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1. Full Text Clinical significance of CD163+ tumor‐associated macrophages in patients with adult T‐cell leukemia/lymphoma
by Komohara, Yoshihiro and Niino, Daisuke and Saito, Yoichi and Ohnishi, Koji and Horlad, Hasita and Ohshima, Koichi and Takeya, Motohiro
Cancer Science, ISSN 1347-9032, 07/2013, Volume 104, Issue 7, pp. 945 - 951
In several malignant tumors including lymphoma, macrophages that infiltrate tumor tissues are called tumor‐associated macrophages (TAMs). We discovered that... 
PATHWAYS | ACTIVATION | INHIBITION | ONCOLOGY | JAK-STAT | GROWTH | P38 MAPK | LEUKEMIA | POLARIZATION | EXPRESSION | PROGRESSION | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | Prognosis | Humans | Complement C5a - metabolism | Receptors, Cell Surface - metabolism | Male | Leukemia-Lymphoma, Adult T-Cell - pathology | Receptors, Cell Surface - immunology | Disease Progression | Antigens, CD - metabolism | Leukemia-Lymphoma, Adult T-Cell - immunology | Macrophages - metabolism | Leukemia-Lymphoma, Adult T-Cell - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Chemokine CCL1 - metabolism | Cell Line, Tumor | Female | Aged | Complement C5a - immunology | Chemokine CXCL1 - metabolism | Interleukin-6 - metabolism | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Care and treatment | Lymphomas | T cells | Macrophages
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2. Full Text Polycomb-Mediated Loss of miR-31 Activates NIK-Dependent NF-κB Pathway in Adult T Cell Leukemia and Other Cancers
by Yamagishi, Makoto and Nakano, Kazumi and Miyake, Ariko and Yamochi, Tadanori and Kagami, Yayoi and Tsutsumi, Akihisa and Matsuda, Yuka and Sato-Otsubo, Aiko and Muto, Satsuki and Utsunomiya, Atae and Yamaguchi, Kazunari and Uchimaru, Kaoru and Ogawa, Seishi and Watanabe, Toshiki
Cancer Cell, ISSN 1535-6108, 01/2012, Volume 21, Issue 1, pp. 121 - 135
Constitutive NF-κB activation has causative roles in adult T cell leukemia (ATL) caused by HTLV-1 and other cancers. Here, we report a pathway involving... 
BREAST-CANCER | ONCOLOGY | VIRUS TYPE-I | PROSTATE-CANCER | KINASE | GROUP PROTEIN EZH2 | HISTONE METHYLTRANSFERASE EZH2 | MICRORNAS | INHIBITOR | EXPRESSION | PROGRESSION | CELL BIOLOGY | Oligonucleotide Array Sequence Analysis | Signal Transduction | Leukemia-Lymphoma, Adult T-Cell - genetics | Protein-Serine-Threonine Kinases - physiology | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | Repressor Proteins - genetics | NF-kappa B - metabolism | Gene Expression Profiling | Polycomb-Group Proteins | Repressor Proteins - physiology | NF-kappa B - genetics | T-Lymphocytes - metabolism | Leukemia-Lymphoma, Adult T-Cell - metabolism | MicroRNAs - genetics | T-Lymphocytes - pathology | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism
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3. Full Text Polycomb-dependent epigenetic landscape in adult T-cell leukemia
by Fujikawa, Dai and Fujikawa, Dai and Nakagawa, Shota and Nakagawa, Shota and Hori, Makoto and Hori, Makoto and Kurokawa, Naoya and Kurokawa, Naoya and Soejima, Ai and Soejima, Ai and Nakano, Kazumi and Nakano, Kazumi and Yamochi, Tadanori and Yamochi, Tadanori and Nakashima, Makoto and Nakashima, Makoto and Kobayashi, Seiichiro and Kobayashi, Seiichiro and Tanaka, Yuetsu and Tanaka, Yuetsu and Iwanaga, Masako and Iwanaga, Masako and Utsunomiya, Atae and Utsunomiya, Atae and Uchimaru, Kaoru and Uchimaru, Kaoru and Yamagishi, Makoto and Yamagishi, Makoto and Watanabe, Toshiki and Watanabe, Toshiki
Blood, ISSN 0006-4971, 04/2016, Volume 127, Issue 14, pp. 1790 - 1802
Adult T-cell leukemia-lymphoma (ATL) shows global gene expression alterations that confer cellular characteristics and unfavorable prognosis. However,... 
LYSINE 27 | HISTONE H3 | VIRUS TYPE-I | EMBRYONIC STEM-CELLS | DOWN-REGULATION | LEUKEMIA/LYMPHOMA | HTLV-1 TAX | HEMATOLOGY | NF-KAPPA-B | CANCER | EZH2 | Polycomb Repressive Complex 2 - genetics | Leukemia-Lymphoma, Adult T-Cell - genetics | Epigenesis, Genetic | Humans | Male | Gene Products, tax - genetics | Gene Expression Regulation, Leukemic | Leukemia-Lymphoma, Adult T-Cell - pathology | Neoplasm Proteins - metabolism | Enhancer of Zeste Homolog 2 Protein | Histones - genetics | Gene Products, tax - metabolism | Leukemia-Lymphoma, Adult T-Cell - metabolism | Cell Line, Tumor | Adult | Female | Human T-lymphotropic virus 1 - metabolism | Human T-lymphotropic virus 1 - genetics | Histones - metabolism | Neoplasm Proteins - genetics | Polycomb Repressive Complex 2 - metabolism | Cell Line, Transformed
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4. Full Text A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
by Simon, Camille and Chagraoui, Jalila and Krosl, Jana and Gendron, Patrick and Wilhelm, Brian and Lemieux, Sébastien and Boucher, Geneviève and Chagnon, Pierre and Drouin, Simon and Lambert, Raphaëlle and Rondeau, Claude and Bilodeau, Annie and Lavallée, Sylvie and Sauvageau, Martin and Hébert, Josée and Sauvageau, Guy
Genes and Development, ISSN 0890-9369, 04/2012, Volume 26, Issue 7, pp. 651 - 656
In this study, we show the high frequency of spontaneous gamma delta T-cell leukemia (T-ALL) occurrence in mice with biallelic deletion of enhancer of zeste... 
PRC2 | JARID2 | T-ALL | Leukemia | DNMT3A | EZH2 | leukemia | EED | DEVELOPMENTAL BIOLOGY | POLYCOMB | SOMATIC MUTATIONS | CELL BIOLOGY | INACTIVATION | GENETICS & HEREDITY | PROTEINS | REPRESSIVE COMPLEX 2 | HEMATOPOIETIC STEM | Acute Disease | Histone-Lysine N-Methyltransferase - genetics | Leukemia-Lymphoma, Adult T-Cell - genetics | Humans | Mice, Inbred C57BL | Repressor Proteins - genetics | Mice, Transgenic | Polycomb-Group Proteins | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Enhancer of Zeste Homolog 2 Protein | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Animals | Histone-Lysine N-Methyltransferase - metabolism | Leukemia-Lymphoma, Adult T-Cell - metabolism | Protein Binding | Mice | Repressor Proteins - metabolism | Gene mutations | Reorganization and restructuring | Acute leukemia | Causes of | Physiological aspects | Genetic aspects | Research | T cells | Gene expression | Cancer | Research Communication
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5. Full Text NF‐κB signaling mechanisms in HTLV‐1‐induced adult T‐cell leukemia/lymphoma
by Harhaj, Edward William and Giam, Chou‐Zen
The FEBS Journal, ISSN 1742-464X, 09/2018, Volume 285, Issue 18, pp. 3324 - 3336
The human T‐cell leukemia virus type 1 (HTLV‐1) is a complex deltaretrovirus linked to adult T‐cell leukemia/lymphoma (ATLL), a fatal CD4 +  malignancy in 3–5%... 
leukemia | Senescence | tax | HTLV‐1 | NF‐κB | NF-κB | HTLV-1 | HTLV-I Infections - pathology | HTLV-I Infections - metabolism | Signal Transduction | Leukemia-Lymphoma, Adult T-Cell - metabolism | Humans | Gene Expression Regulation, Neoplastic | Adult | Human T-lymphotropic virus 1 - pathogenicity | NF-kappa B - metabolism | Leukemia-Lymphoma, Adult T-Cell - pathology | Leukemia-Lymphoma, Adult T-Cell - virology | HTLV-I Infections - virology | Cell proliferation | Tax protein | Cell survival | Leukemia | Lymphocytes T | Malignancy | Gene expression | Lymphoma | CD4 antigen | Signal transduction | Cell activation | Lymphocytes B | Lymphocytes | Lymphomas | Deoxyribonucleic acid--DNA | senescence | Tax
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6. Full Text Variegated RHOA mutations in adult T-cell leukemia/lymphoma
by Nagata, Yasunobu and Kontani, Kenji and Enami, Terukazu and Kataoka, Keisuke and Ishii, Ryohei and Totoki, Yasushi and Kataoka, Tatsuki R and Hirata, Masahiro and Aoki, Kazuhiro and Nakano, Kazumi and Kitanaka, Akira and Sakata-Yanagimoto, Mamiko and Egami, Sachiko and Shiraishi, Yuichi and Chiba, Kenichi and Tanaka, Hiroko and Shiozawa, Yusuke and Yoshizato, Tetsuichi and Suzuki, Hiromichi and Kon, Ayana and Yoshida, Kenichi and Sato, Yusuke and Sato-Otsubo, Aiko and Sanada, Masashi and Munakata, Wataru and Nakamura, Hiromi and Hama, Natsuko and Miyano, Satoru and Nureki, Osamu and Shibata, Tatsuhiro and Haga, Hironori and Shimoda, Kazuya and Katada, Toshiaki and Chiba, Shigeru and Watanabe, Toshiki and Ogawa, Seishi
Blood, ISSN 0006-4971, 02/2016, Volume 127, Issue 5, pp. 596 - 604
Adult T-cell leukemia/lymphoma (ATLL) is a distinct form of peripheral T-cell lymphoma with poor prognosis, which is caused by the human T-lymphotropic virus... 
MOLECULAR CHARACTERIZATION | TRANSFORMATION | ACTIVATION | CRYSTAL-STRUCTURE | LYMPHOMA | LEUKEMIA | HEMATOLOGY | CANCER | EXPRESSION | CARCINOMA | GENOME | Protein Structure, Tertiary | Amino Acid Sequence | rhoA GTP-Binding Protein - chemistry | Leukemia-Lymphoma, Adult T-Cell - genetics | Humans | Models, Molecular | Molecular Sequence Data | rhoA GTP-Binding Protein - metabolism | Guanosine Triphosphate - metabolism | Leukemia-Lymphoma, Adult T-Cell - pathology | rhoA GTP-Binding Protein - genetics | DNA Mutational Analysis | Leukemia-Lymphoma, Adult T-Cell - metabolism | Adult | High-Throughput Nucleotide Sequencing | Guanosine Diphosphate - metabolism | Mutation | Binding Sites | Lymphoid Neoplasia
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7. Full Text Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1—associated adult T-cell leukemia
by Joanna Pancewicz and John M. Taylor and Abhik Datta and Hicham H. Baydoun and Thomas A. Waldmann and Olivier Hermine and Christophe Nicot
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2010, Volume 107, Issue 38, pp. 16619 - 16624
The Notch signaling pathway plays an important role in cellular proliferation, differentiation, and apoptosis. Unregulated activation of Notch signaling can... 
T lymphocytes | Human T lymphotropic virus 1 | Acute T cell leukemia | Cell lines | Cell cycle | Transformed cell line | Pests | T cell leukemia | Genetic mutation | Tumors | APOPTOSIS | ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | RESISTANCE | GAMMA-SECRETASE INHIBITORS | MOLECULAR PATHOGENESIS | MECHANISMS | MUTATIONS | MASTERMIND | F-Box-WD Repeat-Containing Protein 7 | Neoplasm Transplantation | Humans | Receptor, Notch1 - chemistry | Transplantation, Heterologous | DNA Mutational Analysis | Adult | Protein Stability | Protein Structure, Tertiary | F-Box Proteins - metabolism | Leukemia-Lymphoma, Adult T-Cell - genetics | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Ubiquitin-Protein Ligases - metabolism | Leukemia-Lymphoma, Adult T-Cell - pathology | Receptor, Notch1 - metabolism | Animals | Signal Transduction - drug effects | Leukemia-Lymphoma, Adult T-Cell - metabolism | Leukemia-Lymphoma, Adult T-Cell - etiology | Cell Proliferation - drug effects | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Mutation | Receptor, Notch1 - genetics | Virus diseases | Cellular proteins | Leukemia | Development and progression | Chemical properties | T cells | Health aspects | Biological Sciences
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8. Full Text PD-L1 expression on neoplastic or stromal cells is respectively a poor or good prognostic factor for adult T-cell leukemia/lymphoma
by Miyoshi, Hiroaki and Kiyasu, Junichi and Kato, Takeharu and Yoshida, Noriaki and Shimono, Joji and Yokoyama, Shintaro and Taniguchi, Hiroaki and Sasaki, Yuya and Kurita, Daisuke and Kawamoto, Keisuke and Kato, Koji and Imaizumi, Yoshitaka and Seto, Masao and Ohshima, Koichi
Blood, ISSN 0006-4971, 09/2016, Volume 128, Issue 10, pp. 1374 - 1381
Programmed cell death ligand 1 (PD-L1) is expressed on both tumor and tumor-infiltrating nonmalignant cells in lymphoid malignancies. The programmed cell death... 
LEUKEMIA-LYMPHOMA | SURVIVAL | INTERFERON-ALPHA | VIRUS TYPE-I | TUMOR | FOLLICULAR LYMPHOMA | DEATH LIGAND 1 | HEMATOLOGY | CANCER | CLINICAL-SIGNIFICANCE | TRANSPLANTATION | Prognosis | Follow-Up Studies | Stromal Cells - pathology | Humans | Middle Aged | Stromal Cells - metabolism | Tumor Microenvironment | Male | Survival Rate | Combined Modality Therapy | Leukemia-Lymphoma, Adult T-Cell - pathology | B7-H1 Antigen - metabolism | Leukemia-Lymphoma, Adult T-Cell - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Aged | Retrospective Studies | Neoplasm Staging | Leukemia-Lymphoma, Adult T-Cell - therapy
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9. Full Text Molecular pathogenesis of T-cell leukaemia and lymphoma
by Raetz, Elizabeth and Buonamici, Silvia and Aifantis, Iannis
Nature Reviews Immunology, ISSN 1474-1733, 05/2008, Volume 8, Issue 5, pp. 380 - 390
T-cell acute lymphoblastic leukaemia (T-ALL) is induced by the transformation of T-cell progenitors and mainly occurs in children and adolescents. Although... 
TRANSCRIPTION FACTORS | DOUBLE-TRANSGENIC MICE | LOOP-HELIX PROTEINS | BETA-SELECTION CHECKPOINT | ACUTE LYMPHOBLASTIC-LEUKEMIA | PRE-TCR | BONE-MARROW-CELLS | IMMUNOLOGY | NF-KAPPA-B | F-BOX PROTEIN | CHROMOSOMAL TRANSLOCATION | F-Box-WD Repeat-Containing Protein 7 | Translocation, Genetic | Homeodomain Proteins - metabolism | Humans | NF-kappa B - metabolism | Lymphoma - metabolism | Ubiquitination | Basic Helix-Loop-Helix Transcription Factors - metabolism | T-Lymphocytes - metabolism | Cell Cycle Proteins - genetics | Lymphoma - pathology | Thymus Gland - growth & development | Cell Differentiation | Child | Signal Transduction | Leukemia-Lymphoma, Adult T-Cell - genetics | Lymphoma - genetics | Gene Expression Regulation, Leukemic | Leukemia-Lymphoma, Adult T-Cell - pathology | Receptor, Notch1 - metabolism | Transcription Factors - metabolism | Cell Lineage | Animals | T-Lymphocytes - cytology | Leukemia-Lymphoma, Adult T-Cell - metabolism | Thymus Gland - immunology | Mice | Mutation | Receptor, Notch1 - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Physiological aspects | Development and progression | Research | T cells | Leukemia | T cell lymphoma
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10. Full Text Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia lymphoma by translational suppression of c-FLIP expression
by Bleumink, M and Köhler, R and Giaisi, M and Proksch, P and Krammer, P.H and Li-Weber, M
Cell Death and Differentiation, ISSN 1350-9047, 02/2011, Volume 18, Issue 2, pp. 362 - 370
The human T-cell leukemia virus type-1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATL) is incurable by currently known therapies. ATL samples and cell... 
apoptosis | ATL | anticancer drug | TRAIL | c-FLIP | TRANSFORMATION | ACTIVATION | CANCER-CHEMOTHERAPY | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | MEDIATED APOPTOSIS | CELL BIOLOGY | APOPTOSIS-INDUCING LIGAND | INITIATION-FACTORS | NF-KAPPA-B | UP-REGULATION | Fas Ligand Protein - metabolism | Phosphorylation | Protein Biosynthesis | Signal Transduction | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Leukemia-Lymphoma, Adult T-Cell - genetics | Down-Regulation | Humans | Eukaryotic Initiation Factor-4E - metabolism | Benzofurans - pharmacology | Intracellular Signaling Peptides and Proteins - metabolism | MAP Kinase Kinase Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Leukemia-Lymphoma, Adult T-Cell - virology | Human T-lymphotropic virus 1 | Carrier Proteins - metabolism | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Leukemia-Lymphoma, Adult T-Cell - metabolism | Cell Line, Tumor | Antineoplastic Agents - pharmacology | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Protein-Serine-Threonine Kinases - metabolism | Apoptosis | Original Paper
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11. Full Text Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2–dependent adult T-cell leukemia
by Meili Zhang and Lesley A. Mathews Griner and Wei Ju and Damien Y. Duveau and Rajarshi Guha and Michael N. Petrus and Bernard Wen and Michiyuki Maeda and Paul Shinn and Marc Ferrer and Kevin D. Conlon and Richard N. Bamford and John J. O’Shea and Craig J. Thomas and Thomas A. Waldmann
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 40, pp. 12480 - 12485
Adult T-cell leukemia (ATL) develops in individuals infected with human T-cell lymphotropic virus-1 (HTLV-1). Presently there is no curative therapy for ATL.... 
Ruxolitinib|navitoclax | Adult t-cell leukemia|janus kinase | INTERLEUKIN-2 | MYELOFIBROSIS | ORAL JAK1 | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | INTERFERON-ALPHA | navitoclax | JAK2 INHIBITOR | THERAPY | adult T-cell leukemia | Janus kinase | LYMPHOMA | MALIGNANCIES | ruxolitinib | Apoptosis - drug effects | Humans | STAT Transcription Factors - metabolism | Janus Kinases - metabolism | Flow Cytometry | Leukemia-Lymphoma, Adult T-Cell - drug therapy | bcl-X Protein - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Pyrazoles - pharmacology | Interleukin-2 - metabolism | Aniline Compounds - pharmacology | Cells, Cultured | Leukemia-Lymphoma, Adult T-Cell - pathology | Mice, SCID | Sulfonamides - pharmacology | Interleukin Receptor Common gamma Subunit - genetics | Blotting, Western | Mice, Knockout | Interleukin Receptor Common gamma Subunit - deficiency | Janus Kinases - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Leukemia-Lymphoma, Adult T-Cell - metabolism | Cell Line, Tumor | Mice, Inbred NOD | STAT Transcription Factors - antagonists & inhibitors | bcl-X Protein - metabolism | Interleukins | Leukemia | Physiological aspects | Cellular signal transduction | Observations | T cells | Health aspects | Biological Sciences
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