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1. Full Text Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents
by Gasbjerg, Lærke Smidt and Gabe, Maria Buur Nordskov and Hartmann, Bolette and Christensen, Mikkel Bring and Knop, Filip Krag and Holst, Jens Juul and Rosenkilde, Mette Marie
Peptides (New York, N.Y. : 1980), ISSN 0196-9781, 02/2018, Volume 100, pp. 173 - 181
GIP receptor antagonist | GIP receptor | Obesity therapy | Glucose-dependent insulinotropic polypeptide (GIP) | Type 2 diabetes therapy | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Hypoglycemic Agents - therapeutic use | Gastric Inhibitory Polypeptide - metabolism | Humans | Hypoglycemic Agents - chemistry | Diabetes Mellitus, Type 2 - metabolism | Receptors, Gastrointestinal Hormone - therapeutic use | Receptors, Gastrointestinal Hormone - antagonists & inhibitors | Blood Glucose - drug effects | Adipose Tissue - metabolism | Insulin - metabolism | Receptors, Gastrointestinal Hormone - genetics | Glucose - metabolism | Glucagon - metabolism | Diabetes Mellitus, Type 2 - pathology | Diabetes Mellitus, Type 2 - drug therapy | Adipose Tissue - drug effects | Weight reducing preparations | Type 2 diabetes | Medical research | Peptides | Physiological aspects | Medicine, Experimental | Lipoprotein lipase | Hypoglycemic agents | Glucose | Glucose tolerance tests | Dextrose | Membrane proteins | Index Medicus
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2. Full Text The monoacylglycerol lipase inhibitor JZL184 attenuates LPS‐induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action
by Kerr, DM and Harhen, B and Okine, BN and Egan, LJ and Finn, DP and Roche, M
British journal of pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 808 - 819
monoacylglycerol lipase | endocannabinoid | NF‐κB | TNF‐α | 2‐AG | brain | JZL184 | IL‐6 | IL‐1β | frontal cortex | IL‐10 | cytokines | plasma | IL-1β | IL-10 | IL-6 | NF-κB | TNF-α | 2-AG | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Benzodioxoles - antagonists & inhibitors | Spleen - immunology | Frontal Lobe - metabolism | Male | Spleen - drug effects | Prostaglandins - blood | Lipopolysaccharides | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Glycerides - blood | Arachidonic Acids - blood | Enzyme Inhibitors - chemistry | Anti-Anxiety Agents - therapeutic use | Benzodioxoles - therapeutic use | Peritonitis - metabolism | Rats | Encephalitis - immunology | Random Allocation | Glycerides - metabolism | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Cannabinoid Receptor Antagonists - therapeutic use | Monoacylglycerol Lipases - blood | Peritonitis - drug therapy | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Endocannabinoids - metabolism | Nerve Tissue Proteins - blood | Monoacylglycerol Lipases - antagonists & inhibitors | Piperidines - antagonists & inhibitors | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Encephalitis - drug therapy | Encephalitis - metabolism | Cytokines - blood | Nerve Tissue Proteins - antagonists & inhibitors | Cytokines - metabolism | Peritonitis - immunology | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Spleen - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Piperidines - therapeutic use | Frontal Lobe - drug effects | Cannabinoid Receptor Antagonists - chemistry | Frontal Lobe - immunology | Cytokines - antagonists & inhibitors | Endocannabinoids - blood | Prostaglandins - metabolism | Glycerin | Brain | Unsaturated fatty acids | Cytokines | Glycerol | Lipase | Mitogens | Plasma | Rodents | Index Medicus | Cannabinoids 2012, Part Two | Themed Section
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3. Full Text Suppression of adipocyte differentiation and lipid accumulation by stearidonic acid (SDA) in 3T3-L1 cells
by Li, Yueru and Rong, Yinghui and Bao, Lisui and Nie, Ben and Ren, Guang and Zheng, Chen and Amin, Rajesh and Arnold, Robert D and Jeganathan, Ramesh B and Huggins, Kevin W
Lipids in health and disease, ISSN 1476-511X, 09/2017, Volume 16, Issue 1, pp. 181 - 181
Obesity | Adipocyte differentiation | Stearidonic acid | 3T3-L1 | Omega-3 fatty acids | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Fatty Acid Synthase, Type I - genetics | Lipoprotein Lipase - antagonists & inhibitors | Fatty Acid-Binding Proteins - antagonists & inhibitors | Glucose Transporter Type 4 - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - antagonists & inhibitors | Adipocytes - cytology | Adipocytes - drug effects | Fatty Acid-Binding Proteins - metabolism | PPAR gamma - metabolism | Fatty Acids, Omega-3 - pharmacology | CCAAT-Enhancer-Binding Proteins - antagonists & inhibitors | CCAAT-Enhancer-Binding Proteins - genetics | Lipoprotein Lipase - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Glucose Transporter Type 4 - antagonists & inhibitors | Cell Survival - drug effects | Glucose Transporter Type 4 - genetics | Lipoprotein Lipase - genetics | CCAAT-Enhancer-Binding Protein-beta - genetics | Stearoyl-CoA Desaturase - antagonists & inhibitors | 3T3-L1 Cells | Fatty Acid Synthase, Type I - metabolism | Fatty Acid-Binding Proteins - genetics | Stearoyl-CoA Desaturase - genetics | CCAAT-Enhancer-Binding Protein-beta - metabolism | Fatty Acid Synthase, Type I - antagonists & inhibitors | Gene Expression Regulation - drug effects | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Animals | PPAR gamma - antagonists & inhibitors | Sterol Regulatory Element Binding Protein 1 - genetics | Cell Differentiation - drug effects | Adipocytes - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Lipid Metabolism - drug effects | Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors | Stearoyl-CoA Desaturase - metabolism | Mice | CCAAT-Enhancer-Binding Protein-beta - antagonists & inhibitors | Usage | Care and treatment | Analysis | Development and progression | Liquid chromatography | Glucose transporter | Vegetable oils | Soybeans | Transcription factors | Fish oils | Toxicity | Gene regulation | Preadipocytes | Mass spectroscopy | Stearoyl-CoA desaturase | Lipoprotein lipase | Adipocytes | Lipase | Desaturase | Gene expression | Fatty acids | Fatty-acid synthase | Polymerase chain reaction | Rodents | Down-regulation | Sterol regulatory element-binding protein | Index Medicus
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4. Full Text A dual apolipoprotein C-II mimetic-apolipoprotein C-III antagonist peptide lowers plasma triglycerides
by Wolska, Anna and Lo, Larry and Sviridov, Denis O and Pourmousa, Mohsen and Pryor, Milton and Ghosh, Soumitra S and Kakkar, Rahul and Davidson, Michael and Wilson, Sierra and Pastor, Richard W and Goldberg, Ira J and Basu, Debapriya and Drake, Steven K and Cougnoux, Antony and Wu, Ming Jing and Neher, Saskia B and Freeman, Lita A and Tang, Jingrong and Amar, Marcelo and Devalaraja, Matt and Remaley, Alan T
Science translational medicine, ISSN 1946-6234, 01/2020, Volume 12, Issue 528, p. eaaw7905
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Lipoproteins (low density) | Peptides | Transgenic mice | Molecular dynamics | Triglycerides | Lipoprotein lipase | Bioavailability | Lipase | Drug development | Cholesterol | Lipoproteins | Apolipoprotein C-III | Hypertriglyceridemia | Lipoprotein (low density) receptors | Cardiovascular diseases | Lipoproteins (high density) | Index Medicus
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5. Full Text Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling
by Feng, Bo and Tang, Yangshun and Chen, Bin and Xu, Cenglin and Wang, Yi and Dai, Yunjian and Wu, Dengchang and Zhu, Junmin and Wang, Shuang and Zhou, Yudong and Shi, Liyun and Hu, Weiwei and Zhang, Xia and Chen, Zhong
Scientific reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, pp. 21931 - 21931
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA, Small Interfering - genetics | Lipoprotein Lipase - antagonists & inhibitors | Seizures - genetics | Humans | Interleukin 1 Receptor Antagonist Protein - genetics | Seizures - metabolism | Interleukin-1beta - genetics | Seizures, Febrile - pathology | Seizures - physiopathology | Seizures, Febrile - physiopathology | Seizures - pathology | Aging - genetics | Piperidines - pharmacology | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Seizures, Febrile - genetics | Cannabinoid Receptor Antagonists - pharmacology | Lipoprotein Lipase - metabolism | Interleukin-1beta - antagonists & inhibitors | Pyrazoles - pharmacology | Seizures, Febrile - metabolism | Signal Transduction | Lipoprotein Lipase - genetics | Tissue Culture Techniques | Gene Expression Regulation | Morpholines - pharmacology | Hippocampus - pathology | Cyclohexanones - pharmacology | Rats, Sprague-Dawley | Mice, Knockout | Naphthalenes - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Interleukin 1 Receptor Antagonist Protein - antagonists & inhibitors | Benzoxazines - pharmacology | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | RNA, Small Interfering - metabolism | Index Medicus
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6. Full Text Immobilization of lipases on hydrophobic supports involves the open form of the enzyme
by Manoel, Evelin A and dos Santos, José C.S and Freire, Denise M.G and Rueda, Nazzoly and Fernandez-Lafuente, Roberto
Enzyme and microbial technology, ISSN 0141-0229, 04/2015, Volume 71, pp. 53 - 57
Octyl-agarose | Interfacial activation | Detergents | Ionic strength | Irreversible inhibition | Lipase immobilization | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Fungal Proteins - chemistry | Bacterial Proteins - antagonists & inhibitors | Enzymes, Immobilized - chemistry | Enzymes, Immobilized - metabolism | Sepharose - analogs & derivatives | Bacterial Proteins - chemistry | Ascomycota - enzymology | Fungal Proteins - antagonists & inhibitors | Lipase - metabolism | Lipase - chemistry | Osmolar Concentration | Lipase - antagonists & inhibitors | Hydrophobic and Hydrophilic Interactions | Bacterial Proteins - metabolism | Burkholderia cepacia - enzymology | Enzymes, Immobilized - antagonists & inhibitors | Protein Conformation | Kinetics | Cyanogen Bromide | Fungal Proteins - metabolism | Lipase | Catalysis | Index Medicus
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7. Full Text Increased body weight and fat mass after subchronic GIP receptor antagonist, but not GLP-2 receptor antagonist, administration in rats
by Baldassano, Sara and Gasbjerg, Lærke Smidt and Kizilkaya, Hüsün Sheyma and Rosenkilde, Mette Marie and Holst, Jens Juul and Hartmann, Bolette
Frontiers in endocrinology (Lausanne), ISSN 1664-2392, 2019, Volume 10, pp. 492 - 492
GIP receptor antagonist | GIP receptor | Glucagon-like peptide-2 (GLP-2) | Lipid homeostasis | Glucose-dependent insulinotropic polypeptide (GIP) | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Physiological aspects | Body weight | Lipoprotein lipase | lipid homeostasis | glucagon-like peptide-2 (GLP-2) | glucose-dependent insulinotropic polypeptide (GIP)
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