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Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 38, pp. 25593 - 25601
.... The occupied glucocorticoid receptor (GR) is a transcription factor. However, those genes regulating lipid metabolism under GR control are not fully known... 
OBESITY | PLASMA | GENE | CHROMATIN | ANGIOGENESIS | DIET | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPERLIPIDEMIA | MICE | TRANSCRIPTIONAL REGULATION | PROTEIN-4 | Transcription, Genetic - drug effects | Hypertriglyceridemia - genetics | Humans | Dexamethasone - adverse effects | Receptors, Glucocorticoid - metabolism | Hepatocytes - metabolism | Fatty Liver - chemically induced | Adipose Tissue - metabolism | Angiopoietin-like 4 Protein | Dexamethasone - pharmacology | Glucocorticoids - genetics | Glucocorticoids - metabolism | Response Elements - genetics | Lipoprotein Lipase - metabolism | Glucocorticoids - adverse effects | Fatty Liver - genetics | Angiopoietins - metabolism | Fatty Liver - metabolism | Lipoprotein Lipase - genetics | Liver - metabolism | Rats | Hypertriglyceridemia - metabolism | Mice, Knockout | Triglycerides - metabolism | Adipose Tissue, White | Hypertriglyceridemia - chemically induced | Animals | Receptors, Glucocorticoid - genetics | Cell Line, Tumor | Dexamethasone - metabolism | Glucocorticoids - pharmacology | Mice | Transcription, Genetic - genetics | Triglycerides - genetics | Angiopoietins - genetics | Index Medicus | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling | Transcription | Dermatologi och venereologi | Dermatology and Venereal Diseases | Dexamethasone/adverse effects/metabolism/pharmacology | Hypertriglyceridemia/chemically induced/genetics/metabolism | Receptors | Adipose Tissue/metabolism | Liver/metabolism | Tumor | Adipose Tissue | Cell Line | Fatty Liver/chemically induced/genetics/metabolism | Triglycerides/genetics/ metabolism | Response Elements/genetics | Angiopoietins/genetics/ metabolism | Knockout | Lipoprotein Lipase/genetics/metabolism | White | Hepatocytes/metabolism | Genetic/drug effects/genetics | Glucocorticoids/adverse effects/genetics/ metabolism/pharmacology | Glucocorticoid/genetics/ metabolism
Journal Article
Biochimica et biophysica acta. Molecular and cell biology of lipids, ISSN 1388-1981, 06/2016, Volume 1861, Issue 6, pp. 491 - 500
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2011, Volume 334, Issue 6057, pp. 809 - 813
Phospholipase A₂ (PLA₂) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here,... 
Datasets | Brain | Enzymes | Prostaglandins | Cytokines | Neurodegenerative diseases | REPORTS | Eicosanoids | Lipids | Endocannabinoids | Vehicles | SYSTEM | INHIBITION | CYCLOOXYGENASE-2 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | INJURY | LIPOPOLYSACCHARIDE | PHOSPHOLIPASE A | MICE | PARKINSONS-DISEASE | Cannabinoid Receptor Modulators - metabolism | Inflammation - pathology | Metabolomics | Arachidonic Acid - metabolism | Monoacylglycerol Lipases - antagonists & inhibitors | Monoacylglycerol Lipases - genetics | Brain - metabolism | Parkinsonian Disorders - metabolism | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Inflammation Mediators - pharmacology | Lung - metabolism | Cytokines - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Phospholipases A2 - metabolism | Prostaglandins - biosynthesis | Glycerides - metabolism | Brain - drug effects | Hydrolysis | Animals | Parkinsonian Disorders - pathology | Eicosanoids - metabolism | Lipopolysaccharides - pharmacology | Brain - pathology | Mice | Cyclooxygenase 1 - metabolism | Benzodioxoles - pharmacology | Phospholipases A2 - genetics | Prostaglandins - metabolism | Physiological aspects | Inflammation | Research | Risk factors | Hydrology | Neurology | Inflammatory diseases
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 7, p. e0200847
.... They remain viable and functional for 4 weeks expressing typical markers of liver function such as synthesis of albumin, urea, and alpha-1 p450 drug metabolism... 
OVEREXPRESSION | HOMEOSTASIS | LIPID-METABOLISM | MULTIDISCIPLINARY SCIENCES | DISEASE | SENSITIVITY | SYSTEMS | LIPOPROTEIN-LIPASE | Glucose Transporter Type 4 - metabolism | Signal Transduction | Humans | Liver - metabolism | Organoids - cytology | MicroRNAs - metabolism | Necrosis - metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Hepatocytes - metabolism | Insulin Receptor Substrate Proteins - metabolism | Inflammation - metabolism | Insulin - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 8 - metabolism | Organoids - metabolism | Chemokine CCL3 - metabolism | Chemokine CCL2 - metabolism | Kupffer Cells - metabolism | Liver - cytology | Interleukin-6 - metabolism | Care and treatment | MicroRNA | Liver diseases | Development and progression | Insulin resistance | Inflammation | Research | Laboratories | Liver | Kupffer cells | Fluorescence | Lipids | Interleukin 6 | Liver cancer | Fatty liver | Organoids | Rodents | Gastroenterology | Drug metabolism | Lipoprotein (low density) receptors | Inhibition | Lipid metabolism | Stellate cells | Cytokines | Incubation | Internal medicine | CCL3 protein | Regression analysis | Gene expression | Metabolism | Ribonucleic acid--RNA | Insulin | Patients | Fatty acids | Endothelial cells | Gelatinase B | Steatosis | Medicine | Urea | Signaling | Hepatocytes | Tumor necrosis factor | Pharmacy | Fibrosis | Neutrophil collagenase | Diabetes | Chemokines | Monocyte chemoattractant protein 1 | Metabolic disorders | RNA | Ribonucleic acid
Journal Article
Circulation research, ISSN 1524-4571, 2018, Volume 122, Issue 10, pp. 1369 - 1384
RATIONALE:Macrophages face a substantial amount of cholesterol following the ingestion of apoptotic cells and the lysosomal acid lipase (LIPA) has a major role... 
CLEARANCE | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | oxysterols | STORAGE DISEASE | mitochondria | MACROPHAGE FOAM CELLS | macrophage | NLRP3 INFLAMMASOME | AUTOPHAGY | inflammation | APOPTOTIC CELLS | CALCIUM | cholesterol | PERIPHERAL VASCULAR DISEASE | ACID LIPASE | HEMATOLOGY | CORONARY-ARTERY-DISEASE | Cholesterol Esters - metabolism | Inflammasomes - metabolism | Sterol Esterase - metabolism | Inflammation - metabolism | Lysosomes - metabolism | Biological Transport | Oxysterols - metabolism | Lymphocytes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Receptors, LDL - metabolism | Neuropeptides - metabolism | Liver X Receptors - metabolism | Mitochondria - metabolism | Splenomegaly - metabolism | Cholesterol - metabolism | Hydrolysis | Macrophages - metabolism | Animals | Erythrocytes - metabolism | Sterol Esterase - antagonists & inhibitors | Mice | Hypercholesterolemia - metabolism | rac1 GTP-Binding Protein - metabolism | Apoptosis | Usage | Lysosomes | Research | Macrophages | Health aspects | Cholesterol | Spleen | Splenomegaly | Oxidative stress | Liver diseases | Liver X receptors | Erythrocytes | Caspase | Esters | Rac1 protein | Inflammation | Botulinum toxin | Caspase-1 | Mitochondria | Pyrin protein | Hypercholesterolemia | Lymphocytes | LipA protein
Journal Article
Journal of cell science, ISSN 1477-9137, 2009, Volume 122, Issue 11, pp. 1834 - 1841
Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane... 
Lipid homeostasis | ATGL | Lipid droplet | ADIPOSE TRIGLYCERIDE LIPASE | CELLS | GOLGI | CELL BIOLOGY | FAT STORAGE | LIPOLYSIS | LIPODYSTROPHY | ENDOPLASMIC-RETICULUM | BREFELDIN-A | DIFFERENTIATION-RELATED PROTEIN | RNA, Small Interfering - genetics | Fluorescence Recovery After Photobleaching | Humans | Adaptor Proteins, Vesicular Transport - genetics | Endoplasmic Reticulum - metabolism | Lipids | Protein Transport - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Pregnancy Proteins - metabolism | Coat Protein Complex I - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Recombinant Fusion Proteins - metabolism | Endoplasmic Reticulum - ultrastructure | DNA-Binding Proteins - metabolism | Organelles - ultrastructure | Guanine Nucleotide Exchange Factors - metabolism | ADP-Ribosylation Factor 1 - metabolism | Membrane Proteins - metabolism | ADP-Ribosylation Factor 1 - genetics | Golgi Apparatus - ultrastructure | Vesicular Transport Proteins | Guanine Nucleotide Exchange Factors - genetics | Lipase - metabolism | Protein Synthesis Inhibitors - metabolism | Brefeldin A - metabolism | Coatomer Protein - metabolism | Recombinant Fusion Proteins - genetics | Golgi Apparatus - metabolism | HeLa Cells | Organelles - metabolism | Perilipin-3 | Perilipin-2 | Lipase - genetics | RNA, Small Interfering - metabolism
Journal Article
Cell metabolism, ISSN 1550-4131, 2012, Volume 15, Issue 5, pp. 691 - 702
.... Despite its high clinical relevance, the molecular function of ADPN and the mechanism by which I148M variant affects hepatic metabolism are unclear... 
ADIPOSE TRIGLYCERIDE LIPASE | COMPARATIVE GENE IDENTIFICATION-58 | LIPID-METABOLISM | MESSENGER-RNA EXPRESSION | FATTY LIVER-DISEASE | FAMILY-MEMBERS | ENZYMES | ENDOCRINOLOGY & METABOLISM | PNPLA3 | CONGENITAL GENERALIZED LIPODYSTROPHY | CHANARIN-DORFMAN-SYNDROME | CELL BIOLOGY | 1-Acylglycerol-3-Phosphate O-Acyltransferase - genetics | Lysophospholipids - metabolism | Up-Regulation | Lipids - genetics | Humans | Cercopithecus aethiops | Acyl Coenzyme A - genetics | Male | Lipids - biosynthesis | Acyltransferases - metabolism | Acyltransferases - genetics | 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism | Cysteine Endopeptidases - metabolism | Liver - drug effects | Lipid Metabolism - genetics | Membrane Proteins - metabolism | Dietary Sucrose - metabolism | Phospholipids - metabolism | Acyl Coenzyme A - metabolism | CHO Cells | Fatty Liver - genetics | Phosphatidic Acids - genetics | Cricetinae | Fatty Liver - metabolism | Membrane Proteins - genetics | Liver - metabolism | Models, Molecular | Phospholipids - genetics | Hep G2 Cells | Mice, Knockout | Polymorphism, Genetic | Triglycerides - metabolism | Lysophospholipids - genetics | Animals | Cysteine Endopeptidases - genetics | Mice | Phosphatidic Acids - metabolism | Triglycerides - genetics | COS Cells | Physiological aspects | Medical colleges | Disease susceptibility | Liver diseases | Liver cirrhosis
Journal Article
Diabetes (New York, N.Y.), ISSN 1939-327X, 2016, Volume 65, Issue 3, pp. 610 - 618
The innate immune cell sensor leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome controls the activation of caspase-1, and the... 
ACTIVATION | ADIPOCYTES | METABOLISM | ADIPONECTIN | CERAMIDE CONTENT | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | NLRP3 INFLAMMASOME | HEPATIC STEATOSIS | EXPRESSION | INDUCED INSULIN-RESISTANCE | Fatty Acid Synthase, Type I - genetics | Sirtuin 1 - metabolism | Glucose Transporter Type 4 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Obesity - immunology | Humans | Leptin - metabolism | Caspase 1 - metabolism | Male | Gene Expression Profiling | Interleukin-1beta - genetics | PPAR gamma - metabolism | Sirtuin 1 - genetics | Acetyl-CoA Carboxylase - genetics | Subcutaneous Fat - immunology | Subcutaneous Fat - metabolism | Lipogenesis - genetics | Interleukin-1beta - metabolism | Adiponectin - genetics | Adiponectin - metabolism | Female | Adipogenesis - genetics | Child | Lipoprotein Lipase - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | Glucose Transporter Type 4 - genetics | Inflammasomes | Lipoprotein Lipase - genetics | Down-Regulation | Insulin Resistance | Toll-Like Receptor 4 - genetics | Intra-Abdominal Fat - metabolism | Fatty Acid Synthase, Type I - metabolism | Subcutaneous Fat - pathology | Toll-Like Receptor 4 - metabolism | Abdomen | Obesity - metabolism | Carrier Proteins - genetics | Magnetic Resonance Imaging | Sterol Regulatory Element Binding Protein 1 - genetics | Caspase 1 - genetics | Adolescent | Intra-Abdominal Fat - pathology | Acetyl-CoA Carboxylase - metabolism | Adipose tissues | Overweight persons | Care and treatment | Inflammation | Research | Health aspects | Metabolism
Journal Article
The Plant cell, ISSN 1532-298X, 2014, Volume 26, Issue 10, pp. 4119 - 4134
Triacylglycerol (TAG) metabolism is a key aspect of intracellular lipid homeostasis in yeast and mammals, but its role in vegetative tissues of plants remains poorly defined... 
DIACYLGLYCEROL ACYLTRANSFERASE | CONTACT SITES | SHORT-CHAIN | CHLOROPLAST INNER ENVELOPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPID-SYNTHESIS | CARRIER PROTEIN | PLANT SCIENCES | CELL BIOLOGY | OIL CATABOLISM | METABOLISM | ENDOPLASMIC-RETICULUM | PHOSPHATIDIC-ACID | Homeostasis | Acyltransferases - metabolism | Acyltransferases - genetics | Arabidopsis Proteins - metabolism | Lipid Droplets - ultrastructure | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | beta-Glucosidase - genetics | Plants, Genetically Modified | Gene Expression Regulation, Plant | ATP-Binding Cassette Transporters - metabolism | beta-Glucosidase - metabolism | Membrane Transport Proteins - metabolism | Carboxylic Ester Hydrolases - genetics | Lipid Droplets - metabolism | Fatty Acids - metabolism | Microscopy, Electron, Transmission | Arabidopsis Proteins - genetics | Oxidation-Reduction | Lipase - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Peroxisomes - metabolism | Arabidopsis - metabolism | Triglycerides - metabolism | Arabidopsis - genetics | Plant Leaves - genetics | Plant Leaves - metabolism | Models, Biological | Membrane Lipids - metabolism | Mutation | Microscopy, Fluorescence | Plant Leaves - ultrastructure | Carboxylic Ester Hydrolases - metabolism | Lipase - genetics
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2006, Volume 116, Issue 7, pp. 1983 - 1993
Journal Article
Nature medicine, ISSN 1546-170X, 2011, Volume 17, Issue 2, pp. 200 - 205
Journal Article