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Journal of Perinatology, ISSN 0743-8346, 10/2013, Volume 33, Issue 10, pp. 772 - 777
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 539 - 550
In contrast to microbially triggered inflammation, mechanisms promoting sterile inflammation remain poorly understood. Damage-associated molecular patterns... 
MEDICINE, RESEARCH & EXPERIMENTAL | DANGER SIGNALS | STERILE INFLAMMATION | CHROMATIN PROTEIN HMGB1 | IN-VIVO | SEPTIC SHOCK | MOBILITY GROUP BOX-1 | RECEPTOR | DEFICIENT MICE | CELL-DEATH | TRANSGENIC MICE | Acetaminophen - adverse effects | Inflammation - chemically induced | Leukocyte Elastase - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Tumor Necrosis Factor-alpha - genetics | Analgesics, Non-Narcotic - pharmacology | Hepatocytes - pathology | Hepatocytes - metabolism | Neutrophil Infiltration | fas Receptor - metabolism | Necrosis - pathology | HMGB1 Protein - genetics | Shock, Septic - metabolism | Inflammation - metabolism | Acetaminophen - pharmacology | Analgesics, Non-Narcotic - adverse effects | HMGB1 Protein - metabolism | fas Receptor - genetics | Chemical and Drug Induced Liver Injury - pathology | Neutrophils - metabolism | Receptor for Advanced Glycation End Products | Neutrophils - pathology | Shock, Septic - genetics | Shock, Septic - pathology | Lipopolysaccharides - toxicity | Macrophages - pathology | Shock, Septic - chemically induced | Leukocyte Elastase - genetics | Necrosis - metabolism | Chemical and Drug Induced Liver Injury - genetics | Mice, Knockout | Necrosis - chemically induced | Macrophages - metabolism | Animals | Chemical and Drug Induced Liver Injury - metabolism | Inflammation - genetics | Mice | Necrosis - genetics | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Physiological aspects | Causes of | Inflammation | Genetic aspects | Cell death | Necrosis | Chromosomal proteins | Mass spectrometry | Analysis | Proteins | Studies | Rodents | Mortality | Gangrene | Homeostasis | Mitochondrial DNA | Laboratory animals | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Blood, ISSN 0006-4971, 09/2011, Volume 118, Issue 12, pp. e50 - e61
Monocytes are a heterogeneous cell population with subset-specific functions and phenotypes. The differential expression of CD14 and CD16 distinguishes... 
CD16(+) MONOCYTES | SUBPOPULATIONS | HUMAN PERIPHERAL-BLOOD | DIALYSIS PATIENTS | DISEASE | GENE-EXPRESSION PROFILES | INFECTION | ANGIOPOIETIN-2 | IDENTIFICATION | HEMATOLOGY | PREFERENTIALLY HARBORS HIV-1 | Cell Proliferation | Monocytes - cytology | Atherosclerosis - genetics | Humans | RNA, Messenger - analysis | Monocytes - metabolism | Monocytes - immunology | Lipopolysaccharide Receptors - metabolism | HIV Infections - immunology | RNA, Messenger - biosynthesis | Inflammation - metabolism | Flow Cytometry | HIV-1 - physiology | Neovascularization, Pathologic - immunology | Monocytes - classification | Expressed Sequence Tags | Atherosclerosis - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Neovascularization, Physiologic - genetics | HIV Infections - genetics | HIV Infections - virology | Antigen Presentation - genetics | Gene Expression Profiling - methods | Lipopolysaccharide Receptors - immunology | Inflammation - immunology | Antigen Presentation - immunology | Neovascularization, Physiologic - immunology | Atherosclerosis - metabolism | HIV-1 - immunology | Inflammation - genetics | Lipopolysaccharide Receptors - genetics | Neovascularization, Pathologic - genetics | High-Throughput Nucleotide Sequencing | Immunity - genetics | HIV Infections - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/2015, Volume 34, Issue 7, pp. 925 - 939
The development and function of B lymphocytes is regulated by numerous signaling pathways, some emanating from the B‐cell antigen receptor ( BCR ). The spleen... 
BAFF | CD | 2 | receptor | T | Syk | B‐cell antigen receptor | 19 | mb1‐Cre | ER | BAFF receptor | mb1-CreER T 2 | B-cell antigen receptor | CD19 | LYN | ACTIVATION | mb1-CreER(T2) | MARGINAL ZONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE KINASE | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | RECOMBINASE ACTIVITY | IN-VIVO | DIFFERENTIATION | NF-KAPPA-B | ANTIGEN RECEPTOR | Antigens, CD - immunology | CD40 Antigens - antagonists & inhibitors | Cell Survival - genetics | Intracellular Signaling Peptides and Proteins - immunology | Antigens, CD19 - genetics | Antigens, CD - genetics | Phosphatidylinositol 3-Kinases - immunology | Protein-Tyrosine Kinases - immunology | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | ADP-ribosyl Cyclase 1 - immunology | CD40 Antigens - genetics | Interleukin-4 - genetics | Membrane Glycoproteins - immunology | B-Cell Activation Factor Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Antigens, CD19 - immunology | B-Cell Activation Factor Receptor - immunology | B-Lymphocytes - cytology | Interleukin-4 - antagonists & inhibitors | ADP-ribosyl Cyclase 1 - genetics | Signal Transduction - genetics | Cell Survival - immunology | Receptors, Antigen, B-Cell - immunology | Membrane Glycoproteins - genetics | Mice, Knockout | Antibodies - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Interleukin-4 - immunology | Animals | B-Lymphocytes - immunology | Lipopolysaccharides - pharmacology | Receptors, Antigen, B-Cell - genetics | Mice | Oligodeoxyribonucleotides - pharmacology | CD40 Antigens - immunology | Lymphocyte receptors | T cell receptors | Kinases | Immune system | Index Medicus | mb1-CreERT2
Journal Article
The Journal of Immunology, ISSN 0022-1767, 04/2003, Volume 170, Issue 8, pp. 3977 - 3985
Pattern recognition receptors (PRRs), which include the Toll-like receptors (TLRs), are involved in the innate immune response to infection. TLR4 is a model... 
DEXTRAN SULFATE SODIUM | KAPPA-B ACTIVATION | SIGNALING PATHWAYS | COLITIS | LIPOPOLYSACCHARIDE | INNATE IMMUNE-SYSTEM | MICE | IMMUNOLOGY | EXPRESSION | INTESTINAL EPITHELIAL-CELLS | CUTTING EDGE | Toll-Like Receptor 2 | Intestinal Mucosa - metabolism | Toll-Like Receptor 4 | Membrane Glycoproteins - metabolism | Membrane Glycoproteins - biosynthesis | Antigens, Ly - genetics | Colitis - pathology | Colon - immunology | Male | Lipopolysaccharide Receptors - metabolism | Intestinal Mucosa - cytology | Toll-Like Receptors | Receptors, Immunologic - biosynthesis | Antigens, Ly - biosynthesis | Intestinal Mucosa - immunology | Colitis - chemically induced | Antigens, Differentiation - metabolism | Antigens, Ly - metabolism | Models, Animal | Receptors, Cell Surface - biosynthesis | Lymphocyte Antigen 96 | Colitis - immunology | Disease Models, Animal | Lipopolysaccharide Receptors - biosynthesis | Colon - pathology | Gene Expression Regulation - immunology | Receptors, Cell Surface - metabolism | Up-Regulation - genetics | Myeloid Differentiation Factor 88 | Reverse Transcriptase Polymerase Chain Reaction | Colon - metabolism | Dextran Sulfate - toxicity | Macromolecular Substances | Membrane Glycoproteins - genetics | Adaptor Proteins, Signal Transducing | Antigens, Differentiation - biosynthesis | Blotting, Northern | Animals | Up-Regulation - immunology | Lipopolysaccharide Receptors - genetics | Antigens, Differentiation - genetics | Mice | Mice, Inbred BALB C | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Intestinal Mucosa - pathology | Receptors, Cell Surface - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Blood, ISSN 0006-4971, 07/2017, Volume 130, Issue 2, pp. 167 - 175
Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are rare histiocytic disorders induced by somatic mutation of MAPK pathway genes.... 
MANAGEMENT | DENDRITIC CELLS | NEOPLASMS | DISTINCT | MONOCYTES | SUBSETS | NOTCH | MUTATIONS | MATURATION | HEMATOLOGY | BLOOD | Antigens, CD - immunology | Dendritic Cells - immunology | Histiocytosis, Langerhans-Cell - diagnosis | Histiocytosis, Langerhans-Cell - genetics | Humans | Lectins, C-Type - immunology | Dendritic Cells - pathology | Hematopoietic Stem Cells - pathology | Erdheim-Chester Disease - immunology | Male | Receptors, Notch - genetics | Monocytes - immunology | Lectins, C-Type - genetics | Antigens, CD - genetics | Hematopoietic Stem Cells - immunology | Histiocytosis, Langerhans-Cell - pathology | Bone Marrow Cells - immunology | Monocytes - pathology | Adult | Female | Cell Differentiation | Foam Cells - pathology | Glycoproteins - genetics | Transforming Growth Factor beta - immunology | Antigens, CD1 - immunology | Diagnosis, Differential | Erdheim-Chester Disease - genetics | Gene Expression | Bone Marrow Cells - pathology | Immunophenotyping | Lipopolysaccharide Receptors - immunology | Histiocytosis, Langerhans-Cell - immunology | Erdheim-Chester Disease - pathology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Glycoproteins - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Mannose-Binding Lectins - genetics | Mannose-Binding Lectins - immunology | Transforming Growth Factor beta - genetics | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins B-raf - immunology | Alleles | Erdheim-Chester Disease - diagnosis | Lipopolysaccharide Receptors - genetics | Foam Cells - immunology | Antigens, CD1 - genetics | Mutation | Receptors, Notch - immunology | Index Medicus | Abridged Index Medicus | Myeloid Neoplasia
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24748 - 24759
The generation of reactive oxygen species is a central feature of inflammation that results in the oxidation of host phospholipids. Oxidized phospholipids,... 
ACTIVATION | ESCHERICHIA-COLI LIPOPOLYSACCHARIDE | INDUCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID RAFTS | ENDOTHELIAL-CELLS | LOW-DENSITY-LIPOPROTEIN | HEME OXYGENASE-1 | MONOCYTE CHEMOTACTIC PROTEIN-1 | OXIDATION-PRODUCTS | T-LYMPHOCYTES | Phosphatidylcholines - immunology | Reactive Oxygen Species - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lymphocyte Antigen 96 - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Macrophages, Peritoneal - cytology | Flagellin - pharmacology | Lymphocyte Antigen 96 - agonists | Oxidation-Reduction - drug effects | Tumor Necrosis Factor-alpha - immunology | Toll-Like Receptor 4 - agonists | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Carrier Proteins - immunology | Guanosine - analogs & derivatives | Poly I-C - pharmacology | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | I-kappa B Kinase - immunology | Mice | Mice, Inbred BALB C | Macrophages, Peritoneal - metabolism | Oligodeoxyribonucleotides - pharmacology | Immunologic Factors - pharmacology | Lymphocyte Antigen 96 - immunology | Tumor Necrosis Factor-alpha - metabolism | Toll-Like Receptor 2 - agonists | Acute-Phase Proteins - genetics | Lipopolysaccharide Receptors - metabolism | Lymphocyte Antigen 96 - genetics | Carrier Proteins - agonists | I-kappa B Kinase - metabolism | Reactive Oxygen Species - immunology | Female | Membrane Glycoproteins - immunology | Cell Line | Acute-Phase Proteins - metabolism | Phosphatidylcholines - pharmacology | Membrane Glycoproteins - agonists | p38 Mitogen-Activated Protein Kinases - genetics | I-kappa B Kinase - genetics | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Phosphatidylcholines - genetics | Animals | Carrier Proteins - metabolism | RNA - pharmacology | Guanosine - pharmacology | Lipopolysaccharide Receptors - genetics | Signal Transduction - physiology | Acute-Phase Proteins - agonists | Acute-Phase Proteins - immunology | Index Medicus | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling
Journal Article
Human Immunology, ISSN 0198-8859, 2014, Volume 75, Issue 8, pp. 808 - 815
Abstract Background Gastric cancer (GC) is a progressive process initiated by Helicobacter pylori -induced inflammation. Initial recognition of H. pylori... 
Allergy and Immunology | Toll-like receptors | Helicobacter pylori | Stomach neoplasms | Polymorphism | VARIANTS | SUSCEPTIBILITY | RISK | SINGLE-NUCLEOTIDE POLYMORPHISM | IMMUNOLOGY | INFLAMMATION | TLR4 GENE | ZETA-CHAIN | PROMOTER | EXPRESSION | T-CELLS | Toll-Like Receptor 2 - genetics | Humans | Middle Aged | Receptors, Interleukin-1 - genetics | Helicobacter Infections - complications | Male | Acute-Phase Proteins - genetics | Case-Control Studies | Lymphocyte Antigen 96 - genetics | China | Female | Membrane Glycoproteins - immunology | Carrier Proteins - immunology | Stomach Neoplasms - genetics | Gene Expression | Genetic Predisposition to Disease | Stomach Neoplasms - complications | Signal Transduction | Receptors, Interleukin-1 - immunology | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | Helicobacter Infections - immunology | Toll-Like Receptor 4 - immunology | Helicobacter Infections - genetics | Membrane Glycoproteins - genetics | Polymorphism, Genetic | Stomach Neoplasms - immunology | Stomach Neoplasms - microbiology | Carrier Proteins - genetics | Lipopolysaccharide Receptors - genetics | Toll-Like Receptor 2 - immunology | Aged | Helicobacter pylori - physiology | Lymphocyte Antigen 96 - immunology | Acute-Phase Proteins - immunology | Helicobacter Infections - microbiology | Helicobacter infections | Genetic aspects | Health aspects | Stomach cancer | Genetic polymorphisms | Cancer | Index Medicus
Journal Article
Placenta, ISSN 0143-4004, 2008, Volume 29, Issue 3, pp. 274 - 281
Abstract Obesity and pregnancy are associated with a combination of insulin resistance and inflammatory changes which exacerbate in combination. Based on the... 
Internal Medicine | Obstetrics and Gynecology | Pregnancy | Obesity | Placenta | Cytokines | Fetus | Inflammation | Macrophages | MATERNAL OBESITY | HOFBAUER CELLS | pregnancy | LONGITUDINAL CHANGES | GESTATIONAL DIABETES-MELLITUS | NECROSIS-FACTOR-ALPHA | DEVELOPMENTAL BIOLOGY | BODY-COMPOSITION | OBSTETRICS & GYNECOLOGY | macrophages | REPRODUCTIVE BIOLOGY | inflammation | INSULIN-RESISTANCE | placenta | cytokines | TNF-ALPHA | obesity | fetus | GLUCOSE-TOLERANCE | ADIPOSE-TISSUE | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Leukocytes, Mononuclear - metabolism | Pregnancy Complications - blood | Membrane Glycoproteins - metabolism | Receptors, G-Protein-Coupled - metabolism | Obesity - immunology | Cell Count | Humans | Tumor Necrosis Factor-alpha - genetics | Antigens, CD - genetics | Obesity - blood | Antigens, CD - metabolism | Lipopolysaccharide Receptors - metabolism | Inflammation - complications | Placenta - cytology | Mucins - metabolism | Adult | Female | Pregnancy Complications - metabolism | Interleukin-6 - metabolism | Interleukin-6 - genetics | Placenta - immunology | Obesity - complications | Cells, Cultured | Macrophages - cytology | Fetal Blood - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Membrane Glycoproteins - genetics | Obesity - metabolism | Macrophages - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Placenta - pathology | Lipopolysaccharide Receptors - genetics | Receptors, G-Protein-Coupled - genetics | Mucins - genetics | Pregnancy Complications - immunology | Pregnant women | Index Medicus | programming
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 30, pp. 26487 - 26495
Dendritic cells (DCs) and macrophages (MFs) are important multifunctional immune cells. Like other cell types, they express hundreds of different microRNAs... 
MESSENGER-RNA DEGRADATION | TARGET | ACTIVATION | IMMUNE-SYSTEM | IMMUNOTHERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | DIFFERENTIATION | TRANSLATION | PROTEIN-SYNTHESIS | CANCER | Cell Adhesion Molecules - genetics | B7-1 Antigen - genetics | Toll-Like Receptor 4 - biosynthesis | Monocytes - cytology | Dendritic Cells - immunology | Humans | Lectins, C-Type - immunology | MicroRNAs - metabolism | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Cell Adhesion Molecules - immunology | Lectins, C-Type - genetics | Gene Knockdown Techniques | Lipopolysaccharide Receptors - metabolism | Lectins, C-Type - metabolism | Ribonuclease III - immunology | HEK293 Cells | DEAD-box RNA Helicases - metabolism | Cell Differentiation - physiology | Dendritic Cells - metabolism | Macrophages - immunology | Ribonuclease III - genetics | Ribonuclease III - metabolism | B7-1 Antigen - immunology | Gene Expression Regulation - physiology | Receptors, Cell Surface - metabolism | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | MicroRNAs - biosynthesis | B7-1 Antigen - metabolism | Toll-Like Receptor 4 - immunology | Macrophages - cytology | MicroRNAs - immunology | Cell Adhesion Molecules - metabolism | Receptors, Cell Surface - immunology | DEAD-box RNA Helicases - genetics | Macrophages - metabolism | DEAD-box RNA Helicases - immunology | Lipopolysaccharide Receptors - genetics | Dendritic Cells - cytology | MicroRNAs - genetics | Receptors, Cell Surface - genetics | Index Medicus | Toll-like Receptors (TLR) | Gene Expression | Immunology | Dendritic Cells | MicroRNA | CD80 | Microarray | Mannose Receptor
Journal Article