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1. Full Text Denosumab in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer
by Smith, Matthew R and Egerdie, Blair and Toriz, Narciso Hernández and Feldman, Robert and Tammela, Teuvo L.J and Saad, Fred and Heracek, Jiri and Szwedowski, Maciej and Ke, Chunlei and Kupic, Amy and Leder, Benjamin Z and Goessl, Carsten and Denosumab HALT Prostate Canc Study and Denosumab HALT Prostate Cancer Study Group
The New England journal of medicine, ISSN 0028-4793, 08/2009, Volume 361, Issue 8, pp. 745 - 755
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Gynecology. Andrology. Obstetrics | General aspects | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Male genital diseases | Tumors | Lumbar Vertebrae - injuries | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Fractures, Bone - epidemiology | Antibodies, Monoclonal - therapeutic use | Male | Osteoporosis - drug therapy | Prostatic Neoplasms - physiopathology | Bone Remodeling - drug effects | Incidence | Antibodies, Monoclonal, Humanized | Spinal Fractures - prevention & control | RANK Ligand - pharmacology | Injections, Subcutaneous | Aged, 80 and over | RANK Ligand - therapeutic use | Gonadotropin-Releasing Hormone - agonists | Lumbar Vertebrae - physiology | Prostatic Neoplasms - drug therapy | RANK Ligand - adverse effects | Osteoporosis - chemically induced | Bone Density Conservation Agents - adverse effects | Double-Blind Method | Prostatic Neoplasms - surgery | Antibodies, Monoclonal - pharmacology | Spinal Fractures - epidemiology | Bone Density Conservation Agents - therapeutic use | Lumbar Vertebrae - drug effects | Denosumab | Bone Density Conservation Agents - pharmacology | Orchiectomy | Bone Density - drug effects | Androgen Antagonists - therapeutic use | Aged | Androgen Antagonists - adverse effects | Fractures, Bone - prevention & control | Osteoporosis | Bone density | Prostate cancer | Older people | Men | Index Medicus | Abridged Index Medicus
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2. Full Text IL-6 alters osteocyte signaling toward osteoblasts but not osteoclasts
by Bakker, A.D and Kulkarni, R.N and Klein-Nulend, J and Lems, W.F
Journal of dental research, ISSN 0022-0345, 2014, Volume 93, Issue 4, pp. 394 - 399
mechanical loading | bone | cytokines | shear stress | pulsating fluid flow | interleukins | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Osteocytes - drug effects | Mechanotransduction, Cellular - drug effects | Stress, Mechanical | RANK Ligand - drug effects | Pulsatile Flow - physiology | Caspase 3 - drug effects | Cell Culture Techniques | Cell Line | Caspase 7 - drug effects | Gene Expression Regulation - genetics | Osteoblasts - drug effects | Alkaline Phosphatase - drug effects | Culture Media, Conditioned | Bone Density - drug effects | Animals | Core Binding Factor Alpha 1 Subunit - drug effects | Interleukin-6 - pharmacology | Cell Differentiation - drug effects | Cell Communication - drug effects | Osteocalcin - drug effects | Cell Proliferation - drug effects | Mice | 3T3 Cells | Osteoclasts - drug effects | Ki-67 Antigen - drug effects | Osteoprogenitor cells | Alkaline phosphatase | Cbfa-1 protein | Osteocalcin | Cytokines | Fluid flow | Caspase | Osteocytes | Gene expression | Caspase-3 | Osteoblasts | Orthodontics | Osteoclastogenesis | Interleukin 6 | Bone mass | Osteoblastogenesis | Mechanical loading | Bone marrow | Osteoclasts | TRANCE protein | Communication | Apoptosis | Index Medicus | Dentistry
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3. Full Text Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor
by Andersen, Raymond J and Mawji, Nasrin R and Wang, Jun and Wang, Gang and Haile, Simon and Myung, Jae-Kyung and Watt, Kate and Tam, Teresa and Yang, Yu Chi and Bañuelos, Carmen A and Williams, David E and McEwan, Iain J and Wang, Yuzhou and Sadar, Marianne D
Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 535 - 546
CELLCYCLE | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Binding - genetics | Apoptosis - drug effects | Humans | Protein Conformation - drug effects | Transcriptional Activation - drug effects | Male | Neoplasm Recurrence, Local - pathology | Antineoplastic Agents, Hormonal - adverse effects | CREB-Binding Protein - metabolism | Prostate - pathology | Protein Binding - drug effects | Serine Endopeptidases - genetics | Prostate - drug effects | Prostate-Specific Antigen - metabolism | Benzhydryl Compounds - therapeutic use | Prostatic Neoplasms - drug therapy | Chlorohydrins - therapeutic use | Prostate-Specific Antigen - genetics | Prostate - anatomy & histology | DNA - metabolism | Prostate-Specific Antigen - blood | Androgens - pharmacology | Cell Line, Tumor | Ligands | Mice, Inbred NOD | Mice | Protein Multimerization - drug effects | Androgen Receptor Antagonists | Gene Expression - drug effects | Receptors, Androgen - metabolism | Neoplasm Recurrence, Local - drug therapy | Benzhydryl Compounds - adverse effects | Castration | Antineoplastic Agents, Hormonal - therapeutic use | Molecular Structure | Response Elements - genetics | Chlorohydrins - pharmacology | Chlorohydrins - adverse effects | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Prostatic Neoplasms - surgery | Protein Interaction Domains and Motifs - drug effects | Receptors, Steroid - drug effects | Mice, SCID | DNA - genetics | Xenograft Model Antitumor Assays | Animals | Benzhydryl Compounds - pharmacology | Cell Proliferation - drug effects | Chemical oceanography | Prostate cancer | Index Medicus
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4. Full Text Structure-based discovery of opioid analgesics with reduced side effects
by Manglik, Aashish and Lin, Henry and Aryal, Dipendra K and McCorvy, John D and Dengler, Daniela and Corder, Gregory and Levit, Anat and Kling, Ralf C and Bernat, Viachaslau and Hübner, Harald and Huang, Xi-Ping and Sassano, Maria F and Giguère, Patrick M and Löber, Stefan and Duan, Da and Scherrer, Grégory and Kobilka, Brian K and Gmeiner, Peter and Roth, Bryan L and Shoichet, Brian K
Nature (London), ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 185 - 190
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Thiophenes - adverse effects | Analgesia - methods | Humans | Analgesics, Opioid - pharmacology | Male | Structure-Activity Relationship | Receptors, Opioid, mu - agonists | Urea - chemistry | Analgesics, Opioid - adverse effects | Receptors, Opioid, mu - deficiency | Pain - drug therapy | Urea - analogs & derivatives | Analgesics, Opioid - chemistry | HEK293 Cells | Receptors, Opioid, mu - metabolism | Mice, Inbred C57BL | Thiophenes - pharmacology | Drug Discovery | Mice, Knockout | Animals | Urea - adverse effects | Mice | Molecular Docking Simulation | Receptors, Opioid, mu - genetics | Thiophenes - chemistry | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Spiro Compounds - pharmacology | Urea - pharmacology | Pharmaceutical research | Drug metabolism | Bioavailability | Research | Opioids | Complications and side effects | Composition | Analgesics | Causes of | Morphine | Structure | Opium | Opium habit | Ligands | Side effects | Pharmacology | Narcotics | Hydrogen bonds | Index Medicus
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5. Full Text Cooperative Effects between Chiral Cpx–Iridium(III) Catalysts and Chiral Carboxylic Acids in Enantioselective C−H Amidations of Phosphine Oxides
by Jang, Yun‐Suk and Dieckmann, Michael and Cramer, Nicolai
Angewandte Chemie (International ed.), ISSN 1433-7851, 11/2017, Volume 56, Issue 47, pp. 15088 - 15092
iridium | P-chirality | asymmetric catalysis | C−H activation | chiral Cp ligand | Oxides | Catalysis | Enantiomers | Organic acids | Transformation | Catalysts | Phosphine | Phosphorus | Ligands | Carboxylic acids | Iridium | Leucine | Phosphine oxide
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6. Full Text BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction
by Meng, S and Zhang, L and Tang, Y and Tu, Q and Zheng, L and Yu, L and Murray, D and Cheng, J and Kim, S.H and Zhou, X and Chen, J
Journal of dental research, ISSN 0022-0345, 7/2014, Volume 93, Issue 7, pp. 657 - 662
Epigenetics | Osteoclasts | BRD4 protein | Experimental animal models | Periodontitis | Anti-inflammatory agents | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Interleukin-1beta - drug effects | Transcription Factor AP-1 - drug effects | Toll-Like Receptor 2 - antagonists & inhibitors | Alveolar Bone Loss - prevention & control | Cathepsin K - drug effects | Tartrate-Resistant Acid Phosphatase | Promoter Regions, Genetic - drug effects | Lipopolysaccharides - adverse effects | RANK Ligand - drug effects | Proto-Oncogene Proteins c-ets - drug effects | Cell Differentiation | Toll-Like Receptor 4 - antagonists & inhibitors | Acid Phosphatase - drug effects | Transcription Factors - therapeutic use | Cell Line | Proto-Oncogene Proteins c-fos - drug effects | Nuclear Proteins - therapeutic use | Periodontitis - prevention & control | NFATC Transcription Factors - drug effects | Animals | Tumor Necrosis Factor-alpha - drug effects | Isoenzymes - drug effects | Mice | Osteoclasts - drug effects | NF-kappa B - drug effects | Phosphorylation | Chromatin | Immunoprecipitation | Disease | Transcription | Laboratories | Calcineurin | Inflammatory diseases | Lipopolysaccharides | Interleukin 6 | Proteins | Toll-like receptors | Bacteria | Tumor necrosis factor-TNF | TRANCE protein | Bone loss | c-Fos protein | NF-κB protein | Medical research | Cathepsin K | Cytokines | Therapeutic applications | Alveolar bone | Inflammation | RNA polymerase | Tumor necrosis factor-α | Gene expression | Nuclear transport | Polymerase chain reaction | Lymphocytes B | TLR2 protein | Acid phosphatase (tartrate-resistant) | Index Medicus | Dentistry | experimental animal models | periodontitis | osteoclasts | anti-inflammatory agents | Research Reports | epigenetics
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7. Full Text Protective Mechanisms of Simvastatin in Experimental Periodontal Disease
by Dalcico, Roberta and de Menezes, Adriana M. A and Deocleciano, Otacilio B and Oriá, Reinaldo B and Vale, Mariana L and Ribeiro, Ronaldo A and Brito, Gerly A. de C
Journal of periodontology (1970), ISSN 0022-3492, 08/2013, Volume 84, Issue 8, pp. 1145 - 1157
hydroxymethylglutaryl‐CoA reductase inhibitors | inflammation | Alveolar bone loss | periodontitis | Inflammation | Hydroxymethylglutaryl-CoA reductase inhibitors | Periodontitis | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Interleukin-1beta - drug effects | Simvastatin - therapeutic use | Bone Morphogenetic Protein 2 - drug effects | Rats, Wistar | Matrix Metalloproteinase 8 - drug effects | Alveolar Bone Loss - prevention & control | Receptor Activator of Nuclear Factor-kappa B - drug effects | RANK Ligand - drug effects | Malondialdehyde - analysis | Alanine Transaminase - drug effects | Gingiva - drug effects | Glutathione - drug effects | Anti-Inflammatory Agents - therapeutic use | Female | Osteoprotegerin - drug effects | Interleukin-10 - analysis | Nitrates - analysis | Peroxidase - drug effects | Matrix Metalloproteinase 1 - drug effects | Nitric Oxide Synthase Type II - drug effects | Rats | Aspartate Aminotransferases - drug effects | Alkaline Phosphatase - drug effects | Periodontitis - prevention & control | Antioxidants - therapeutic use | Animals | Tumor Necrosis Factor-alpha - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Nitrites - analysis | Oxidative Stress - drug effects | Index Medicus | Dentistry
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8. Full Text Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α‑Synuclein
by Konijnenberg, Albert and Ranica, Simona and Narkiewicz, Joanna and Legname, Giuseppe and Grandori, Rita and Sobott, Frank and Natalello, Antonino
Analytical chemistry (Washington), ISSN 0003-2700, 09/2016, Volume 88, Issue 17, pp. 8468 - 8475
Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Catechin | Usage | Dopamine | Chemical properties | Mass spectrometry | Index Medicus | Proteins | Binding | Covalence | Ion mobility | Ligands | Nanostructure | Agglomeration
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