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American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2013, Volume 304, Issue 4, pp. 567 - 578
MG-132, a proteasome inhibitor, can upregulate nuclear factor (NF) erythroid 2-related factor 2 (Nrf2)-mediated antioxidative function and downregulate... 
Diabetic cardiomyopathy | MG132 | Nuclear factor-κB | Proteasome inhibitor | Therapeutic effect | Nuclear factor erythroid 2-related factor 2 | OXIDATIVE STRESS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | nuclear factor-kappa B | 26S PROTEASOMES | diabetic cardiomyopathy | MELLITUS | NEPHROPATHY | therapeutic effect | proteasome inhibitor | PATHWAY | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | INHIBITOR | nuclear factor erythroid 2-related factor 2 | EXPRESSION | NF-E2-Related Factor 2 - physiology | Diabetic Cardiomyopathies - drug therapy | Antioxidants - metabolism | Myocarditis - drug therapy | Oxidative Stress - physiology | Diabetes Mellitus, Type 1 - complications | Diabetic Cardiomyopathies - physiopathology | Ultrasonography | Female | Diabetes Mellitus, Experimental - complications | Hypertrophy, Left Ventricular - drug therapy | Disease Models, Animal | Cysteine Proteinase Inhibitors - therapeutic use | Diabetic Cardiomyopathies - diagnostic imaging | Hypertrophy, Left Ventricular - etiology | Diabetes Mellitus, Type 1 - pathology | Gene Expression Regulation - physiology | Mice, Transgenic | Leupeptins - therapeutic use | Proteasome Inhibitors - therapeutic use | Gene Expression Regulation - drug effects | Animals | NF-kappa B - physiology | Diabetes Mellitus, Experimental - pathology | Mice | Hypertrophy, Left Ventricular - physiopathology | Oxidative Stress - drug effects | Myocarditis - physiopathology
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 05/2013, Volume 18, Issue 5, pp. 557 - 567
Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D-serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of schizophrenia... 
serine racemase | MK-801 | D-serine | astrocytes | schizophrenia | DISC1 | MOUSE-BRAIN | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISC1 PROTEIN | D-ASPARTATE RECEPTOR | NEUROSCIENCES | TARGETED DISRUPTION | GLUTAMATE NEUROTRANSMISSION | MICE | MENTAL-ILLNESS | RAT-BRAIN | GLIA | INDUCIBLE EXPRESSION | Neuroprotective Agents - therapeutic use | Glial Fibrillary Acidic Protein - genetics | Humans | Nerve Tissue Proteins - deficiency | Male | Reflex, Startle - genetics | Schizophrenia - pathology | Dopamine Agents - therapeutic use | Glial Fibrillary Acidic Protein - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Exploratory Behavior - physiology | Racemases and Epimerases - metabolism | Schizophrenia - genetics | Transfection | Schizophrenia - physiopathology | Protein Binding - drug effects | Acoustic Stimulation - adverse effects | Dizocilpine Maleate - therapeutic use | Female | Disease Models, Animal | Inhibition (Psychology) | Astrocytes - drug effects | Amphetamine - therapeutic use | Mice, Inbred C57BL | Mice, Transgenic | Mutation - genetics | Cycloheximide - pharmacology | Brain - drug effects | Animals | Leupeptins | Maze Learning | Analysis of Variance | Serine - pharmacology | Cysteine Proteinase Inhibitors - pharmacology | Mice | Schizophrenia - drug therapy | Cell Line, Transformed | Astrocytes - metabolism | Physiology, Pathological | Serine | Schizophrenia | Physiological aspects | Research | Health aspects | Protein binding
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 01/2013, Volume 304, Issue 1, pp. 87 - 99
Oxidative stress is a major cause of diabetic nephropathy. Upregulation of the key antioxidative transcription factor, nuclear factor-erythroid 2-related... 
MG132 | Diabetic nephropathy | Nrf2 | Proteasome inhibitor | Therapeutic effect | DEFENSE | OXIDATIVE STRESS | PHYSIOLOGY | PROTEASOME INHIBITION | ANGIOTENSIN-II | SKELETAL-MUSCLE | therapeutic effect | proteasome inhibitor | PATHWAY | BARDOXOLONE METHYL | ENDOTHELIAL-CELLS | KIDNEY-FUNCTION | ENDOCRINOLOGY & METABOLISM | INFLAMMATORY CYTOKINES | diabetic nephropathy | Kidney - physiology | NF-E2-Related Factor 2 - physiology | Diabetes Mellitus, Experimental - drug therapy | NF-E2-Related Factor 2 - antagonists & inhibitors | Streptozocin | Transcriptional Activation - drug effects | Diabetes Mellitus, Experimental - genetics | Diabetic Nephropathies - drug therapy | Kidney - metabolism | Female | NF-E2-Related Factor 2 - genetics | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - complications | Cysteine Proteinase Inhibitors - therapeutic use | Kidney - drug effects | RNA, Small Interfering - pharmacology | Cells, Cultured | Diabetic Nephropathies - chemically induced | Diabetic Nephropathies - genetics | Mice, Transgenic | Leupeptins - therapeutic use | Gene Expression Regulation - drug effects | Animals | NF-E2-Related Factor 2 - metabolism | Mice | Transcriptional Activation - physiology | Prevention | Oxidative stress | Transcription factors | Diabetic nephropathies | Physiological aspects | Genetic aspects | Health aspects
Journal Article
Journal Article
Journal Article
Haematologica, ISSN 0390-6078, 01/2011, Volume 96, Issue 1, pp. 69 - 77
Journal Article
Diabetes, ISSN 0012-1797, 03/2011, Volume 60, Issue 3, pp. 981 - 992
OBJECTIVE-Chronic hypoxia has been recognized as a key regulator in renal tubulointerstitial fibrosis, as seen in diabetic nephropathy, which is associated... 
HYPOXIA PROMOTES FIBROGENESIS | KIDNEY-DISEASE | INSULIN | RESPIRATORY-CHAIN | TO-MESENCHYMAL TRANSITION | ACTIVATED PROTEIN-KINASE | EPITHELIAL-CELLS | MITOCHONDRIAL COMPLEX-I | PATHWAY | ENDOCRINOLOGY & METABOLISM | GLUCOSE-TRANSPORT | Immunohistochemistry | Epithelial Cells - metabolism | Metformin - therapeutic use | Diabetes Mellitus, Type 2 - genetics | Epithelial Cells - drug effects | Humans | Male | Diabetes Mellitus, Type 2 - metabolism | Oxygen Consumption - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Adenylate Kinase - metabolism | Diabetic Nephropathies - prevention & control | Hypoglycemic Agents - therapeutic use | Cell Line | Insulin - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Diabetic Nephropathies - metabolism | Metformin - pharmacology | Rats | Diabetic Nephropathies - genetics | Reverse Transcriptase Polymerase Chain Reaction | Hypoglycemic Agents - pharmacology | Rats, Zucker | Leupeptins - pharmacology | Animals | Analysis of Variance | Signal Transduction - drug effects | Oxygen Consumption - drug effects | Cysteine Proteinase Inhibitors - pharmacology | Kidney Tubules, Proximal - metabolism | Signal Transduction - physiology | Diabetes Mellitus, Type 2 - drug therapy | Adenylate Kinase - genetics | Insulin - therapeutic use | Kidney Tubules, Proximal - drug effects | Complications
Journal Article
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 12/2011, Volume 20, Issue 24, pp. 4891 - 4902
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0170197
Pancreatic cancer (PC) evades immune destruction by favoring the development of regulatory T cells (Tregs) that inhibit effector T cells. The transcription... 
BREAST-CANCER | IN-VITRO | PROTEIN PHOSPHATASE 1 | DENDRITIC CELLS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | CASEIN KINASE-II | FLAVONOID APIGENIN | SUPPRESSOR-CELLS | LEUKEMIA | PROTEASOME ACTIVITY | Tumor Suppressor Proteins - metabolism | Pancreatic Neoplasms - metabolism | Apigenin - therapeutic use | Mice, Inbred C57BL | Casein Kinase II - antagonists & inhibitors | Down-Regulation - drug effects | Leupeptins - therapeutic use | Proteasome Inhibitors - therapeutic use | Lymphocyte Culture Test, Mixed | Pancreatic Neoplasms - drug therapy | Protein Phosphatase 1 - metabolism | Animals | T-Lymphocytes - drug effects | Pancreatic Neoplasms - immunology | Cell Line, Tumor | Female | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Homeostasis - drug effects | Ikaros Transcription Factor - metabolism | Casein | Pancreatic cancer | Homeostasis | Genetic aspects | Research | T cells | Gene expression | Health aspects | Ubiquitin | Splenomegaly | Deregulation | Phosphorylation | Ikaros protein | CD8 antigen | Phosphoprotein phosphatase | Leukemia | Effector cells | Cytotoxicity | Lymphocytes T | Kinases | Casein kinase II | Restoration | Lymphocytes | Splenocytes | Cell cycle | CD25 antigen | Localization | Antigens | Immune response | Dendritic cells | Immunoregulation | Pharmacology | Chemical compounds | CD4 antigen | Medicine | Studies | Inhibitors | Diet | γ-Interferon | Isoforms | Proteasomes | Interferon | Protein phosphatase | Cancer
Journal Article
Phytomedicine, ISSN 0944-7113, 2010, Volume 17, Issue 5, pp. 356 - 362
We investigated the anticancer effect of EGCG treatment on a breast carcinoma cell line resistant to tamoxifen (MCF-7Tam cells). As there are no reports about... 
BCRP | Breast carcinoma | MRP1 | P-gp | Tamoxifen | Green tea | GLYCOPROTEIN EXPRESSION | CHEMISTRY, MEDICINAL | PROTEIN | GREEN TEA POLYPHENOLS | GALLATE | PLANT SCIENCES | BREAST-CANCER CELLS | ACUTE-LEUKEMIA | THERAPY | PHARMACOLOGY & PHARMACY | CHEMORESISTANCE | MULTIDRUG-RESISTANCE | CLINICAL-SIGNIFICANCE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Camellia sinensis - chemistry | Apoptosis - drug effects | Plant Extracts - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Protease Inhibitors - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Catechin - therapeutic use | Multidrug Resistance-Associated Proteins - genetics | Antineoplastic Agents, Phytogenic - therapeutic use | Catechin - pharmacology | Neoplasm Proteins - genetics | Protease Inhibitors - therapeutic use | Gene Expression | Down-Regulation | bcl-2-Associated X Protein - metabolism | Breast Neoplasms - drug therapy | Leupeptins - pharmacology | Breast Neoplasms - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cell Line, Tumor | Catechin - analogs & derivatives | Cell Proliferation - drug effects | Mitoxantrone - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Multidrug Resistance-Associated Proteins - metabolism | Plant Extracts - therapeutic use | Drug Resistance, Neoplasm - drug effects | Care and treatment | Breast cancer | Genetic aspects | Research | Drug resistance | Health aspects | Isoflavones
Journal Article