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British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 808 - 819
Background and purpose JZL184 is a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme that preferentially catabolizes the endocannabinoid... 
monoacylglycerol lipase | endocannabinoid | | frontal cortex | NF‐κB | cytokines | brain | plasma | JZL | 184 | TNF | 10 | IL-1β | IL-10 | IL-6 | JZL184 | NF-κB | TNF-α | 2-AG | CELLS | IL-1 | 2-ARACHIDONYL GLYCEROL | NF-B | RECEPTOR | NECROSIS-FACTOR-ALPHA | ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL | COX-2 EXPRESSION | IN-VIVO | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | CANNABINOIDS | Benzodioxoles - antagonists & inhibitors | Spleen - immunology | Frontal Lobe - metabolism | Male | Spleen - drug effects | Prostaglandins - blood | Lipopolysaccharides | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Glycerides - blood | Arachidonic Acids - blood | Enzyme Inhibitors - chemistry | Anti-Anxiety Agents - therapeutic use | Benzodioxoles - therapeutic use | Peritonitis - metabolism | Rats | Encephalitis - immunology | Random Allocation | Glycerides - metabolism | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Cannabinoid Receptor Antagonists - therapeutic use | Monoacylglycerol Lipases - blood | Peritonitis - drug therapy | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Endocannabinoids - metabolism | Nerve Tissue Proteins - blood | Monoacylglycerol Lipases - antagonists & inhibitors | Piperidines - antagonists & inhibitors | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Encephalitis - drug therapy | Encephalitis - metabolism | Cytokines - blood | Nerve Tissue Proteins - antagonists & inhibitors | Cytokines - metabolism | Peritonitis - immunology | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Spleen - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Piperidines - therapeutic use | Frontal Lobe - drug effects | Cannabinoid Receptor Antagonists - chemistry | Frontal Lobe - immunology | Cytokines - antagonists & inhibitors | Endocannabinoids - blood | Prostaglandins - metabolism | Glycerin | Brain | Unsaturated fatty acids | Cytokines | Glycerol | Lipase | Mitogens | Plasma | Rodents | Cannabinoids 2012, Part Two | Themed Section
Journal Article
Peptides, ISSN 0196-9781, 02/2018, Volume 100, pp. 173 - 181
Journal Article
Lipids in Health and Disease, ISSN 1476-511X, 09/2017, Volume 16, Issue 1, pp. 181 - 10
Background: Increased consumption of omega-3 (omega-3) fatty acids found in cold-water fish and fish oil has been reported to protect against obesity. A... 
Obesity | Adipocyte differentiation | Stearidonic acid | 3T3-L1 | Omega-3 fatty acids | ECHIUM OIL | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-3 FATTY-ACIDS | NUTRITION & DIETETICS | DOCOSAHEXAENOIC ACID | INSULIN-RESISTANCE | ENRICHED SOYBEAN-OIL | GENE-EXPRESSION | LINSEED OIL | RED-BLOOD-CELL | EICOSAPENTAENOIC ACID | ALPHA-LINOLENIC ACID | Fatty Acid Synthase, Type I - genetics | Lipoprotein Lipase - antagonists & inhibitors | Fatty Acid-Binding Proteins - antagonists & inhibitors | Glucose Transporter Type 4 - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - antagonists & inhibitors | Adipocytes - cytology | Adipocytes - drug effects | Fatty Acid-Binding Proteins - metabolism | PPAR gamma - metabolism | Fatty Acids, Omega-3 - pharmacology | CCAAT-Enhancer-Binding Proteins - antagonists & inhibitors | CCAAT-Enhancer-Binding Proteins - genetics | Lipoprotein Lipase - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Glucose Transporter Type 4 - antagonists & inhibitors | Cell Survival - drug effects | Glucose Transporter Type 4 - genetics | Lipoprotein Lipase - genetics | CCAAT-Enhancer-Binding Protein-beta - genetics | Stearoyl-CoA Desaturase - antagonists & inhibitors | 3T3-L1 Cells | Fatty Acid Synthase, Type I - metabolism | Fatty Acid-Binding Proteins - genetics | Stearoyl-CoA Desaturase - genetics | CCAAT-Enhancer-Binding Protein-beta - metabolism | Fatty Acid Synthase, Type I - antagonists & inhibitors | Gene Expression Regulation - drug effects | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Animals | PPAR gamma - antagonists & inhibitors | Sterol Regulatory Element Binding Protein 1 - genetics | Cell Differentiation - drug effects | Adipocytes - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Lipid Metabolism - drug effects | Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors | Stearoyl-CoA Desaturase - metabolism | Mice | CCAAT-Enhancer-Binding Protein-beta - antagonists & inhibitors | Usage | Care and treatment | Analysis | Development and progression | Liquid chromatography | Glucose transporter | Vegetable oils | Soybeans | Transcription factors | Fish oils | Toxicity | Gene regulation | Preadipocytes | Mass spectroscopy | Stearoyl-CoA desaturase | Lipoprotein lipase | Adipocytes | Lipase | Desaturase | Gene expression | Fatty acids | Fatty-acid synthase | Polymerase chain reaction | Rodents | Down-regulation | Sterol regulatory element-binding protein
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 21931
It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1 beta... 
FREELY-MOVING RATS | HIPPOCAMPAL EXCITABILITY | TEMPORAL-LOBE EPILEPSY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | THERAPEUTIC TIME WINDOW | CONVULSIONS | MODEL | BLOCKADE | CANNABINOIDS | PLASTICITY | RNA, Small Interfering - genetics | Lipoprotein Lipase - antagonists & inhibitors | Seizures - genetics | Humans | Interleukin 1 Receptor Antagonist Protein - genetics | Seizures - metabolism | Interleukin-1beta - genetics | Seizures, Febrile - pathology | Seizures - physiopathology | Seizures, Febrile - physiopathology | Seizures - pathology | Aging - genetics | Piperidines - pharmacology | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Seizures, Febrile - genetics | Cannabinoid Receptor Antagonists - pharmacology | Lipoprotein Lipase - metabolism | Interleukin-1beta - antagonists & inhibitors | Pyrazoles - pharmacology | Seizures, Febrile - metabolism | Signal Transduction | Lipoprotein Lipase - genetics | Tissue Culture Techniques | Gene Expression Regulation | Morpholines - pharmacology | Hippocampus - pathology | Cyclohexanones - pharmacology | Rats, Sprague-Dawley | Mice, Knockout | Naphthalenes - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Interleukin 1 Receptor Antagonist Protein - antagonists & inhibitors | Benzoxazines - pharmacology | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | RNA, Small Interfering - metabolism
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 784 - 793
Background and Purpose The development of potent and selective inhibitors of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) via DAG... 
inhibitor | anti‐obesity effects | cannabinoid | serine lipase | diacylglycerol | 2‐arachidonoylglycerol | anti-obesity effects | 2-arachidonoylglycerol | SYSTEM | HIGH-FAT DIET | HYDROLYSIS | OBESITY | PHARMACOLOGY & PHARMACY | ANTAGONISTS | RECEPTORS | PREFERENCE | Lipoprotein Lipase - antagonists & inhibitors | Obesity - drug therapy | Humans | Sterol Esterase - metabolism | Male | Anti-Obesity Agents - therapeutic use | Arachidonic Acids - metabolism | Liver - drug effects | Behavior, Animal - drug effects | Neurons - metabolism | Hypothalamus - drug effects | Lipoprotein Lipase - metabolism | Anti-Obesity Agents - administration & dosage | Organophosphonates - therapeutic use | Oleic Acids - therapeutic use | Liver - metabolism | Enzyme Inhibitors - pharmacology | Glycerophospholipids - therapeutic use | Rats | Recombinant Proteins - chemistry | Energy Intake - drug effects | Glycerides - metabolism | Enzyme Inhibitors - therapeutic use | Arachidonic Acids - antagonists & inhibitors | Hypothalamus - metabolism | Neurons - enzymology | Hypothalamus - enzymology | Sterol Esterase - antagonists & inhibitors | Mice | Anti-Obesity Agents - pharmacology | Endocannabinoids - antagonists & inhibitors | Endocannabinoids - metabolism | Liver - enzymology | Glycerophospholipids - pharmacology | Cercopithecus aethiops | Glycerophospholipids - administration & dosage | Dose-Response Relationship, Drug | Oleic Acids - pharmacology | Neurons - drug effects | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Lipoprotein Lipase - genetics | Mice, Inbred C57BL | Nerve Tissue Proteins - genetics | Obesity - metabolism | Nerve Tissue Proteins - metabolism | Organophosphonates - administration & dosage | Organophosphonates - pharmacology | Animals | Oleic Acids - administration & dosage | Glycerides - antagonists & inhibitors | Obesity - enzymology | Physiological aspects | Obesity | Amino acids | Chemical properties | Lipase | Fatty acids | Medical research | Biosynthesis | Rodents | Cannabinoids 2012, Part Two | Themed Section
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 12/2018, Volume 10, Issue 472, p. eaat3392
Glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) has been identified in multiple genome-wide association studies (GWAS) as a contributor to... 
GLUCAGON-SECRETION | MEDICINE, RESEARCH & EXPERIMENTAL | BODY-WEIGHT | OBESITY | GLUCOSE | RECEPTOR | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | LIPOPROTEIN-LIPASE | EXPRESSION | ADIPOSE-TISSUE | CELL BIOLOGY
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 08/2011, Volume 25, Issue 8, pp. 2711 - 2721
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions for which new therapeutic approaches are needed. Genetic and pharmacological data point... 
Fatty acid amide hydrolase | Lipopolysaccharide | Monoacylglycerol lipase | Endocannabinoid | Anandamide | monoacylglycerol lipase | endocannabinoid | CANNABINOID RECEPTOR 2 | CROHNS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ULCERATIVE-COLITIS | ENDOCANNABINOID SYSTEM | BOWEL-DISEASE | CELL BIOLOGY | fatty acid amide hydrolase | ACID AMIDE HYDROLASE | ALPHA PRODUCTION | BIOLOGY | ANTAGONIST RIMONABANT | lipopolysaccharide | anandamide | INTESTINAL PERMEABILITY | Inflammation - pathology | Endotoxemia - prevention & control | Monoacylglycerol Lipases - antagonists & inhibitors | Humans | Colitis - pathology | Male | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Arachidonic Acids - metabolism | Inflammation - metabolism | Piperidines - pharmacology | Colitis - chemically induced | Indoles - pharmacology | Endocannabinoids | Disease Models, Animal | Pyrazoles - pharmacology | Inflammatory Bowel Diseases - drug therapy | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Inflammation Mediators - blood | Glycerides - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Colitis - metabolism | Inflammation - prevention & control | Mice | Trinitrobenzenesulfonic Acid - toxicity | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Colitis - prevention & control | Benzodioxoles - pharmacology
Journal Article
Journal Article