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Journal of Hepatology, ISSN 0168-8278, 2011, Volume 54, Issue 4, pp. 773 - 794
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a reactive metabolite generated through cytochromes P450... 
Gastroenterology and Hepatology | Drugs | Obesity | Oxidative stress | Mitochondria | Cell death | Lipids | Hepatotoxicity | Steatosis | TRIGLYCERIDE TRANSFER PROTEIN | DNA-POLYMERASE-GAMMA | PREGNANE X-RECEPTOR | PROLIFERATOR-ACTIVATED RECEPTOR | HEPATIC CYTOCHROME-P450 2E1 | ELEMENT-BINDING PROTEINS | FATTY-ACID OXIDATION | CONSTITUTIVE ANDROSTANE RECEPTOR | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RELATED PARAMETERS | GASTROENTEROLOGY & HEPATOLOGY | Carbohydrate Metabolism - drug effects | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Leptin - metabolism | Oxidative Phosphorylation - drug effects | Adipose Tissue - metabolism | Adiponectin - metabolism | Hepatitis C - complications | Cell Death - drug effects | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Diabetes Mellitus, Type 2 - complications | Genetic Predisposition to Disease | Fatty Liver - metabolism | Oxidation-Reduction | Obesity - complications | Insulin Resistance | Mitochondrial Membrane Transport Proteins - drug effects | Chemical and Drug Induced Liver Injury - genetics | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | Lipid Metabolism - drug effects | Alcoholic Intoxication - complications | Genome, Mitochondrial | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Fatty Liver - etiology | Divalproex | Liver diseases | Thiols | Liver | Cytochrome P-450 | Mitochondrial DNA | Triglycerides | Stavudine | Permeability | Valproic acid | Fatty acids | Cells | Carnitine | Metabolites | Glutathione transferase | Acetaminophen | Physiological aspects | DNA polymerases | Health aspects | Zidovudine | Index Medicus | Reactive Oxygen Species | Fatty Acids | Adiponectin | Mitochondria, Liver | Life Sciences | Mitochondrial Membrane Transport Proteins | Cell Death | Diabetes Mellitus, Type 2 | Adipose Tissue | Alcoholic Intoxication | Hépatology and Gastroenterology | Oxidative Phosphorylation | Carbohydrate Metabolism | Lipid Metabolism | Drug-Induced Liver Injury | Fatty Liver | Human health and pathology | Energy Metabolism | Leptin | Hepatitis C
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 03/2018, Volume 10, Issue 3, p. n/a
.... These effects coincided with decreased brown adipocyte lipid content and increased nutrient uptake by BAT, confirming increased BAT activity... 
GPR120 | brown adipose tissue | Ca2 | mitochondria | lipid metabolism | Ca | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | ACTIVATION | PROTEIN | INSULIN-SECRETION | THERMOGENESIS | POTENT | GLUCOSE-METABOLISM | GENE-EXPRESSION | ACID RECEPTOR GPR40 | ADIPOSE-TISSUE | Adipocytes, White - cytology | Adipocytes, Brown - metabolism | Receptors, G-Protein-Coupled - metabolism | Adipose Tissue, White - metabolism | Body Weight - drug effects | Lipids | Male | Receptors, G-Protein-Coupled - agonists | Adipocytes, White - drug effects | Biphenyl Compounds - pharmacology | Cell Respiration - drug effects | Adiposity - drug effects | Oxidation-Reduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Phenylpropionates - pharmacology | Animals | Receptors, G-Protein-Coupled - deficiency | Cell Differentiation - drug effects | Models, Biological | Oxygen Consumption - drug effects | Glucose - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Adipocytes, Brown - cytology | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Physiological aspects | Obesity | G proteins | Body weight | Membrane proteins | Pharmacology & Drug Discovery | Metabolism
Journal Article
Circulation research, ISSN 1524-4571, 2007, Volume 100, Issue 3, pp. 328 - 341
The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. It is activated by... 
Calcium signaling | Signaling pathways | Diabetes | Metabolism | Insulin | RAT-LIVER | CARDIAC & CARDIOVASCULAR SYSTEMS | insulin | 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE | STIMULATED GLUCOSE-TRANSPORT | calcium signaling | ACETYL-COA CARBOXYLASE | COENZYME-A CARBOXYLASE | SKELETAL-MUSCLE | signaling pathways | FATTY-ACID OXIDATION | ENDOTHELIAL-CELLS | CELL-PERMEABLE ACTIVATOR | PANCREATIC BETA-CELLS | PERIPHERAL VASCULAR DISEASE | metabolism | HEMATOLOGY | diabetes | Consensus Sequence | Protein Subunits | Protein-Serine-Threonine Kinases - deficiency | Insulin - physiology | Obesity - drug therapy | Humans | Muscle Cells - drug effects | Adipocytes - drug effects | AMP-Activated Protein Kinases | Aminoimidazole Carboxamide - pharmacology | Multienzyme Complexes - deficiency | Calcium - physiology | Adenosine Triphosphate - metabolism | Energy Metabolism - physiology | Binding Sites | Peptide Hormones - physiology | Hypoglycemic Agents - therapeutic use | Amino Acid Sequence | Diabetes Mellitus - drug therapy | Models, Molecular | Rats | Hypoglycemic Agents - pharmacology | Mice, Knockout | Calcium-Calmodulin-Dependent Protein Kinase Kinase | Carbohydrate Metabolism - physiology | Aminoimidazole Carboxamide - analogs & derivatives | Diabetes Mellitus - therapy | Protein-Serine-Threonine Kinases - drug effects | Mice | Protein-Serine-Threonine Kinases - chemistry | Cell Cycle - drug effects | Energy Metabolism - drug effects | Lipid Metabolism - physiology | Multienzyme Complexes - drug effects | Carbohydrate Metabolism - drug effects | Phosphorylation | Metformin - therapeutic use | Molecular Sequence Data | Hepatocytes - metabolism | Ribonucleotides - pharmacology | Hepatocytes - drug effects | Adenosine Monophosphate - metabolism | Protein-Serine-Threonine Kinases - physiology | Metformin - pharmacology | Muscle Cells - metabolism | Protein-Serine-Threonine Kinases - genetics | Diabetes Mellitus - metabolism | Neoplasms - enzymology | Multienzyme Complexes - genetics | Enzyme Activation - drug effects | Protein Processing, Post-Translational - physiology | Multienzyme Complexes - chemistry | Obesity - metabolism | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Oxygen Consumption - drug effects | Adipocytes - metabolism | Multienzyme Complexes - physiology | Lipid Metabolism - drug effects | Cell Cycle - physiology | Neoplasms - pathology
Journal Article
Cell metabolism, ISSN 1550-4131, 2016, Volume 24, Issue 6, pp. 795 - 806
.... Without any obvious toxicity or deleterious effects, NMN suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma... 
NAD | NAD+ precursor | insulin sensitivity | eye function | anti-aging | mitochondria | aging | nicotinamide mononucleotide | glucose metabolism | NMN | energy metabolism | precursor | LIFE-SPAN | STEM-CELLS | ACTIVATION | MITOCHONDRIAL | NAD BIOSYNTHESIS | INSULIN-SECRETION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | RIBOSIDE | SIRT1 | ADIPOSE-TISSUE | CELL BIOLOGY | Darkness | Aging - drug effects | Male | Muscle, Skeletal - metabolism | Nicotinamide Mononucleotide - administration & dosage | Aging - genetics | Time Factors | Lipids - blood | Muscle, Skeletal - drug effects | Cell Respiration - drug effects | Myeloid Cells - drug effects | Weight Gain - drug effects | NAD - metabolism | Physical Conditioning, Animal | Food | Lymphocytes - metabolism | Insulin - pharmacology | Administration, Oral | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Eating - drug effects | Bone Density - drug effects | Animals | Aging - physiology | Lymphocytes - drug effects | Myeloid Cells - metabolism | Nicotinamide Mononucleotide - pharmacology | Drinking - drug effects | Nicotinamide Mononucleotide - blood | Energy Metabolism - drug effects | Niacinamide | Medical colleges | Exercise | Pharmacy | Genes | Body weight | Physiological aspects | Muscles | Mice | Ophthalmology | Gene expression
Journal Article
American journal of physiology: endocrinology and metabolism, ISSN 1522-1555, 2019, Volume 316, Issue 1, pp. E16 - E33
.... The aim of this study was to investigate the effects and mechanisms of action of metformin and flutamide on plasma lipid-apolipoprotein (Apo... 
lipid and insulin metabolism | flutamide | metformin | PCOS | POLYCYSTIC-OVARY-SYNDROME | INTIMA-MEDIA THICKNESS | PHYSIOLOGY | OBESE WOMEN | GLUCOSE-HOMEOSTASIS | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | RECEPTOR GENE | PARTICLE-SIZE | YOUNG-WOMEN | CAG REPEAT POLYMORPHISM | HYPOCALORIC DIET | Apolipoproteins B - metabolism | Cardiovascular Diseases | Intestinal Mucosa - metabolism | Apolipoprotein B-48 - metabolism | Metabolic Syndrome - metabolism | Risk | Mitogen-Activated Protein Kinase 1 - drug effects | Apolipoproteins B - drug effects | Apolipoprotein B-100 - metabolism | Ovarian Follicle - drug effects | Liver - drug effects | Female | Ovary - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Follicular Phase | Polycystic Ovary Syndrome - metabolism | Liver - metabolism | Metformin - pharmacology | Insulin Resistance | Androgen Antagonists - pharmacology | Rats | Flutamide - pharmacology | Hypoglycemic Agents - pharmacology | Triglycerides - metabolism | Blood Glucose - drug effects | Estrogen Receptor alpha - drug effects | Insulin - metabolism | Animals | Estrogen Receptor alpha - genetics | Receptor, Insulin - drug effects | Receptor, Insulin - metabolism | Apolipoprotein B-100 - drug effects | Apolipoprotein B-48 - drug effects | Blood Glucose - metabolism | RNA, Messenger | Mitogen-Activated Protein Kinase 1 - metabolism | Proto-Oncogene Proteins c-akt - drug effects | Drugs | Estrogens | Estrogen | Dyslipidemia | Estrogen receptors | Lipids | Effects | Glucose | Risk factors | Glucose metabolism | Signal transduction | Pathways | Intestine | Rodents | Lipid metabolism | Diabetes mellitus (non-insulin dependent) | Polycystic ovary syndrome | Secretion | Diabetes mellitus | AKT2 protein | Health risks | Triglycerides | Risk analysis | Gene expression | Apolipoproteins | Metabolism | Insulin | Glucose tolerance | Intolerance | Signaling | Androgens | Flutamide | Hypertriglyceridemia | Metformin | Cardiovascular diseases | Metabolic disorders
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 535, Issue 7610, pp. 153 - 158
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When activated, they cleave mouse and... 
LISTERIA-MONOCYTOGENES | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | MIXED LINEAGE KINASE | PERFORIN | NLRP3 INFLAMMASOME | INTRACELLULAR BACTERIA | GRANZYMES | CASPASE-1 ACTIVATION | GRANULYSIN | CELL-DEATH | Conserved Sequence - genetics | Inflammasomes - metabolism | Phosphatidylinositol Phosphates - metabolism | Pyroptosis - drug effects | Escherichia coli - drug effects | Humans | Molecular Sequence Data | Neoplasm Proteins - pharmacology | Escherichia coli - cytology | Neoplasm Proteins - metabolism | Escherichia coli - metabolism | Protein Multimerization - genetics | Listeria monocytogenes - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Listeria monocytogenes - cytology | Porosity - drug effects | Neoplasm Proteins - genetics | Cell Membrane - drug effects | Staphylococcus aureus - metabolism | Amino Acid Sequence | Cell Line | Microbial Viability - drug effects | Membrane Proteins - genetics | Mice, Inbred C57BL | Phosphatidylserines - metabolism | Neoplasm Proteins - chemistry | Cardiolipins - metabolism | Cell Membrane - ultrastructure | Protein Structure, Tertiary - genetics | Microscopy, Electron | Pyroptosis - genetics | Protein Transport | Liposomes - chemistry | Animals | Membrane Proteins - chemistry | Cell Membrane Permeability - drug effects | Staphylococcus aureus - cytology | Liposomes - metabolism | Mice | Mutation | Staphylococcus aureus - drug effects | Listeria monocytogenes - drug effects | Observations | Apoptosis | Proteins | Membranes | Bacterial infections | Immunology | Plasmids | Bacteria | Infections | Cells
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2016, Volume 311, Issue 6, pp. H1360 - H1366
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20944
... the gut with beneficial effect for host adiposity. We test the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX... 
BACTERIAL COMMUNITY | INSULIN | IN-VITRO | LIPID-METABOLISM | PLASMA | MECHANISM | LINOLEIC-ACID | GLUCOSE | MULTIDISCIPLINARY SCIENCES | LIVER | GUT MICROBIOTA | Intestines - drug effects | Obesity - diet therapy | Molecular Weight | Xylans - pharmacology | Diet - adverse effects | Cholesterol - blood | Body Weight - drug effects | Male | Linoleic Acids, Conjugated - metabolism | Obesity - microbiology | Metagenome - physiology | Bacterial Load - drug effects | Subcutaneous Fat - metabolism | Prevotella - physiology | Subcutaneous Fat - drug effects | Obesity - etiology | Bifidobacterium - physiology | Biomarkers - metabolism | Dietary Fats - adverse effects | Metagenome - drug effects | Mice, Inbred C57BL | Bacteroides - physiology | Insulin Resistance | Obesity - metabolism | Prebiotics | Gene Expression Regulation - drug effects | Animals | Intestines - microbiology | Xylans - chemistry | Xylans - therapeutic use | Mice | Triticum - chemistry | Microbiota (Symbiotic organisms) | Diet | Analysis | Body weight | Physiological aspects | Insulin resistance | Wheat | Fatty acids | Dysbacteriosis | Adipose tissue | Fat metabolism | Enzyme activity | Lipids | Glucose | Molecular weight | High fat diet | Proteins | Microbiota | Enzymatic activity | Rodents | Nutrients | Bacteria | Oxidation | Colon | Lipid metabolism | Supplementation | Arabinoxylans | Food | Carbohydrates | Obesity | Dietary supplements | Polymerization | Inflammation | Ecology | Metabolism | Fermentation | Gene expression | Insulin | Body weight gain | Cholesterol | Studies | Nutrition research | Correlation analysis | Laboratory animals
Journal Article