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1. Full Text Polyphenol oxidase activity and antioxidant properties of Yomra apple (Malus communis L.) from Turkey
by Can, Zehra and Dincer, Barbaros and Sahin, Huseyin and Baltas, Nimet and Yildiz, Oktay and Kolayli, Sevgi
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 12/2014, Volume 29, Issue 6, pp. 829 - 835
Abstract In this study, firstly, antioxidant and polyphenol oxidase (PPO) properties of Yomra apple were investigated. Seventeen phenolic constituents were... 
polyphenoloxidase | Antioxidant | Yomra apple | Malus communis L | phenolics | Phenolics | Polyphenoloxidase | CAPACITY | FRUITS | CHEMISTRY, MEDICINAL | PHENOLIC-COMPOUNDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORGANIC-ACIDS | BY-PRODUCTS | PPO | MESPILUS-GERMANICA L | PURIFICATION | DIPHENOLASE | HPLC | Plant Extracts - chemistry | Antioxidants - chemistry | Coumaric Acids - chemistry | Phenylpropionates - chemistry | Catechol Oxidase - chemistry | Levodopa - chemistry | Caffeic Acids - isolation & purification | Biphenyl Compounds - antagonists & inhibitors | Quercetin - isolation & purification | Plant Proteins - chemistry | Enzyme Inhibitors - chemistry | Picrates - chemistry | Chlorogenic Acid - isolation & purification | Ascorbic Acid - chemistry | Biphenyl Compounds - chemistry | Parabens - isolation & purification | Plant Proteins - isolation & purification | Polyphenols - isolation & purification | Quercetin - chemistry | Oxidation-Reduction | Fruit - chemistry | Malus - chemistry | Caffeic Acids - chemistry | Sulfites - chemistry | Levodopa - isolation & purification | Phenylpropionates - isolation & purification | Picrates - antagonists & inhibitors | Catechol Oxidase - isolation & purification | Antioxidants - isolation & purification | Coumaric Acids - isolation & purification | Polyphenols - chemistry | Propionates | Catechin - isolation & purification | Parabens - chemistry | Kinetics | Chlorogenic Acid - chemistry | Catechin - chemistry | Index Medicus
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2. Full Text A degradable polydopamine coating based on disulfide-exchange reaction
by Hong, Daewha and Lee, Hojae and Kim, Beom Jin and Park, Taegyun and Choi, Ji Yu and Park, Matthew and Lee, Juno and Cho, Hyeoncheol and Hong, Seok-Pyo and Yang, Sung Ho and Jung, Sun Ho and Ko, Sung-Bo and Choi, Insung S
Nanoscale, ISSN 2040-3364, 12/2015, Volume 7, Issue 47, pp. 20149 - 20154
Although the programmed degradation of biocompatible films finds applications in various fields including biomedical and bionanotechnological areas, coating... 
Dopamine - chemistry | Tissue Engineering - methods | Nanotechnology - methods | Biocompatible Materials - chemistry | Coated Materials, Biocompatible - chemistry | Doxorubicin - chemistry | Spectroscopy, Fourier Transform Infrared | Adhesives - chemistry | Drug Delivery Systems | Levodopa - chemistry | Animals | Bivalvia | Disulfides - chemistry | Surface Properties | Water - chemistry | Polymers - chemistry | Glutathione - chemistry | Proteins - chemistry | Buffers | Indoles - chemistry
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3. Full Text The study of inhibitory effects and mechanism of carboxylate chitooligomer on melanin, prepared by laccase/TEMPO system
by Zhen, Xiaoqin and Hao, Dongzhao and Pei, Jicheng and Zhang, Fangdong and Zhang, Xinli and Liu, Haitang and Wang, Jing and Bian, Nengyuan and Li, Ying and Bu, Xin
Carbohydrate Polymers, ISSN 0144-8617, 03/2019, Volume 207, pp. 391 - 397
Schematic illustration of reaction mechanism of C-COS and tyrosinase. A carboxylate chitooligomer (C-COS) containing carboxyl groups attached to chitooligomer... 
Inhibition | Chitooligomer (COS) | Pigmentation | Laccase/TEMPO | Tyrosinase (TYR) | Mechanism | OXIDATION | POLYMER SCIENCE | ACID | LOADED MICELLES | CHITOSAN | CHEMISTRY, ORGANIC | TYROSINASE INHIBITORS | ADSORPTION | IMPROVEMENT | CHEMISTRY, APPLIED | EXTRACTS | SPECTRA | WHITENING AGENTS | Chitin - chemical synthesis | Melanins - antagonists & inhibitors | Melanins - chemistry | Oxidation-Reduction | Chelating Agents - chemistry | Skin Lightening Preparations - chemistry | Chitin - chemistry | Laccase - chemistry | Monophenol Monooxygenase - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Levodopa - chemistry | Cyclic N-Oxides - chemistry | Copper - chemistry | Chitin - analogs & derivatives | Green Chemistry Technology - methods | Skin Lightening Preparations - chemical synthesis | Models, Biological | Enzyme Inhibitors - chemistry | Chelating Agents - chemical synthesis | Agaricales - enzymology | Monophenol Monooxygenase - chemistry | Tyrosine - chemistry
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4. Full Text One-pot green synthesis of oxygen-rich nitrogen-doped graphene quantum dots and their potential application in pH-sensitive photoluminescence and detection of mercury(II) ions
by Shi, Bingfang and Zhang, Liangliang and Lan, Chuanqing and Zhao, Shulin and Zhao, Jingjin and Su, Yubin
Talanta, ISSN 0039-9140, 09/2015, Volume 142, pp. 131 - 139
Nitrogen doping has been a powerful method to modulate the properties of carbon materials for various applications, and N-doped graphene quantum dots (GQDs)... 
Fluorescence probe | Green synthesis | Oxygen-rich nitrogen-doped graphene quantum dots | pH-Sensitive photoluminescence | Mercury | CHEMISTRY, ANALYTICAL | OXIDE | YIELD | SENSOR | ULTRASENSITIVE DETECTION | SULFUR | HG2 | SURFACE | FLUORESCENT-PROBE | CARBON DOTS | Mercury - analysis | Luminescence | Water Pollutants, Chemical - chemistry | Mercury - chemistry | Water Pollutants, Chemical - analysis | Levodopa - chemistry | Citric Acid - chemistry | Quantum Dots - chemistry | Ultraviolet Rays | Nitrogen - chemistry | Rivers - chemistry | Oxygen - chemistry | Nitrogen - radiation effects | Oxygen - radiation effects | Graphite - chemistry | Graphite - radiation effects | Quantum Dots - radiation effects | Hydrogen-Ion Concentration | Phenylalanine | Graphene | Graphite | Photoluminescence | Sensors | Nitrogen | Citric acid
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5. Full Text Tyrosinase Inhibitory Effects and Antioxidative Activities of Saponins from Xanthoceras Sorbifolia Nutshell
by Zhang, Hongmei and Zhou, Quancheng
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e70090
Certain saponins are bioactive compounds with anticancer, antivirus and antioxidant activities. This paper discussed inhibitory effects of saponins from... 
ACID | TRITERPENOID SAPONINS | MUSHROOM TYROSINASE | MECHANISM | CHINA | MULTIDISCIPLINARY SCIENCES | ENERGY PLANTS | EXTRACTS | Nuts | Reactive Oxygen Species | Antioxidants - chemistry | Oxidative Stress | Free Radical Scavengers - chemistry | Superoxides - chemistry | Industrial Waste | Saponins - chemistry | Dose-Response Relationship, Drug | Levodopa - chemistry | Sapindaceae - chemistry | Triterpenes - chemistry | Absorption | Time Factors | Hydroxyl Radical - chemistry | Oxygen - chemistry | Kinetics | Oils - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Monophenol Monooxygenase - chemistry | Antioxidants | Saponins | Superoxide | Hydroxides | Dihydroxyphenylalanine | Free radicals | Ethanol | Research & development--R&D | Scavenging | Food science | Agricultural engineering | Anticancer properties | Studies | Nutrition research | Flavonoids | Sterols | Bioactive compounds | Hydroxyl radicals | Oxidation | Levodopa | Food quality | Dopa | Tyrosinase | Research & development | R&D
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6. Full Text Involvement of phenoloxidase in browning during grinding of Tenebrio molitor larvae
by Janssen, Renske H and Lakemond, Catriona M. M and Fogliano, Vincenzo and Renzone, Giovanni and Scaloni, Andrea and Vincken, Jean-Paul
PLoS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, p. e0189685
Insects are investigated as alternative protein source to meet the increasing demand for proteins in the future. Enzymatic browning occurring during grinding... 
PROTEIN | ACID | BIOCHEMISTRY | TYROSINASE | MULTIDISCIPLINARY SCIENCES | COLEOPTERAN INSECT | MELANIN | Coleoptera - genetics | Dopamine - chemistry | Amino Acid Sequence | Coleoptera - chemistry | Dopamine - genetics | Insect Proteins - genetics | Diptera - chemistry | Diptera - genetics | Levodopa - chemistry | Sequence Homology, Amino Acid | Tenebrio - genetics | Animals | Oxygen Consumption - genetics | Insect Proteins - chemistry | Maillard Reaction | Levodopa - genetics | Larva - chemistry | Larva - genetics | Monophenol Monooxygenase - genetics | Tenebrio - chemistry | Monophenol Monooxygenase - chemistry | Tyrosine - chemistry | Tyrosine - genetics | Larvae | Enzyme activity | Laboratories | Biochemistry | Tyrosine 3-monooxygenase | pH effects | Grinding | Proteins | Enzymatic activity | Anion-exchange chromatography | Peroxidase | Levodopa | Food quality | Laccase | Food | Tyrosine | Dihydroxyphenylalanine | Enzymes | Fractionation | Dopamine | Phenylalanine | Incubation | Hydroxylase | Color | Oxygen consumption | Substrates | Phenoloxidase | Browning | Insects | Anion exchanging | Proteomics | Scientific imaging | Dopa | Mass spectrometry | Tyrosinase | Food Chemistry Group | Levensmiddelenchemie | Food Quality and Design | VLAG | Food Chemistry | Leerstoelgroep Levensmiddelenchemie
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7. Full Text Solid-state NMR reveals the carbon-based molecular architecture of Cryptococcus neoformans fungal eumelanins in the cell wall
by Chatterjee, Subhasish and Prados-Rosales, Rafael and Itin, Boris and Casadevall, Arturo and Stark, Ruth E
Journal of Biological Chemistry, ISSN 0021-9258, 05/2015, Volume 290, Issue 22, pp. 13779 - 13790
Melanin pigments protect against both ionizing radiation and free radicals and have potential soil remediation capabilities. Eumelanins produced by pathogenic... 
SPINNING C-13 | ASSISTED ROTATIONAL RESONANCE | SPECTROSCOPY | SIGNAL ENHANCEMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR-MAGNETIC-RESONANCE | HIGH-RESOLUTION | CHITIN | CROSS-POLARIZATION | C-13 NMR | MELANIN | Glycerides - chemistry | Magnetic Resonance Spectroscopy - methods | Melanins - chemistry | Free Radicals - chemistry | Cryptococcus neoformans - chemistry | Virulence Factors - chemistry | Cell Wall - chemistry | Pigmentation | Carbon - chemistry | Drug Delivery Systems | Levodopa - chemistry | Glucose - chemistry | Polysaccharides - chemistry | Indoles - chemistry | Cryptococcus neoformans | Molecular Biophysics | fungi | melanogenesis | fungal melanin | solid state NMR | structural biology | biomaterials | biophysics | eumelanin
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8. Full Text Medicinal Chemistry of Catechol O‑Methyltransferase (COMT) Inhibitors and Their Therapeutic Utility
by Kiss, László E and Soares-da-Silva, Patrício
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2014, Volume 57, Issue 21, pp. 8692 - 8717
Catechol O-methyltransferase (COMT) is the enzyme responsible for the O-methylation of endogenous neurotransmitters and of xenobiotic substances and hormones... 
VITRO/IN-VIVO EVALUATION | BISUBSTRATE INHIBITORS | CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | IN-VIVO | GENE VAL158MET POLYMORPHISM | LEVODOPA PHARMACOKINETICS | PERIPHERALLY SELECTIVE INHIBITOR | METHYL TRANSFERASE-ACTIVITY | BLOOD-PRESSURE | PARKINSONS-DISEASE | Humans | Models, Molecular | Rats | Catechol O-Methyltransferase Inhibitors - therapeutic use | Crystallography, X-Ray | Male | Clinical Trials as Topic | Parkinson Disease - drug therapy | Prodrugs - chemistry | Catechol O-Methyltransferase Inhibitors - pharmacokinetics | Oxadiazoles - therapeutic use | Catechol O-Methyltransferase - metabolism | Animals | Acetophenones - therapeutic use | Catechols - therapeutic use | Inhibitory Concentration 50 | Prodrugs - chemical synthesis | Catalysis | Levodopa - metabolism | Nitriles - therapeutic use
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9. Full Text Identification of p-hydroxybenzyl alcohol, tyrosol, phloretin and its derivate phloridzin as tyrosinase substrates
by Ortiz-Ruiz, Carmen Vanessa and Berna, Jose and Garcia-Molina, Maria del Mar and Tudela, Jose and Tomas, Virginia and Garcia-Canovas, Francisco
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3738 - 3746
In recent years, the hydroxyalkylphenols -hydroxybenzyl alcohol and tyrosol, and the compound phloretin and its derivate phloridzin have been described as... 
p-Hydroxybenzyl alcohol | Alternative substrate | Phloretin | Tyrosinase | Tyrosol | Phloridzin | P-Hydroxybenzyl alcohol | DIPHENOLASE ACTIVITY | CHEMISTRY, MEDICINAL | ANTITYROSINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ACTION MECHANISM | 3,4-DIHYDROXYMANDELIC ACID | INDUCED MELANOGENESIS | MUSHROOM TYROSINASE | PATHWAY | MONOPHENOLS | STEADY-STATE | HYDROQUINONE | Fungal Proteins - chemistry | Benzyl Alcohols - chemistry | Phenylethyl Alcohol - analogs & derivatives | Substrate Specificity | Phlorhizin - chemistry | Enzyme Assays | Fungal Proteins - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Phenylacetates - chemistry | Levodopa - chemistry | Enzyme Inhibitors - chemistry | Phloretin - chemistry | Kinetics | Monophenol Monooxygenase - chemistry | Tyrosine - chemistry | Phenylethyl Alcohol - chemistry | Tyrosine | Physiological aspects | Quinone | Resveratrol
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10. Full Text Biomimetic sensor for certain catecholamines employing copper(II) complex and silver nanoparticle modified glassy carbon paste electrode
by Sanghavi, Bankim J and Mobin, Shaikh M and Mathur, Pradeep and Lahiri, Goutam K and Srivastava, Ashwini K
Biosensors and Bioelectronics, ISSN 0956-5663, 01/2013, Volume 39, Issue 1, pp. 124 - 132
A dimeric Cu(II) complex [Cu( -hep)(hep-H)] ·2ClO ( ) containing bidentate (hep- =2-(2-hydroxyethyl)pyridine) ligand was synthesized and characterized by... 
Biomimetic sensor | Catecholamines | Glassy carbon paste electrode | Copper complex | Adsorptive stripping voltammetry | Silver nanoparticles | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | VOLTAMMETRIC DETERMINATION | NOREPINEPHRINE | NANOSCIENCE & NANOTECHNOLOGY | HYDROPHILIC INTERACTION CHROMATOGRAPHY | ASCORBIC-ACID | FOLIC-ACID | BIOPHYSICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | L-DOPA | NANOTUBES | ELECTROCHEMICAL SENSOR | POTENTIOMETRIC STRIPPING ANALYSIS | URIC-ACID | Nanoparticles - chemistry | Humans | Norepinephrine - urine | Dopamine - blood | Catecholamines - urine | Norepinephrine - analysis | Carbon - chemistry | Electrodes | Dopamine - urine | Copper - chemistry | X-Ray Diffraction | Catecholamines - analysis | Dopamine - analysis | Limit of Detection | Silver - chemistry | Epinephrine - analysis | Epinephrine - urine | Catecholamines - blood | Coordination Complexes - chemistry | Levodopa - blood | Levodopa - analysis | Norepinephrine - blood | Epinephrine - blood | Pharmaceutical Preparations - chemistry | Levodopa - urine | Biosensing Techniques - methods | Electrochemical Techniques - methods | Epinephrine | Pyridine | Biological products | Biomimetics | Analysis | Copper compounds | Sensors | Dopa
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11. Full Text Antimicrobial Surfaces through Natural Product Hybrids
by Wach, Jean‐Yves and Bonazzi, Simone and Gademann, Karl
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2008, Volume 47, Issue 37, pp. 7123 - 7126
The power of two! A natural product hybrid (see structure) composed of a siderophore and an antibiotic separated by a poly(ethylene glycol) linker enables the... 
natural products | conjugates | biomaterials | antibiotics | siderophores | Conjugates | Siderophores | Antibiotics | Natural products | Biomaterials | URINARY-TRACT-INFECTIONS | ANTIBIOTIC SUSCEPTIBILITY | DRUG-RESISTANCE | CHEMISTRY, MULTIDISCIPLINARY | BACTERIAL BIOFILMS | ALKYLATED POLYETHYLENIMINE | VANCOMYCIN | ANACHELIN CHROMOPHORE | COATINGS | STAPHYLOCOCCUS-AUREUS | BACILLUS | Propionates - chemistry | Dimethylformamide | Bacillus subtilis - cytology | Vancomycin - chemical synthesis | Anti-Infective Agents - pharmacology | Oxides - chemistry | Titanium - chemistry | Anti-Infective Agents - chemical synthesis | Levodopa - chemistry | Anhydrides - chemistry | Formamides - chemistry | Vancomycin - chemistry | Biological Products - chemistry | Quinolinium Compounds - pharmacology | Fluorenes - chemistry | Anti-Infective Agents - chemistry | Surface Properties | Vancomycin - analogs & derivatives | Vancomycin - pharmacology | Quinolinium Compounds - chemical synthesis | Microscopy, Fluorescence | Quinolinium Compounds - chemistry | Bacillus subtilis - drug effects
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12. Full Text An Enzyme Cascade for Selective Modification of Tyrosine Residues in Structurally Diverse Peptides and Proteins
by Struck, Anna-Winona and Bennett, Matthew R and Shepherd, Sarah A and Law, Brian J. C and Zhuo, Ying and Wong, Lu Shin and Micklefield, Jason
Journal of the American Chemical Society, ISSN 0002-7863, 03/2016, Volume 138, Issue 9, pp. 3038 - 3045
Bioorthogonal chemistry enables a specific moiety in a complex biomolecule to be selectively modified in the presence of many reactive functional groups and... 
CATECHOL-O-METHYLTRANSFERASE | AMINO-ACID | MUSHROOM TYROSINASE | L-METHIONINE ANALOGS | L-DOPA | CROSS-LINKING | CHEMISTRY | CHEMICAL-MODIFICATION | CHEMISTRY, MULTIDISCIPLINARY | BACILLUS-ANEURINOLYTICUS | LIVING CELLS | Fungal Proteins - chemistry | Hydroxylation | Peptides - chemistry | Agaricales - metabolism | Alkylation | Peptides, Cyclic - chemistry | Peptides, Cyclic - metabolism | Monophenol Monooxygenase - metabolism | Levodopa - chemistry | Catechol O-Methyltransferase - metabolism | Tyrosine - metabolism | Peptides - metabolism | Proteins - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Catalysis | Catechol O-Methyltransferase - chemistry | Proteins - chemistry | Agaricales - enzymology | Levodopa - metabolism | Monophenol Monooxygenase - chemistry | Tyrosine - chemistry | Fungal Proteins - metabolism | Tyrosine | Proteins | Enzymes | Peptides | Analysis | Research | Chemical properties
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13. Full Text Multi‐Drug‐Loaded Microcapsules with Controlled Release for Management of Parkinson's Disease
by Baek, Jong‐Suep and Choo, Chee Chong and Qian, Cheng and Tan, Nguan Soon and Shen, Zexiang and Loo, Say Chye Joachim
Small, ISSN 1613-6810, 07/2016, Volume 12, Issue 27, pp. 3712 - 3722
Parkinson's disease (PD) is a progressive disease of the nervous system, and is currently managed through commercial tablets that do not sufficiently enable... 
controlled release | Parkinson's disease | drug delivery | spray‐coating | spray-coating | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | MICROSPHERES | VIVO EVALUATION | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | MICROPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | DOSAGE FORM | LEVODOPA | DISSOLUTION | IN-VITRO EVALUATION | SUSTAINED-RELEASE | LEVODOPA/CARBIDOPA/ENTACAPONE | MICROBALLOONS | Levodopa - therapeutic use | Humans | Capsules - chemistry | Catechols - chemistry | Caproates - chemistry | Parkinson Disease - drug therapy | Carbidopa - chemistry | Levodopa - chemistry | Nitriles - administration & dosage | Microscopy, Confocal | Polyesters - chemistry | Carbidopa - therapeutic use | Animals | Levodopa - administration & dosage | Catechols - therapeutic use | Nitriles - chemistry | Drug Liberation | Hydrophobic and Hydrophilic Interactions | Catechols - administration & dosage | Carbidopa - administration & dosage | Delayed-Action Preparations | Drug Delivery Systems - methods | Lactones - chemistry | Nitriles - therapeutic use | Drugs | Drug delivery systems | Carbidopa | Dopa | Vehicles | Kinetics | Parkinsons disease | Controllers | Tablets | Programmable logic devices | Control systems | Sustained release | Management
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14. Full Text An electrochemical biosensor based on nanoporous stainless steel modified by gold and palladium nanoparticles for simultaneous determination of levodopa and uric acid
by Rezaei, Behzad and Shams-Ghahfarokhi, Leila and Havakeshian, Elaheh and Ensafi, Ali A
Talanta, ISSN 0039-9140, 09/2016, Volume 158, pp. 42 - 50
In this paper, an electrochemical biosensor based on gold and palladium nano particles-modified nanoporous stainless steel (Au-Pd/NPSS) electrode has been... 
Galvanic replacement | Gold and palladium nanoparticles | Levodopa | Uric acid | Nanoporous stainless steel | Biosensor | CHEMISTRY, ANALYTICAL | SELECTIVE OXIDATION | HUMAN PLASMA | GLASSY-CARBON ELECTRODE | SPECTROPHOTOMETRIC DETERMINATION | ASCORBIC-ACID | CO OXIDATION | PERFORMANCE LIQUID-CHROMATOGRAPHY | L-DOPA | BIMETALLIC CATALYSTS | Gold - chemistry | Electrochemical Techniques | Stainless Steel - chemistry | Humans | Metal Nanoparticles - chemistry | Nanopores | Levodopa - blood | Levodopa - analysis | Levodopa - chemistry | Uric Acid - chemistry | Uric Acid - urine | Biosensing Techniques | Levodopa - urine | Tablets - chemistry | Uric Acid - blood | Palladium - chemistry | Nanoparticles | Biological products | Steel, Stainless | Detectors | Palladium | X-ray spectroscopy | Dopa | Organic acids | Electrodes | Gold | Nanostructure | Biosensors | Stainless steels | Electrochemical impedance spectroscopy
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