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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2016, Volume 113, Issue 36, pp. 10127 - 10132
Systemic autoinflammatory diseases are caused by mutations in genes that function in innate immunity. Here, we report an autoinflammatory disease caused by... 
Autoinflammatory disease | Cytokines | Nf-κb pathway | Linear deubiquitinase | OTULIN | ACTIVATION | AMYLOPECTINOSIS | NF-kappa B pathway | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | linear deubiquitinase | ASSEMBLY COMPLEX | CELL-DEATH | HOIP | SHARPIN | autoinflammatory disease | INFLAMMATION | LUBAC DEFICIENCY | cytokines | IMMUNODEFICIENCY | Fibroblasts - enzymology | Humans | NF-kappa B - immunology | Child, Preschool | Male | Fever - physiopathology | Leukocytes, Mononuclear - immunology | HEK293 Cells | Female | Child | Cytokines - genetics | Failure to Thrive - physiopathology | Hereditary Autoinflammatory Diseases - pathology | Cytokines - immunology | Dermatitis - physiopathology | Signal Transduction | Hereditary Autoinflammatory Diseases - enzymology | Gene Expression Regulation | Ubiquitin - genetics | Endopeptidases - deficiency | Hereditary Autoinflammatory Diseases - diagnosis | Fibroblasts - pathology | Endopeptidases - immunology | Leukocytes, Mononuclear - pathology | Endopeptidases - genetics | NF-kappa B - genetics | Pedigree | Age of Onset | Alleles | Fibroblasts - immunology | Leukocytes, Mononuclear - enzymology | Panniculitis - physiopathology | Consanguinity | Mutation | Ubiquitin - immunology | Hereditary Autoinflammatory Diseases - genetics | Allelomorphism | Genetic aspects | Gene mutations | Autoimmune diseases | Health aspects | Biological Sciences | NF-κB pathway
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2010, Volume 159, Issue 4, pp. 842 - 855
Background and purpose:  Apremilast is an orally administered phosphodiesterase-4 inhibitor, currently in phase 2 clinical studies of psoriasis and other... 
immunopharmacology | anti-inflammatory drugs | PDE inhibitor | chemokines | inflammation | skin pharmacology | anti‐inflammatory drugs | Skin pharmacology | Inflammation | Anti-inflammatory drugs | Immunopharmacology | Chemokines | TRANSCRIPTION FACTORS | DIFFERENTIAL EXPRESSION | ELEMENT-BINDING PROTEIN | NECROSIS-FACTOR-ALPHA | PERITONEAL-MACROPHAGES | PDE4 INHIBITORS | OBSTRUCTIVE PULMONARY-DISEASE | CYCLIC-AMP PHOSPHODIESTERASE | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | PLAQUE-TYPE PSORIASIS | Humans | Middle Aged | Thalidomide - pharmacology | RNA, Messenger - metabolism | Zymosan - metabolism | Thalidomide - analogs & derivatives | Ultraviolet Rays | Psoriasis - pathology | Time Factors | U937 Cells | Anti-Inflammatory Agents - administration & dosage | Skin Transplantation | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cytokines - genetics | Keratinocytes - enzymology | Disease Models, Animal | Psoriasis - immunology | Leukocytes, Mononuclear - drug effects | Psoriasis - drug therapy | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Thalidomide - administration & dosage | Skin - enzymology | Keratinocytes - immunology | Killer Cells, Natural - enzymology | Keratinocytes - drug effects | Lipopolysaccharides - pharmacology | Killer Cells, Natural - drug effects | Mice | Transplantation, Heterologous | Dose-Response Relationship, Drug | Psoriasis - genetics | Enterotoxins - immunology | Leukocytes, Mononuclear - immunology | Inflammation Mediators - metabolism | Phosphodiesterase 4 Inhibitors | Killer Cells, Natural - immunology | Adult | Skin - pathology | Skin - immunology | Severity of Illness Index | Cytokines - metabolism | Phosphodiesterase Inhibitors - pharmacology | Mice, SCID | Gene Expression Regulation - drug effects | Phosphodiesterase Inhibitors - administration & dosage | Animals | Skin - radiation effects | Leukocytes, Mononuclear - enzymology | Cell Proliferation - drug effects | Psoriasis - enzymology | Skin - drug effects | Psoriasis | Tumor necrosis factor-TNF | Rodents | Research Papers
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2008, Volume 26, Issue 13, pp. 2139 - 2146
Purpose To assess the tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of the mitogenactivated protein kinase kinase (MEK) 1/2 inhibitor... 
MEK INHIBITOR | POTENT | VIVO | ONCOLOGY | PATHWAY | GROWTH | COLON | TUMORS | ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins p21(ras) | Humans | Middle Aged | Melanoma - enzymology | Male | Antineoplastic Agents - administration & dosage | Extracellular Signal-Regulated MAP Kinases - metabolism | Protein Kinase Inhibitors - adverse effects | Dose-Response Relationship, Drug | Benzimidazoles - administration & dosage | Neoplasms - genetics | Antineoplastic Agents - adverse effects | DNA Mutational Analysis | Melanoma - genetics | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Benzimidazoles - adverse effects | Protein Kinase Inhibitors - pharmacokinetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Leukocytes, Mononuclear - drug effects | Drug Administration Schedule | Administration, Oral | Benzimidazoles - pharmacokinetics | Neoplasms - enzymology | MAP Kinase Kinase 1 - metabolism | Proto-Oncogene Proteins - genetics | Treatment Outcome | MAP Kinase Kinase 2 - metabolism | Melanoma - pathology | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Maximum Tolerated Dose | Ki-67 Antigen - analysis | MAP Kinase Kinase 2 - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Leukocytes, Mononuclear - enzymology | Aged | Cell Proliferation - drug effects | Mutation | Neoplasm Staging | Neoplasms - pathology | Index Medicus
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 01/2015, Volume 78, pp. 224 - 232
Heme oxygenase (HO)-1 is the inducible isoform of the heme-degrading enzyme HO, which is upregulated by multiple stress stimuli. HO-1 has major... 
Lipopolysaccharide | Bach1 | Inflammation | Mononuclear cells | Toll-like receptor | Heme oxygenase-1 | Toll-likereceptor | IMMUNE-RESPONSE | ACTIVATION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | ENDOTOXIN | INDUCTION | SIGNALING PATHWAY | MONOXIDE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NITRIC-OXIDE | Gene Expression Regulation, Enzymologic - drug effects | Heme Oxygenase-1 - metabolism | Basic-Leucine Zipper Transcription Factors - metabolism | Endotoxemia - enzymology | Leukemia, Monocytic, Acute - pathology | Monocytes - cytology | Humans | Endotoxemia - pathology | Leukemia, Monocytic, Acute - enzymology | Heme Oxygenase-1 - genetics | Fanconi Anemia Complementation Group Proteins - metabolism | Real-Time Polymerase Chain Reaction | Leukemia, Monocytic, Acute - drug therapy | Leukocytes, Mononuclear - drug effects | Down-Regulation | Endotoxemia - drug therapy | RNA, Messenger - genetics | Fanconi Anemia Complementation Group Proteins - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Macrophages - cytology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Macrophages - enzymology | Monocytes - drug effects | Monocytes - enzymology | Animals | Lipopolysaccharides - pharmacology | Leukocytes, Mononuclear - cytology | Leukocytes, Mononuclear - enzymology | Macrophages - drug effects | Mice | COX-2 inhibitors | Enzymes | RNA | Dendritic cells | Analysis | Leukemia | Heme | Gene expression | Mitogens | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e41582
Background: Severe asthma accounts for a small number of asthmatics but represents a disproportionate cost to health care systems. The underlying mechanism in... 
RHEUMATOID-ARTHRITIS | INFLAMMATION | BIOLOGY | GENE-EXPRESSION | DOUBLE-BLIND | RECEPTOR | FACTOR-KAPPA-B | MAPK INHIBITOR | INSENSITIVE ASTHMA | T-CELLS | RESISTANT ASTHMA | Severity of Illness Index | Leukocytes, Mononuclear - drug effects | Asthma - enzymology | Humans | Adrenal Cortex Hormones - pharmacology | Male | Imidazoles - pharmacology | Protein Transport - drug effects | Receptors, Glucocorticoid - metabolism | Phosphoserine - metabolism | Cell Nucleus - metabolism | Models, Biological | U937 Cells | Asthma - blood | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Adult | Female | Leukocytes, Mononuclear - enzymology | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Cell Nucleus - drug effects | Interleukin-8 - blood | Dexamethasone | Tumor necrosis factor | Comparative analysis | Mitogens | Protein kinases | Medical care, Cost of | Asthma | Steroids | Health care | Heart | Phosphorylation | Transcription factors | Biomedical research | Glucocorticoids | Immunocytochemistry | Serine | Leukocytes (mononuclear) | Arthritis | Kinases | Blood | Proteins | Interleukin 4 | Immunology | Restoration | Granulocytes | Interleukin 2 | Peripheral blood mononuclear cells | Inhibition | Prednisolone | Interleukin 8 | Enzyme-linked immunosorbent assay | Translocation | Cytokines | CD3 antigen | Tumor necrosis factor-α | Gene expression | Nuclear transport | Studies | Sensitivity | Inhibitors | Protein kinase | Biomarkers
Journal Article
Life Sciences, ISSN 0024-3205, 03/2016, Volume 148, pp. 80 - 85
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2009, Volume 27, Issue 16, pp. 2705 - 2711
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 01/2017, Volume 13, Issue 1, pp. 46 - 53
Journal Article