X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chemistry, medicinal (8) 8
index medicus (8) 8
ligand-lipophilicity efficiency (8) 8
ligand efficiency (7) 7
humans (6) 6
lipophilicity (6) 6
chemistry, organic (5) 5
biochemistry & molecular biology (4) 4
discovery (4) 4
drug discovery (4) 4
ligand lipophilicity efficiency (4) 4
animals (3) 3
drug design (3) 3
inverse agonist (3) 3
molecular weight (3) 3
obesity (3) 3
polar surface area (3) 3
3,4-dihydro-2h-thiochromene 1,1-dioxide (2) 2
absorption (2) 2
antagonist (2) 2
binding efficiency index (2) 2
cannabinoid cb2 receptor (2) 2
clearance (2) 2
design (2) 2
lipophilic efficiency (2) 2
log d (2) 2
microsomes, liver - metabolism (2) 2
obesity - drug therapy (2) 2
oral absorption (2) 2
phenoxyethylamine derivatives (2) 2
physical properties (2) 2
rats (2) 2
safety (2) 2
solubility (2) 2
structure-activity relationship (2) 2
subtype selectivity (2) 2
6-aminonicotinamide - analogs & derivatives (1) 1
6-aminonicotinamide - metabolism (1) 1
6-aminonicotinamide - pharmacology (1) 1
acetyl-coa carboxylase (1) 1
acetyl-coa carboxylase - antagonists & inhibitors (1) 1
acetyl-coa carboxylase - metabolism (1) 1
acid-related diseases (1) 1
administration, oral (1) 1
agonist (1) 1
alpha-adrenoceptor subtypes (1) 1
analogs (1) 1
animal anatomy / morphology / histology (1) 1
anti-obesity agents - chemistry (1) 1
anti-obesity agents - metabolism (1) 1
anti-obesity agents - pharmacology (1) 1
aromaticity (1) 1
atp-binding cassette, sub-family b, member 1 - metabolism (1) 1
attrition (1) 1
benign prostatic hyperplasia (1) 1
benzo[d]thiazole (1) 1
binding (1) 1
biological-properties (1) 1
biophysics (1) 1
blockade (1) 1
caco-2 cells (1) 1
cannabinoid receptor (1) 1
cannabinoids - antagonists & inhibitors (1) 1
cannabinoids - metabolism (1) 1
cell line (1) 1
cell survival - drug effects (1) 1
cells (1) 1
cellular toxicity (1) 1
central nervous system (1) 1
central nervous system - drug effects (1) 1
central nervous system agents - chemistry (1) 1
central nervous system agents - metabolism (1) 1
central nervous system agents - pharmacology (1) 1
central-nervous-system (1) 1
chemistry (1) 1
chemistry, multidisciplinary (1) 1
chemists (1) 1
cho cells (1) 1
chromatographic hydrophocbity measurements (1) 1
cloning (1) 1
cns candidates (1) 1
cns drugs (1) 1
coenzyme (1) 1
combinatorial chemistry techniques (1) 1
complications (1) 1
computer applications in chemistry (1) 1
computer science, interdisciplinary applications (1) 1
contraction (1) 1
cricetinae (1) 1
cricetulus (1) 1
crystallography, x-ray (1) 1
cytochrome p-450 cyp3a - metabolism (1) 1
cytochrome p450 (1) 1
cytochrome-p450 enzymes (1) 1
density (1) 1
derivatives (1) 1
developability (1) 1
developability classification system (1) 1
diabetes mellitus, type 2 - drug therapy (1) 1
diabetes mellitus, type 2 - enzymology (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2009, Volume 19, Issue 19, pp. 5560 - 5564
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 03/2010, Volume 1, Issue 6, pp. 420 - 434
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 05/2012, Volume 3, Issue 5, pp. 397 - 401
Antagonism of cannabinoid-1 (CB1) receptor signaling has been demonstrated to inhibit feeding behaviors in humans, but CB1-mediated central nervous system... 
Obesity | ligand-lipophilicity efficiency | CHEMISTRY, MEDICINAL | SAFETY | ENDOCANNABINOID SYSTEM | multidrug resistance protein 1 | cannabinoid receptor | antagonist | TRENDS | PHARMACOLOGY | clearance | CENTRAL-NERVOUS-SYSTEM | COMPLICATIONS | BLOCKADE | ligand efficiency | polar surface area | RATIONAL DESIGN
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2017, Volume 139, pp. 114 - 127
...–AR antagonists containing the phenoxyethylamine motif. Study of structure activity relationship guided by a targeted ligand-lipophilicity efficiency score led... 
3,4-Dihydro-2H-thiochromene 1,1-dioxide | Phenoxyethylamine derivatives | Selective human α1D adrenoceptor antagonist | Ligand–lipophilicity efficiency (LLE)
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2017, Volume 25, Issue 13, pp. 3406 - 3430
...]thiazole core from the four designed scaffolds. Optimization of this scaffold in terms of EP1 antagonist potency and ligand-lipophilicity efficiency (LLE; pIC50-clogP... 
Ligand-lipophilicity efficiency | Benzo[d]thiazole | EP1 antagonist | antagonist | CELLS | DESIGN | CHEMISTRY, MEDICINAL | SUBTYPES | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | CHEMISTRY, ORGANIC | DISCOVERY | PROSTANOID RECEPTORS | SMOOTH-MUSCLE
Journal Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 10/2017, Volume 139, pp. 114 - 127
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 3, pp. 1084 - 1089
...– 20 represent a novel chemotype of potent and CB 2/CB 1 selective cannabinoid CB 2 receptor antagonists/inverse agonists with very high binding efficiencies in combination with favourable log P... 
Polar surface area | Lipophilic efficiency | Inverse agonist | Ligand-lipophilicity efficiency | Ligand efficiency | Binding efficiency index | Subtype selectivity | Lipophilicity | Cannabinoid CB2 receptor
Journal Article
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, ISSN 0037-9980, 03/2019, Volume 77, Issue 3, pp. 254 - 261
...), and its pharmacophore for potent inhibitory activity was identified. Following optimization by focusing on compounds with high ligand-lipophilicity efficiency (LLE... 
H+,K+-ATPase | potassium-competitive acid blocker (P-CAB) | TAK-438 | ligand-lipophilicity efficiency (LLE) | CHEMISTRY, ORGANIC | acid-related diseases | Vonoprazan Fumarate (Takecab (R)) | high through-put screening (HTS)
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 10, pp. 3039 - 3053
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.