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Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24770 - 24780
Accumulation of indigestible lipofuscin and decreased mitochondrial energy production are characteristic age-related changes of post-mitotic retinal pigment... 
LIPOFUSCIN FLUOROPHORE | RAT | DYSTROPHY | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACULAR DEGENERATION | COMPONENT | RPE CELLS | N-RETINYLIDENE ETHANOLAMINE | BINDING | PHOTORECEPTORS | Retinoids - metabolism | Epithelial Cells - metabolism | Lipofuscin - pharmacology | Antioxidants - metabolism | Humans | Lysosomes - genetics | Rats, Long-Evans | Adenosine Triphosphate - genetics | Phagocytosis - genetics | Membrane Potential, Mitochondrial - drug effects | Mitosis - genetics | Oxidative Phosphorylation - drug effects | DNA, Mitochondrial - genetics | Lysosomes - metabolism | Aging - genetics | Cell Death - genetics | Mitochondria - genetics | Adenosine Triphosphate - metabolism | Membrane Potential, Mitochondrial - genetics | Pyruvic Acid - metabolism | Lysosomes - pathology | Cell Death - drug effects | Cell Line | Phagocytosis - drug effects | DNA, Mitochondrial - metabolism | Rats | Epithelial Cells - pathology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - pathology | Aging - pathology | Pigment Epithelium of Eye - metabolism | Macular Degeneration - metabolism | Point Mutation | Pyridinium Compounds - pharmacology | Animals | Mitosis - drug effects | Macular Degeneration - genetics | Glucose - metabolism | Pigment Epithelium of Eye - pathology | Pyridinium Compounds - metabolism | Lipofuscin - metabolism | Retinoids - pharmacology | Aging - metabolism | Macular Degeneration - pathology | Index Medicus | Molecular Basis of Cell and Developmental Biology
Journal Article
Molecular Medicine, ISSN 1076-1551, 2010, Volume 16, Issue 7-8, pp. 235 - 246
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 02/2012, Volume 16, Issue 3, pp. 263 - 274
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2015, Volume 290, Issue 45, pp. 27215 - 27227
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e41309 - e41309
Aging of retinal pigment epithelial (RPE) cells of the eye is marked by accumulations of bisretinoid fluorophores; two of the compounds within this lipofuscin... 
LIPOFUSCIN FLUOROPHORE | OXIDATIVE STRESS | PIGMENT EPITHELIAL-CELLS | A2E | RPE | MULTIDISCIPLINARY SCIENCES | FACTOR-H POLYMORPHISM | ALPHA-OXOALDEHYDES | BRUCHS MEMBRANE | PROTEINS | GLYCATION END-PRODUCTS | Retinoids - metabolism | Retina - metabolism | Glyoxal - metabolism | Enzyme-Linked Immunosorbent Assay | Retinal Drusen - metabolism | Humans | Cells, Cultured | Retinaldehyde - metabolism | Retinaldehyde - analogs & derivatives | Macular Degeneration - metabolism | Pyruvaldehyde - metabolism | Phenylhydrazines - metabolism | Spectrometry, Mass, Electrospray Ionization | Glycation End Products, Advanced - metabolism | Chromatography, Liquid | Pyridinium Compounds - metabolism | Guanidines - metabolism | Lipofuscin - metabolism | Retina - pathology | Macular degeneration | Proteins | Physiological aspects | Liquid chromatography | Ionization | Oxidative stress | Radiation | Irradiated | Fluorescence | Retina | Aldehydes | Eye | Rodents | Atherosclerosis | Pigments | Aging | Oxidation | Degeneration | Localization | Age | Enzyme-linked immunosorbent assay | Photodegradation | Photosensitivity | Diabetes mellitus | Mass spectroscopy | Glycoproteins | Glycosylation | Chemical compounds | Arteriosclerosis | Fluorophores | Irradiation | Diabetes | Pyruvaldehyde | Mass spectrometry | Photooxidation | Structure-function relationships | Index Medicus
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Journal Article
Journal Article
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 02/2014, Volume 6, Issue 2, pp. 194 - 211
Retinal gene therapy with adeno‐associated viral ( AAV ) vectors is safe and effective in humans. However, AAV 's limited cargo capacity prevents its... 
ABCA | gene therapy | MYO | retina | AAV | Retina | MYO7A | Gene therapy | ABCA4 | MEDICINE, RESEARCH & EXPERIMENTAL | ROD OUTER SEGMENTS | PACKAGING CAPACITY | USHER-SYNDROME 1B | MACULAR DEGENERATION | MYOSIN VIIA | ADENOASSOCIATED VIRAL VECTORS | RIM PROTEIN | IN-VIVO | LEBERS CONGENITAL AMAUROSIS | VIRUS VECTORS | Retinal Pigment Epithelium - metabolism | Usher Syndromes - therapy | Retina - metabolism | Genetic Vectors - administration & dosage | Humans | Rhodopsin - metabolism | Usher Syndromes - genetics | HEK293 Cells | ATP-Binding Cassette Transporters - metabolism | Myosins - metabolism | Disease Models, Animal | Gene Transfer Techniques | Transduction, Genetic | Dependovirus - metabolism | Mice, Inbred C57BL | Genetic Vectors - metabolism | Injections | Phenotype | Animals | Macular Degeneration - congenital | Macular Degeneration - genetics | Macular Degeneration - therapy | Mice | Photoreceptor Cells, Vertebrate - metabolism | Lipofuscin - metabolism | Melanosomes - metabolism | Sus scrofa | Trans-Splicing - genetics | Genetic research | Swine | Analysis | Genes | Genomics | Phenotypes | Animal models | Disease | Splicing | Homologous recombination | Infections | Genomes | Research | Gene expression | Phosphatase | Experiments | Vectors (Biology) | Capsids | Hogs | Photoreceptors | Mutation | Expression vectors | Index Medicus
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Journal Article