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1. Full Text The monoacylglycerol lipase inhibitor JZL184 attenuates LPS‐induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action
by Kerr, DM and Harhen, B and Okine, BN and Egan, LJ and Finn, DP and Roche, M
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 808 - 819
Background and purpose JZL184 is a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme that preferentially catabolizes the endocannabinoid... 
monoacylglycerol lipase | endocannabinoid | 1β | frontal cortex | NF‐κB | cytokines | brain | plasma | JZL | 184 | TNF | 10 | IL-1β | IL-10 | IL-6 | JZL184 | NF-κB | TNF-α | 2-AG | CELLS | IL-1 | 2-ARACHIDONYL GLYCEROL | NF-B | RECEPTOR | NECROSIS-FACTOR-ALPHA | ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL | COX-2 EXPRESSION | IN-VIVO | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | CANNABINOIDS | Benzodioxoles - antagonists & inhibitors | Spleen - immunology | Frontal Lobe - metabolism | Male | Spleen - drug effects | Prostaglandins - blood | Lipopolysaccharides | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Glycerides - blood | Arachidonic Acids - blood | Enzyme Inhibitors - chemistry | Anti-Anxiety Agents - therapeutic use | Benzodioxoles - therapeutic use | Peritonitis - metabolism | Rats | Encephalitis - immunology | Random Allocation | Glycerides - metabolism | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Cannabinoid Receptor Antagonists - therapeutic use | Monoacylglycerol Lipases - blood | Peritonitis - drug therapy | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Endocannabinoids - metabolism | Nerve Tissue Proteins - blood | Monoacylglycerol Lipases - antagonists & inhibitors | Piperidines - antagonists & inhibitors | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Encephalitis - drug therapy | Encephalitis - metabolism | Cytokines - blood | Nerve Tissue Proteins - antagonists & inhibitors | Cytokines - metabolism | Peritonitis - immunology | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Spleen - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Piperidines - therapeutic use | Frontal Lobe - drug effects | Cannabinoid Receptor Antagonists - chemistry | Frontal Lobe - immunology | Cytokines - antagonists & inhibitors | Endocannabinoids - blood | Prostaglandins - metabolism | Glycerin | Brain | Unsaturated fatty acids | Cytokines | Glycerol | Lipase | Mitogens | Plasma | Rodents | Cannabinoids 2012, Part Two | Themed Section
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2. Full Text Mechanochemical enzymatic synthesis of 1,4‐dihydropyridine calcium antagonists and derivatives
by Jiang, Ling and Ye, Li‐dan and Gu, Jia‐li and Su, Wei‐ke and Ye, Wen‐ting
Journal of Chemical Technology & Biotechnology, ISSN 0268-2575, 08/2019, Volume 94, Issue 8, pp. 2555 - 2560
BACKGROUND Enzyme promiscuity has attracted significant attention from chemists and biochemists in recent years. However, long reaction time and use of toxic... 
1,4‐dihydropyridine calcium antagonists | multicomponent reactions | ball milling | Lipozyme® RM IM | enzymatic promiscuity | CATALYTIC PROMISCUITY | METHYLENE-COMPOUNDS | RESOLUTION | BAYLIS-HILLMAN REACTION | KNOEVENAGEL CONDENSATION | CHEMISTRY, MULTIDISCIPLINARY | ENGINEERING, CHEMICAL | ENGINEERING, ENVIRONMENTAL | Lipozyme (R) RM IM | WARFARIN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LIPASE | 4-dihydropyridine calcium antagonists | BIOH | Hypertension | Chemical industry | Herbicides | Pesticides industry | Enzymes | Usage | Triglycerides | Production processes | Chemicals | Nifedipine | Felodipine | Promiscuity
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3. Full Text Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents
by Gasbjerg, LĂŚrke Smidt and Gabe, Maria Buur Nordskov and Hartmann, Bolette and Christensen, Mikkel Bring and Knop, Filip Krag and Holst, Jens Juul and Rosenkilde, Mette Marie
Peptides, ISSN 0196-9781, 02/2018, Volume 100, pp. 173 - 181
Glucose-dependent insulinotropic polypeptide (GIP) is an intestinal hormone with a broad range of physiological actions. In the postprandial state, the hormone... 
GIP receptor antagonist | GIP receptor | Obesity therapy | Glucose-dependent insulinotropic polypeptide (GIP) | Type 2 diabetes therapy | BIOCHEMISTRY & MOLECULAR BIOLOGY | 1ST-DEGREE RELATIVES | COMPETITIVE ANTAGONIST | GLUCAGON-LIKE PEPTIDE-1 | BIOLOGICAL-ACTIVITY | ENDOCRINOLOGY & METABOLISM | SYNTHETIC FRAGMENT PEPTIDES | PHARMACOLOGY & PHARMACY | ORAL GLUCOSE | GASTRIC-INHIBITORY POLYPEPTIDE | GLP-1 RECEPTOR | CRYO-EM STRUCTURE | ADIPOSE-TISSUE | Hypoglycemic Agents - therapeutic use | Gastric Inhibitory Polypeptide - metabolism | Humans | Hypoglycemic Agents - chemistry | Diabetes Mellitus, Type 2 - metabolism | Receptors, Gastrointestinal Hormone - therapeutic use | Receptors, Gastrointestinal Hormone - antagonists & inhibitors | Blood Glucose - drug effects | Adipose Tissue - metabolism | Insulin - metabolism | Receptors, Gastrointestinal Hormone - genetics | Glucose - metabolism | Glucagon - metabolism | Diabetes Mellitus, Type 2 - pathology | Diabetes Mellitus, Type 2 - drug therapy | Adipose Tissue - drug effects | Weight reducing preparations | Type 2 diabetes | Medical research | Peptides | Physiological aspects | Medicine, Experimental | Lipoprotein lipase | Hypoglycemic agents | Glucose | Glucose tolerance tests | Dextrose | Membrane proteins
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4. Full Text Suppression of adipocyte differentiation and lipid accumulation by stearidonic acid (SDA) in 3T3-L1 cells
by Li, Yueru and Rong, Yinghui and Bao, Lisui and Nie, Ben and Ren, Guang and Zheng, Chen and Amin, Rajesh and Arnold, Robert D and Jeganathan, Ramesh B and Huggins, Kevin W
Lipids in Health and Disease, ISSN 1476-511X, 09/2017, Volume 16, Issue 1, pp. 181 - 10
Background: Increased consumption of omega-3 (omega-3) fatty acids found in cold-water fish and fish oil has been reported to protect against obesity. A... 
Obesity | Adipocyte differentiation | Stearidonic acid | 3T3-L1 | Omega-3 fatty acids | ECHIUM OIL | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-3 FATTY-ACIDS | NUTRITION & DIETETICS | DOCOSAHEXAENOIC ACID | INSULIN-RESISTANCE | ENRICHED SOYBEAN-OIL | GENE-EXPRESSION | LINSEED OIL | RED-BLOOD-CELL | EICOSAPENTAENOIC ACID | ALPHA-LINOLENIC ACID | Fatty Acid Synthase, Type I - genetics | Lipoprotein Lipase - antagonists & inhibitors | Fatty Acid-Binding Proteins - antagonists & inhibitors | Glucose Transporter Type 4 - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - antagonists & inhibitors | Adipocytes - cytology | Adipocytes - drug effects | Fatty Acid-Binding Proteins - metabolism | PPAR gamma - metabolism | Fatty Acids, Omega-3 - pharmacology | CCAAT-Enhancer-Binding Proteins - antagonists & inhibitors | CCAAT-Enhancer-Binding Proteins - genetics | Lipoprotein Lipase - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Glucose Transporter Type 4 - antagonists & inhibitors | Cell Survival - drug effects | Glucose Transporter Type 4 - genetics | Lipoprotein Lipase - genetics | CCAAT-Enhancer-Binding Protein-beta - genetics | Stearoyl-CoA Desaturase - antagonists & inhibitors | 3T3-L1 Cells | Fatty Acid Synthase, Type I - metabolism | Fatty Acid-Binding Proteins - genetics | Stearoyl-CoA Desaturase - genetics | CCAAT-Enhancer-Binding Protein-beta - metabolism | Fatty Acid Synthase, Type I - antagonists & inhibitors | Gene Expression Regulation - drug effects | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Animals | PPAR gamma - antagonists & inhibitors | Sterol Regulatory Element Binding Protein 1 - genetics | Cell Differentiation - drug effects | Adipocytes - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Lipid Metabolism - drug effects | Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors | Stearoyl-CoA Desaturase - metabolism | Mice | CCAAT-Enhancer-Binding Protein-beta - antagonists & inhibitors | Usage | Care and treatment | Analysis | Development and progression | Liquid chromatography | Glucose transporter | Vegetable oils | Soybeans | Transcription factors | Fish oils | Toxicity | Gene regulation | Preadipocytes | Mass spectroscopy | Stearoyl-CoA desaturase | Lipoprotein lipase | Adipocytes | Lipase | Desaturase | Gene expression | Fatty acids | Fatty-acid synthase | Polymerase chain reaction | Rodents | Down-regulation | Sterol regulatory element-binding protein
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5. Full Text Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling
by Feng, Bo and Tang, Yangshun and Chen, Bin and Xu, Cenglin and Wang, Yi and Dai, Yunjian and Wu, Dengchang and Zhu, Junmin and Wang, Shuang and Zhou, Yudong and Shi, Liyun and Hu, Weiwei and Zhang, Xia and Chen, Zhong
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 21931
It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1 beta... 
FREELY-MOVING RATS | HIPPOCAMPAL EXCITABILITY | TEMPORAL-LOBE EPILEPSY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | THERAPEUTIC TIME WINDOW | CONVULSIONS | MODEL | BLOCKADE | CANNABINOIDS | PLASTICITY | RNA, Small Interfering - genetics | Lipoprotein Lipase - antagonists & inhibitors | Seizures - genetics | Humans | Interleukin 1 Receptor Antagonist Protein - genetics | Seizures - metabolism | Interleukin-1beta - genetics | Seizures, Febrile - pathology | Seizures - physiopathology | Seizures, Febrile - physiopathology | Seizures - pathology | Aging - genetics | Piperidines - pharmacology | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Seizures, Febrile - genetics | Cannabinoid Receptor Antagonists - pharmacology | Lipoprotein Lipase - metabolism | Interleukin-1beta - antagonists & inhibitors | Pyrazoles - pharmacology | Seizures, Febrile - metabolism | Signal Transduction | Lipoprotein Lipase - genetics | Tissue Culture Techniques | Gene Expression Regulation | Morpholines - pharmacology | Hippocampus - pathology | Cyclohexanones - pharmacology | Rats, Sprague-Dawley | Mice, Knockout | Naphthalenes - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Interleukin 1 Receptor Antagonist Protein - antagonists & inhibitors | Benzoxazines - pharmacology | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | RNA, Small Interfering - metabolism
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6. Full Text A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2‐arachidonoylglycerol with potential anti‐obesity effects
by Bisogno, Tiziana and Mahadevan, Anu and Coccurello, Roberto and Chang, Jae Won and AllarĂ , Marco and Chen, Yugang and Giacovazzo, Giacomo and Lichtman, Aron and Cravatt, Benjamin and Moles, Anna and Di Marzo, Vincenzo
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 784 - 793
Background and Purpose The development of potent and selective inhibitors of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) via DAG... 
inhibitor | anti‐obesity effects | cannabinoid | serine lipase | diacylglycerol | 2‐arachidonoylglycerol | anti-obesity effects | 2-arachidonoylglycerol | SYSTEM | HIGH-FAT DIET | HYDROLYSIS | OBESITY | PHARMACOLOGY & PHARMACY | ANTAGONISTS | RECEPTORS | PREFERENCE | Lipoprotein Lipase - antagonists & inhibitors | Obesity - drug therapy | Humans | Sterol Esterase - metabolism | Male | Anti-Obesity Agents - therapeutic use | Arachidonic Acids - metabolism | Liver - drug effects | Behavior, Animal - drug effects | Neurons - metabolism | Hypothalamus - drug effects | Lipoprotein Lipase - metabolism | Anti-Obesity Agents - administration & dosage | Organophosphonates - therapeutic use | Oleic Acids - therapeutic use | Liver - metabolism | Enzyme Inhibitors - pharmacology | Glycerophospholipids - therapeutic use | Rats | Recombinant Proteins - chemistry | Energy Intake - drug effects | Glycerides - metabolism | Enzyme Inhibitors - therapeutic use | Arachidonic Acids - antagonists & inhibitors | Hypothalamus - metabolism | Neurons - enzymology | Hypothalamus - enzymology | Sterol Esterase - antagonists & inhibitors | Mice | Anti-Obesity Agents - pharmacology | Endocannabinoids - antagonists & inhibitors | Endocannabinoids - metabolism | Liver - enzymology | Glycerophospholipids - pharmacology | Cercopithecus aethiops | Glycerophospholipids - administration & dosage | Dose-Response Relationship, Drug | Oleic Acids - pharmacology | Neurons - drug effects | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Lipoprotein Lipase - genetics | Mice, Inbred C57BL | Nerve Tissue Proteins - genetics | Obesity - metabolism | Nerve Tissue Proteins - metabolism | Organophosphonates - administration & dosage | Organophosphonates - pharmacology | Animals | Oleic Acids - administration & dosage | Glycerides - antagonists & inhibitors | Obesity - enzymology | Physiological aspects | Obesity | Amino acids | Chemical properties | Lipase | Fatty acids | Medical research | Biosynthesis | Rodents | Cannabinoids 2012, Part Two | Themed Section
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7. Full Text Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
by Killion, EA and Wang, JH and Yie, JM and Shi, SDH and Bates, D and Min, XS and Komorowski, R and Hager, T and Deng, LY and Atangan, L and Lu, SC and Kurzeja, RJM and Sivits, G and Lin, J and Chen, Q and Wang, ZL and Thibault, SA and Abbott, CM and Meng, T and Clavette, B and Murawsky, CM and Foltz, IN and Rottman, JB and Hale, C and Veniant, MM and Lloyd, DJ
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 12/2018, Volume 10, Issue 472, p. eaat3392
Glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) has been identified in multiple genome-wide association studies (GWAS) as a contributor to... 
GLUCAGON-SECRETION | MEDICINE, RESEARCH & EXPERIMENTAL | BODY-WEIGHT | OBESITY | GLUCOSE | RECEPTOR | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | LIPOPROTEIN-LIPASE | EXPRESSION | ADIPOSE-TISSUE | CELL BIOLOGY
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8. Full Text Adipose tissue is a major source of interleukin-1 receptor antagonist: Upregulation in obesity and inflammation
by Juge-Aubry, Cristiana E and Somm, Emmanuel and Giusti, Vittorio and Pernin, Agnès and Chicheportiche, Rachel and Verdumo, Chantal and Rohner-Jeanrenaud, Françoise and Burger, Danielle and Dayer, Jean-Michel and Meier, Christoph A
Diabetes, ISSN 0012-1797, 05/2003, Volume 52, Issue 5, pp. 1104 - 1110
The secreted form of the interleukin-1 receptor antagonist (IL-1Ra) is an acute-phase protein intervening in the counterregulation of inflammatory processes.... 
RHEUMATOID-ARTHRITIS | LEPTIN | CELLS | LIPOPROTEIN-LIPASE ACTIVITY | INSULIN-RESISTANCE | DISEASE | ENDOCRINOLOGY & METABOLISM | NECROSIS-FACTOR-ALPHA | IL-1-BETA | HUMAN MONOCYTES | EXPRESSION | Sialoglycoproteins - genetics | Obesity - immunology | Humans | Mice, Inbred C57BL | RNA, Messenger - genetics | Sialoglycoproteins - metabolism | Tumor Necrosis Factor-alpha - genetics | Adipose Tissue - physiopathology | Gene Expression Regulation | Reference Values | Inflammation - immunology | Obesity - genetics | Sialoglycoproteins - drug effects | Animals | Interferon-beta - pharmacology | Tumor Necrosis Factor-alpha - physiology | Inflammation - genetics | Interleukin 1 Receptor Antagonist Protein | Mice, Obese | Mice | Adipose Tissue - drug effects | Organ Culture Techniques | Measurement | Adipose tissues | Obesity | Interleukin-1 | Physiological aspects | Diabetes | Research
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9. Full Text Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation
by Alhouayek, Mireille and Lambert, Didier M and Delzenne, Nathalie M and Cani, Patrice D and Muccioli, Giulio G
FASEB Journal, ISSN 0892-6638, 08/2011, Volume 25, Issue 8, pp. 2711 - 2721
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions for which new therapeutic approaches are needed. Genetic and pharmacological data point... 
Fatty acid amide hydrolase | Lipopolysaccharide | Monoacylglycerol lipase | Endocannabinoid | Anandamide | monoacylglycerol lipase | endocannabinoid | CANNABINOID RECEPTOR 2 | CROHNS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ULCERATIVE-COLITIS | ENDOCANNABINOID SYSTEM | BOWEL-DISEASE | CELL BIOLOGY | fatty acid amide hydrolase | ACID AMIDE HYDROLASE | ALPHA PRODUCTION | BIOLOGY | ANTAGONIST RIMONABANT | lipopolysaccharide | anandamide | INTESTINAL PERMEABILITY | Inflammation - pathology | Endotoxemia - prevention & control | Monoacylglycerol Lipases - antagonists & inhibitors | Humans | Colitis - pathology | Male | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Arachidonic Acids - metabolism | Inflammation - metabolism | Piperidines - pharmacology | Colitis - chemically induced | Indoles - pharmacology | Endocannabinoids | Disease Models, Animal | Pyrazoles - pharmacology | Inflammatory Bowel Diseases - drug therapy | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Inflammation Mediators - blood | Glycerides - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Colitis - metabolism | Inflammation - prevention & control | Mice | Trinitrobenzenesulfonic Acid - toxicity | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Colitis - prevention & control | Benzodioxoles - pharmacology
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10. Full Text Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats
by Baidassano, S and Gasbjerg, LS and Kizilkaya, HS and Rosenkilde, MM and Holst, JJ and Hartmann, B
FRONTIERS IN ENDOCRINOLOGY, ISSN 1664-2392, 08/2019, Volume 10, p. 492
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are hormones secreted from the enteroendocrine cells after a meal. They... 
GIP receptor | LIPID ABSORPTION | lipid homeostasis | LIPOPROTEIN-LIPASE | glucose-dependent insulinotropic polypeptide (GIP) | BONE-RESORPTION | glucagon-like peptide-2 (GLP-2) | GLUCOSE-HOMEOSTASIS | COMPETITIVE ANTAGONIST | GLUCAGON-LIKE PEPTIDE-2 | DENSITY-LIPOPROTEIN | ENDOCRINOLOGY & METABOLISM | GIP receptor antagonist | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | ADIPOSE-TISSUE | Physiological aspects | Body weight | Lipoprotein lipase
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11. Full Text Immobilization of lipases on hydrophobic supports involves the open form of the enzyme
by Manoel, Evelin A and dos Santos, JosĂŠ C.S and Freire, Denise M.G and Rueda, Nazzoly and Fernandez-Lafuente, Roberto
Enzyme and Microbial Technology, ISSN 0141-0229, 04/2015, Volume 71, pp. 53 - 57
The lipases from and have been immobilized on octyl and cyanogen bromide (CNBr) agarose beads. The immobilization on octyl-agarose is slowed with increasing... 
Octyl-agarose | Interfacial activation | Detergents | Ionic strength | Irreversible inhibition | Lipase immobilization | BIOTECHNOLOGY | CELLS | COMPLEX | CRYSTAL-STRUCTURE | PERFORMANCE | MICROBIAL LIPASES | CATALYTIC-PROPERTIES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PURIFICATION | Fungal Proteins - chemistry | Bacterial Proteins - antagonists & inhibitors | Enzymes, Immobilized - chemistry | Enzymes, Immobilized - metabolism | Sepharose - analogs & derivatives | Bacterial Proteins - chemistry | Ascomycota - enzymology | Fungal Proteins - antagonists & inhibitors | Lipase - metabolism | Lipase - chemistry | Osmolar Concentration | Lipase - antagonists & inhibitors | Hydrophobic and Hydrophilic Interactions | Bacterial Proteins - metabolism | Burkholderia cepacia - enzymology | Enzymes, Immobilized - antagonists & inhibitors | Protein Conformation | Kinetics | Cyanogen Bromide | Fungal Proteins - metabolism | Lipase | Catalysis
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12. Full Text New lipid‐lowering drugs: an update
by Wierzbicki, A. S and Hardman, T. C and Viljoen, A
International Journal of Clinical Practice, ISSN 1368-5031, 03/2012, Volume 66, Issue 3, pp. 270 - 280
Lipid lowering is established as a proven intervention to reduce atherosclerosis and its complications. Statins form the basis of care but are not able to... 
TRIGLYCERIDE TRANSFER PROTEIN | STATIN-TREATED PATIENTS | LDL CHOLESTEROL | MEDICINE, GENERAL & INTERNAL | DENSITY-LIPOPROTEIN CHOLESTEROL | CARDIOVASCULAR EVENTS | DOUBLE-BLIND | PHOSPHOLIPASE A | HDL CHOLESTEROL | CORONARY-HEART-DISEASE | APOLIPOPROTEIN-A-I | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Proprotein Convertases - antagonists & inhibitors | Peroxisome Proliferator-Activated Receptors - antagonists & inhibitors | Cholesterol, HDL - drug effects | Humans | Hyperlipidemias - drug therapy | Carrier Proteins - antagonists & inhibitors | Acetyl-CoA C-Acetyltransferase - antagonists & inhibitors | Lipotropic Agents - therapeutic use | Triglycerides - antagonists & inhibitors | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | Oligonucleotides, Antisense - therapeutic use | Hypolipidemic Agents - therapeutic use | Drug Combinations | Genetic Therapy - methods | Peptides | Low density lipoproteins | Atherosclerosis | Clinical trials | Triglycerides | Lipoprotein lipase | Phospholipases | Health aspects | Statins | Cholesterol | Cardiovascular agents
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