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1. Full Text Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain
by Puskarjov, Martin and Ahmad, Faraz and Kaila, Kai and Blaesse, Peter
Journal of Neuroscience, ISSN 0270-6474, 08/2012, Volume 32, Issue 33, pp. 11356 - 11364
The K-Cl cotransporter KCC2 plays a crucial role in neuronal chloride regulation. In mature central neurons, KCC2 is responsible for the low intracellular Cl-... 
PROTEOLYTIC CLEAVAGE | NMDA RECEPTOR | SYNAPTIC FUNCTION | GABAERGIC TRANSMISSION | AXON INITIAL SEGMENT | DOWN-REGULATION | DEVELOPMENTAL-CHANGES | RAT HIPPOCAMPUS | MEMBRANE TRAFFICKING | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | Calpain - metabolism | Rats, Wistar | Calcium - metabolism | Emetine - pharmacology | Male | N-Methylaspartate - pharmacology | Dose-Response Relationship, Drug | Pyramidal Cells - physiology | Statistics, Nonparametric | Calcium Ionophores - pharmacology | Pyramidal Cells - drug effects | Protein Synthesis Inhibitors - pharmacology | Action Potentials - drug effects | Animals, Newborn | Membrane Potentials - drug effects | Dipeptides - pharmacology | Valine - analogs & derivatives | Gene Expression Regulation - physiology | Rats | Magnesium - metabolism | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Cycloheximide - pharmacology | Symporters - metabolism | Gene Expression Regulation - drug effects | Leupeptins - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Cysteine Proteinase Inhibitors - pharmacology | Calpain - pharmacology | Ionomycin - pharmacology | Valine - pharmacology | Dizocilpine Maleate - pharmacology | In Vitro Techniques | Index Medicus
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2. Full Text Zinc pyrithione inhibits caspase-3 activity, promotes ErbB1-ErbB2 heterodimerization and suppresses ErbB2 downregulation in cardiomyocytes subjected to ischemia/reperfusion
by Bodiga, Vijaya Lakshmi and Bodiga, Sreedhar and Thokala, Sandhya and Vemuri, Praveen Kumar
Journal of Inorganic Biochemistry, ISSN 0162-0134, 12/2015, Volume 153, pp. 49 - 59
Heart tissue becomes zinc-depleted and the capacity to mobilize labile zinc is diminished, indicating zinc dyshomeostasis during ischemia/reperfusion (I/R).... 
Hypoxia | Reoxygenation | Proteolysis | Caspase-3 | Zinc | Apoptosis | ACTIVATION | RAT | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | CARDIOMYOPATHY | CARDIAC-CELLS | DEATH | INTRACELLULAR ZINC | CHEMISTRY, INORGANIC & NUCLEAR | ACUTE MYOCARDIAL-INFARCTION | Receptor, Epidermal Growth Factor - genetics | Caspase Inhibitors - pharmacology | Phosphorylation | Receptor, ErbB-2 - genetics | Protein Multimerization | Caspase 3 - metabolism | Receptor, ErbB-2 - metabolism | RNA, Messenger - metabolism | Cell Hypoxia | Receptor, Epidermal Growth Factor - metabolism | Zinc Compounds - pharmacology | Amino Acid Chloromethyl Ketones - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Benzothiazoles - pharmacology | Chlorides - pharmacology | Down-Regulation | RNA, Messenger - genetics | Rats | Tyrphostins - pharmacology | Cardiotonic Agents - pharmacology | Leupeptins - pharmacology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Thiones - pharmacology | Quinazolines - pharmacology | Organometallic Compounds - pharmacology | Proteins | Membrane lipids | Inositol | RNA | Antifungal agents | Permeability | Antibacterial agents | Phosphotransferases | Tyrosine | Cell death | Index Medicus
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3. Full Text Profiling drug-induced cell death pathways in the zebrafish lateral line
by Coffin, Allison B and Williamson, Kay L and Mamiya, Anna and Raible, David W and Rubel, Edwin W
Apoptosis, ISSN 1360-8185, 4/2013, Volume 18, Issue 4, pp. 393 - 408
Programmed cell death (PCD) is an important process in development and disease, as it allows the body to rid itself of unwanted or damaged cells. However, PCD... 
Biochemistry, general | Biomedicine | Gentamicin | Neomycin | Cancer Research | Oncology | Hair cell | Cisplatin | Cell Biology | Virology | Ototoxicity | NAFAMOSTAT MESILATE | INDUCED HAIR CELL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASPASE-INDEPENDENT NECROPTOSIS | APOPTOSIS PROTEIN | CELL BIOLOGY | HEARING-LOSS | SERINE-PROTEASE | PROTECTS COCHLEAR | CALPAIN INHIBITOR | Caspase Inhibitors - pharmacology | Reactive Oxygen Species - metabolism | Cross-Linking Reagents - pharmacology | Cells, Cultured | Guanidines - pharmacology | Methionine - pharmacology | Zebrafish | Antioxidants - pharmacology | Cisplatin - pharmacology | Hair Cells, Auditory, Inner - drug effects | Leupeptins - pharmacology | Protease Inhibitors - pharmacology | Animals | Gentamicins - pharmacology | Hair Cells, Auditory, Inner - metabolism | Cell Death | Lateral Line System - drug effects | Neomycin - pharmacology | Protein Synthesis Inhibitors - pharmacology | Oligopeptides - pharmacology | Calpain - antagonists & inhibitors | Lateral Line System - cytology | Drugs | Antioxidants | Chemotherapy | Cell death | Protein biosynthesis | Calpain | Aminoglycosides | Biochemistry | Universities and colleges | Antibacterial agents | Cancer | Index Medicus | gentamicin | cisplatin | ototoxicity | neomycin
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4. Full Text Dynamic Translational and Proteasomal Regulation of Fragile X Mental Retardation Protein Controls mGluR-Dependent Long-Term Depression
by Hou, Lingfei and Antion, Marcia D and Hu, Daoying and Spencer, Corinne M and Paylor, Richard and Klann, Eric
Neuron, ISSN 0896-6273, 2006, Volume 51, Issue 4, pp. 441 - 454
Genetic deletion of fragile X mental retardation protein (FMRP) has been shown to enhance mGluR-dependent long-term depression (LTD). Herein, we demonstrate... 
HUMDISEASE | MOLNEURO | SYSTEM | MESSENGER-RNAS | SYNAPSES | UBIQUITIN | FMR1 | MOUSE MODEL | DEGRADATION | GLUTAMATE-RECEPTOR ACTIVATION | HIPPOCAMPAL AREA CA1 | SYNAPTIC PLASTICITY | NEUROSCIENCES | Glycine - analogs & derivatives | Microtubule-Associated Proteins - metabolism | Protein Biosynthesis - physiology | Receptors, Metabotropic Glutamate - physiology | Male | Fragile X Mental Retardation Protein - metabolism | Long-Term Synaptic Depression - drug effects | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Drug Interactions | Protein Synthesis Inhibitors - pharmacology | Animals, Newborn | Long-Term Synaptic Depression - physiology | Blotting, Western - methods | Fluorescent Antibody Technique - methods | Excitatory Amino Acid Antagonists - pharmacology | Mice, Knockout | Leupeptins - pharmacology | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Glycine - pharmacology | Signal Transduction - drug effects | Models, Biological | Cysteine Proteinase Inhibitors - pharmacology | Benzoates - pharmacology | Anisomycin - pharmacology | Protein Biosynthesis - drug effects | Fragile X Mental Retardation Protein - genetics | Mice | Pyridines - pharmacology | Proteasome Endopeptidase Complex - metabolism | In Vitro Techniques | Ubiquitin | Physiological aspects | Neurosciences | Proteolysis | Mental retardation | Depression, Mental | Proteins | Studies | Software | Protein synthesis | Experiments | Index Medicus
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5. Full Text Aberrant Endoplasmic Reticulum Stress in Vascular Smooth Muscle Increases Vascular Contractility and Blood Pressure in Mice Deficient of AMP-Activated Protein Kinase-Ī±2 In Vivo
by Liang, Bin and Wang, Shuangxi and Wang, Qilong and Zhang, Wencheng and Viollet, Benoit and Zhu, Yi and Zou, Ming-Hui
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2013, Volume 33, Issue 3, pp. 595 - 604
OBJECTIVEā€”The endoplasmic reticulum (ER) plays a critical role in ensuring proper folding of newly synthesized proteins. Aberrant ER stress is reported to play... 
ER stress | AMPK | vascular smooth muscle | hypertension | Enzyme Activators - pharmacology | Antihypertensive Agents - pharmacology | Phosphorylation | Humans | AMP-Activated Protein Kinases - deficiency | Nitric Oxide Synthase Type III - deficiency | Aminoimidazole Carboxamide - pharmacology | Dose-Response Relationship, Drug | Ribonucleotides - pharmacology | Taurochenodeoxycholic Acid - pharmacology | Phenylephrine - pharmacology | Time Factors | Hypertension - chemically induced | Hypertension - prevention & control | Phenylbutyrates - pharmacology | Blood Pressure - drug effects | Hypertension - enzymology | Angiotensin II | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Vasoconstrictor Agents - pharmacology | Endoplasmic Reticulum Stress - drug effects | Cells, Cultured | Nitric Oxide Synthase Type III - genetics | Vasoconstriction - drug effects | Hypertension - physiopathology | Mice, Knockout | Leupeptins - pharmacology | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Tunicamycin - pharmacology | Mice | Myosin Light Chains - metabolism | Enzyme Activation | Muscle, Smooth, Vascular - enzymology | AMP-Activated Protein Kinases - genetics | Index Medicus
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6. Full Text Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase
by Foley, Emily A and Maldonado, Maria and Kapoor, Tarun M
Nature Cell Biology, ISSN 1465-7392, 10/2011, Volume 13, Issue 10, pp. 1265 - 1271
Error-free chromosome segregation depends on the precise regulation of phosphorylation to stabilize kinetochore-microtubule attachments (K-fibres) on sister... 
CELL-DIVISION | AURORA B KINASE | COHESION | PROPER CHROMOSOME SEGREGATION | HUMAN CANCERS | MEIOSIS-I | PROTEINS | SPINDLE-ASSEMBLY CHECKPOINT | REVEALS | CELL BIOLOGY | Phosphorylation | Humans | Nocodazole - pharmacology | Chromosome Segregation - drug effects | Recombinant Fusion Proteins - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Aurora Kinase B | Transfection | RNA Interference | Time Factors | Microtubules - drug effects | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Benzamides - pharmacology | Kinetochores - enzymology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein Phosphatase 2 - genetics | Aurora Kinases | Sulfonamides - pharmacology | Leupeptins - pharmacology | Microtubules - enzymology | Protein Phosphatase 2 - metabolism | Kinetochores - drug effects | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Quinazolines - pharmacology | Microscopy, Fluorescence | Physiological aspects | Phosphatases | Research | Kinetochores | Microtubules | Index Medicus
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7. Full Text Mast cell tryptase regulates rat colonic myocytes through proteinase- activated receptor 2
by Corvera, Carlos U and DƩry, Olivier and McConalogue, K and Bƶhm, Stephan K and Khitin, Lev M and Caughey, George H and Payan, Donald G and Bunnett, Nigel W
Journal of Clinical Investigation, ISSN 0021-9738, 09/1997, Volume 100, Issue 6, pp. 1383 - 1393
Proteinase-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin-like enzymes. PAR-2 is highly expressed by... 
Smooth muscle | Trypsin | Inflammation | Ileus | Bradykinin - analogs & derivatives | Tryptases | Calcium - metabolism | Receptors, Cell Surface - analysis | Colon - chemistry | Gastrointestinal Motility - drug effects | Serine Endopeptidases - pharmacology | Substance P - pharmacology | Nitroprusside - pharmacology | Dose-Response Relationship, Drug | Adrenergic beta-Antagonists - pharmacology | Receptor, PAR-2 | Trypsin - pharmacology | Time Factors | Inflammation Mediators - pharmacology | Receptors, Cell Surface - physiology | Tetrodotoxin - pharmacology | Bradykinin - pharmacology | Fluorescent Antibody Technique, Indirect | NG-Nitroarginine Methyl Ester - pharmacology | Dinoprostone - pharmacology | Chymases | Cells, Cultured | Rats | Mast Cells - enzymology | Indomethacin - pharmacology | Muscle, Smooth - chemistry | Cyclooxygenase Inhibitors - pharmacology | Leupeptins - pharmacology | Animals | Benzimidazoles - pharmacology | Serine Endopeptidases - metabolism | In Vitro Techniques | Index Medicus | Abridged Index Medicus
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8. Full Text Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma
by Hui, Bo and Shi, Yingā€Hong and Ding, Zhenā€Bin and Zhou, Jian and Gu, Chengā€Yu and Peng, Yuanā€Fei and Yang, Hua and Liu, Weiā€Ren and Shi, Guoā€Ming and Fan, Jia
Cancer, ISSN 0008-543X, 11/2012, Volume 118, Issue 22, pp. 5560 - 5571
BACKGROUND: The ubiquitin-proteasome system and autophagy-lysosome system are 2 major protein degradation pathways in eukaryotic cells, which are tightly... 
proteasome | apoptosis | autophagy | proliferation | hepatocellular carcinoma | SYSTEM | TARGET | UBIQUITIN | MECHANISMS | DEATH | BORTEZOMIB | CANCER | ONCOLOGY | PROTEIN-DEGRADATION | RESISTANCE | AGENTS | Beclin-1 | Adenine - analogs & derivatives | Bortezomib | Proteasome Inhibitors - pharmacology | Microtubule-Associated Proteins - metabolism | Humans | Adenine - pharmacology | Autophagy - drug effects | Apoptosis Regulatory Proteins - metabolism | Chloroquine - pharmacology | Leupeptins - pharmacology | Carcinoma, Hepatocellular - drug therapy | Amino Acid Chloromethyl Ketones - pharmacology | Cysteine Proteinase Inhibitors - pharmacology | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Membrane Proteins - metabolism | Proteasome Endopeptidase Complex - metabolism | Pyrazines - pharmacology | Apoptosis | Boronic Acids - pharmacology | Physiological aspects | Care and treatment | Research | Hepatoma | Protease inhibitors | Index Medicus | Abridged Index Medicus
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9. Full Text Hypercontractility of intestinal longitudinal smooth muscle induced by cytokines is mediated by the nuclear factor-ĪŗB/AMP-activated kinase/myosin light chain kinase pathway
by Nalli, Ancy D and Kumar, Divya P and Mahavadi, Sunila and Al-Shboul, Othman and Alkahtani, Reem and Kuemmerle, John F and Grider, John R and Murthy, Karnam S
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2014, Volume 350, Issue 1, pp. 89 - 98
Recent studies have identified AMP-activated kinase (AMPK) as a target ofCa21/calmodulin-dependent kinase kinase (CaMKKb) and a negative regulator of myosin... 
RAT AORTA | CELLS | SIGNALING PATHWAYS | EXPERIMENTAL COLITIS | CONTRACTILITY | CA2+ MOBILIZATION | PHOSPHORYLATION | PROTEIN-KINASE | PHARMACOLOGY & PHARMACY | UP-REGULATION | EXPRESSION | AMP-Activated Protein Kinases - metabolism | Interleukin-1beta - pharmacology | Colon - drug effects | Male | NF-kappa B - metabolism | Peptide Fragments - pharmacology | Muscle, Smooth - drug effects | Drug Interactions | Carrier Proteins - pharmacology | Colitis - chemically induced | Phosphorylation - drug effects | NF-kappa B - antagonists & inhibitors | Acetylcholine - pharmacology | Myosin-Light-Chain Kinase - metabolism | Muscle, Smooth - metabolism | Colon - metabolism | Leupeptins - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Naphthalimides - pharmacology | Signal Transduction - drug effects | Muscle Contraction - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Kinase - antagonists & inhibitors | Colitis - metabolism | Benzimidazoles - pharmacology | Mice | Myosin Light Chains - metabolism | Cytokines - pharmacology | Trinitrobenzenesulfonic Acid - pharmacology | Index Medicus | Gastrointestinal, Hepatic, Pulmonary, and Renal
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10. Full Text Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition
by Ye, Peng and Mimura, Junsei and Okada, Tomomi and Sato, Hideyo and Liu, Tao and Maruyama, Atsushi and Ohyama, Chikara and Itoh, Ken
Molecular and Cellular Biology, ISSN 0270-7306, 2014, Volume 34, Issue 18, pp. 3421 - 3434
The ubiquitin-proteasome pathway degrades ubiquitinated proteins to remove damaged or misfolded protein and thus plays an important role in the maintenance of... 
CANCER-CELLS | MULTIPLE-MYELOMA | BORTEZOMIB RESISTANCE | HEPATOCELLULAR-CARCINOMA | CYSTINE/GLUTAMATE ANTIPORTER | PROTEIN-DEGRADATION | PRECLINICAL MODELS | TRANSPORTER GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACTIVATING TRANSCRIPTION FACTOR-4 | MOLECULAR-MECHANISMS | CELL BIOLOGY | Glycine - analogs & derivatives | Bortezomib | Glutathione - metabolism | Humans | RNA, Small Interfering - pharmacology | Sulfasalazine - pharmacology | Gene Knockdown Techniques | Leupeptins - pharmacology | Amino Acid Transport System y+ - metabolism | Activating Transcription Factor 4 - metabolism | Glycine - pharmacology | NF-E2-Related Factor 2 - metabolism | HEK293 Cells | Urinary Bladder Neoplasms - pathology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cysteine - metabolism | Gene Expression Regulation, Neoplastic - drug effects | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Oligopeptides - pharmacology | Pyrazines - pharmacology | Urinary Bladder Neoplasms - metabolism | Boronic Acids - pharmacology | Index Medicus
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11. Full Text Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik
by Chen, Shuang and Zhou, Liang and Zhang, Yu and Leng, Yun and Pei, Xin-Yan and Lin, Hui and Jones, Richard and Orlowski, Robert Z and Dai, Yun and Grant, Steven
Molecular and Cellular Biology, ISSN 0270-7306, 2014, Volume 34, Issue 18, pp. 3435 - 3449
In selective autophagy, the adaptor protein SQSTM1/p62 plays a critical role in recognizing/loading cargo (e.g., malfolded proteins) into autophagosomes for... 
CELLS | BECLIN 1-DEPENDENT AUTOPHAGY | BIOGENESIS | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASPASE-MEDIATED CLEAVAGE | DEGRADATION | ENDOPLASMIC-RETICULUM | PROTEINS | SELECTIVE AUTOPHAGY | CANCER | CELL BIOLOGY | Cyclin T - metabolism | Apoptosis - drug effects | Sequestosome-1 Protein | Humans | Mitochondrial Proteins - genetics | Protein Transport - drug effects | Autophagy - drug effects | Piperidines - pharmacology | Mitochondrial Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Bortezomib | Membrane Proteins - genetics | Heat-Shock Proteins - metabolism | RNA, Small Interfering - pharmacology | Cells, Cultured | Gene Expression Regulation | Cycloheximide - pharmacology | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Leupeptins - pharmacology | Pyrroles - pharmacology | Animals | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cyclin-Dependent Kinase 9 - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Pyrazines - pharmacology | Boronic Acids - pharmacology | Index Medicus
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12. Full Text Antioxidants block proteasome inhibitor function in endometrial carcinoma cells
by Llobet, David and Eritja, Nuria and Encinas, Mario and Sorolla, Anabel and Yeramian, Andree and Schoenenberger, Joan Antoni and Llombart-Cussac, Antonio and Marti, Rosa M and Matias-Guiu, Xavier and Dolcet, Xavier
Anti-Cancer Drugs, ISSN 0959-4973, 02/2008, Volume 19, Issue 2, pp. 115 - 124
We have recently demonstrated that proteasome inhibitors can be effective in inducing apoptotic cell death in endometrial carcinoma cell lines and primary... 
Antioxidant | Endometrial carcinoma | Proteasome inhibitor | Apoptosis | MULTIPLE-MYELOMA | VITAMIN-C | EDARAVONE | antioxidant | apoptosis | endometrial carcinoma | ENDOPLASMIC-RETICULUM STRESS | BORTEZOMIB | PS-341 | proteasome inhibitor | ONCOLOGY | RADICAL SCAVENGER | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | PANCREATIC-CANCER CELLS | Caspase 9 - metabolism | Apoptosis - drug effects | Antipyrine - pharmacology | Humans | Caspase 3 - metabolism | Endometrial Neoplasms - metabolism | Ubiquitin - metabolism | Vitamins - pharmacology | Dose-Response Relationship, Drug | Butylated Hydroxyanisole - pharmacology | Antipyrine - analogs & derivatives | Female | Cell Survival - drug effects | Bortezomib | Antioxidants - pharmacology | Caspase Inhibitors | Blotting, Western | Coumarins - pharmacology | Leupeptins - pharmacology | Cysteine Proteinase Inhibitors - pharmacology | Ascorbic Acid - pharmacology | Cell Line, Tumor | Ergothioneine - pharmacology | Endometrial Neoplasms - pathology | Oligopeptides - pharmacology | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Vitamin E - pharmacology | Index Medicus
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13. Full Text A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbĪ±
by Benfante, Roberta and Valnegri, Pamela and Sala, Carlo and Chelly, Jamel and Dorseuil, Olivier and Khelfaoui, Malik and Billuart, Pierre and Lagneaux, Celine and Gianfelice, Antonella and Passafaro, Maria and Bassani, Silvia
Nature Neuroscience, ISSN 1097-6256, 10/2011, Volume 14, Issue 10, pp. 1293 - 1301
Oligophrenin-1 regulates dendritic spine morphology in the brain. Mutations in the oligophrenin-1 gene (OPHN1) cause intellectual disability. We discovered a... 
RESPONSE ELEMENT | INTELLECTUAL DISABILITY | LINKED MENTAL-RETARDATION | SUPRACHIASMATIC NUCLEUS | KAINIC ACID NEUROTOXICITY | GENE-EXPRESSION | ORPHAN RECEPTOR | PROTEIN OLIGOPHRENIN-1 | VENTRICULAR ENLARGEMENT | NEUROSCIENCES | CEREBELLAR HYPOPLASIA | Cytoskeletal Proteins - genetics | Embryo, Mammalian | Humans | Circadian Clocks - genetics | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Drug Interactions | Time Factors | Nuclear Proteins - deficiency | Tetrodotoxin - pharmacology | GABA-A Receptor Antagonists - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Bicuculline - pharmacology | Mutation - genetics | Mice, Knockout | Leupeptins - pharmacology | Analysis of Variance | Cysteine Proteinase Inhibitors - pharmacology | Mice | GTPase-Activating Proteins - genetics | Circadian Clocks - physiology | GTPase-Activating Proteins - deficiency | Immunoprecipitation | Cercopithecus aethiops | Neurons - cytology | GTPase-Activating Proteins - metabolism | Cerebral Cortex - cytology | Cytoskeletal Proteins - deficiency | Quinoxalines - pharmacology | Transfection - methods | Neurons - physiology | Cytoskeletal Proteins - metabolism | Neurons - drug effects | Nuclear Proteins - genetics | Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism | Dendrites - metabolism | ARNTL Transcription Factors - genetics | Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics | Gene Expression Regulation - genetics | RNA, Small Interfering - pharmacology | Valine - analogs & derivatives | Cells, Cultured | ARNTL Transcription Factors - metabolism | Nuclear Proteins - metabolism | Sodium Channel Blockers - pharmacology | Hippocampus - cytology | Two-Hybrid System Techniques | Animals | Valine - pharmacology | Index Medicus | Life Sciences | Neurons and Cognition
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