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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2008, Volume 105, Issue 43, pp. 16695 - 16700
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 05/2015, Volume 135, Issue 5, pp. 1358 - 1366.e11
Prostaglandin D (PGD ) and cysteinyl leukotrienes (cysLTs) are lipid mediators derived from mast cells, which activate T 2 cells. The combination of PGD and... 
leukotriene E4 | TH2 cells | Prostaglandin D2 | chemoattractant receptor-homologous molecule expressed on TH2 cells | neutrophils | leukotriene E | Prostaglandin D | chemoattractant receptor-homologous molecule expressed on T | 2 cells | Leukotriene E4 - metabolism | Cell Communication - immunology | Cell Adhesion Molecules - genetics | Apoptosis - drug effects | Humans | Gene Expression Profiling | Th2 Cells - immunology | Th2 Cells - drug effects | Leukotriene E4 - pharmacology | Chemotaxis, Leukocyte - genetics | Chemotaxis, Leukocyte - drug effects | Prostaglandin D2 - metabolism | Inflammation Mediators - metabolism | Neutrophils - metabolism | Gene Expression | Neutrophils - drug effects | Neutrophils - immunology | Cell Communication - genetics | Cell Adhesion Molecules - metabolism | Th2 Cells - metabolism | Drug Synergism | Apoptosis - immunology | Cell Communication - drug effects | Prostaglandin D2 - pharmacology | Chemotaxis, Leukocyte - immunology | Cluster Analysis | Index Medicus | Abridged Index Medicus | LTE4, Cysteinyl leukotriene E4 | CysLT2, Cysteinyl leukotriene receptor 2 | CRTH2, Chemoattractant receptor-homologous molecule expressed on TH2 cells | PMA, Phorbol 12-myristate 13-acetate | LTC4, Cysteinyl leukotriene C4 | PGD2, Prostaglandin D2 | CAIA, Cell activation–induced aggregation | cysLT, Cysteinyl leukotriene | qPCR, Quantitative PCR | PI3K, Phosphoinositide 3-kinase | LTD4, Cysteinyl leukotriene D4 | CysLT1, Cysteinyl leukotriene receptor 1 | ICAM, Intercellular adhesion molecule | RORγt, Retinoic acid–related orphan receptor γt | Mechanisms of Allergy and Clinical Immunology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2008, Volume 105, Issue 2, pp. 680 - 685
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2014, Volume 289, Issue 51, pp. 35314 - 35325
Calcium/voltage-gated, large conductance potassium (BK) channels control numerous physiological processes, including myogenic tone. BK channel regulation by... 
Computer Modeling | BETA-1 SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CA2+-ACTIVATED K+ CHANNELS | TRANSMEMBRANE DOMAIN | FATTY-ACIDS | Ion Channel | Patch Clamp | ARACHIDONIC-ACID | Leukotriene | SMOOTH-MUSCLE | MAXIK CHANNEL | BK CHANNELS | Drug Design | BILE-ACIDS | MODULATION | Large-Conductance Calcium-Activated Potassium Channel beta Subunits - metabolism | Leukotriene E4 - metabolism | Large-Conductance Calcium-Activated Potassium Channel beta Subunits - chemistry | Calcium - metabolism | RNA, Complementary - administration & dosage | Leukotriene E4 - pharmacology | Ion Channel Gating - physiology | RNA, Complementary - genetics | Leukotriene B4 - metabolism | Oocytes - drug effects | Female | Molecular Structure | Leukotriene C4 - pharmacology | Large-Conductance Calcium-Activated Potassium Channel beta Subunits - genetics | Leukotriene D4 - metabolism | Cerebral Arteries - cytology | Membrane Potentials - drug effects | Protein Structure, Tertiary | Leukotriene D4 - pharmacology | Leukotriene A4 - chemistry | Microinjections | Oocytes - metabolism | Xenopus laevis | Muscle Cells - metabolism | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - chemistry | Leukotriene E4 - chemistry | Models, Molecular | Rats | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - metabolism | Leukotriene A4 - metabolism | Muscle Cells - cytology | Leukotriene B4 - pharmacology | Patch-Clamp Techniques | Animals | Ion Channel Gating - genetics | Oocytes - physiology | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - genetics | Protein Binding | Leukotriene A4 - pharmacology | Leukotriene D4 - chemistry | Leukotriene C4 - metabolism | Leukotriene B4 - chemistry | Leukotriene C4 - chemistry | Ion Channel Gating - drug effects | Neurobiology
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e71536
Cysteinyl leukotrienes (cys-LTs) are a group of lipid mediators that are potent bronchoconstrictors, powerful inducers of vascular leakage and potentiators of... 
RESPONSES | ACTIVATION | ANTAGONIST | DESENSITIZATION | MULTIDISCIPLINARY SCIENCES | PULMONARY INFLAMMATION | PROLIFERATION | ASTHMATIC SUBJECTS | EXPRESSION | HYPERRESPONSIVENESS | INTESTINAL EPITHELIAL-CELLS | Calcium - metabolism | Humans | Leukotrienes - pharmacology | Proto-Oncogene Proteins c-fos - metabolism | Protein Kinase C - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Mast Cells - enzymology | Mast Cells - drug effects | Receptors, Leukotriene - metabolism | Leukotriene E4 - pharmacology | Gene Knockdown Techniques | Signal Transduction - drug effects | Calcium Signaling - drug effects | Isoenzymes - metabolism | Models, Biological | Protein Kinase C - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Cysteine - pharmacology | Mast Cells - metabolism | Chemokine CCL4 - metabolism | Protein Kinase Inhibitors - pharmacology | Phosphorylation - drug effects | RNA, Small Interfering - metabolism | Respiratory agents | Protein kinases | Asthma | Cell culture | Protein kinase C | Calcium | Downstream effects | Leukemia | Bronchoconstrictors | Allergic reactions | Kinases | Calcium influx | Respiratory tract | Proteins | Signal transduction | Inhibition | c-Fos protein | Inducers | Cytokines | Hypersensitivity | Inflammation | Gene expression | Allergies | Human subjects | Signaling | Chemistry | Leukotrienes | Isoforms | Stem cells | Mast cells
Journal Article
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 2002, Volume 109, Issue 6, pp. 975 - 979
Background: Eosinophils contain preformed stores of IL-4 within their cytoplasmic granules, but physiologic stimuli to release IL-4 from eosinophils are not... 
Leukotriene receptors | Cysteinyl leukotrienes | IL-4 | Leukotriene E | Leukotriene C | Leukotriene D | Eosinophils | leukotriene receptors | CELLS | INTERLEUKIN-4 | eosinophils | RECEPTOR | CD34(+) PROGENITORS | IMMUNOLOGY | BASOPHIL GRANULOCYTES | IDENTIFICATION | IN-VITRO | ALLERGY | cysteinyl leukotrienes | leukotriene C-4 | MOLECULAR-CLONING | DIFFERENTIATION | EXPRESSION | leukotriene D-4 | leukotriene E-4 | Immunohistochemistry | Propionates - pharmacology | Inflammation Mediators - administration & dosage | Eosinophils - metabolism | Tetrazoles - pharmacology | Eosinophils - drug effects | Humans | Leukotriene C4 - administration & dosage | Leukotriene D4 - administration & dosage | Leukotrienes - pharmacology | Virulence Factors, Bordetella - pharmacology | Leukotrienes - administration & dosage | Leukotriene E4 - pharmacology | Quinolines - pharmacology | Cysteine - administration & dosage | Dose-Response Relationship, Drug | Leukotrienes - chemistry | Time Factors | Inflammation Mediators - pharmacology | Acetophenones - pharmacology | Cysteine - pharmacology | Leukotriene E4 - administration & dosage | Leukotriene C4 - pharmacology | Leukotriene D4 - pharmacology | Rabbits | Electrophoresis, Polyacrylamide Gel | Pertussis Toxin | Cysteine - chemistry | Fetal Blood - cytology | Receptors, Leukotriene - metabolism | Isoxazoles - pharmacology | Membrane Proteins | Interleukin-4 - blood | Animals | Inflammation Mediators - chemistry | Microscopy, Fluorescence | Allergy | Allergic reaction | Long-term care of the sick | Proteins | Medical research | Cytokines | Blood
Journal Article