics | Genetic Vectors - chemistry | Signal Transduction | Antigens, Neoplasm - immunology | Cell Survival | Leukemia-Lymphoma, Adult T-Cell - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Genetic Vectors - metabolism | Gene Expression Regulation, Leukemic | Leukemia-Lymphoma, Adult T-Cell - pathology | Gammaretrovirus - metabolism | Animals | Gammaretrovirus - genetics | NF-kappa B - genetics | Mice, Inbred NOD | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Chimeric antigen receptor
Journal Article