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index medicus (98) 98
ubiquitin (75) 75
humans (74) 74
nf-kappa-b (66) 66
cell biology (58) 58
signal transduction (54) 54
animals (53) 53
ubiquitination (53) 53
biochemistry & molecular biology (52) 52
inflammation (42) 42
activation (31) 31
linear ubiquitin (30) 30
apoptosis (29) 29
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proteins (27) 27
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mice (26) 26
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lubac (24) 24
nf-kappa b - metabolism (24) 24
ubiquitin - metabolism (24) 24
ubiquitin-protein ligases - metabolism (24) 24
immunology (21) 21
linear polyubiquitin chains (21) 21
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kinases (20) 20
phosphorylation (20) 20
structural basis (17) 17
a20 (16) 16
article (16) 16
chain assembly complex (16) 16
complex (16) 16
enzymes (15) 15
linear ubiquitin chains (15) 15
mutation (15) 15
binding (14) 14
endopeptidases - metabolism (14) 14
molecular biology (14) 14
polyubiquitin chains (14) 14
post-translational modification (14) 14
protein processing, post-translational (14) 14
review (14) 14
hek293 cells (13) 13
kappa-b activation (13) 13
models, molecular (13) 13
multidisciplinary sciences (13) 13
spata2 links cyld (13) 13
ubiquitin-protein ligases - chemistry (13) 13
ubiquitin-protein ligases - genetics (13) 13
zinc-finger 7 (13) 13
cancer (12) 12
linear polyubiquitin (12) 12
otulin (12) 12
tumor necrosis factor (12) 12
ubiquitin - chemistry (12) 12
chains (11) 11
cyld (11) 11
deubiquitinase (11) 11
ligases (11) 11
nemo (11) 11
nf-κb (11) 11
sharpin (11) 11
signaling (11) 11
signaling complex (11) 11
tnf (11) 11
ubiquitin - genetics (11) 11
assembly complex (10) 10
biochemistry (10) 10
cytokines (10) 10
deubiquitinating enzyme cyld (10) 10
polyubiquitin - metabolism (10) 10
analysis (9) 9
biology (9) 9
biophysics (9) 9
crystallography, x-ray (9) 9
gene expression (9) 9
lysine - metabolism (9) 9
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receptor-interacting protein serine-threonine kinases - metabolism (9) 9
research (9) 9
binding sites (8) 8
endopeptidases - chemistry (8) 8
endopeptidases - genetics (8) 8
physiological aspects (8) 8
proteolysis (8) 8
receptors, tumor necrosis factor, type i - metabolism (8) 8
recognition (8) 8
tumor necrosis factor receptors (8) 8
amino acid sequence (7) 7
catalysis (7) 7
e3 ligase (7) 7
gene expression regulation (7) 7
genetic aspects (7) 7
immune-responses (7) 7
inhibition (7) 7
innate immunity (7) 7
mass spectrometry (7) 7
negative regulator (7) 7
nf-kappa b (7) 7
nf-kappa b - genetics (7) 7
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Journal Article
EMBO reports, ISSN 1469-221X, 07/2014, Volume 15, Issue 7, pp. 775 - 783
Journal Article
Cell, ISSN 0092-8674, 08/2016, Volume 166, Issue 5, pp. 1215 - 1230.e20
Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators... 
MET1-LINKED UBIQUITINATION | ACTIVATION | LINEAR UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE | SHARPIN CONTROLS | NF-KAPPA-B | LUBAC | IMMUNODEFICIENCY | HOIP | AUTOINFLAMMATION | CELL BIOLOGY | Ubiquitin | Autoimmunity | Viral antibodies | Analysis | Medical genetics | Antibodies | Inflammation | T cells | Molecular biology | Resveratrol
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2016, Volume 113, Issue 36, pp. 10127 - 10132
Systemic autoinflammatory diseases are caused by mutations in genes that function in innate immunity. Here, we report an autoinflammatory disease caused by... 
Autoinflammatory disease | Cytokines | Nf-κb pathway | Linear deubiquitinase | OTULIN | ACTIVATION | AMYLOPECTINOSIS | NF-kappa B pathway | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | linear deubiquitinase | ASSEMBLY COMPLEX | CELL-DEATH | HOIP | SHARPIN | autoinflammatory disease | INFLAMMATION | LUBAC DEFICIENCY | cytokines | IMMUNODEFICIENCY | Fibroblasts - enzymology | Humans | NF-kappa B - immunology | Child, Preschool | Male | Fever - physiopathology | Leukocytes, Mononuclear - immunology | HEK293 Cells | Female | Child | Cytokines - genetics | Failure to Thrive - physiopathology | Hereditary Autoinflammatory Diseases - pathology | Cytokines - immunology | Dermatitis - physiopathology | Signal Transduction | Hereditary Autoinflammatory Diseases - enzymology | Gene Expression Regulation | Ubiquitin - genetics | Endopeptidases - deficiency | Hereditary Autoinflammatory Diseases - diagnosis | Fibroblasts - pathology | Endopeptidases - immunology | Leukocytes, Mononuclear - pathology | Endopeptidases - genetics | NF-kappa B - genetics | Pedigree | Age of Onset | Alleles | Fibroblasts - immunology | Leukocytes, Mononuclear - enzymology | Panniculitis - physiopathology | Consanguinity | Mutation | Ubiquitin - immunology | Hereditary Autoinflammatory Diseases - genetics | Allelomorphism | Genetic aspects | Gene mutations | Autoimmune diseases | Health aspects | Biological Sciences | NF-κB pathway
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2015, Volume 290, Issue 21, pp. 13372 - 13385
Journal Article