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Autophagy, ISSN 1554-8627, 09/2011, Volume 7, Issue 9, pp. 1045 - 1051
Multiple stress pathways result in the induction of autophagy and apoptosis. Current methods (e.g., protein gel blot, microscopy) do not offer quantitative... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Autophagy | Multispectral imaging cytometry | Influenza | New methodology | Apoptosis | influenza | CROSS-TALK | new methodology | autophagy | BECLIN 1 | multispectral imaging cytometry | apoptosis | CELL-DEATH | CELL BIOLOGY | Leukocytes, Mononuclear - metabolism | Image Cytometry - methods | Apoptosis - drug effects | Apoptosis - radiation effects | Autophagy - radiation effects | Microtubule-Associated Proteins - metabolism | Humans | Autophagy - drug effects | Lysosomes - radiation effects | Chloroquine - pharmacology | Lysosomes - metabolism | Ultraviolet Rays | Time Factors | Leukocytes, Mononuclear - radiation effects | Signal Transduction - radiation effects | Fibroblasts - metabolism | Lysosomes - drug effects | Leukocytes, Mononuclear - drug effects | Animals | Fibroblasts - radiation effects | Signal Transduction - drug effects | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Leukocytes, Mononuclear - cytology | Fibroblasts - cytology | Mice | Autophagy/radiation effects | Signal Transduction/radiation effects | Image Cytometry/methods | Autophagy/drug effects | Life Sciences | Lysosomes/drug effects | Immunology | Fibroblasts/metabolism | Leukocytes, Mononuclear/radiation effects | Fibroblasts/drug effects | Leukocytes, Mononuclear/metabolism | Apoptosis/radiation effects | Leukocytes, Mononuclear/drug effects | Fibroblasts/cytology | Apoptosis/drug effects | Fibroblasts/radiation effects | Lysosomes/metabolism | Leukocytes, Mononuclear/cytology | Signal Transduction/drug effects | Chloroquine/pharmacology | Embryo, Mammalian/cytology | Lysosomes/radiation effects | Microtubule-Associated Proteins/metabolism
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2013, Volume 123, Issue 8, pp. 3272 - 3291
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 5, p. e10431
... their relevance for pre-clinical drug discovery, disease modeling and basic research. Primary and non-transformed prostate epithelial cells, but also several PrCa lines, formed well... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | GENE-EXPRESSION SIGNATURE | STEM-CELLS | MAMMARY EPITHELIA | METASTASIS | BIOLOGY | TUMOR-CELL INVASION | DIFFERENTIATION | CULTURE MODEL | LINES | Laminin - pharmacology | Epithelial Cells - drug effects | Humans | Mesoderm - drug effects | Spheroids, Cellular - pathology | Male | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Spheroids, Cellular - enzymology | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - metabolism | Prostate - pathology | Prostatic Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Prostate - drug effects | Antineoplastic Agents - pharmacology | Collagen - pharmacology | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Principal Component Analysis | Prostatic Neoplasms - drug therapy | Epithelium - drug effects | Prostatic Neoplasms - pathology | Epithelium - pathology | Neoplasm Invasiveness | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Epithelial Cells - pathology | Cell Shape - drug effects | Phenotype | Proteoglycans - pharmacology | Signal Transduction - drug effects | Models, Biological | Prostatic Neoplasms - enzymology | Cell Proliferation - drug effects | TOR Serine-Threonine Kinases | Cell Transformation, Neoplastic - pathology | Mesoderm - pathology | Drug Combinations | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Epigenetic inheritance | Growth | Oncology, Experimental | Genes | Research | Gene expression | Ionizing radiation | Stem cells | Physiological aspects | Models | Drug discovery | Drug therapy | Prostate cancer | Integrins | Cancer | Cell culture | Biotechnology | Transformation | Motility | Leukocyte migration | Mesenchyme | Epithelial cells | Homeostasis | AKT protein | Metastasis | Drug resistance | Tissues | Ovarian cancer | Cell adhesion & migration | Metastases | Rodents | Fibroblasts | Extracellular matrix | Basal lamina | Lipid metabolism | Medical research | Invasiveness | Phenotypic plasticity | Tumor cell lines | Metabolism | Spheroids | 1-Phosphatidylinositol 3-kinase | Signaling | Interferon | Three dimensional models | Prostate | Cell migration
Journal Article
PloS one, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64010
...) and inhibited the transmission of HIV captured by DC-SIGN(+)-cells to uninfected CD4(+) T cells (EC50:4.1 mu M). Time-of-drug... 
TARGET | HERPES-SIMPLEX-VIRUS | IN-VITRO | ENTRY | MULTIDISCIPLINARY SCIENCES | GRIFFITHSIN | INFECTION | SYNERGISTIC ACTIVITY | SEXUAL TRANSMISSION | TENOFOVIR | GEL | Anti-HIV Agents - pharmacology | Leukocytes, Mononuclear - metabolism | Lactobacillus - growth & development | Simplexvirus - physiology | Bacteriocins - chemistry | Epithelial Cells - drug effects | Giant Cells - drug effects | Humans | Virus Internalization - drug effects | HIV Envelope Protein gp120 - metabolism | Leukocytes, Mononuclear - virology | Lectins, C-Type - metabolism | HIV-1 - physiology | HIV Infections - pathology | HIV-1 - isolation & purification | Lactobacillus - drug effects | Protein Binding - drug effects | Female | Vagina - pathology | Simplexvirus - drug effects | Virus Replication - drug effects | Leukocytes, Mononuclear - drug effects | Receptors, CXCR5 - metabolism | HIV-1 - drug effects | HIV Infections - virology | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Nisin - metabolism | Cell Adhesion Molecules - metabolism | Receptors, CXCR4 - metabolism | Leukocytes, Mononuclear - pathology | Nisin - pharmacology | Epithelial Cells - microbiology | Bacteriocins - pharmacology | Drug Resistance, Viral - drug effects | Vagina - microbiology | Kinetics | CD4 Antigens - metabolism | Prevention | Technology application | Disease transmission | Peptides | T cells | HIV (Viruses) | Acyclovir | Antibacterial agents | Drugs | Sexually transmitted diseases--STD | Toxicity | Amino acids | Viruses | Lymphocytes T | Infections | Lantibiotics | Drug resistance | Proteins | Tenofovir | Synergistic effects | Saquinavir | CD69 antigen | Receptors | Microbicides | Enfuvirtide | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Antiviral activity | Lead | CD25 antigen | Bacteria | Inhibition | Pretreatment | Heparan sulfate | Medical research | Enzymes | Cytokines | Lactobacilli | Vagina | Envelope protein | Inflammation | Virology | CD4 antigen | DC-SIGN protein | Studies | Glycoprotein gp120 | Chemokines | STD | Sexually transmitted diseases | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 2014, Volume 211, Issue 13, pp. 2549 - 2566
DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when... 
MEDICINE, RESEARCH & EXPERIMENTAL | HERPES-SIMPLEX-VIRUS | IN-VITRO | DENDRITIC CELLS | LEUKOCYTE MIGRATION | VARICELLA-ZOSTER-VIRUS | RM CELLS | TISSUE | IMMUNOLOGY | ALDRICH-SYNDROME PROTEIN | MEMORY T-CELLS | IMMUNOLOGICAL SYNAPSES
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 09/2016, Volume 5, Issue 9, p. n/a
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 5, p. e36831
.... We focused on the in vitro effects of MJ-29 on ER stress and mitochondria-dependent apoptotic death in WEHI-3 cells, and to hypothesize that MJ-29 might fully impair the orthotopic leukemic mice... 
PERMEABILITY TRANSITION PORE | IMMUNE-RESPONSE | ACUTE LYMPHOBLASTIC-LEUKEMIA | IN-VIVO | BIOLOGY | TUBULIN POLYMERIZATION | DEATH | ANTITUMOR-ACTIVITY | BINDING AGENTS | CANCER | BALB/C MICE | Leukocytes, Mononuclear - metabolism | Reactive Oxygen Species | Apoptosis - drug effects | Calcium - metabolism | Body Weight - drug effects | Male | Leukemia - metabolism | Antineoplastic Agents - administration & dosage | Antigens, CD - metabolism | Antineoplastic Agents - toxicity | Lymphocytes - immunology | Antineoplastic Agents - pharmacology | Macrophages - immunology | Quinazolinones - pharmacology | Cell Survival - drug effects | Unfolded Protein Response - drug effects | Phagocytosis - drug effects | Leukocytes, Mononuclear - drug effects | Endoplasmic Reticulum Stress - drug effects | Leukemia - drug therapy | Mitochondria - drug effects | Organ Size - drug effects | Animals | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Lymphocytes - drug effects | Cell Line, Tumor | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Leukemia - mortality | Chemotherapy | Immunotherapy | Leukemia | Calpain | B cells | Cancer | Apoptosis | Flow cytometry | Liver | Body weight | Red pulp | Intracellular signalling | Cytotoxicity | Macrophages | Drug resistance | Cancer therapies | Pulp | Proteins | Mitochondria | Animal tissues | Cell cycle | Life sciences | Quinazolinone | Deoxyribonucleic acid--DNA | Spleen | Stresses | Myelomonocytic leukemia | Immune response | Calcium (intracellular) | Permeability | Stress | Cytometry | Monocytes | Lymphocytes B | Infiltration | Annexin V | Endoplasmic reticulum | Pharmaceuticals | Deoxyribonucleic acid | DNA
Journal Article
Disease models & mechanisms, ISSN 1754-8403, 07/2013, Volume 6, Issue 4, pp. 1012 - 1020
We and others have previously demonstrated that heme oxygenase 1 (HO-1) induction by acute hemin administration exerts cardioprotective effects... 
ISCHEMIA-REPERFUSION INJURY | SYSTEM | BILIRUBIN | PROTEIN-KINASE PATHWAY | APOPTOSIS | ISCHEMIA/REPERFUSION INJURY | CARBON-MONOXIDE | INVOLVEMENT | PATHOLOGY | CORONARY-ARTERY-DISEASE | TRANSGENIC MICE | CELL BIOLOGY | Heme Oxygenase-1 - metabolism | Apoptosis - drug effects | Heart Failure - enzymology | Heart Failure - physiopathology | Male | Myocardial Infarction - diagnostic imaging | Carbon Monoxide - metabolism | Myocardial Reperfusion Injury - enzymology | Myocardial Reperfusion Injury - pathology | Heart Ventricles - ultrastructure | Myocardial Infarction - pathology | Lipid Peroxidation - drug effects | Ultrasonography | Free Radicals - metabolism | Myocardial Infarction - physiopathology | Hemin - pharmacology | Heart Ventricles - pathology | Disease Models, Animal | Myocardial Infarction - enzymology | Biomarkers - metabolism | Ventricular Function, Left - drug effects | Rats | Heart Failure - pathology | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Myocardial Reperfusion Injury - physiopathology | Myocardial Reperfusion Injury - diagnostic imaging | Animals | Heart Ventricles - physiopathology | Signal Transduction - drug effects | Survival Analysis | Leukocytes - drug effects | Heart Function Tests - drug effects | DNA Damage | Oxidative Stress - drug effects | Leukocytes - metabolism | Heart Ventricles - drug effects
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2007, Volume 293, Issue 4, pp. 2210 - 2218
Targeting cannabinoid-2 (CB2) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms by which CB2 activation exerts its anti-inflammatory effects... 
Adhesion molecules | Inflammation | RhoA | Endothelial activation | C-REACTIVE PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MOLECULE EXPRESSION | ATHEROSCLEROSIS | NECROSIS-FACTOR-ALPHA | KNOCKOUT MICE | endothelial activation | CANNABINOID RECEPTORS | inflammation | adhesion molecules | NITRIC-OXIDE | THERAPEUTIC TARGETS | PERIPHERAL VASCULAR DISEASE | POTENTIAL ROLE | CB2 RECEPTOR ACTIVATION | Inflammation - chemically induced | Leukocyte Rolling - drug effects | Tumor Necrosis Factor-alpha - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Male | Monocytes - metabolism | NF-kappa B - metabolism | rhoA GTP-Binding Protein - metabolism | Aorta - metabolism | RNA, Messenger - metabolism | Receptor, Cannabinoid, CB2 - genetics | Coronary Vessels - metabolism | Lipopolysaccharides | Dose-Response Relationship, Drug | Inflammation - metabolism | Anti-Inflammatory Agents - therapeutic use | Chemokine CCL2 - metabolism | Disease Models, Animal | Coronary Vessels - drug effects | Anti-Inflammatory Agents - pharmacology | Endothelial Cells - metabolism | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Cannabinoids - pharmacology | Monocytes - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Intercellular Adhesion Molecule-1 - metabolism | Animals | Signal Transduction - drug effects | Inflammation - prevention & control | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Endothelial Cells - drug effects
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 10, p. e25900
...) and measured effects on pro-catabolic gene expression. Sclerostin dose-dependently up-regulated the expression of receptor activator of nuclear factor kappa B (RANKL... 
MESSENGER-RNA | BONE MORPHOGENETIC PROTEIN | MULTIDISCIPLINARY SCIENCES | HUMAN PRIMARY OSTEOBLASTS | RECEPTOR ACTIVATOR | MECHANICAL STIMULATION | PARATHYROID-HORMONE | CELL-DIFFERENTIATION | WNT | EXPRESSION | KAPPA-B LIGAND | Osteocytes - drug effects | RANK Ligand - metabolism | Apoptosis - drug effects | Humans | Tartrate-Resistant Acid Phosphatase | Osteoclasts - cytology | Cell Differentiation - genetics | Acid Phosphatase - metabolism | Isoenzymes - metabolism | Adult | Osteoblasts - cytology | Bone Morphogenetic Proteins - pharmacology | Osteogenesis - genetics | Cell Survival - drug effects | Calcification, Physiologic - drug effects | Osteocytes - metabolism | Osteoblasts - drug effects | Osteocytes - cytology | Osteogenesis - drug effects | Cells, Cultured | Genetic Markers | Recombinant Proteins - pharmacology | Osteoclasts - metabolism | Gene Expression Regulation - drug effects | RANK Ligand - genetics | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Mice | Osteoblasts - metabolism | Osteoclasts - drug effects | Bones | RNA | Gene expression | Density | Genes | Homeostasis | Osteocytes | Leukocytes (mononuclear) | SOST protein | Biology | Kinases | Osteoprotegerin | Monoculture | Ethics | Genotype & phenotype | Splenocytes | Peripheral blood mononuclear cells | Tumor necrosis factor-TNF | Biocompatibility | TRANCE protein | Discipline | Cytokines | Caspase | Bone mass | Osteoblastogenesis | Low density lipoprotein receptors | Osteoclasts | Acid phosphatase (tartrate-resistant) | Apoptosis
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2017, Volume 292, Issue 28, pp. 11682 - 11701
HIV-1 infection causes AIDS, infecting millions worldwide. The virus can persist in a state of chronic infection due to its ability to become latent. We have... 
ESCRT-II | HEPATITIS-C VIRUS | EXTRACELLULAR VESICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATRIX PROTEIN | IMMUNE ACTIVATION | HUMAN-IMMUNODEFICIENCY-VIRUS | GENOMIC RNA | TYPE-1 | EXPRESSION | CURRENT KNOWLEDGE | Exosomes - drug effects | Transcription, Genetic - drug effects | Monocytes - cytology | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Monocytes - immunology | Ultracentrifugation | RNA Polymerase II - metabolism | Promoter Regions, Genetic - drug effects | Leukocytes, Mononuclear - virology | Virus Latency - drug effects | Exocytosis - drug effects | T-Lymphocytes - virology | HIV-1 - physiology | RNA Interference | Cattle | Endosomal Sorting Complexes Required for Transport - antagonists & inhibitors | T-Lymphocytes - drug effects | Exosomes - physiology | Leukocytes, Mononuclear - immunology | Exosomes - immunology | RNA Polymerase II - chemistry | Cell Line | Leukocytes, Mononuclear - drug effects | Immunity, Innate - drug effects | HIV-1 - drug effects | Anti-Retroviral Agents - pharmacology | Cells, Cultured | Endosomal Sorting Complexes Required for Transport - metabolism | Monocytes - drug effects | Monocytes - virology | HIV-1 - immunology | Models, Immunological | Animals | Virus Activation - drug effects | T-Lymphocytes - cytology | Leukocytes, Mononuclear - cytology | T-Lymphocytes - immunology | exosome (vesicle) | endosomal sorting complexes required for transport (ESCRT) | Microbiology | human immunodeficiency virus (HIV) | T-cell | transcription | latency | monocyte | small interfering RNA (siRNA)
Journal Article