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The Journal of Immunology, ISSN 0022-1767, 01/2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 03/2013, Volume 309, Issue 11, pp. 1154 - 1162
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7450, pp. 498 - 502
.... Here we report that therapeutic administration of Eritoran (also known as E5564)-a potent, well-tolerated, synthetic TLR4 antagonist(3,4... 
UNITED-STATES | 1918 SPANISH INFLUENZA | ACTIVATION | VIRUS | ENDOTOXIN ANTAGONIST | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | LIPOPOLYSACCHARIDE | INHIBITORS | TETRASODIUM E5564 | SEVERE SEPSIS | Disaccharides - metabolism | Lymphocyte Antigen 96 - metabolism | Lipopolysaccharide Receptors - metabolism | Disaccharides - pharmacology | Sugar Phosphates - pharmacology | Time Factors | Acute Lung Injury - prevention & control | Female | Acute Lung Injury - drug therapy | Disaccharides - therapeutic use | Toll-Like Receptor 4 - antagonists & inhibitors | Cytokines - genetics | Orthomyxoviridae Infections - drug therapy | Cytokines - immunology | Antiviral Agents - pharmacology | Sugar Phosphates - therapeutic use | Antiviral Agents - therapeutic use | Mice, Inbred C57BL | Orthomyxoviridae Infections - pathology | Influenza A Virus, H1N1 Subtype - pathogenicity | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Influenza A Virus, H1N1 Subtype - drug effects | Acute Lung Injury - pathology | Animals | Sugar Phosphates - metabolism | Survival Analysis | Toll-Like Receptor 2 - immunology | Ligands | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Acute Lung Injury - complications | Prevention | Toll-like receptors | Health aspects | Influenza | Pathology | Cell culture | Respiratory distress syndrome | Cytokines | Mortality | Rodents | Sepsis | Infections | Gene expression | Drug dosages
Journal Article
British journal of nutrition, ISSN 0007-1145, 04/2014, Volume 111, Issue 7, pp. 1221 - 1230
Several reports have indicated that dietary intake of DHA is associated with lower prevalence of periodontitis. In the present study, we investigated the... 
Full Papers | Nutritional Immunology | Lipopolysaccharide | Proinflammatory mediators | Prevotella intermedia | DHA | INFLAMMATORY DISEASES | ACTIVE RHEUMATOID-ARTHRITIS | PORPHYROMONAS-GINGIVALIS | GINGIVAL CREVICULAR FLUID | ACTINOBACILLUS-ACTINOMYCETEMCOMITANS | NUTRITION & DIETETICS | NITRIC-OXIDE PRODUCTION | POLYUNSATURATED FATTY-ACIDS | STIMULATES RELEASE | DESTRUCTIVE PERIODONTAL-DISEASE | NF-KAPPA-B | Dietary Fats - metabolism | Heme Oxygenase-1 - metabolism | Interleukin-6 - antagonists & inhibitors | Periodontitis - microbiology | Protoporphyrins - pharmacology | NF-kappa B - metabolism | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Metalloporphyrins - pharmacology | Periodontitis - metabolism | Heme Oxygenase-1 - genetics | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Docosahexaenoic Acids - antagonists & inhibitors | Interleukin-1beta - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Inflammation Mediators - metabolism | Inflammation Mediators - antagonists & inhibitors | Membrane Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Interleukin-6 - metabolism | Macrophages - immunology | Interleukin-1beta - antagonists & inhibitors | NF-kappa B - antagonists & inhibitors | Lipopolysaccharides - toxicity | Periodontitis - immunology | Interleukin-6 - genetics | Membrane Proteins - genetics | Nitric Oxide - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Dietary Fats - antagonists & inhibitors | Heme Oxygenase-1 - antagonists & inhibitors | Membrane Proteins - agonists | Periodontitis - prevention & control | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | MAP Kinase Signaling System - drug effects | Membrane Proteins - antagonists & inhibitors | Nitric Oxide Synthase Type II - genetics | Prevotella intermedia - metabolism | Macrophages - drug effects | Mice | Lipopolysaccharides - isolation & purification | Macrophage Activation - drug effects | Nitric Oxide - metabolism | Cell Line, Transformed | Docosahexaenoic Acids - metabolism | Nitric Oxide Synthase Type II - metabolism | Pathogens | Immunology | Nutrition | Gum disease | Fatty acids | Rodents
Journal Article
by Park, SE and Sapkota, K and Kim, S and Kim, H and Kim, SJ
British Journal of Pharmacology, ISSN 0007-1188, 10/2011, Volume 164, Issue 3, pp. 1008 - 1025
BACKGROUND AND PURPOSE Kaempferol, a dietary flavonoid and phyto‐oestrogen, is known to have anti‐inflammatory properties. Microglial activation has been... 
mitogen‐activated protein kinases | NF‐κB | kaempferol | neuroinflammation | AKT | lipopolysaccharide | microglia | NF-κB | mitogen-activated protein kinases | NITRIC-OXIDE SYNTHASE | ALZHEIMERS-DISEASE | NEURODEGENERATIVE DISEASES | MATRIX METALLOPROTEINASES | NF-kappa B | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | NF-KAPPA-B | INNATE IMMUNITY | PARKINSONS-DISEASE | Microglia - metabolism | Reactive Oxygen Species - metabolism | Dinoprostone - biosynthesis | NF-kappa B - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Cyclooxygenase 2 - genetics | Nitric Oxide Synthase Type II - antagonists & inhibitors | Protein Binding - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Toll-Like Receptor 4 - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Survival - drug effects | Nitric Oxide - biosynthesis | NF-kappa B - antagonists & inhibitors | Phagocytosis - drug effects | Microglia - drug effects | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Microglia - enzymology | Matrix Metalloproteinase 3 - metabolism | Toll-Like Receptor 4 - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | Nitric Oxide Synthase Type II - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Matrix Metalloproteinase Inhibitors | Kaempferols - pharmacology | Mice | Dinoprostone - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Kinases | Research Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2016, Volume 173, Issue 5, pp. 856 - 869
.... The opioid inactive isomers (+)‐naltrexone and (+)‐naloxone act as TLR4 antagonists, reversing neuropathic pain and reducing opioid and cocaine reward and reinforcement... 
NEUROPATHIC PAIN | CELLS | ACTIVATION | NALOXONE | NITRIC-OXIDE | LIPOPOLYSACCHARIDE | BINDING-SITE | SPINAL-CORD | PHARMACOLOGY & PHARMACY | TRIF | TLR4 | Tumor Necrosis Factor-alpha - metabolism | Cell Line | Microglia - metabolism | Phagocytosis - drug effects | Reactive Oxygen Species - metabolism | Microglia - drug effects | Cells, Cultured | Male | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Naltrexone - pharmacology | Animals | Interferon-beta - metabolism | Interleukin-1beta - metabolism | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Lipopolysaccharides - pharmacology | Mice | Toll-Like Receptor 4 - antagonists & inhibitors | Macrophages, Peritoneal - metabolism | Nitric Oxide - metabolism | Macrophages, Peritoneal - drug effects | Narcotics | Rodents | Reactive oxygen species | Animal models | Three axis | Fluorescence | Reversing | Activation | Neuropathy | Macrophages | Naltrexone | Isomers | Western blotting | Lipopolysaccharides | Pain | Interleukin 1 | Toll-like receptors | Reinforcement | Drug interaction | Inhibition | Enzyme-linked immunosorbent assay | NF-κB protein | Opioid receptors | JNK protein | Inflammation | TLR4 protein | Microglia | Signaling | Naloxone | Inhibitors | Interferon regulatory factor 3 | Tumor necrosis factor | Cocaine | Phagocytosis | Peritoneum | Research Papers | Research Paper
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 808 - 819
.... Experimental approach JZL184 and/or the CB1 receptor antagonist, AM251 or the CB2receptor antagonist, AM630 were administered to rats 30... 
monoacylglycerol lipase | endocannabinoid | NF‐κB | TNF‐α | 2‐AG | brain | JZL184 | IL‐6 | IL‐1β | frontal cortex | IL‐10 | cytokines | plasma | IL-1β | IL-10 | IL-6 | NF-κB | TNF-α | 2-AG | CELLS | IL-1 | 2-ARACHIDONYL GLYCEROL | NF-B | RECEPTOR | NECROSIS-FACTOR-ALPHA | TNF | ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL | COX-2 EXPRESSION | IN-VIVO | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | CANNABINOIDS | Benzodioxoles - antagonists & inhibitors | Spleen - immunology | Frontal Lobe - metabolism | Male | Spleen - drug effects | Prostaglandins - blood | Lipopolysaccharides | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Glycerides - blood | Arachidonic Acids - blood | Enzyme Inhibitors - chemistry | Anti-Anxiety Agents - therapeutic use | Benzodioxoles - therapeutic use | Peritonitis - metabolism | Rats | Encephalitis - immunology | Random Allocation | Glycerides - metabolism | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Cannabinoid Receptor Antagonists - therapeutic use | Monoacylglycerol Lipases - blood | Peritonitis - drug therapy | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Endocannabinoids - metabolism | Nerve Tissue Proteins - blood | Monoacylglycerol Lipases - antagonists & inhibitors | Piperidines - antagonists & inhibitors | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Encephalitis - drug therapy | Encephalitis - metabolism | Cytokines - blood | Nerve Tissue Proteins - antagonists & inhibitors | Cytokines - metabolism | Peritonitis - immunology | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Spleen - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Piperidines - therapeutic use | Frontal Lobe - drug effects | Cannabinoid Receptor Antagonists - chemistry | Frontal Lobe - immunology | Cytokines - antagonists & inhibitors | Endocannabinoids - blood | Prostaglandins - metabolism | Glycerin | Brain | Unsaturated fatty acids | Cytokines | Glycerol | Lipase | Mitogens | Plasma | Rodents | Cannabinoids 2012, Part Two | Themed Section
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 06/2002, Volume 168, Issue 12, pp. 6404 - 6411
Previous studies have shown that IL-10 can induce the expression of the suppressor of cytokine signaling 3 (SOCS-3) mRNA in human monocytes and neutrophils,... 
EXPERIMENTAL ENDOTOXEMIA | TUMOR-NECROSIS-FACTOR | CHRONIC ENTEROCOLITIS | HUMAN NEUTROPHILS | MESSENGER-RNA | INTERFERON-GAMMA | NEGATIVE REGULATION | INTERLEUKIN-10 RECEPTOR | TNF-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | Sialoglycoproteins - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Repressor Proteins | Tumor Necrosis Factor-alpha - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Nitric Oxide Synthase Type II | RNA, Messenger - biosynthesis | Sialoglycoproteins - biosynthesis | Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis | Interleukin-6 - metabolism | Nitric Oxide - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Interleukin-6 - genetics | Macrophage Activation - immunology | Macrophages, Peritoneal - immunology | Signal Transduction - genetics | Mice, Knockout | Macrophages - metabolism | Up-Regulation - immunology | Lipopolysaccharides - pharmacology | Mice | Transcription Factors | Macrophages, Peritoneal - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Macrophage Activation - genetics | Nitric Oxide Synthase - antagonists & inhibitors | Nitric Oxide Synthase - genetics | MAP Kinase Signaling System - immunology | Interleukin-10 - physiology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Transfection | RNA, Messenger - antagonists & inhibitors | Nitric Oxide Synthase - biosynthesis | Macrophages - immunology | Cell Line | Proteins - physiology | Nitric Oxide - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Up-Regulation - genetics | Proteins - genetics | Suppressor of Cytokine Signaling 3 Protein | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors | Interleukin 1 Receptor Antagonist Protein | Trans-Activators - metabolism | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Receptors, Interleukin-1 - antagonists & inhibitors | Interleukin-10 - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2018, Volume 200, Issue 7, pp. 2291 - 2303
Binge/moderate alcohol suppresses TLR4-MyD88 proinflammatory cytokines; however, alcohol's effects on TLR-TRIF signaling, especially after in vivo exposure in... 
TOLL-LIKE RECEPTOR | IN-VIVO | FACTOR-KAPPA-B | ENDOPLASMIC-RETICULUM STRESS | PROINFLAMMATORY CYTOKINES | IMMUNOLOGY | PATTERN-RECOGNITION RECEPTORS | HUMAN MONOCYTES | RESPIRATORY SYNCYTIAL VIRUS |