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Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 06/2015, Volume 13, Issue 6, pp. 1090 - 1102
Background and objectivesCarboxypeptidase B2 (CPB2) is a basic carboxypeptidase with fibrin and complement C3a and C5a as physiological substrates. We... 
fibrinolysis | carboxypeptidase B2 | inflammation | anaphylatoxin | sepsis | Carboxypeptidase B2 | Sepsis | Inflammation | Anaphylatoxin | Fibrinolysis | ACTIVATABLE FIBRINOLYSIS INHIBITOR | MOUSE | INJURY | RECEPTOR | PROTECTS | TAFI | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | MICE | PROCARBOXYPEPTIDASE-B | HEMATOLOGY | Blood Coagulation Disorders - enzymology | Liver - microbiology | Complement C5a - metabolism | Male | Cecum - microbiology | Protective Factors | Blood Coagulation Disorders - genetics | Liver - immunology | Cecum - surgery | Time Factors | Peritonitis - genetics | Complement C3a - antagonists & inhibitors | Carboxypeptidase B2 - deficiency | Disease Models, Animal | Leukopenia - microbiology | Risk Factors | Macrophages, Peritoneal - enzymology | Macrophages, Peritoneal - immunology | Macrophage Activation | Mice, Knockout | Peritonitis - enzymology | Sepsis - enzymology | Complement C3a - immunology | Enzyme Activation | Fibrin - metabolism | Leukopenia - immunology | Liver - enzymology | Leukopenia - genetics | Peritonitis - microbiology | Thrombomodulin - metabolism | Ligation | Carboxypeptidase B2 - genetics | Complement C3a - metabolism | Sepsis - immunology | Mice, Inbred C57BL | Cells, Cultured | Inflammation Mediators - blood | Punctures | Blood Coagulation Disorders - microbiology | Peritonitis - immunology | Sepsis - genetics | Complement C5a - antagonists & inhibitors | Animals | Macrophages, Peritoneal - microbiology | Blood Coagulation Disorders - immunology | Antifibrinolytic Agents - pharmacology | Leukopenia - enzymology | Complement C5a - immunology | Thrombin - metabolism | Sepsis - microbiology | Fibrin | Thrombin | Analysis | Liver | Medical research | Rodents | Index Medicus
Journal Article
Cell Death and Disease, ISSN 2041-4889, 08/2015, Volume 6, Issue 8, pp. e1856 - e1856
Journal Article
Circulation Research, ISSN 0009-7330, 03/2008, Volume 102, Issue 6, pp. 669 - 676
Sphingosine 1-phosphate (S1P), an abundant lipid mediator in plasma, regulates vascular and immune cells by activating S1P receptors. In this report, we... 
Plasma S1P gradient | Shear stress | S1P lyase (Sgpl) | Sphingosine 1-phosphate (S1P) | Sphingosine kinase (Sphk) | CELLS | sphingosine kinase (Sphk) | CARDIAC & CARDIOVASCULAR SYSTEMS | EXTRACELLULAR EXPORT | LIPID PHOSPHATE PHOSPHATASES | MECHANISMS | SPHINGOLIPIDS | plasma S1P gradient | KINASE-1 | SPHINGOSINE-1-PHOSPHATE | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | sphingosine 1-phosphate (S1P) | MICE | HEMATOLOGY | BLOOD | Lysophospholipids - metabolism | Whole-Body Irradiation | Liver - enzymology | Anemia - blood | Bone Marrow Cells - enzymology | Humans | Half-Life | Stress, Mechanical | Endothelium, Vascular - enzymology | Leukopenia - blood | RNA Interference | Time Factors | Bone Marrow Transplantation | Adenoviridae - genetics | Membrane Proteins - metabolism | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Disease Models, Animal | Cell Line | Transduction, Genetic | Endothelial Cells - metabolism | Liver - metabolism | Mice, Inbred C57BL | Phosphotransferases (Alcohol Group Acceptor) - deficiency | Thrombocytopenia - immunology | Cells, Cultured | Anemia - chemically induced | Phosphotransferases (Alcohol Group Acceptor) - genetics | Lysophospholipids - blood | Antibodies, Monoclonal | Bone Marrow Cells - radiation effects | Phenylhydrazines | Thrombocytopenia - blood | Mice, Knockout | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sphingosine - analogs & derivatives | Animals | Endothelium, Vascular - metabolism | Aldehyde-Lyases - metabolism | Cell Line, Tumor | Sphingosine - blood | Mice | Genetic Vectors | Phosphoric Monoester Hydrolases - metabolism | Endothelial Cells - enzymology | Bone Marrow Cells - metabolism | Platelet Glycoprotein GPIb-IX Complex - immunology | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 15, pp. 9531 - 9542
Pathology data from the anthrax animal models show evidence of significant increases in vascular permeability coincident with hemostatic imbalances manifested... 
RICKETTSIA-RICKETTSII INFECTION | VACCINE CANDIDATES | VONWILLEBRAND-FACTOR MULTIMERS | IN-VITRO | HEMOLYTIC-UREMIC SYNDROME | LETHAL TOXIN | PLATELET-AGGREGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHALATIONAL ANTHRAX | THROMBOTIC THROMBOCYTOPENIC PURPURA | GLYCOPROTEIN-IB | Blood Platelets - pathology | Humans | Metalloendopeptidases - metabolism | Thrombocytopenia - microbiology | Metalloproteases - metabolism | Endothelial Cells - microbiology | Anthrax - enzymology | Ristocetin - pharmacology | Time Factors | Plasma - microbiology | Protein Binding - drug effects | Spores, Bacterial - enzymology | Disseminated Intravascular Coagulation - pathology | Platelet Aggregation - drug effects | Anthrax - pathology | Disease Models, Animal | von Willebrand Factor - metabolism | Hemostasis - drug effects | Protein Structure, Tertiary | Leukopenia - microbiology | Thrombosis - microbiology | Endothelial Cells - metabolism | Thrombosis - enzymology | Thrombocytopenia - pathology | ADAMTS13 Protein | Leukopenia - pathology | Disseminated Intravascular Coagulation - microbiology | Collagen - metabolism | Disseminated Intravascular Coagulation - enzymology | Thrombocytopenia - enzymology | Thrombosis - pathology | ADAM Proteins - metabolism | Animals | Substrate Specificity - drug effects | Blood Platelets - metabolism | Plasma - enzymology | Cell Communication - drug effects | Leukopenia - enzymology | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Mice | Blood Platelets - microbiology | Endothelial Cells - pathology | Urea - pharmacology | Index Medicus
Journal Article
British Journal of Haematology, ISSN 0007-1048, 10/2015, Volume 171, Issue 1, pp. 109 - 115
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2001, Volume 7, Issue 9, pp. 2832 - 2839
Deficiency of dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme in 5-fluorouracil (5-FU) catabolism, has been linked to toxic side effects of... 
CANCER-PATIENTS | RNA | PHARMACOKINETICS | ONCOLOGY | COLORECTAL-CANCER | POLYMERASE CHAIN-REACTION | PHARMACOGENETICS | FAMILIAL PYRIMIDINEMIA | FLUOROURACIL | DEFICIENCY | CHEMOTHERAPY | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Humans | Middle Aged | DNA, Complementary - genetics | Male | Diarrhea - chemically induced | Diarrhea - pathology | Fluorouracil - therapeutic use | Breast Neoplasms - enzymology | Rectal Neoplasms - genetics | Fluorouracil - adverse effects | Stomatitis - pathology | Leukopenia - chemically induced | Adult | Female | Rectal Neoplasms - drug therapy | Severity of Illness Index | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Introns - genetics | Oxidoreductases - metabolism | Oxidoreductases - genetics | Alternative Splicing - genetics | Gene Frequency | Exons - genetics | Genotype | Thrombocytopenia - chemically induced | Stomach Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Thrombocytopenia - pathology | Breast Neoplasms - drug therapy | Leukopenia - pathology | Rectal Neoplasms - enzymology | Homozygote | Point Mutation | Antimetabolites, Antineoplastic - therapeutic use | Breast Neoplasms - genetics | Stomatitis - chemically induced | Antimetabolites, Antineoplastic - adverse effects | Heterozygote | Aged | Colonic Neoplasms - enzymology | Dihydrouracil Dehydrogenase (NADP) | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 4, pp. 907 - 917.e7
Background & Aims More than 20% of patients with inflammatory bowel disease (IBD) discontinue thiopurine therapy because of severe adverse drug reactions... 
Gastroenterology and Hepatology | Side Effect | Pharmacogenetic | Leukocyte | Adverse Event | CROHNS-DISEASE | RANDOMIZED-TRIAL | TOXICITY | AMINOSALICYLATES | MYELOSUPPRESSION | INOSINE TRIPHOSPHATE PYROPHOSPHATASE | S-METHYLTRANSFERASE ACTIVITY | AZATHIOPRINE THERAPY | GENES | PHARMACOGENETICS | GASTROENTEROLOGY & HEPATOLOGY | Crohn Disease - genetics | Predictive Value of Tests | Azathioprine - administration & dosage | Colitis, Ulcerative - enzymology | Genetic Testing | Prospective Studies | Humans | Methyltransferases - metabolism | Middle Aged | Colitis, Ulcerative - genetics | Gastrointestinal Agents - administration & dosage | Methyltransferases - genetics | Male | Anti-Inflammatory Agents - metabolism | Genetic Variation | Young Adult | Drug Dosage Calculations | Netherlands | Anti-Inflammatory Agents - adverse effects | Crohn Disease - diagnosis | Leukopenia - chemically induced | Mercaptopurine - metabolism | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Colitis, Ulcerative - drug therapy | Leukopenia - prevention & control | Crohn Disease - enzymology | Pharmacogenetics | Azathioprine - metabolism | Risk Factors | Mercaptopurine - administration & dosage | Mercaptopurine - adverse effects | Treatment Outcome | Thrombocytopenia - chemically induced | Homozygote | Phenotype | Colitis, Ulcerative - diagnosis | Crohn Disease - drug therapy | Thrombocytopenia - prevention & control | Heterozygote | Gastrointestinal Agents - adverse effects | Azathioprine - adverse effects | Gastrointestinal Agents - metabolism | Enzymes | Care and treatment | Metabolites | Analysis | Gastrointestinal diseases | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Pharmacogenomics Journal, ISSN 1470-269X, 06/2016, Volume 16, Issue 3, pp. 280 - 285
The efficacy of thiopurines, including azathioprine (AZA) and 6-mercaptopurine (6MP), has been demonstrated for the treatment of inflammatory bowel disease... 
CONTROLLED-TRIAL | INFLAMMATORY-BOWEL-DISEASE | S-METHYLTRANSFERASE | THERAPY | CROHNS-DISEASE | VARIANTS | SUSCEPTIBILITY | GENETICS & HEREDITY | AZATHIOPRINE | PACSIN2 | PHARMACOLOGY & PHARMACY | ASSOCIATION | Multivariate Analysis | Azathioprine - administration & dosage | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Gastrointestinal Agents - administration & dosage | Pyrophosphatases - genetics | Leukopenia - genetics | Male | Crohn Disease - ethnology | Dose-Response Relationship, Drug | Young Adult | Colitis, Ulcerative - ethnology | Anti-Inflammatory Agents - adverse effects | Alopecia - genetics | Leukopenia - chemically induced | Alopecia - enzymology | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Colitis, Ulcerative - drug therapy | Odds Ratio | Severity of Illness Index | Genetic Predisposition to Disease | Genetic Association Studies | Leukopenia - ethnology | Gene Frequency | Japan | Risk Factors | Alopecia - ethnology | Kaplan-Meier Estimate | Mercaptopurine - administration & dosage | Mercaptopurine - adverse effects | Logistic Models | Treatment Outcome | Chi-Square Distribution | Pyrophosphatases - metabolism | Phenotype | Crohn Disease - drug therapy | Leukopenia - enzymology | Alopecia - chemically induced | Gastrointestinal Agents - adverse effects | Azathioprine - adverse effects | Antimitotic agents | Drugs | Inflammatory bowel diseases | Care and treatment | Genetic variation | Patient outcomes | Drug metabolism | Adverse and side effects | Genetic aspects | Antineoplastic agents | Health aspects | Risk factors | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 05/2017, Volume 129, Issue 21, pp. 2928 - 2938
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e89916 - e89916
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 6, pp. 4081 - 4089
The unfolded protein response (UPR) is a homeostatic signaling mechanism that balances the protein folding capacity of the endoplasmic reticulum (ER) with the... 
INSULIN | RESPIRATORY-CHAIN | ADIPOCYTES | GENE | ADIPONECTIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | CELL DIFFERENTIATION | ENDOPLASMIC-RETICULUM STRESS | CDNA CLONING | EXPRESSION | Mitochondria - enzymology | Humans | Endoplasmic Reticulum - metabolism | Leukopenia - genetics | Adenosine Triphosphate - genetics | Mitochondrial Proteins - genetics | X-Box Binding Protein 1 | RNA Splicing - physiology | RNA, Messenger - biosynthesis | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Adenylate Kinase - metabolism | Adiponectin - genetics | Adiponectin - metabolism | Plasma Cells - metabolism | Energy Metabolism - physiology | Cell Differentiation - physiology | Severe Combined Immunodeficiency - enzymology | Endoplasmic Reticulum - genetics | RNA, Messenger - genetics | Hematopoiesis - genetics | Transcription Factors - biosynthesis | Transcription Factors - genetics | 3T3-L1 Cells | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Severe Combined Immunodeficiency - genetics | Animals | Leukopenia - enzymology | Signal Transduction - physiology | Mice | Mutation | Adenylate Kinase - genetics | DNA-Binding Proteins - biosynthesis | Unfolded Protein Response - physiology | Immunoglobulin M | Enzymes | Energy metabolism | Transcription factors | Splicing | RNA-mediated interference | Adenine | Adipocytes | Chaperones | Nucleotides | Adiponectin | Mitochondria | Adenylate kinase | Lymphocytes B | Protein folding | Plasma cells | Differentiation | Endoplasmic reticulum | Index Medicus | Protein Secretion | Adipocyte | ER Stress | Unfolded Protein Response | ATP | Lymphocyte | Cell Biology | Endoplasmic Reticulum (ER)
Journal Article