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animals (256) 256
fatty acid desaturases - metabolism (223) 223
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male (160) 160
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microsomes, liver - enzymology (56) 56
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lipids (46) 46
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cloning, molecular (45) 45
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liver (42) 42
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lipid metabolism (38) 38
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rats, wistar (35) 35
cloning (32) 32
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stearoyl-coa desaturase (31) 31
alpha-linolenic acid (30) 30
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gamma-linolenic acid (29) 29
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expression (28) 28
middle aged (28) 28
docosahexaenoic acid (27) 27
fatty acids, omega-3 - metabolism (27) 27
polyunsaturated fatty-acids (27) 27
rna, messenger - genetics (27) 27
rna, messenger - metabolism (27) 27
saccharomyces cerevisiae - genetics (27) 27
delta-6 desaturase (26) 26
kinetics (26) 26
linoleic acid - metabolism (25) 25
adult (24) 24
arachidonic-acid (24) 24
polyunsaturated fatty acids (24) 24
fatty acids, unsaturated - biosynthesis (23) 23
linoleoyl-coa desaturase - chemistry (23) 23
phylogeny (23) 23
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cholesterol (22) 22
fatty acids, essential - metabolism (22) 22
nutrition (22) 22
docosahexaenoic acids - metabolism (21) 21
linoleoyl-coa desaturase - blood (21) 21
sequence homology, amino acid (21) 21
stearoyl-coa desaturase - metabolism (21) 21
desaturation (20) 20
base sequence (19) 19
delta-6 (19) 19
essential fatty acids (19) 19
fatty-acids (19) 19
insulin resistance (19) 19
microsomes, liver - drug effects (19) 19
acetyltransferases - metabolism (18) 18
analysis (18) 18
biochemistry, general (18) 18
biotechnology & applied microbiology (18) 18
cell biology (18) 18
chromatography, gas (18) 18
dietary fats - administration & dosage (18) 18
dietary fats - pharmacology (18) 18
plasma (18) 18
sequence alignment (18) 18
substrate specificity (18) 18
aged (17) 17
gamma-linolenic acid - metabolism (17) 17
gene-expression (17) 17
linolenic acids - metabolism (17) 17
phospholipids (17) 17
pregnancy (17) 17
rats, sprague-dawley (17) 17
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Journal Article
Schizophrenia Research, ISSN 0920-9964, 2009, Volume 109, Issue 1, pp. 113 - 120
.... Here we determined Δ5 desaturase ( FADS1 ), Δ6 desaturase ( FADS2 ), elongase ( HELO1 [ ELOVL5 ]), peroxisomal ( PEX19 ), and Δ9 desaturase (stearoyl-CoA desaturase, SCD... 
Psychiatry | Monounsaturated fatty acids | Delta-6 desaturase ( FADS2) | Peroxisome ( PEX19) | Polyunsaturated fatty acids | Postmortem | Schizophrenia | Delta-5 desaturase ( FADS1) | Stearoyl-CoA desaturase ( SCD) | Prefrontal cortex | Saturated fatty acids | Elongase ( HELO1) | Delta-5 desaturase (FADS1) | Elongase (HELO1) | Delta-6 desaturase (FADS2) | Peroxisome (PEX19) | Stearoyl-CoA desaturase (SCD) | PSYCHIATRY | NEVER-MEDICATED 1ST-EPISODE | ARACHIDONIC-ACID | CEREBROSPINAL-FLUID | PSYCHOTIC-PATIENTS | STEAROYL-COA DESATURASE | METABOLISM | DOCOSAHEXAENOIC ACID | GENE-EXPRESSION | ORBITOFRONTAL CORTEX | BLOOD-CELLS | Fatty Acids, Unsaturated - genetics | Schizophrenia - metabolism | Humans | Middle Aged | Molecular Sequence Data | Male | RNA, Messenger - metabolism | Fatty Acids, Unsaturated - biosynthesis | Linoleoyl-CoA Desaturase - genetics | Schizophrenia - genetics | Antipsychotic Agents - therapeutic use | Autopsy | Adult | Female | Prefrontal Cortex - enzymology | Fatty Acid Desaturases - genetics | Gene Expression | Fatty Acid Desaturases - metabolism | RNA, Messenger - genetics | Linoleoyl-CoA Desaturase - metabolism | Fatty Acids, Unsaturated - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Stearoyl-CoA Desaturase - genetics | Linoleoyl-CoA Desaturase - analysis | Stearoyl-CoA Desaturase - metabolism | Aged | Schizophrenia - drug therapy | Enzymes | Prostaglandins | Messenger RNA | Antipsychotic drugs | Biological products | Synthesis | Analysis | Physiological aspects | Prostanoids
Journal Article
Diabetologia, ISSN 0012-186X, 2/2008, Volume 51, Issue 2, pp. 328 - 335
Journal Article
Journal Article
Lipids in Health and Disease, ISSN 1476-511X, 04/2017, Volume 16, Issue 1, pp. 64 - 16
...) through the action of Delta 5 and Delta 6-desaturases. High-fat diet (HFD) decreases the activity of both desaturases and LCPUFA accretion in liver and other tissues. Hydroxytyrosol (HT... 
Hydroxytyrosol | Antioxidant capacity | Liver and extrahepatic tissues | LCPUFA | Oxidative stress | Δ5/Δ6 Desaturase activity | B PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUTATHIONE-PEROXIDASE | N-3 LCPUFA | NUTRITION & DIETETICS | OBESE-PATIENTS | OLIVE OIL | DOCOSAHEXAENOIC ACID | ANTIOXIDANT | ENDOTHELIAL-CELLS | Delta 5/Delta 6 Desaturase activity | BODY SYNTHESIS RATES | ALPHA-LINOLENIC ACID | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Liver - enzymology | Oxidative Stress | Phenylethyl Alcohol - analogs & derivatives | Weaning | Diet, High-Fat - adverse effects | Non-alcoholic Fatty Liver Disease - etiology | Male | Fatty Acid Desaturases - chemistry | Fatty Acids, Omega-6 - agonists | Biomarkers - metabolism | Fatty Acids, Omega-3 - metabolism | Linoleoyl-CoA Desaturase - chemistry | Hydroxylation | Fatty Acid Desaturases - metabolism | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Linoleoyl-CoA Desaturase - metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Biomarkers - blood | Random Allocation | Organ Specificity | Fatty Acids, Omega-6 - metabolism | Fatty Acids, Omega-3 - agonists | Antioxidants - therapeutic use | Animals | Non-alcoholic Fatty Liver Disease - prevention & control | Dietary Supplements | Phenylethyl Alcohol - therapeutic use | Liver | Homeostasis | Superoxide dismutase | Esters | Nervous system | Arachidonic acid | Kinases | Desaturase | Docosahexaenoic acid | High fat diet | Antioxidants | Proteins | Fatty liver | Catalase | Glutathione reductase | Rodents | Polyphenols | Enzyme-linked immunosorbent assay | Food | Glutathione peroxidase | Carbohydrates | Enzymes | Dietary supplements | Liquid chromatography | Olive oil | Metabolism | Gene expression | Fatty acids | Insulin | Cholesterol | Linoleic acid | Linolenic acid | Diet | Insulin resistance | Spectrophotometry | Eicosapentaenoic acid
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 10, p. e47567
.... Delta-6 desaturase (D6D) is the rate-limiting enzyme responsible for the synthesis of n-6 AA and increased D6D activity can lead to enhanced n-6 AA production... 
ACTIVATION | ANGIOGENESIS | FAT-1 MICE | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | IN-VIVO | GENE-EXPRESSION | POLYUNSATURATED FATTY-ACIDS | LIPID MEDIATORS | TRANSGENIC MICE | CHRONIC DISEASES | Lung Neoplasms - genetics | Genetic Therapy | RNA, Small Interfering - genetics | Up-Regulation | Lung - pathology | Lung Neoplasms - enzymology | Mice, Inbred C57BL | Melanoma - enzymology | Lung Neoplasms - pathology | Linoleoyl-CoA Desaturase - metabolism | Lung Neoplasms - therapy | Melanoma - pathology | Enzyme Inhibitors - therapeutic use | Linoleoyl-CoA Desaturase - antagonists & inhibitors | Animals | RNA Interference | Melanoma - genetics | RNA, Small Interfering - therapeutic use | Eicosanoids - metabolism | Lung - drug effects | Female | Lung - metabolism | Mice | Melanoma - therapy | Enzymes | Unsaturated fatty acids | Metabolites | Growth | Lung cancer | Melanoma | Gene therapy | Arachidonic acid | Health aspects | Cancer | Cytochrome | Laboratories | Eicosanoids | Lipids | Metastasis | Kinases | Desaturase | Cancer therapies | Medical schools | Angiogenesis | Cell growth | Transgenic animals | Rodents | Genetics | Tumorigenesis | Pharmaceutical sciences | RNA-mediated interference | Inflammation | Metabolism | Fatty acids | Inflammatory bowel disease | Medicine | Nutrition research | Hospitals | Lungs | Plasmids | Liquid oxygen | Metabolic pathways | Prostate cancer
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 1999, Volume 274, Issue 1, pp. 471 - 477
Journal Article