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Science, ISSN 0036-8075, 10/2011, Volume 334, Issue 6054, pp. 376 - 380
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 04/2011, Volume 22, Issue 8, pp. 1191 - 1206
Mitosis requires precise coordination of multiple global reorganizations of the nucleus and cytoplasm. Cyclin-dependent kinase 1 (Cdk1) is the primary upstream... 
ANAPHASE-PROMOTING COMPLEX | XENOPUS EGG EXTRACTS | PROTEIN PHOSPHATASES | CYCLE-DEPENDENT PHOSPHORYLATION | UBIQUITIN LIGASE | M-PHASE | CHROMOSOME ALIGNMENT | CELL-CYCLE | TUMOR-CELLS | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Cyclin-Dependent Kinases - metabolism | Gene Expression - drug effects | Xenopus Proteins - genetics | Mitosis | Protein-Tyrosine Kinases - metabolism | Humans | Phosphoprotein Phosphatases - metabolism | G2 Phase - drug effects | CDC2 Protein Kinase - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Cyclin B - genetics | cdc25 Phosphatases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Prometaphase - drug effects | Female | Cyclin-Dependent Kinases - antagonists & inhibitors | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | Cyclin-Dependent Kinases - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | CDC2 Protein Kinase - genetics | Protein Phosphatase 2 - antagonists & inhibitors | CDC2 Protein Kinase - antagonists & inhibitors | Xenopus laevis | Cell Cycle Proteins - metabolism | Protein Phosphatase 2 - genetics | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Phosphoprotein Phosphatases - antagonists & inhibitors | cdc25 Phosphatases - genetics | Xenopus Proteins - antagonists & inhibitors | Membrane Proteins | Animals | Phosphoprotein Phosphatases - genetics | Nuclear Proteins - antagonists & inhibitors | Protein Phosphatase 2 - metabolism | Cyclin B - metabolism | Feedback, Physiological - drug effects | Xenopus Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | S Phase - drug effects | HeLa Cells | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Cancer Research, ISSN 0008-5472, 01/2017, Volume 77, Issue 1, pp. 86 - 99
Triple-negative breast cancer (TNBC) is a highly aggressive, heterogeneous disease with poor prognosis and no effective targeted therapies. EGFR is highly... 
METASTASIS SUPPRESSOR | GROWTH-FACTOR RECEPTOR | THERAPY | ONCOLOGY | TYROSINE KINASE | OVERCOME RESISTANCE | FOCAL ADHESION KINASE | INHIBITORS | NDRG1 | BREAST | FAMILY | Immunohistochemistry | Immunoprecipitation | Oligonucleotide Array Sequence Analysis | Humans | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | Focal Adhesion Kinase 2 - antagonists & inhibitors | Triple Negative Breast Neoplasms - pathology | Female | Nedd4 Ubiquitin Protein Ligases | Antineoplastic Agents - pharmacology | Cell Cycle Proteins - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Receptor, ErbB-3 - genetics | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Triple Negative Breast Neoplasms - metabolism | Fluorescent Antibody Technique | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Signal Transduction - physiology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Cell proliferation | Ubiquitin | Tyrosine | Epidermal growth factor receptors | Stat3 protein | Extracellular signal-regulated kinase | AKT protein | Activation | Antagonists | Breast cancer | Myc protein | Drug resistance | Kinases | Degradation | Signaling | Pathways | Medical prognosis | Xenografts | Proteasomes | Inhibition | Focal adhesion kinase | Ubiquitin-protein ligase | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2008, Volume 105, Issue 14, pp. 5632 - 5637
Journal Article
Cell Death and Disease, ISSN 2041-4889, 10/2012, Volume 3, Issue 10, pp. e411 - e411
The strategy of clinically targeting cancerous cells at their most vulnerable state during mitosis has instigated numerous studies into the mitotic cell death... 
Chemotherapy | Mitotic slippage | Tumor growth | Antimitotic | Cancer | ADVANCED SOLID TUMORS | mitotic slippage | POLO-LIKE KINASES | CELL-CYCLE ARREST | antimitotic | HUMAN BREAST-CANCER | DEPENDENT KINASE INHIBITOR | chemotherapy | CHRONIC MYELOID-LEUKEMIA | SMALL-MOLECULE INHIBITOR | CELL BIOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | tumor growth | CHRONIC LYMPHOCYTIC-LEUKEMIA | cancer | SPINDLE PROTEIN INHIBITOR | Anaphase-Promoting Complex-Cyclosome | Humans | Ubiquitin-Protein Ligase Complexes - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Multiprotein Complexes - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Molecular Motor Proteins - antagonists & inhibitors | Molecular Motor Proteins - metabolism | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Proteasome Endopeptidase Complex - chemistry | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Adenosine Triphosphatases - antagonists & inhibitors | Mitosis - drug effects | Ubiquitin-Protein Ligase Complexes - metabolism | Myeloid Cell Leukemia Sequence 1 Protein | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proteasome Endopeptidase Complex - metabolism | Review
Journal Article
Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7309, pp. 941 - 946
Journal Article
Cell, ISSN 0092-8674, 05/2018, Volume 173, Issue 4, pp. 972 - 988.e23
Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining... 
DNA damage repair | proximity labeling | shieldin | proteomics | 53BP1 | PARP inhibitors | telomere maintenance | antibody class-switch recombination | NHEJ | BRCA1 | PATHWAYS | CELLS | RESECTION | DAMAGE-RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASS-SWITCH RECOMBINATION | HOMOLOGOUS RECOMBINATION | DOUBLE-STRAND BREAK | TELOMERES | CELL BIOLOGY | Mad2 Proteins - metabolism | Humans | Ubiquitin-Protein Ligases - antagonists & inhibitors | DNA Breaks, Double-Stranded | Mad2 Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Telomere-Binding Proteins - genetics | RNA Interference | BRCA1 Protein - metabolism | Trans-Activators - genetics | Immunoglobulin Class Switching - drug effects | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | DNA End-Joining Repair - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Mutagenesis, Site-Directed | Tumor Suppressor p53-Binding Protein 1 - genetics | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Telomere-Binding Proteins - antagonists & inhibitors | Tumor Suppressor p53-Binding Protein 1 - antagonists & inhibitors | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | BRCA1 Protein - antagonists & inhibitors | Mad2 Proteins - genetics | Cell Line, Tumor | Trans-Activators - metabolism | Ubiquitin-Protein Ligases - genetics | RNA, Small Interfering - metabolism | DNA damage | Genomics | Antibodies | Genomes | DNA repair | Proteins | Viral antibodies | Telomeres | Evolutionary biology | Analysis | DNA | Genetic research | Mass spectrometry
Journal Article