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Nature (London), ISSN 1476-4687, 2011, Volume 472, Issue 7343, pp. 361 - 365
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus... 
HIV-1 | CYCLOPHILIN-A | UNANCHORED POLYUBIQUITIN CHAINS | TRIM5-ALPHA PROTEIN | RECOGNITION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | INFECTION | RESTRICTION | Capsid - chemistry | Receptors, Pattern Recognition - immunology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | Lipopolysaccharides - immunology | Transcription Factor AP-1 - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | HIV-1 - chemistry | HEK293 Cells | Carrier Proteins - immunology | Cell Line | Retroviridae - chemistry | Ubiquitin-Protein Ligases - metabolism | Retroviridae - immunology | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - metabolism | Capsid - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | HIV-1 - immunology | Carrier Proteins - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Protein Binding | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Signal transduction | Efficiency | RNA polymerase | Pattern recognition | Kinases | Evacuations & rescues | Immune system | HIV-1/immunology | Capsid/immunology | Life Sciences | MAP Kinase Kinase Kinases/metabolism | Carrier Proteins/immunology | Immunology | Transcription Factors/metabolism | Capsid/chemistry | HIV-1/chemistry | Ubiquitin/metabolism | Receptors, Pattern Recognition/immunology | Retroviridae/chemistry | Ubiquitin-Protein Ligases/immunology | Ubiquitin-Conjugating Enzymes/metabolism | HumansImmunity, Innate/immunology | Lipopolysaccharides/pharmacology | Signal Transduction/drug effects | Retroviridae/immunology | Transcription Factor AP-1/metabolism | Lipopolysaccharides/immunology | Ubiquitin-Protein Ligases/metabolism | Carrier Proteins/genetics | Signal Transduction/immunology | NF-kappa B/metabolism | Ubiquitin-Protein Ligases/genetics | Carrier Proteins/metabolism | Receptors, Pattern Recognition/metabolism
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 06/2010, Volume 70, Issue 11, pp. 4335 - 4345
Journal Article
Nature immunology, ISSN 1529-2916, 2010, Volume 11, Issue 5, pp. 411 - 418
Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 130, Issue 2, pp. 523 - 530.e9
Background There is evidence that gene expression of innate immunity receptors is upregulated by farming-related exposures. Objective We sought to determine... 
Allergy and Immunology | nutrition | childhood | prenatal | farming | farm milk | Toll-like receptors | Innate immunity | CD14 | FARM MILK CONSUMPTION | TIME QUANTITATIVE PCR | POLYMORPHISM | IMMUNOLOGY | CHILDHOOD ASTHMA | CHILDREN | PROTECT | TOLL-LIKE RECEPTOR-2 | ALLERGY | HEALTH | ALLERGIC DISEASES | ATOPIC SENSITIZATION | RNA, Messenger - immunology | Prospective Studies | Humans | Immunity, Innate - genetics | Prenatal Exposure Delayed Effects - prevention & control | Infant | Male | Maternal Exposure | RNA, Messenger - biosynthesis | Rural Population | Fetal Blood - chemistry | Gene Expression - immunology | Hypersensitivity, Immediate - immunology | Adult | Female | Surveys and Questionnaires | Agriculture | Milk - immunology | Polymorphism, Single Nucleotide - immunology | Fetal Blood - immunology | Cats | Toll-Like Receptors - immunology | Hypersensitivity, Immediate - genetics | Lipopolysaccharide Receptors - immunology | Hypersensitivity, Immediate - prevention & control | Pregnancy | Prenatal Exposure Delayed Effects - genetics | Immunity, Innate - immunology | Animals | Prenatal Exposure Delayed Effects - immunology | Toll-Like Receptors - genetics | Lipopolysaccharide Receptors - genetics | Polymorphism, Single Nucleotide - genetics | Allergy | Medical colleges | Pregnant women | Analysis | Genes | Environmental health | Genetic research | Respiratory tract diseases | Gene expression | Allergic reaction | Biometry | Public health | Disease | Rural areas | Farm buildings | Allergies | Asthma | Hay fever | Womens health | Questionnaires | Age | Immune system | Farming | Neonates | Inventories | TLR7 protein | TLR5 protein | Hypersensitivity | Single-nucleotide polymorphism | Regression analysis | TLR4 protein | CD14 antigen | Gene polymorphism | Immunity | Rural environments | TLR9 protein | Cord blood | Farms | Pasture | Prenatal experience | Food | Milk | Prenatal Exposure Delayed Effects | Antigens, CD14 | Hypersensitivity, Immediate | Life Sciences | Toll-Like Receptors | Pulmonology and respiratory tract | Gene Expression | Immunity, Innate | Human health and pathology | Polymorphism, Single Nucleotide | RNA, Messenger | Fetal Blood
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2013, Volume 131, Issue 2, pp. 549 - 561
Background Allergic rhinitis (AR) and asthma are 2 entities of allergic airway diseases that frequently occur together, which is referred to as united airways... 
Allergy and Immunology | pathogen associated molecular pattern | allergic asthma | innate immunity | house dust mite | Allergic rhinitis | reactive oxygen species | epithelium | β-glucans | dual oxidase 2 | Toll-like receptor | ACTIVATION | beta-glucans | DENDRITIC CELLS | IMMUNOLOGY | DECTIN-1 | RHINITIS | TOLL-LIKE RECEPTOR-2 | RESPONSES | EPITHELIAL-CELLS | ALLERGY | INFLAMMATION | LIPID RAFTS | ASTHMA | Asthma - metabolism | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Rhinitis, Allergic | NADPH Oxidases - metabolism | Hypersensitivity - immunology | NADPH Oxidases - immunology | Lipopolysaccharides - immunology | Rhinitis, Allergic, Perennial - metabolism | Hypersensitivity - metabolism | Reactive Oxygen Species - immunology | Respiratory Mucosa - immunology | Asthma - immunology | Lung - metabolism | Nasal Mucosa - metabolism | beta-Glucans - immunology | Respiratory System - immunology | Rhinitis, Allergic, Perennial - immunology | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Immunity, Innate - immunology | beta-Glucans - metabolism | Animals | Nasal Mucosa - immunology | Respiratory System - metabolism | Epithelial Cells - immunology | Toll-Like Receptor 2 - immunology | Mice | Respiratory Mucosa - metabolism | Dual Oxidases | Lung - immunology | Pyroglyphidae - immunology | Medical colleges | Asthma | Lipids | Gene expression | Allergies | Immune system
Journal Article
Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2003, Volume 171, Issue 7, pp. 3645 - 3654
textabstractThe prevalence of atopic asthma, a Th2-dependent disease, is reaching epidemic proportions partly due to improved hygiene in industrialized... 
Bone Marrow Cells/immunology/metabolism | Interleukin-12/biosynthesis/genetics/physiology | CD4-Positive T-Lymphocytes/immunology/metabolism | Ovalbumin/administration & dosage/immunology | Adoptive Transfer | Lung/cytology/immunology/metabolism | Pulmonary Eosinophilia/immunology/pathology/prevention & control | Cell Division/immunology | Lipopolysaccharides/administration & dosage/pharmacology | Female | Epitopes, T-Lymphocyte/immunology | Growth Inhibitors/administration & dosage | Cells, Cultured | Protein Subunits/biosynthesis/genetics/physiology | T-Lymphocyte Subsets/cytology/immunology/transplantation | Mice, Transgenic | Immunosuppressive Agents/administration & dosage/pharmacology | Mice, Knockout | Cell Movement/immunology | Animals | Research Support, Non-U.S. Gov't | Cell Differentiation/immunology | Lymphocyte Activation/immunology | Mice | Mice, Inbred BALB C | Dendritic Cells/cytology/immunology/metabolism | Th2 Cells/cytology/immunology/metabolism | CPG OLIGODEOXYNUCLEOTIDES | INHALED ANTIGEN | IFN-GAMMA | IMMUNE-RESPONSES | IN-VIVO | BONE-MARROW | REGULATORY T-CELLS | ASTHMA | CYTOKINE | IMMUNOLOGY | MURINE | T-Lymphocyte Subsets - immunology | Ovalbumin - immunology | T-Lymphocyte Subsets - cytology | Interleukin-12 - genetics | Dendritic Cells - immunology | Lipopolysaccharides - administration & dosage | Interleukin-12 - physiology | Th2 Cells - immunology | Lung - cytology | CD4-Positive T-Lymphocytes - immunology | Cell Movement - immunology | Lymphocyte Activation - immunology | Cell Division - immunology | Bone Marrow Cells - immunology | Lung - metabolism | Epitopes, T-Lymphocyte - immunology | Protein Subunits - physiology | Immunosuppressive Agents - pharmacology | Dendritic Cells - metabolism | Immunosuppressive Agents - administration & dosage | Interleukin-12 - biosynthesis | Protein Subunits - genetics | Pulmonary Eosinophilia - immunology | Pulmonary Eosinophilia - prevention & control | CD4-Positive T-Lymphocytes - metabolism | Th2 Cells - cytology | Protein Subunits - biosynthesis | T-Lymphocyte Subsets - transplantation | Pulmonary Eosinophilia - pathology | Th2 Cells - metabolism | Cell Differentiation - immunology | Growth Inhibitors - administration & dosage | Ovalbumin - administration & dosage | Lipopolysaccharides - pharmacology | Dendritic Cells - cytology | Bone Marrow Cells - metabolism | Lung - immunology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2007, Volume 282, Issue 36, pp. 26014 - 26025
Mycobacterium tuberculosis lipomannans (LMs) modulate the host innate immune response. The total fraction of Mycobacterium bovis BCG LM was shown both to... 
BACILLUS-CALMETTE-GUERIN | C-TYPE LECTIN | DENDRITIC CELLS | MULTIACYLATED FORMS | SURFACTANT PROTEIN-A | NITRIC-OXIDE SYNTHASE | DC-SIGN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELECTIVE RECOGNITION | MYO-INOSITOL ANCHOR | 2-DEFICIENT MICE | Mannose-Binding Lectins - metabolism | Mycobacterium bovis - immunology | Toll-Like Receptor 2 - agonists | Membrane Glycoproteins - metabolism | Humans | Lectins, C-Type - immunology | Mycobacterium tuberculosis - immunology | Lipopolysaccharides - metabolism | Cell Adhesion Molecules - immunology | Lipopolysaccharides - immunology | Lectins, C-Type - metabolism | Signal Transduction - immunology | Inflammation - metabolism | Macrophages - secretion | Toll-Like Receptor 1 - agonists | Myeloid Differentiation Factor 88 - immunology | Tumor Necrosis Factor-alpha - immunology | Toll-Like Receptor 4 - agonists | Interleukin-12 Subunit p40 - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Acylation | Cell Line | Nitric Oxide - immunology | Immunity, Innate - drug effects | Macrophage Activation - immunology | Receptors, Interleukin-1 - immunology | Tumor Necrosis Factor-alpha - secretion | Receptors, Cell Surface - metabolism | Inflammation - immunology | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Cell Adhesion Molecules - metabolism | Receptors, Cell Surface - immunology | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Nitric Oxide - secretion | Animals | Mannose-Binding Lectins - immunology | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Toll-Like Receptor 1 - immunology | Macrophage Activation - drug effects | Myeloid Differentiation Factor 88 - metabolism | Toll-Like Receptor 1 | Toll-Like Receptor 2 | Toll-Like Receptor 4 | Cell Adhesion Molecules | Receptors, Cell Surface | Macrophages | Lipopolysaccharides | Life Sciences | Immunology | Membrane Glycoproteins | Mannose-Binding Lectins | Mycobacterium bovis | Signal Transduction | Lectins, C-Type | Inflammation | Myeloid Differentiation Factor 88 | Nitric Oxide | Tumor Necrosis Factor-alpha | Immunity, Natural | Macrophage Activation | Mycobacterium tuberculosis | Receptors, Interleukin-1 | Interleukin-12 Subunit p40
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 1, pp. 212 - 217
Journal Article
PloS one, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, p. e27944
Inflammatory mediators in the tumour microenvironment promote tumour growth, vascular development and enable evasion of anti-tumour immune responses, by... 
MIGRATION | ACTIVATION | FUNCTIONAL MATURATION | ANGIOGENESIS | VEGF | MULTIDISCIPLINARY SCIENCES | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | CXC CHEMOKINES | G-CSF | T-CELLS | ENDOTHELIAL GROWTH-FACTOR | Antigens, CD - immunology | Immunoglobulins - immunology | Membrane Glycoproteins - metabolism | Chemokine CCL2 - immunology | Coculture Techniques | Dendritic Cells - immunology | Humans | Culture Media, Conditioned - pharmacology | Male | Vascular Endothelial Growth Factor A - metabolism | Chemokine CXCL5 - metabolism | Interferon-gamma - metabolism | Chemokine CXCL1 - pharmacology | Lipopolysaccharides - immunology | Antigens, CD - metabolism | Immunoglobulins - metabolism | Chemokine CXCL5 - pharmacology | Flow Cytometry | Female | Chemokine CCL2 - metabolism | Membrane Glycoproteins - immunology | B7-2 Antigen - immunology | Chemokine CXCL1 - metabolism | HLA-DR Antigens - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Colorectal Neoplasms - metabolism | Dendritic Cells - metabolism | Tumor Microenvironment - drug effects | Enzyme-Linked Immunosorbent Assay | Intercellular Adhesion Molecule-1 - immunology | Tissue Culture Techniques | Cells, Cultured | Vascular Endothelial Growth Factor A - immunology | Tumor Microenvironment - immunology | B7-2 Antigen - metabolism | Cell Differentiation - immunology | Chemokine CXCL1 - immunology | Intercellular Adhesion Molecule-1 - metabolism | Colorectal Neoplasms - immunology | Chemokine CCL2 - pharmacology | Cell Differentiation - drug effects | Chemokine CXCL5 - immunology | Interferon-gamma - immunology | Lipopolysaccharides - pharmacology | Aged | HLA-DR Antigens - immunology | Colorectal Neoplasms - pathology | Culture Media, Conditioned - metabolism | Care and treatment | Dendritic cells | Vascular endothelial growth factor | Colorectal cancer | Tumors | CD86 antigen | Colorectal carcinoma | Biochemistry | Metastasis | Kinases | Lipopolysaccharides | Proteins | Angiogenesis | Signal transduction | Lymphocytes | Inhibition | Pretreatment | Conditioning | Antigens | Immune response | Cytokines | Maturation | Neutrophils | Interleukin 12 | CD80 antigen | Inflammation | CD83 antigen | Interleukin 10 | Ligands | Histocompatibility antigen HLA | Prostate cancer | Chemokines | Monocyte chemoattractant protein 1 | Apoptosis
Journal Article