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Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 2762 - 14
Thrombin-derived C-terminal peptides (TCPs) of about 2 kDa are present in wounds, where they exert anti-endotoxic functions. Employing a combination of nuclear... 
HOST-DEFENSE PEPTIDES | NMR STRUCTURES | MOLECULAR-DYNAMICS | PROTEIN | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTOR | OUTER-MEMBRANE-PERMEABILIZATION | FORCE-FIELD | ANTIMICROBIAL PEPTIDES | LIPOPOLYSACCHARIDE LPS | MECHANISTIC-INSIGHTS | Antimicrobial Cationic Peptides - immunology | Humans | Lipopolysaccharides - metabolism | Neutralization Tests | Antimicrobial Cationic Peptides - metabolism | Lipopolysaccharides - immunology | Lipopolysaccharide Receptors - metabolism | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Thrombin - immunology | Lipopolysaccharide Receptors - chemistry | Amino Acid Sequence | Protein Conformation, alpha-Helical | Antimicrobial Cationic Peptides - chemistry | THP-1 Cells | Lipopolysaccharide Receptors - immunology | Leukocyte Elastase - chemistry | Protein Conformation, beta-Strand | Escherichia coli - genetics | Thrombin - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Lipopolysaccharides - chemistry | Thrombin - metabolism | Leukocyte Elastase - immunology | Nuclear magnetic resonance--NMR | Complex formation | Antiinflammatory agents | Peptides | Thrombin | Mass spectroscopy | Inflammation | Hydrophobicity | Endotoxin shock | CD14 antigen | Molecular chains | Lipopolysaccharides | Magnetic resonance spectroscopy | Sepsis | Elastase | Mass spectrometry | Conformation | Biofysiks | Biological Sciences | Biologi | Naturvetenskap | Natural Sciences | Biophysics
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 8, pp. e0202664 - 24
Escherichia coli is one of the major pathogens causing mastitis in dairy cattle. Yet, the factors which mediate the ability for E. coli to develop in the... 
SIGNALING PATHWAYS | COMPLEMENT FRAGMENT C5A | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | BOVINE MASTITIS | STAPHYLOCOCCUS-AUREUS | POLYACRYLAMIDE GELS | REDUCES SEVERITY | INTRAMAMMARY INFECTIONS | KAPPA-B | INFLAMMATORY CYTOKINES | Epithelial Cells - metabolism | Milk - microbiology | O Antigens - metabolism | Humans | Lipopolysaccharides - metabolism | Recombinant Proteins - biosynthesis | Lipopolysaccharides - immunology | Lipopolysaccharide Receptors - metabolism | Mastitis, Bovine - pathology | Cattle | DNA Transposable Elements - genetics | Escherichia coli - metabolism | HEK293 Cells | Female | Escherichia coli - growth & development | Mastitis, Bovine - immunology | Epithelial Cells - cytology | O Antigens - chemistry | Lipopolysaccharide Receptors - chemistry | Cell Line | Cytokines - metabolism | Recombinant Proteins - chemistry | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mastitis, Bovine - microbiology | Animals | Mutagenesis | Escherichia coli - isolation & purification | Milk - metabolism | Lipopolysaccharides - analysis | Lipopolysaccharide Receptors - genetics | Chemokines - metabolism | Bacterial antigens | Epithelial cells | Escherichia coli | Dairy cattle | Genetic aspects | Research | Lipopolysaccharides | Lipids | Inflammatory response | Biosynthesis | Infections | CD14 antigen | Polysaccharides | E coli | Bacteria | Tumor necrosis factor-TNF | Gram-negative bacteria | Mammary gland | Udder | Milk | Antigens | Mastitis | Bacterial infections | Neutrophils | Mammary glands | Inflammation | Yang, Cindy | Biological activity | Mutants | Hypotheses | Colonization | Life Sciences | Microbiology and Parasitology
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 545, Issue 7654, pp. 305 - 310
Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no effective medical therapies yet exist. CCMs arise from the loss of an... 
BACTERIA | ANGIOGENESIS | MEKK3 | DISEASE | RECEPTOR | COMMUNITIES | PROTEINS | ENDOGENOUS LIGANDS | EXPRESSION | LPS | INTERFACE | STABILITY | MULTIDISCIPLINARY SCIENCES | GENES | LIPOPOLYSACCHARIDE | HOST | INSIGHTS | Injections, Intravenous | Humans | Lipopolysaccharides - administration & dosage | Male | Hemangioma, Cavernous, Central Nervous System - immunology | Gram-Negative Bacteria - immunology | Lipopolysaccharides - immunology | Lipopolysaccharide Receptors - metabolism | Toll-Like Receptor 4 - deficiency | Female | Toll-Like Receptor 4 - antagonists & inhibitors | Disease Susceptibility | Hemangioma, Cavernous, Central Nervous System - microbiology | Signal Transduction | Endothelial Cells - metabolism | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Immunity, Innate | Animals | Hemangioma, Cavernous, Central Nervous System - pathology | Germ-Free Life | Lipopolysaccharide Receptors - genetics | Anti-Bacterial Agents - pharmacology | Mice | Gastrointestinal Microbiome - immunology | Anti-Bacterial Agents - administration & dosage | Toll-like receptors | Physiological aspects | Health aspects | Hemangioma, Cavernous | Brain | Stroke | Gnotobiotics | Pathogenesis | Pharmacology | TLR4 protein | Gene expression | CD14 antigen | Endothelial cells | Proteins | Signal transduction | Signaling | Stimulants | Antibiotics | Bacteria | Gram-negative bacteria | Lung Kruppel-like factor | Brain diseases | Immune system | Index Medicus
Journal Article
Innate immunity, ISSN 1743-4267, 2008
Journal
Journal
Journal Article
Journal Article
Atherosclerosis, ISSN 0021-9150, 2013, Volume 229, Issue 2, pp. 356 - 362
Journal Article
Marine Drugs, ISSN 1660-3397, 07/2017, Volume 15, Issue 7, p. 201
The structural characterization of the lipopolysaccharide (LPS) from extremophiles has important implications in several biomedical and therapeutic... 
Core oligosaccharide | Extremophiles | Halophiles | Halobacteroides | Innate immunity | Lipid A | Deep-sea hypersaline anoxic basins (DHABs) | Lipopolysaccharide (LPS) | lipopolysaccharide (LPS) | ACTIVATION | CHEMISTRY, MEDICINAL | RECOGNITION | halophiles | deep-sea hypersaline anoxic basins (DHABs) | lipid A | OLIGOSACCHARIDE | STRUCTURE ELUCIDATION | innate immunity | ABSOLUTE-CONFIGURATION | extremophiles | LIPID-A | KDO | BACTERIAL LIPOPOLYSACCHARIDES | SPECTRA | core oligosaccharide | Cell Line | Seawater - microbiology | Gram-Negative Anaerobic Bacteria - isolation & purification | Immunity, Innate - drug effects | Magnetic Resonance Spectroscopy | Humans | Mice, Inbred C57BL | Extremophiles - chemistry | Escherichia coli - chemistry | Animals | Lipopolysaccharides - pharmacology | Female | Lipopolysaccharides - chemistry | Mice | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Lipopolysaccharides - isolation & purification | Gram-Negative Anaerobic Bacteria - chemistry | Extremophiles - isolation & purification | Deep sea | Anoxia | Chemical analysis | Therapeutic applications | Analytical techniques | Ions | Mass spectroscopy | Desorption | Deep water | Immunity | Deep sea environments | Anoxic basins | Lipopolysaccharides | Magnetic resonance spectroscopy | Organic chemistry | Immunology | E coli | Ionization | Lasers | Biocompatibility | NMR spectroscopy | Mass spectrometry | Structural analysis | Index Medicus
Journal Article