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Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 11, pp. 1327 - 1333
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2016, Volume 23, Issue 6, pp. 1154 - 1166
During insulin-resistant states such as type II diabetes mellitus (T2DM), insulin fails to suppress hepatic glucose production (HGP) yet promotes lipid... 
HEPATIC GLUCOKINASE | LIPID-METABOLISM | TRANSCRIPTION FACTOR FOXO1 | IN-VIVO | FATTY-ACID | LIVER | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | RESISTANCE | METABOLOMIC ANALYSIS | GLUCOKINASE EXPRESSION | CELL BIOLOGY | TOR Serine-Threonine Kinases - metabolism | Gluconeogenesis - drug effects | Vagus Nerve - drug effects | Male | Glucose - biosynthesis | Hepatocytes - metabolism | Mechanistic Target of Rapamycin Complex 1 | Liver - innervation | Adipose Tissue - metabolism | Efferent Pathways - drug effects | Fatty Acids, Nonesterified - metabolism | Multiprotein Complexes - metabolism | Lipogenesis - genetics | Liver - drug effects | Gene Deletion | Postprandial Period - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Heparin - pharmacology | Hepatocytes - drug effects | Forkhead Box Protein O1 - metabolism | Insulin - pharmacology | Glucose Tolerance Test | Liver - metabolism | Insulin Resistance | Signal Transduction - genetics | Glucokinase - metabolism | Efferent Pathways - metabolism | Mice, Knockout | Gene Expression Regulation - drug effects | Vagus Nerve - physiology | Insulin - metabolism | Animals | Gluconeogenesis - genetics | Diet | Signal Transduction - drug effects | Lipogenesis - drug effects | Glucagon - metabolism | Adipose Tissue - drug effects | Medical colleges | Glucagon | Analysis | Liver | Insulin resistance | Diabetes | Glucose | Insulin | Dextrose | Index Medicus
Journal Article
Endocrinology, ISSN 0013-7227, 03/2016, Volume 157, Issue 3, pp. 1029 - 1042
Journal Article
Journal Article
Molecular Nutrition and Food Research, ISSN 1613-4125, 12/2011, Volume 55, Issue 12, pp. 1809 - 1818
Scope: Mangiferin, a natural polyphenol, has been shown to have hypolipidemic effect in rat and mouse. However, the mechanism of action is not well understood.... 
Acyl-CoA:diacylglycerol acyltransferase 2 | Hyperlipidemia | Peroxisome proliferator-activated receptor-α | Hamster | Mangiferin | INDUCED HEPATIC STEATOSIS | PPAR-ALPHA | ACID | FOOD SCIENCE & TECHNOLOGY | RATS | MODEL | LIVER-INJURY | DIET | INSULIN-RESISTANCE | Peroxisome proliferator-activated receptor-alpha | UP-REGULATION | EXPRESSION | Hypertriglyceridemia - drug therapy | Up-Regulation | Acetyl-CoA Carboxylase - drug effects | Carnitine O-Palmitoyltransferase - genetics | PPAR alpha - drug effects | CD36 Antigens - genetics | Lipoprotein Lipase - drug effects | Body Weight - drug effects | Male | Carrier Proteins - drug effects | RNA, Messenger - metabolism | Xanthones - pharmacology | Acetyl-CoA Carboxylase - genetics | CD36 Antigens - metabolism | Lipogenesis - genetics | Liver - drug effects | Carnitine O-Palmitoyltransferase - metabolism | Diet, High-Fat | Dietary Fats - administration & dosage | Carnitine O-Palmitoyltransferase - drug effects | Fatty Acids, Nonesterified - blood | Lipid Metabolism - genetics | Lipoprotein Lipase - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Cricetinae | Sterol Regulatory Element Binding Protein 1 - drug effects | Lipoprotein Lipase - genetics | Down-Regulation | Hyperlipidemias - drug therapy | Liver - metabolism | RNA, Messenger - genetics | PPAR alpha - genetics | CD36 Antigens - drug effects | Diacylglycerol O-Acyltransferase - drug effects | Hypolipidemic Agents - pharmacology | Carrier Proteins - genetics | Organ Size - drug effects | Animals | Carrier Proteins - metabolism | Diacylglycerol O-Acyltransferase - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Lipogenesis - drug effects | Lipid Metabolism - drug effects | Triglycerides - blood | PPAR alpha - metabolism | Diacylglycerol O-Acyltransferase - metabolism | Adipose Tissue - drug effects | Acetyl-CoA Carboxylase - metabolism
Journal Article
Journal of Experimental Biology, ISSN 0022-0949, 08/2012, Volume 215, Issue 15, pp. 2567 - 2578
Previous studies in two rainbow trout lines divergently selected for lean (L) or fat (F) muscle suggested that they differ in their ability to metabolise... 
Carbohydrates | Fish nutrition | Genetic selection | Gene expression | Metabolism | carbohydrates | ACTIVATED PROTEIN-KINASE | genetic selection | ONCORHYNCHUS-MYKISS | NUTRITIONAL REGULATION | LIPOGENIC ENZYME-ACTIVITIES | HEPATIC GLUCOSE-METABOLISM | CHEMICAL-COMPOSITION | BIOLOGY | GENE-EXPRESSION | fish nutrition | metabolism | SALMON SALMO-SALAR | FISH-OIL | gene expression | ATLANTIC SALMON | Gene Expression Regulation, Enzymologic - drug effects | Liver - enzymology | Ribosomal Protein S6 Kinases - metabolism | Gluconeogenesis - drug effects | RNA, Messenger - metabolism | Glycolysis - drug effects | Proto-Oncogene Proteins c-akt - genetics | Glycolysis - genetics | Adipose Tissue - metabolism | Lipogenesis - genetics | Liver - drug effects | Adenylate Kinase - metabolism | Oxidation-Reduction - drug effects | Postprandial Period - drug effects | Phosphorylation - drug effects | Muscles - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids - metabolism | Oncorhynchus mykiss - metabolism | Dietary Carbohydrates - pharmacology | RNA, Messenger - genetics | Oncorhynchus mykiss - genetics | Transcription Factors - genetics | Oncorhynchus mykiss - blood | Blotting, Western | Oncorhynchus mykiss - growth & development | Feeding Behavior - drug effects | Transcription Factors - metabolism | Animals | Gluconeogenesis - genetics | Lipogenesis - drug effects | Muscles - drug effects | Adenylate Kinase - genetics | Adipose Tissue - drug effects | Ribosomal Protein S6 Kinases - genetics | Adipose tissues | Hyperglycemia | Research | Diagnosis
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e28784
Background: Mechanisms underlying the attenuation of body weight gain and insulin resistance in response to high fat diet (HFD) by the curry compound curcumin... 
3T3-L1 ADIPOCYTES | OXIDATIVE STRESS | ACTIVATION | WNT SIGNALING PATHWAYS | INDUCED SUPPRESSION | MULTIDISCIPLINARY SCIENCES | ELEMENT-BINDING PROTEIN | BETA-CATENIN | HEPATIC STEATOSIS | CELL | GENE-TRANSCRIPTION | Inflammation - pathology | Liver - pathology | Humans | Male | Adipocytes - drug effects | Curcumin - administration & dosage | Adipose Tissue - metabolism | Lipogenesis - genetics | Liver - drug effects | Time Factors | Dietary Fats - pharmacology | Weight Gain - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Insulin - pharmacology | Adiposity - drug effects | Liver - metabolism | Mice, Inbred C57BL | Adipose Tissue - pathology | Curcumin - pharmacology | Insulin Resistance | Rats | Adipocytes - pathology | Hep G2 Cells | Obesity - metabolism | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Adipocytes - metabolism | Lipogenesis - drug effects | Obesity - prevention & control | Glucose - metabolism | Inflammation - genetics | Mice | Adipose Tissue - drug effects | Dietary Supplements | Type 2 diabetes | Prevention | Liver | Body weight | Insulin resistance | Glucose | Gene expression | Reducing diets | Dextrose | Adipose tissue | Wnt protein | Inflammatory response | Adipocytes | Kinases | Macrophages | Low fat | High fat diet | Signal transduction | Rodents | Polyphenols | Attenuation | Curcumin | Lipogenesis | Nutrient deficiency | Inflammation | Insulin | Body weight gain | Signaling | Diet | Low fat diet | Infiltration
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2013, Volume 19, Issue 8, pp. 1054 - 1060
Increased hepatic lipid content is an early correlate of insulin resistance and can be caused by nutrient-induced activation of mammalian target of rapamycin... 
MAMMALIAN TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | COMPLEX | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | PATHWAY | TRANSCRIPTION FACTOR FOXO1 | INSULIN-RESISTANCE | LIPOGENESIS | PPAR-GAMMA | MICE | ADIPOSE-TISSUE | TOR Serine-Threonine Kinases - metabolism | Fatty Liver - pathology | Receptors, Notch - metabolism | Humans | Body Weight - drug effects | Male | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Receptors, Notch - antagonists & inhibitors | Lipogenesis - genetics | Liver - drug effects | Diet, High-Fat | HEK293 Cells | Lipid Metabolism - genetics | Proto-Oncogene Proteins c-akt - metabolism | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Insulin - pharmacology | Fatty Liver - metabolism | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Enzyme Activation - drug effects | Blotting, Western | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Lipogenesis - drug effects | Protein Stability - drug effects | Lipid Metabolism - drug effects | Cell Line, Tumor | Mice | Obesity | Complications and side effects | Physiological aspects | Insulin resistance | Development and progression | Cellular signal transduction | Genetic aspects | Research | Lipids | Liver diseases | Metabolic syndrome | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31812
The pathogenesis of fatty liver is not understood in detail, but lipid overflow as well as de novo lipogenesis (DNL) seem to be the key points of hepatocyte... 
DE-NOVO LIPOGENESIS | INSULIN-RESISTANCE | BIOLOGY | GENE-EXPRESSION | ACID SYNTHESIS | LIPID HOMEOSTASIS | CULTURED-CELLS | HEPATIC STEATOSIS | ALPHA-FETOPROTEIN | TRANSGENIC MICE | ADIPOSE-TISSUE | Organ Specificity - drug effects | Sterol Regulatory Element Binding Protein 1 - chemistry | Transcription, Genetic - drug effects | Acetyltransferases - metabolism | Adipocytes - secretion | Liver - pathology | Liver - enzymology | Fatty Liver - pathology | Humans | Male | Adipocytes - drug effects | Lipogenesis - genetics | Liver - drug effects | Body Composition - drug effects | Intra-Abdominal Fat - drug effects | Fatty Acids - metabolism | Cytokines - blood | Fatty Liver - genetics | Protein Structure, Tertiary | Insulin - pharmacology | Adiposity - drug effects | Fatty Liver - blood | Liver - metabolism | Cytokines - secretion | Insulin Resistance | Mice, Transgenic | Intra-Abdominal Fat - metabolism | Gene Expression Regulation - drug effects | Organ Size - drug effects | Phenotype | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Lipogenesis - drug effects | Stearoyl-CoA Desaturase - metabolism | Mice | Intra-Abdominal Fat - pathology | Type 2 diabetes | Enzymes | Obesity | Liver | Genes | Albumin | Amino acids | Triglycerides | Genetic transcription | Fatty acids | Fatty liver | Analysis | Physiological aspects | Insulin resistance | Protein binding | Transcription factors | Lipid composition | Adipose tissue | Body fat | Pathogenesis | Homeostasis | Lipids | Biochemistry | Adipocytes | Medical diagnosis | Accumulation | Overflow | Sterols | Transgenic animals | Rodents | Atherosclerosis | Sterol regulatory element-binding protein | Lipid metabolism | Lipogenesis | Desaturation | Hypertension | Carbohydrates | Phenotypes | Liver diseases | Internal medicine | Nutrition | Metabolism | Gene expression | Insulin | Overexpression | Epigenetics | Growth hormones | Diabetes | Metabolic disorders
Journal Article
Diabetologia, ISSN 0012-186X, 2005, Volume 48, Issue 11, pp. 2365 - 2375
Aims/hypothesis Intake of n-3 polyunsaturated fatty acids reduces adipose tissue mass, preferentially in the abdomen. The more pronounced effect of... 
Medicine | Mitochondria | Adipose tissue | n -3 Polyunsaturated fatty acids | PGC-1 | Flax-seed oil | Metabolism | Fish oil | PPARGC1A | Carnitine palmitoyltransferase 1 | n-3 Polyunsaturated fatty acids | ACTIVATED PROTEIN-KINASE | mitochondria | DIETARY FISH-OIL | fish oil | adipose tissue | LINOLENIC ACID | OBESITY | MESSENGER-RNA | carnitine palmitoyltransferase 1 | CPT-I | n-3 polyunsaturated fatty acids | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | flax-seed oil | metabolism | COACTIVATOR PGC-1-ALPHA | ADIPOSE-TISSUE | Epididymis - metabolism | Carnitine O-Palmitoyltransferase - genetics | Trans-Activators - drug effects | Male | NF-E2-Related Factor 1 - genetics | Adipocytes - drug effects | Mitochondrial Proteins - drug effects | alpha-Linolenic Acid - pharmacology | Adipose Tissue - metabolism | Subcutaneous Fat - metabolism | Eicosapentaenoic Acid - pharmacology | Mitochondrial Proteins - metabolism | NF-E2-Related Factor 1 - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Subcutaneous Fat - drug effects | Trans-Activators - genetics | Carnitine O-Palmitoyltransferase - drug effects | Epididymis - drug effects | Oxidation-Reduction | Mice, Inbred C57BL | Cells, Cultured | Fatty Acids, Unsaturated - pharmacology | Mitochondria - metabolism | Fatty Acids, Unsaturated - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Docosahexaenoic Acids - pharmacology | Animals | Fatty Acids, Unsaturated - isolation & purification | Adipocytes - metabolism | Lipogenesis - drug effects | Obesity - prevention & control | Mice | Transcription Factors | Adipose Tissue - drug effects | Fish Oils - chemistry | activated protein-kinase | linolenic acid | cpt-i | messenger-rna | gene-expression | coactivator pgc-1-alpha | adipose-tissue | dietary fish-oil | obesity
Journal Article