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Journal Article
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7394, pp. 333 - 338
The prevalence of obesity and type 2 diabetes is increasing worldwide and threatens to shorten lifespan. Impaired insulin action in peripheral tissues is a... 
DIABETES-MELLITUS | FATTY-ACID SYNTHESIS | GENE | INSULIN-RESISTANCE | LIPOGENESIS | MULTIDISCIPLINARY SCIENCES | CARBOHYDRATE-RESPONSE ELEMENT | LIVER | BINDING-PROTEIN CHREBP | UCSC GENOME BROWSER | TRANSGENIC MICE | Transcription Factors - chemistry | Diabetes Mellitus - genetics | Humans | Male | RNA, Messenger - metabolism | Adipose Tissue - metabolism | Protein Isoforms - chemistry | Nuclear Proteins - deficiency | Lipogenesis | Body Mass Index | Glucose Transporter Type 4 - genetics | Adipose Tissue - pathology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - chemistry | Genotype | Glucose - pharmacology | Nuclear Proteins - chemistry | Mice, Knockout | Insulin - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Insulin Resistance - genetics | Glucose - metabolism | Mice | Blood Glucose - metabolism | Homeostasis - genetics | Cohort Studies | Diabetes Mellitus - blood | Body Weight | Glucose Transporter Type 4 - metabolism | Transcription Factors - deficiency | Adipose Tissue - cytology | Molecular Sequence Data | Obesity - genetics | Promoter Regions, Genetic - genetics | Protein Isoforms - metabolism | Adiposity | Female | Nuclear Proteins - genetics | Insulin - pharmacology | Glucose Intolerance - genetics | Cross-Sectional Studies | Gene Expression Regulation - genetics | RNA, Messenger - genetics | Cells, Cultured | Diabetes Mellitus - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Obesity - metabolism | Transcription Factors - metabolism | Animals | Glucose Transporter Type 4 - biosynthesis | Adipocytes - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Protein Isoforms - genetics | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | Index Medicus | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2016, Volume 126, Issue 11, pp. 4372 - 4386
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant.... 
RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | DE-NOVO LIPOGENESIS | TRANSCRIPTION FACTOR FOXO1 | FATTY LIVER-DISEASE | OB/OB MICE | ELEMENT-BINDING PROTEIN | HEPATIC STEATOSIS | ADIPOSE-TISSUE | PLASMA TRIGLYCERIDES | Glucose Intolerance - metabolism | Glucose-6-Phosphatase - genetics | Fatty Liver - pathology | Humans | Male | Glucose - biosynthesis | Glucose Intolerance - pathology | Fatty Liver - chemically induced | Glycolysis - drug effects | Glycolysis - genetics | Lipogenesis - genetics | Female | Glucose Intolerance - chemically induced | Insulin - genetics | Nuclear Proteins - genetics | Fatty Liver - genetics | Forkhead Box Protein O1 - metabolism | Glucose Intolerance - genetics | Fatty Liver - metabolism | Fructose - toxicity | Insulin Resistance | Glucose - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | Glucose-6-Phosphatase - metabolism | Mice, Knockout | Transcription Factors - metabolism | Insulin - metabolism | Animals | Signal Transduction - drug effects | Lipogenesis - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Forkhead Box Protein O1 - genetics | Obesity | Analysis | Insulin resistance | Genetic aspects | Genetic transcription | Research | Risk factors | Protein binding | Glucose | Metabolites | Rodents | Liver | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 35, pp. 29579 - 29588
Mammalian target of rapamycin complex 2 (mTORC2) is a key activator of protein kinases that act downstream of insulin and growth factor signaling. Here we... 
TRANSCRIPTION FACTORS | DIABETES-MELLITUS | LIPID-METABOLISM | AKT/PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | MOTIF PHOSPHORYLATION | RICTOR | MICE | KINASE-B | INDUCED INSULIN-RESISTANCE | Phosphorylation - physiology | Humans | Glycogen Synthase Kinase 3 beta | GTPase-Activating Proteins - metabolism | Phosphoproteins - metabolism | Cholesterol - genetics | Proto-Oncogene Proteins c-akt - genetics | Fatty Acids - genetics | Forkhead Transcription Factors - metabolism | Insulin Resistance - physiology | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Insulin - genetics | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids - metabolism | Lipogenesis - physiology | Sterol Regulatory Element Binding Protein 1 - metabolism | Tumor Suppressor Proteins - metabolism | Liver - metabolism | Gene Expression Regulation - physiology | Glucose - genetics | Mice, Transgenic | Phosphoproteins - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Insulin - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | GTPase-Activating Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cholesterol - biosynthesis | Index Medicus | mTOR Complex (mTORC) | Liver Metabolism | mTOR Complex 2 (mTORC2) | Akt | Metabolism | Lipogenesis | Insulin | Gluconeogenesis
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e49030 - e49030
Persimmon Leaf (PL), commonly consumed as herbal tea and traditional medicines, contains a variety of compounds that exert antioxidant, alpha-amylase and... 
RAT-LIVER | RESPONSE ELEMENT | OXIDATIVE STRESS | ANIMAL-TISSUES | DIOSPYROS-KAKI | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | ACTIVATED-RECEPTOR-GAMMA | PPAR-GAMMA | PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE | ADIPOSE-TISSUE | Diabetes Mellitus, Experimental - drug therapy | Gene Expression - genetics | Cholesterol - blood | Diabetes Mellitus, Experimental - genetics | Male | PPAR gamma - metabolism | Lipogenesis - genetics | Liver - drug effects | Adiponectin - genetics | Lipid Metabolism - genetics | Phytotherapy - methods | PPAR gamma - genetics | Fatty Liver - metabolism | Liver - metabolism | Glucokinase - genetics | Glucokinase - metabolism | Hypoglycemic Agents - pharmacology | Triglycerides - metabolism | Blood Glucose - drug effects | Hyperglycemia - metabolism | Dyslipidemias - metabolism | Blood Glucose - genetics | Mice | Oxidative Stress - drug effects | Triglycerides - genetics | Blood Glucose - metabolism | Dyslipidemias - genetics | Gene Expression - drug effects | Diabetes Mellitus, Type 2 - genetics | Glycogen - genetics | Plant Leaves | Diabetes Mellitus, Type 2 - metabolism | Hyperglycemia - drug therapy | Hyperglycemia - genetics | Glycogen - metabolism | Plant Preparations - pharmacology | Adiponectin - metabolism | Diabetes Mellitus, Experimental - metabolism | Fatty Liver - genetics | Dyslipidemias - drug therapy | Mice, Inbred C57BL | RNA, Messenger - genetics | Insulin Resistance | Oxidative Stress - genetics | Antioxidants - pharmacology | Cholesterol - metabolism | Diabetes Mellitus, Type 2 - blood | Animals | Lipogenesis - drug effects | Lipid Metabolism - drug effects | Triglycerides - blood | Diospyros | Diabetes Mellitus, Type 2 - drug therapy | Dietary Supplements | Type 2 diabetes | RNA | Isoenzymes | Blood sugar | Glycogen | Liver | Genes | Dietary supplements | Triglycerides | Genetic transcription | Fatty acids | Antioxidants | Hyperglycemia | Oxidative stress | Dyslipidemia | Homeostasis | Lipids | Glucose | Adiponectin | Leaves | Fatty liver | Rodents | Oxidation | Supplementation | Lipogenesis | Lipoproteins (high density) | Enzymes | Hyperlipidemia | Diabetes mellitus | Glucosidase | Gene expression | Cholesterol | Steatosis | Herbal tea | Herbal medicine | Tea | Diet | Glucokinase | Insulin resistance | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e85757 - e85757
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 725 - 738
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to... 
TRANSCRIPTION FACTORS | LIPID-METABOLISM | INSULIN-RESISTANCE | ELEMENT-BINDING PROTEIN-1C | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MOTIF PHOSPHORYLATION | DIABETIC-NEPHROPATHY | GLUCOSE-UTILIZATION | CELL-GROWTH | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | Glucose Intolerance - metabolism | Phosphorylation | Liver - enzymology | TOR Serine-Threonine Kinases - metabolism | Homeostasis | Glycogen Synthase Kinase 3 beta | Male | Hepatocytes - metabolism | Mechanistic Target of Rapamycin Complex 2 | Hyperglycemia - genetics | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Forkhead Transcription Factors - metabolism | Trans-Activators - genetics | Hyperinsulinism - genetics | Insulin - genetics | Lipogenesis | Proto-Oncogene Proteins c-akt - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Gluconeogenesis | Hyperinsulinism - metabolism | Glucose Intolerance - genetics | Signal Transduction | Liver - metabolism | Glucokinase - genetics | Glucose - genetics | Lipid Metabolism | Forkhead Transcription Factors - genetics | Glucokinase - metabolism | Glycogen Synthase Kinase 3 - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Proteins - genetics | Insulin - metabolism | Animals | Proteins - metabolism | Trans-Activators - deficiency | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Glucose - metabolism | Glycolysis | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | Transcription Factors | Glucose metabolism | Hyperglycemia | Glucose | Isoenzymes | Dextrose | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 09/2015, Volume 6, Issue 1, pp. 8261 - 8261
Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation... 
GLUCOSE-HOMEOSTASIS | MESSENGER-RNA | GENE | INITIATION | FATTY LIVER-DISEASE | PROBE LEVEL | MULTIDISCIPLINARY SCIENCES | CELL-PROLIFERATION | DIET-INDUCED OBESITY | PROTEIN-SYNTHESIS | CANCER | Fatty Acids | Fatty Acid Synthases - metabolism | Humans | Hepatocytes - metabolism | RNA, Messenger - metabolism | Mesenchymal Stem Cells | Gene Knockdown Techniques | Glycolysis - genetics | Glycogen - metabolism | Lipogenesis - genetics | Liver - diagnostic imaging | HEK293 Cells | Histone Code | Lipid Metabolism - genetics | CCAAT-Enhancer-Binding Protein-delta - metabolism | Protein Biosynthesis - genetics | Acetylation | Adipogenesis - genetics | Fatty Acid Synthases - genetics | Real-Time Polymerase Chain Reaction | Glucose Tolerance Test | Oxidation-Reduction | CCAAT-Enhancer-Binding Protein-beta - genetics | Electrophoresis, Polyacrylamide Gel | Lactic Acid - metabolism | Liver - metabolism | Gene Expression Regulation | Activating Transcription Factor 4 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | Peptide Initiation Factors - metabolism | Radiography | Peptide Initiation Factors - genetics | Animals | Activating Transcription Factor 4 - metabolism | CCAAT-Enhancer-Binding Protein-delta - genetics | Adipocytes - metabolism | Insulin Resistance - genetics | Glucose - metabolism | Mice | Transcription, Genetic - genetics | 3T3 Cells | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76951 - e76951
Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions to fibrosis and, finally, into cancer. Many etiological factors,... 
TRANSGENIC ZEBRAFISH | HEPATOCELLULAR-CARCINOMA | HEPATITIS-B-VIRUS | TUMOR PROGRESSION | GENE | X-PROTEIN | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | FAMILY KINASES | TP53 MUTATIONS | HUMAN CANCER | Cell Cycle - genetics | Liver - pathology | Humans | Apoptosis - genetics | Tumor Suppressor Protein p53 - genetics | Neoplasm Metastasis | Glycogen - metabolism | Hyperplasia - genetics | Lipogenesis - genetics | Carcinoma, Hepatocellular - genetics | Trans-Activators - genetics | Biomarkers, Tumor - metabolism | Liver Neoplasms - pathology | Gene Expression | Liver Neoplasms - genetics | Animals, Genetically Modified | Liver - metabolism | Carcinogenesis - genetics | Signal Transduction - genetics | Organ Specificity | Zebrafish - genetics | Animals | Zebrafish - metabolism | Carcinoma, Hepatocellular - pathology | Fibrosis | Liver Neoplasms - metabolism | Recombinant Fusion Proteins - genetics | Mutation | Enzyme Activation - genetics | Proliferating Cell Nuclear Antigen - metabolism | src-Family Kinases - genetics | Carcinoma, Hepatocellular - metabolism | Glycogen | Liver | Animal genetic engineering | Development and progression | Glucose metabolism | Liver cancer | Physiological aspects | Genetic aspects | Diagnosis | Tumor proteins | Health aspects | Hepatitis B | Cancer | p53 Protein | Genes | Gene regulation | Hyperplasia | Transgenic | AKT protein | Viruses | Hepatocellular carcinoma | Activation | Myc protein | Kinases | Drug screening | Proteins | Hepatitis | Synergistic effects | Fatty liver | Etiology | Rodents | Cell cycle | Tumorigenesis | Lipid metabolism | Hepatitis B virus | Vascular endothelial growth factor | Protein-tyrosine kinase | Tyrosine | Extracellular signal-regulated kinase | Zebrafish | Gene expression | Metabolism | Molecular chains | Steatosis | Index Medicus
Journal Article