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1. Full Text Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain
by Puskarjov, Martin and Ahmad, Faraz and Kaila, Kai and Blaesse, Peter
The Journal of neuroscience, ISSN 0270-6474, 08/2012, Volume 32, Issue 33, pp. 11356 - 11364
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Calpain - metabolism | Rats, Wistar | Calcium - metabolism | Emetine - pharmacology | Male | N-Methylaspartate - pharmacology | Dose-Response Relationship, Drug | Pyramidal Cells - physiology | Statistics, Nonparametric | Calcium Ionophores - pharmacology | Pyramidal Cells - drug effects | Protein Synthesis Inhibitors - pharmacology | Action Potentials - drug effects | Animals, Newborn | Membrane Potentials - drug effects | Dipeptides - pharmacology | Valine - analogs & derivatives | Gene Expression Regulation - physiology | Rats | Magnesium - metabolism | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Cycloheximide - pharmacology | Symporters - metabolism | Gene Expression Regulation - drug effects | Leupeptins - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Cysteine Proteinase Inhibitors - pharmacology | Calpain - pharmacology | Ionomycin - pharmacology | Valine - pharmacology | Dizocilpine Maleate - pharmacology | In Vitro Techniques | Index Medicus
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2. Full Text Zinc pyrithione inhibits caspase-3 activity, promotes ErbB1-ErbB2 heterodimerization and suppresses ErbB2 downregulation in cardiomyocytes subjected to ischemia/reperfusion
by Bodiga, Vijaya Lakshmi and Thokala, Sandhya and Vemuri, Praveen Kumar and Bodiga, Sreedhar
Journal of inorganic biochemistry, ISSN 0162-0134, 12/2015, Volume 153, pp. 49 - 59
Hypoxia | Reoxygenation | Proteolysis | Caspase-3 | Zinc | Apoptosis | Biochemistry & Molecular Biology | Physical Sciences | Chemistry, Inorganic & Nuclear | Chemistry | Life Sciences & Biomedicine | Science & Technology | Receptor, Epidermal Growth Factor - genetics | Caspase Inhibitors - pharmacology | Phosphorylation | Receptor, ErbB-2 - genetics | Protein Multimerization | Caspase 3 - metabolism | Receptor, ErbB-2 - metabolism | RNA, Messenger - metabolism | Cell Hypoxia | Receptor, Epidermal Growth Factor - metabolism | Zinc Compounds - pharmacology | Amino Acid Chloromethyl Ketones - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Benzothiazoles - pharmacology | Chlorides - pharmacology | Down-Regulation | RNA, Messenger - genetics | Rats | Tyrphostins - pharmacology | Cardiotonic Agents - pharmacology | Leupeptins - pharmacology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Thiones - pharmacology | Quinazolines - pharmacology | Organometallic Compounds - pharmacology | Proteins | Membrane lipids | Inositol | RNA | Antifungal agents | Permeability | Antibacterial agents | Phosphotransferases | Tyrosine | Cell death | Index Medicus
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3. Full Text Profiling drug-induced cell death pathways in the zebrafish lateral line
by Coffin, Allison B and Williamson, Kay L and Mamiya, Anna and Raible, David W and Rubel, Edwin W
Apoptosis (London), ISSN 1360-8185, 4/2013, Volume 18, Issue 4, pp. 393 - 408
Biochemistry, general | Biomedicine | Gentamicin | Neomycin | Cancer Research | Oncology | Hair cell | Cisplatin | Cell Biology | Virology | Ototoxicity | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Caspase Inhibitors - pharmacology | Reactive Oxygen Species - metabolism | Cross-Linking Reagents - pharmacology | Cells, Cultured | Guanidines - pharmacology | Methionine - pharmacology | Zebrafish | Antioxidants - pharmacology | Cisplatin - pharmacology | Hair Cells, Auditory, Inner - drug effects | Leupeptins - pharmacology | Protease Inhibitors - pharmacology | Animals | Gentamicins - pharmacology | Hair Cells, Auditory, Inner - metabolism | Cell Death | Lateral Line System - drug effects | Neomycin - pharmacology | Protein Synthesis Inhibitors - pharmacology | Oligopeptides - pharmacology | Calpain - antagonists & inhibitors | Lateral Line System - cytology | Drugs | Antioxidants | Chemotherapy | Cell death | Protein biosynthesis | Calpain | Aminoglycosides | Biochemistry | Universities and colleges | Antibacterial agents | Cancer | Index Medicus | gentamicin | cisplatin | ototoxicity | neomycin
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4. Full Text Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells
by Inoue, Chisato and Sobue, Sayaka and Kawamoto, Yoshiyuki and Nishizawa, Yuji and Ichihara, Masatoshi and Abe, Akihiro and Hayakawa, Fumihiko and Suzuki, Motoshi and Nozawa, Yoshinori and Murate, Takahsi
Biochemical and biophysical research communications, ISSN 0006-291X, 05/2020, Volume 525, Issue 4, pp. 1074 - 1080
Protein degradation | c-myc | Ponatinib | MCL1 inhibitors | T315I-positive Ph+ leukemia cell | MCL1 | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cyclin D2 - genetics | Cyclin D2 - metabolism | Phosphorylation | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Phosphatidylinositol 3-Kinases - metabolism | Pyridazines - pharmacology | Macrocyclic Compounds - pharmacology | Proteolysis - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Death - genetics | Phosphatidylinositol 3-Kinases - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Phosphoinositide-3 Kinase Inhibitors - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Imatinib Mesylate - pharmacology | Imidazoles - pharmacology | Signal Transduction - genetics | Glycogen Synthase Kinase 3 - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Drug Synergism | Leupeptins - pharmacology | Drug Resistance, Neoplasm - genetics | Pyrroles - pharmacology | Signal Transduction - drug effects | Wortmannin - pharmacology | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Synthesis | Glycogen | Proteolysis | Cell death | Leukemia | Index Medicus
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5. Full Text Aberrant Endoplasmic Reticulum Stress in Vascular Smooth Muscle Increases Vascular Contractility and Blood Pressure in Mice Deficient of AMP-Activated Protein Kinase-α2 In Vivo
by Liang, Bin and Wang, Shuangxi and Wang, Qilong and Zhang, Wencheng and Viollet, Benoit and Zhu, Yi and Zou, Ming-Hui
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 03/2013, Volume 33, Issue 3, pp. 595 - 604
ER stress | AMPK | vascular smooth muscle | hypertension | Enzyme Activators - pharmacology | Antihypertensive Agents - pharmacology | Phosphorylation | Humans | AMP-Activated Protein Kinases - deficiency | Nitric Oxide Synthase Type III - deficiency | Aminoimidazole Carboxamide - pharmacology | Dose-Response Relationship, Drug | Ribonucleotides - pharmacology | Taurochenodeoxycholic Acid - pharmacology | Phenylephrine - pharmacology | Time Factors | Hypertension - chemically induced | Hypertension - prevention & control | Phenylbutyrates - pharmacology | Blood Pressure - drug effects | Hypertension - enzymology | Angiotensin II | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Vasoconstrictor Agents - pharmacology | Endoplasmic Reticulum Stress - drug effects | Cells, Cultured | Nitric Oxide Synthase Type III - genetics | Vasoconstriction - drug effects | Hypertension - physiopathology | Mice, Knockout | Leupeptins - pharmacology | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Tunicamycin - pharmacology | Mice | Myosin Light Chains - metabolism | Enzyme Activation | Muscle, Smooth, Vascular - enzymology | AMP-Activated Protein Kinases - genetics | Index Medicus
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6. Full Text Dynamic Translational and Proteasomal Regulation of Fragile X Mental Retardation Protein Controls mGluR-Dependent Long-Term Depression
by Hou, Lingfei and Antion, Marcia D and Hu, Daoying and Spencer, Corinne M and Paylor, Richard and Klann, Eric
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2006, Volume 51, Issue 4, pp. 441 - 454
HUMDISEASE | MOLNEURO | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Glycine - analogs & derivatives | Microtubule-Associated Proteins - metabolism | Protein Biosynthesis - physiology | Receptors, Metabotropic Glutamate - physiology | Male | Fragile X Mental Retardation Protein - metabolism | Long-Term Synaptic Depression - drug effects | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Drug Interactions | Protein Synthesis Inhibitors - pharmacology | Animals, Newborn | Long-Term Synaptic Depression - physiology | Blotting, Western - methods | Fluorescent Antibody Technique - methods | Excitatory Amino Acid Antagonists - pharmacology | Mice, Knockout | Leupeptins - pharmacology | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Glycine - pharmacology | Signal Transduction - drug effects | Models, Biological | Cysteine Proteinase Inhibitors - pharmacology | Benzoates - pharmacology | Anisomycin - pharmacology | Protein Biosynthesis - drug effects | Fragile X Mental Retardation Protein - genetics | Mice | Pyridines - pharmacology | Proteasome Endopeptidase Complex - metabolism | In Vitro Techniques | Ubiquitin | Physiological aspects | Proteolysis | Mental retardation | Depression, Mental | Proteins | Studies | Software | Protein synthesis | Experiments | Index Medicus
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7. Full Text Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition
by Ye, Peng and Mimura, Junsei and Okada, Tomomi and Sato, Hideyo and Liu, Tao and Maruyama, Atsushi and Ohyama, Chikara and Itoh, Ken
Molecular and cellular biology, ISSN 0270-7306, 2014, Volume 34, Issue 18, pp. 3421 - 3434
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Glycine - analogs & derivatives | Bortezomib | Glutathione - metabolism | Humans | RNA, Small Interfering - pharmacology | Sulfasalazine - pharmacology | Gene Knockdown Techniques | Leupeptins - pharmacology | Amino Acid Transport System y+ - metabolism | Activating Transcription Factor 4 - metabolism | Glycine - pharmacology | NF-E2-Related Factor 2 - metabolism | HEK293 Cells | Urinary Bladder Neoplasms - pathology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cysteine - metabolism | Gene Expression Regulation, Neoplastic - drug effects | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Oligopeptides - pharmacology | Pyrazines - pharmacology | Urinary Bladder Neoplasms - metabolism | Boronic Acids - pharmacology | Index Medicus
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8. Full Text Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase
by Foley, Emily A and Maldonado, Maria and Kapoor, Tarun M
Nature cell biology, ISSN 1465-7392, 10/2011, Volume 13, Issue 10, pp. 1265 - 1271
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphorylation | Humans | Nocodazole - pharmacology | Chromosome Segregation - drug effects | Recombinant Fusion Proteins - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Aurora Kinase B | Transfection | RNA Interference | Time Factors | Microtubules - drug effects | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Benzamides - pharmacology | Kinetochores - enzymology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein Phosphatase 2 - genetics | Aurora Kinases | Sulfonamides - pharmacology | Leupeptins - pharmacology | Microtubules - enzymology | Protein Phosphatase 2 - metabolism | Kinetochores - drug effects | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Quinazolines - pharmacology | Microscopy, Fluorescence | Physiological aspects | Phosphatases | Research | Kinetochores | Microtubules | Index Medicus
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9. Full Text Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik
by Chen, Shuang and Zhou, Liang and Zhang, Yu and Leng, Yun and Pei, Xin-Yan and Lin, Hui and Jones, Richard and Orlowski, Robert Z and Dai, Yun and Grant, Steven
Molecular and cellular biology, ISSN 0270-7306, 2014, Volume 34, Issue 18, pp. 3435 - 3449
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cyclin T - metabolism | Apoptosis - drug effects | Sequestosome-1 Protein | Humans | Mitochondrial Proteins - genetics | Protein Transport - drug effects | Autophagy - drug effects | Piperidines - pharmacology | Mitochondrial Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Bortezomib | Membrane Proteins - genetics | Heat-Shock Proteins - metabolism | RNA, Small Interfering - pharmacology | Cells, Cultured | Gene Expression Regulation | Cycloheximide - pharmacology | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Leupeptins - pharmacology | Pyrroles - pharmacology | Animals | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cyclin-Dependent Kinase 9 - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Pyrazines - pharmacology | Boronic Acids - pharmacology | Index Medicus
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