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Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 2762 - 14
Thrombin-derived C-terminal peptides (TCPs) of about 2 kDa are present in wounds, where they exert anti-endotoxic functions. Employing a combination of nuclear... 
HOST-DEFENSE PEPTIDES | NMR STRUCTURES | MOLECULAR-DYNAMICS | PROTEIN | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTOR | OUTER-MEMBRANE-PERMEABILIZATION | FORCE-FIELD | ANTIMICROBIAL PEPTIDES | LIPOPOLYSACCHARIDE LPS | MECHANISTIC-INSIGHTS | Antimicrobial Cationic Peptides - immunology | Humans | Lipopolysaccharides - metabolism | Neutralization Tests | Antimicrobial Cationic Peptides - metabolism | Lipopolysaccharides - immunology | Lipopolysaccharide Receptors - metabolism | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Thrombin - immunology | Lipopolysaccharide Receptors - chemistry | Amino Acid Sequence | Protein Conformation, alpha-Helical | Antimicrobial Cationic Peptides - chemistry | THP-1 Cells | Lipopolysaccharide Receptors - immunology | Leukocyte Elastase - chemistry | Protein Conformation, beta-Strand | Escherichia coli - genetics | Thrombin - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Lipopolysaccharides - chemistry | Thrombin - metabolism | Leukocyte Elastase - immunology | Nuclear magnetic resonance--NMR | Complex formation | Antiinflammatory agents | Peptides | Thrombin | Mass spectroscopy | Inflammation | Hydrophobicity | Endotoxin shock | CD14 antigen | Molecular chains | Lipopolysaccharides | Magnetic resonance spectroscopy | Sepsis | Elastase | Mass spectrometry | Conformation | Biofysiks | Biological Sciences | Biologi | Naturvetenskap | Natural Sciences | Biophysics
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 8, pp. e0202664 - 24
Escherichia coli is one of the major pathogens causing mastitis in dairy cattle. Yet, the factors which mediate the ability for E. coli to develop in the... 
SIGNALING PATHWAYS | COMPLEMENT FRAGMENT C5A | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | BOVINE MASTITIS | STAPHYLOCOCCUS-AUREUS | POLYACRYLAMIDE GELS | REDUCES SEVERITY | INTRAMAMMARY INFECTIONS | KAPPA-B | INFLAMMATORY CYTOKINES | Epithelial Cells - metabolism | Milk - microbiology | O Antigens - metabolism | Humans | Lipopolysaccharides - metabolism | Recombinant Proteins - biosynthesis | Lipopolysaccharides - immunology | Lipopolysaccharide Receptors - metabolism | Mastitis, Bovine - pathology | Cattle | DNA Transposable Elements - genetics | Escherichia coli - metabolism | HEK293 Cells | Female | Escherichia coli - growth & development | Mastitis, Bovine - immunology | Epithelial Cells - cytology | O Antigens - chemistry | Lipopolysaccharide Receptors - chemistry | Cell Line | Cytokines - metabolism | Recombinant Proteins - chemistry | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mastitis, Bovine - microbiology | Animals | Mutagenesis | Escherichia coli - isolation & purification | Milk - metabolism | Lipopolysaccharides - analysis | Lipopolysaccharide Receptors - genetics | Chemokines - metabolism | Bacterial antigens | Epithelial cells | Escherichia coli | Dairy cattle | Genetic aspects | Research | Lipopolysaccharides | Lipids | Inflammatory response | Biosynthesis | Infections | CD14 antigen | Polysaccharides | E coli | Bacteria | Tumor necrosis factor-TNF | Gram-negative bacteria | Mammary gland | Udder | Milk | Antigens | Mastitis | Bacterial infections | Neutrophils | Mammary glands | Inflammation | Yang, Cindy | Biological activity | Mutants | Hypotheses | Colonization | Life Sciences | Microbiology and Parasitology
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 545, Issue 7654, pp. 305 - 310
Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no effective medical therapies yet exist. CCMs arise from the loss of an... 
BACTERIA | ANGIOGENESIS | MEKK3 | DISEASE | RECEPTOR | COMMUNITIES | PROTEINS | ENDOGENOUS LIGANDS | EXPRESSION | LPS | INTERFACE | STABILITY | MULTIDISCIPLINARY SCIENCES | GENES | LIPOPOLYSACCHARIDE | HOST | INSIGHTS | Injections, Intravenous | Humans | Lipopolysaccharides - administration & dosage | Male | Hemangioma, Cavernous, Central Nervous System - immunology | Gram-Negative Bacteria - immunology | Lipopolysaccharides - immunology | Lipopolysaccharide Receptors - metabolism | Toll-Like Receptor 4 - deficiency | Female | Toll-Like Receptor 4 - antagonists & inhibitors | Disease Susceptibility | Hemangioma, Cavernous, Central Nervous System - microbiology | Signal Transduction | Endothelial Cells - metabolism | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Immunity, Innate | Animals | Hemangioma, Cavernous, Central Nervous System - pathology | Germ-Free Life | Lipopolysaccharide Receptors - genetics | Anti-Bacterial Agents - pharmacology | Mice | Gastrointestinal Microbiome - immunology | Anti-Bacterial Agents - administration & dosage | Toll-like receptors | Physiological aspects | Health aspects | Hemangioma, Cavernous | Brain | Stroke | Gnotobiotics | Pathogenesis | Pharmacology | TLR4 protein | Gene expression | CD14 antigen | Endothelial cells | Proteins | Signal transduction | Signaling | Stimulants | Antibiotics | Bacteria | Gram-negative bacteria | Lung Kruppel-like factor | Brain diseases | Immune system | Index Medicus
Journal Article
Atherosclerosis, ISSN 0021-9150, 2013, Volume 229, Issue 2, pp. 356 - 362
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 2, pp. 1174 - 1182
In the current study, we examined the role of CD14 in regulating LPS activation of corneal epithelial cells and Pseudomonas aeruginosa corneal infection. Our... 
CORNEAL INFLAMMATION | EXOENZYME-S | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | HOST-DEFENSE | KERATITIS | MICE | INFECTION | INDEPENDENT PATHWAYS | LIPOPOLYSACCHARIDE LPS | TERMINAL KINASE | Pseudomonas aeruginosa - immunology | Epithelial Cells - metabolism | Interferon-beta - immunology | Protein-Tyrosine Kinases - metabolism | Humans | Cornea - immunology | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Pseudomonas aeruginosa - physiology | Lipopolysaccharides - immunology | Protein-Tyrosine Kinases - immunology | Host-Pathogen Interactions - immunology | Lipopolysaccharide Receptors - metabolism | Cornea - cytology | Chemokine CCL5 - metabolism | Phosphorylation - immunology | Phosphorylation - drug effects | Syk Kinase | Neutrophil Infiltration - drug effects | Endocytosis - immunology | Interferon Regulatory Factor-3 - immunology | Neutrophil Infiltration - immunology | Cornea - microbiology | Cell Line | Endocytosis - drug effects | Mice, Inbred C57BL | Cells, Cultured | Lipopolysaccharide Receptors - immunology | Toll-Like Receptor 4 - immunology | Pseudomonas Infections - microbiology | Toll-Like Receptor 4 - metabolism | Blotting, Western | Mice, Knockout | Pseudomonas Infections - immunology | Animals | Interferon-beta - metabolism | Epithelial Cells - immunology | Epithelial Cells - microbiology | Lipopolysaccharides - pharmacology | Interferon Regulatory Factor-3 - metabolism | Lipopolysaccharide Receptors - genetics | Mice | Chemokine CCL5 - immunology | Cornea | Immunology | Toll-like Receptors (TLRs) | Epithelial Cell | Pseudomonas aeruginosa | Inflammation | Neutrophil | Lipopolysaccharide (LPS)
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2017, Volume 47, Issue 4, pp. 697 - 709.e3
A heterogeneous mixture of lipids called oxPAPC, derived from dying cells, can hyperactivate dendritic cells (DCs) but not macrophages. Hyperactive DCs are... 
hyperactivation | macrophages | interleukin-1 | dendritic cells | Toll-like Receptor | innate immunity | inflammasome | oxPAPC | SMOC | DANGER | ACTIVATION | BACTERIA | IMMUNE-SYSTEM | MURINE MACROPHAGES | LIPOPOLYSACCHARIDE | MICE | INTRACELLULAR LPS | IMMUNOLOGY | ENDOCYTOSIS | ENDOTOXIC-SHOCK | Phosphatidylcholines - immunology | Inflammasomes - metabolism | Dendritic Cells - immunology | Humans | Phosphatidylcholines - metabolism | Lipopolysaccharide Receptors - metabolism | Flow Cytometry | HEK293 Cells | Interleukin-1 - immunology | Female | Adaptive Immunity - immunology | Dendritic Cells - metabolism | Macrophages - immunology | Endocytosis - immunology | Cell Line | Interleukin-1 - metabolism | Endocytosis - drug effects | Mice, Inbred C57BL | Lipopolysaccharide Receptors - immunology | Phagocytes - metabolism | Cell Survival - immunology | Phagocytes - immunology | Blotting, Western | Mice, Knockout | Macrophages - metabolism | Animals | Inflammasomes - immunology | Lipopolysaccharides - pharmacology | Lipopolysaccharide Receptors - genetics | Lipids | Interleukins | Dendritic cells | Macrophages | Immunotherapy | Analysis | Mitogens | Antigens | Animal models | Interleukin | Inflammation | Lethality | Adaptive immunity | Gene expression | CD14 antigen | Immunity | Aptitude | Signal transduction | Phagocytes | Cell fate | Rodents | Interleukin 1 | Bacteria | Sepsis | Ligands | Immune system
Journal Article
Journal Article