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Journal of Controlled Release, ISSN 0168-3659, 02/2012, Volume 157, Issue 3, pp. 354 - 365
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, p. e0148984
The induction of high levels of systemic and mucosal humoral immunity is a key goal for many prophylactic vaccines. However, adjuvant strategies developed in... 
PATHWAYS | IMMUNIZATION | RESPONSES | DENDRITIC CELLS | PROTECTION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MUCOSAL | LIGAND | SECRETION | EXPRESSION | HIV Antibodies - blood | Antibody Specificity | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Toll-Like Receptor 8 - administration & dosage | Lipid A - analogs & derivatives | AIDS Vaccines - immunology | Immunity, Mucosal - drug effects | Toll-Like Receptor 8 - immunology | 1,2-Dipalmitoylphosphatidylcholine - administration & dosage | Immunoglobulin G - biosynthesis | Swine | HIV Antibodies - biosynthesis | Toll-Like Receptor 4 - agonists | Models, Animal | Lipid A - administration & dosage | Antibody Affinity | Toll-Like Receptor 4 - immunology | Lipid A - pharmacology | Toll-Like Receptor 7 - administration & dosage | 1,2-Dipalmitoylphosphatidylcholine - pharmacology | AIDS Vaccines - administration & dosage | Adjuvants, Immunologic - pharmacology | Dose-Response Relationship, Immunologic | env Gene Products, Human Immunodeficiency Virus - immunology | Vagina - immunology | Imidazoles - administration & dosage | Neutralization Tests | Toll-Like Receptor 4 - administration & dosage | Antigens - administration & dosage | Immunization, Secondary | Vaccination - methods | HIV Antibodies - immunology | Immunoglobulin G - immunology | Toll-Like Receptor 7 - immunology | Swine, Miniature | Female | Injections, Intradermal | Toll-Like Receptor 8 - agonists | Toll-Like Receptor 7 - agonists | Immunity, Innate | Organ Specificity | Administration, Intranasal | Animals | Nasal Mucosa - immunology | env Gene Products, Human Immunodeficiency Virus - administration & dosage | Antigens - immunology | Imidazoles - antagonists & inhibitors | Drug Combinations | Physiological aspects | Toll-like receptors | Genetic aspects | Immune response | Research | Animal models | Mucosal immunity | Mucosa | Immunoglobulin G | Infections | Vaccines | Immunity | Proteins | Signal transduction | Inoculation | Immunology | Pathways | Rodents | Human immunodeficiency virus--HIV | Immunity (humoral) | Immune system | Antigens | Medical research | TLR7 protein | Vagina | Priming | Glycoproteins | TLR4 protein | Gene expression | Immune response (humoral) | Medicine | Signaling | Infectious diseases | Ligands | HIV | Human immunodeficiency virus
Journal Article
Clinical Immunology, ISSN 1521-6616, 2015, Volume 168, pp. 6 - 15
Abstract In the present study, the combined adjuvant effect of 7DW8-5, a potent α-GalCer-analog, and MPLA, a TLR4 agonist, on the induction of vaccine-induced... 
Allergy and Immunology | Cancer vaccine | NKT cells | Malaria vaccine | Memory-like effector NKT cells | WT-1 | Adjuvant | CD1d | TLR4 | Circumsporozoite protein | Glycolipid | GENE WT1 PRODUCT | DENDRITIC CELLS | IMMUNOLOGY | CANCER | TUMOR-IMMUNITY | PROTECTIVE IMMUNITY | IMMUNE-RESPONSES | IN-VIVO | TOLL-LIKE RECEPTORS | MICE | HLA-A2 Antigen - genetics | Humans | Lipid A - analogs & derivatives | Interferon-gamma - metabolism | Galactosylceramides - administration & dosage | Galactosylceramides - pharmacology | Protective Agents - pharmacology | WT1 Proteins - immunology | CD8-Positive T-Lymphocytes - metabolism | Killer Cells, Natural - immunology | Toll-Like Receptor 4 - agonists | Protozoan Proteins - chemistry | Epitopes, T-Lymphocyte - immunology | WT1 Proteins - genetics | Immunologic Memory - immunology | Amino Acid Sequence | Lipid A - administration & dosage | Plasmodium yoelii - physiology | HLA-A2 Antigen - immunology | Immunization - methods | Malaria - immunology | Mice, Inbred C57BL | Peptides - immunology | Mice, Transgenic | Plasmodium yoelii - immunology | Toll-Like Receptor 4 - metabolism | Drug Synergism | Malaria - prevention & control | Models, Immunological | Animals | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Lipid A - pharmacology | Malaria - parasitology | Cell Line, Tumor | Killer Cells, Natural - drug effects | Mice, Inbred BALB C | Killer Cells, Natural - metabolism | Protective Agents - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Protozoan Proteins - immunology
Journal Article
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 10/2018, Volume 549, Issue 1-2, pp. 404 - 414
This study reports on the immunogenicity assessment of a novel chimeric peptide vaccine including Tax, gp21, gp46, and gag immunodominant epitopes of human... 
Chimeric peptide vaccine | HTLV-1 | Cell-mediated immune response | Mucosal immunity | ISCOMATRIX | MPLA | EFFECTOR T-CELLS | TGF-BETA | DENDRITIC CELLS | TH1 CELLS | LYMPHOTROPIC VIRUS TYPE-1 | DELIVERY | CYTOKINE PRODUCTION | INTERFERON-GAMMA | PHARMACOLOGY & PHARMACY | STIMULATING COMPLEXES | THERAPEUTIC VACCINES | Immunogenicity, Vaccine | Adjuvants, Immunologic - administration & dosage | Saponins - administration & dosage | Vaccine Potency | Cholesterol - administration & dosage | Lipid A - analogs & derivatives | Immunity, Mucosal | Cholesterol - immunology | Male | Antibodies, Viral - blood | HTLV-I Antigens - administration & dosage | Lipid A - immunology | Injections, Subcutaneous | Human T-lymphotropic virus 1 - immunology | Cytokines - blood | Nasal Mucosa - virology | Immunization | Lipid A - administration & dosage | Phospholipids - administration & dosage | Phospholipids - immunology | Saponins - immunology | Vaccines, Subunit - immunology | Administration, Intranasal | HTLV-I Antigens - immunology | Viral Vaccines - administration & dosage | Animals | Nasal Mucosa - immunology | Vaccines, Subunit - administration & dosage | Mice, Inbred BALB C | Immunity, Cellular | Viral Vaccines - immunology | Drug Combinations | Immunodominant Epitopes | Immune response | Peptides | Analysis | Pharmacy | Lipids | Bone morphogenetic proteins | Vaccines | Transforming growth factors | T cells | Nanotechnology | Antigenic determinants
Journal Article
Cancer Research, ISSN 0008-5472, 03/2014, Volume 74, Issue 6, pp. 1670 - 1681
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 2005, Volume 115, Issue 6, pp. 1109 - 1117
It has been hypothesized that decreasing antioxidant (fruit and vegetables), increased n-6 polyunsaturated fatty acid (PUFA; (margarine, vegetable oil), and... 
n-6 polyunsaturated fatty acid | atopic dermatitis | antioxidants | n-3 polyunsaturated fatty acid | Asthma | Antioxidants | N-6 polyunsaturated fatty acid | N-3 polyunsaturated fatty acid | Atopic dermatitis | FRESH FRUIT CONSUMPTION | LUNG-FUNCTION | asthma | PULMONARY-FUNCTION | VITAMIN-E SUPPLEMENTATION | IMMUNOLOGY | ANTIOXIDANT VITAMIN | CHILDHOOD ASTHMA | ALLERGY | UMBILICAL-CORD | T-HELPER-1 CYTOKINE PRODUCTION | POLYUNSATURATED FATTY-ACIDS | antiovidants | PLACEBO-CONTROLLED TRIAL | Dietary Fats - metabolism | Vegetables | Asthma - prevention & control | Antioxidants - metabolism | Humans | Child, Preschool | Male | Vitamin A - administration & dosage | Dietary Fats - administration & dosage | Female | Fish Oils - administration & dosage | Asthma - etiology | Disease Models, Animal | Pregnancy Complications - etiology | Fruit | Risk Factors | Ascorbic Acid - administration & dosage | Lipid Metabolism | Clinical Trials as Topic | Lipids - administration & dosage | Hypersensitivity, Immediate - prevention & control | Pregnancy | Hypersensitivity, Immediate - etiology | Animals | Diet | Antioxidants - administration & dosage | Vitamin E - administration & dosage | Fish Oils - metabolism | Pregnancy Complications - prevention & control | Dietary Supplements | Selenium - administration & dosage | Enzymes | Unsaturated fatty acids | Prostaglandins E | Dietary supplements | Physiological aspects | Risk factors | Omega-3 fatty acids | Lipids | Metabolites | Fish oils | Dermatitis | Fatty acids | Vitamin C
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2011, Volume 108, Issue 19, pp. 7914 - 7919
Vaccines can greatly reduce the spread of and deaths from many infectious diseases. However, many infections have no successful vaccines. Better understanding... 
T lymphocytes | Antigens | Influenza A virus | Aluminum | Vaccination | Memory | Antibodies | Infections | Ova | Cellular differentiation | Cross-presentation | MHC tetramer | Toll-like receptor | Cytokine | cytokine | CROSS-REACT | IMMUNITY | VIRUS | MULTIDISCIPLINARY SCIENCES | INFLUENZA | B SURFACE-ANTIGEN | NALP3 INFLAMMASOME | H5N1 | RESPONSES | cross-presentation | INFECTION | LYMPHOCYTES-T | Orthomyxoviridae Infections - prevention & control | Adjuvants, Immunologic - administration & dosage | Ovalbumin - immunology | Serum Albumin, Bovine - administration & dosage | Humans | Lipid A - analogs & derivatives | RNA-Binding Proteins - administration & dosage | Antigen Presentation | Cattle | Female | Influenza A virus - immunology | Apoptosis Regulatory Proteins - biosynthesis | T-Lymphocytes, Cytotoxic - immunology | Lipid A - administration & dosage | Interleukin-6 - genetics | Serum Albumin, Bovine - immunology | RNA-Binding Proteins - immunology | Antigens, Surface - biosynthesis | Mice, Transgenic | Interleukin-6 - deficiency | Mice, Knockout | Animals | Ovalbumin - administration & dosage | Vaccines, Subunit - administration & dosage | Interleukin-6 - biosynthesis | Immunologic Memory | Programmed Cell Death 1 Receptor | Viral Core Proteins - immunology | Mice | Alum Compounds - administration & dosage | Cytokines - biosynthesis | Orthomyxoviridae Infections - immunology | Viral Core Proteins - administration & dosage | Toll-like receptors | Physiological aspects | Immunological adjuvants | Properties | T cells | Biological Sciences
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 43, pp. E6639 - E6648
Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We... 
Vaccination kinetics | Antigen retention | Computational immunology | Humoral response | Germinal center formation | HIV-1 | CENTER B-CELLS | IMMUNE-RESPONSE | antigen retention | computational immunology | vaccination kinetics | PERSISTENCE | MULTIDISCIPLINARY SCIENCES | FOLLICULAR HELPER-CELL | RELEASE | INDUCTION | ADJUVANT | DELIVERY | germinal center formation | MALARIA ANTIGEN | humoral response | Immunogenicity, Vaccine | Osmotic Pressure | Adjuvants, Immunologic - administration & dosage | Cricetulus | Germinal Center - immunology | Humans | Lipid A - analogs & derivatives | Germinal Center - drug effects | Vaccination - methods | HEK293 Cells | Female | Germinal Center - cytology | Recombinant Fusion Proteins - administration & dosage | CHO Cells | Antibodies, Viral - biosynthesis | Recombinant Fusion Proteins - biosynthesis | B-Lymphocytes - cytology | Infusion Pumps, Implantable | Lipid A - administration & dosage | Drug Administration Schedule | Mice, Inbred C57BL | Antibody Affinity | HIV Envelope Protein gp120 - administration & dosage | HIV Envelope Protein gp120 - biosynthesis | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | Vaccination - instrumentation | Mice | AIDS Vaccines - administration & dosage | Antigen-antibody reactions | Observations | Vaccination | Patient outcomes | Biological Sciences | PNAS Plus
Journal Article