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Free radical biology & medicine, ISSN 0891-5849, 08/2014, Volume 73, pp. 51 - 59
Microglia are the resident immune cells in the brain. Microglial activation is characteristic of several inflammatory and neurodegenerative diseases including... 
Peroxynitrite | Free radicals | Protein radical | Inducible nitric oxide synthase | Lipopolysaccharide | Nitrone adducts | Parkinson disease | Microglia | NADPH OXIDASE | OXIDATIVE STRESS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOS EXPRESSION | KAPPA-B | LIPOPOLYSACCHARIDE-ACTIVATED MICROGLIA | REACTIVE OXYGEN | ENDOCRINOLOGY & METABOLISM | GENERATION | TYROSINE NITRATION | PARKINSONS-DISEASE | Microglia - metabolism | Metalloporphyrins - pharmacology | Lipopolysaccharides | Thiocarbamates - pharmacology | RNA Interference | Nitric Oxide Synthase Type II - antagonists & inhibitors | Spin Trapping | Acetophenones - pharmacology | Free Radicals - metabolism | Proline - pharmacology | Microglia - cytology | NG-Nitroarginine Methyl Ester - pharmacology | NF-kappa B - antagonists & inhibitors | Proline - analogs & derivatives | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Antioxidants - pharmacology | Neurodegenerative Diseases - metabolism | Coumarins - pharmacology | Animals | Nitric Oxide Synthase Type II - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Peroxynitrous Acid - metabolism | Amidines - pharmacology | Mice | Pyridines - pharmacology | RNA, Small Interfering | Benzylamines - pharmacology | Cell Line, Transformed | Boronic Acids - pharmacology | Nitric Oxide Synthase Type II - metabolism | Nitration | Nervous system diseases | Multiple sclerosis | Analysis | Nitric oxide | Environmental health | Physiological aspects | Alzheimer's disease | Index Medicus | Inducible nitric | oxide synthase | LPS | Parkinson’s disease
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2011, Volume 16, Issue 2, pp. 1021 - 1043
..., Konkuk University, Chungju 380-701, Korea 2 Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School... 
Neuroprotection | Neuroinflammation | Natural products | Neurodegeneration | Microglia | INDUCED CELL-DEATH | BIOCHEMISTRY & MOLECULAR BIOLOGY | LINE RAW 264.7 | neurodegeneration | NECROSIS-FACTOR-ALPHA | LIPOPOLYSACCHARIDE-ACTIVATED MICROGLIA | NETTLE LEAF EXTRACT | CHEMISTRY, MULTIDISCIPLINARY | PERFORMANCE LIQUID-CHROMATOGRAPHY | natural products | GREEN TEA | NITRIC-OXIDE PRODUCTION | neuroinflammation | neuroprotection | microglia | NF-KAPPA-B | GASTRODIA-ELATA BLUME | Encephalitis - prevention & control | Neuroprotective Agents - therapeutic use | Plant Extracts - chemistry | Stilbenes - therapeutic use | Biological Products - pharmacology | Fatty Alcohols - therapeutic use | Ginsenosides - pharmacology | Stilbenes - pharmacology | Benzyl Alcohols - therapeutic use | Biphenyl Compounds - therapeutic use | Ginsenosides - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Fatty Alcohols - pharmacology | Microglia - physiology | Neuroprotective Agents - pharmacology | Biphenyl Compounds - pharmacology | Encephalitis - drug therapy | Catechols - therapeutic use | Nerve Degeneration - prevention & control | Benzyl Alcohols - pharmacology | Resveratrol | Catechols - pharmacology | Catechin - therapeutic use | Glucosides - therapeutic use | Molecular Structure | Catechin - pharmacology | Biological Products - therapeutic use | Glucosides - pharmacology | Curcumin - therapeutic use | Microglia - drug effects | Curcumin - pharmacology | Phenyl Ethers - pharmacology | Nerve Degeneration - pathology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Phenyl Ethers - therapeutic use | Catechin - analogs & derivatives
Journal Article
International journal of oncology, ISSN 1019-6439, 12/2013, Volume 43, Issue 6, pp. 1787 - 1798
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2009, Volume 296, Issue 2, pp. 470 - 479
Bacterial endotoxin lipopolysaccharide (LPS) is responsible for the multiorgan dysfunction that characterizes septic shock and is causal in the myocardial... 
Green fluorescent protein- Microtubule-associated protein light chain 3 | Lipopolysaccharide | Oxidative stress | Hl-1 cardiac myocyte | TRANSCRIPTIONAL ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | HL-1 cardiac myocyte | CARDIAC MYOCYTES | ENDOTOXIN | MYOCARDIAL DEPRESSION | CELL-DEATH | IN-VITRO | SCAVENGER RECEPTOR | green fluorescent protein-microtubule-associated protein light chain 3 | PERIPHERAL VASCULAR DISEASE | TNF-ALPHA | lipopolysaccharide | EXPRESSION | oxidative stress | Tumor Necrosis Factor-alpha - metabolism | Mitochondria, Heart - metabolism | Glutathione - metabolism | Mitochondria, Heart - pathology | Nitric Oxide Synthase - antagonists & inhibitors | omega-N-Methylarginine - pharmacology | Mitochondria, Heart - drug effects | Nitroprusside - pharmacology | Autophagy - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Nitric Oxide Donors - pharmacology | Cytoprotection | Animals, Newborn | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Mice, Transgenic | Imidazoles - pharmacology | Tyrphostins - pharmacology | Antioxidants - pharmacology | Sirolimus - pharmacology | Hydrogen Peroxide - metabolism | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Acetylcysteine - pharmacology | Lipopolysaccharides - pharmacology | Myocytes, Cardiac - metabolism | Mice | Nitric Oxide Synthase - metabolism | Pyridines - pharmacology | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Index Medicus
Journal Article
British journal of pharmacology, ISSN 0007-1188, 08/2015, Volume 172, Issue 15, pp. 3805 - 3816
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 43, pp. 17253 - 17258
Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Although much is known about how soluble factors... 
Phenotypes | Cell growth | Cytokines | Stem cells | Cell lines | Actins | Physiological regulation | Macrophages | Endothelial cells | Cells | FIBER | MATRIX | ACTIVATION | ACTIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DIFFERENTIATION | SCAFFOLDS | CULTURE | MESENCHYMAL STEM-CELLS | Mannose-Binding Lectins - metabolism | Arginase - metabolism | Lectins, C-Type - immunology | Cell Shape - immunology | Myosin-Light-Chain Kinase - antagonists & inhibitors | Cytochalasin D - pharmacology | Lectins, C-Type - metabolism | Arginase - immunology | Interleukin-4 - pharmacology | Flow Cytometry | Doxorubicin - analogs & derivatives | Inflammation Mediators - metabolism | Female | Immunophenotyping - methods | Cell Polarity - drug effects | Doxorubicin - metabolism | Macrophages - immunology | Cytokines - immunology | Amides - pharmacology | Biomarkers - metabolism | Inflammation Mediators - immunology | Cell Polarity - immunology | Cytokines - metabolism | Myosin-Light-Chain Kinase - metabolism | Mice, Inbred C57BL | Biomarkers - analysis | Cells, Cultured | Receptors, Cell Surface - metabolism | Macrophages - cytology | Interleukin-13 - pharmacology | Receptors, Cell Surface - immunology | Azepines - pharmacology | Cell Shape - drug effects | Macrophages - metabolism | Animals | Mannose-Binding Lectins - immunology | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Doxorubicin - immunology | Interferon-gamma - pharmacology | Microscopy, Fluorescence | Physiological aspects | Microbial genetics | Phenotype | Genetic aspects | Research | Biological Sciences | Physical Sciences
Journal Article
British journal of pharmacology, ISSN 0007-1188, 2015, Volume 172, Issue 1, pp. 24 - 37
Background and Purpose N-docosahexaenoylethanolamine (DHEA) is the ethanolamine conjugate of the long-chain polyunsaturated n-3 fatty acid docosahexaenoic... 
arrive guidelines | pharmacology | fatty-acids | cannabinoid receptor | prostaglandin e-2 | nitric-oxide synthase | anandamide | fish-oil | concise guide | kappa-b | PLASMA | CONCISE GUIDE | NITRIC-OXIDE SYNTHASE | INFLAMMATION | OXYGENATION | ANANDAMIDE | PHARMACOLOGY & PHARMACY | FATTY-ACIDS | FISH-OIL | KAPPA-B | ETHANOLAMIDE | Endocannabinoids - metabolism | Bornanes - pharmacology | Male | NF-kappa B - metabolism | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | PPAR gamma - metabolism | Piperidines - pharmacology | Thiazolidinediones - pharmacology | Pyrazoles - pharmacology | Cell Line | Indenes - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Dehydroepiandrosterone - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Arachidonic Acids - pharmacology | Mice, Knockout | Dinoprostone - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Macrophages - metabolism | Animals | PPAR gamma - antagonists & inhibitors | Interferon-beta - metabolism | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Nitric Oxide - metabolism | Myeloid Differentiation Factor 88 - metabolism | Androgens | Dehydroepiandrosterone | DNA microarrays | Anti-inflammatory drugs | RNA | Ethanolamines | Macrophages | Gene expression | Fatty acids | Medical research | Rodents | Research Papers
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2007, Volume 104, Issue 24, pp. 9982 - 9987
Arginine contains the guanidinium group and thus has structural similarity to ligands of imidazoline and α-2 adrenoceptors (α-2 AR). Therefore, we investigated... 
Cell culture techniques | Signal transduction | Receptors | Imidazolines | Fluorescence | Agonists | Ligands | Toxins | Endothelial cells | Whooping cough | Calcium | Agmatine | Rauwolscine | rauwolscine | calcium | DEPENDENT VASODILATION | VASCULAR RELAXATION | MULTIDISCIPLINARY SCIENCES | agmatine | RELAXING FACTOR | PORCINE CORONARY-ARTERIES | RELEASE | SYNTHASE | SMOOTH-MUSCLE | CHOLESTEROL-FED RABBITS | S-NITROSOTHIOLS | Endothelium, Vascular - cytology | Aniline Compounds | Humans | Receptors, Adrenergic, alpha-2 - metabolism | Culture Media, Serum-Free | Adrenergic alpha-Antagonists - pharmacology | Calcium - analysis | Agmatine - pharmacology | Virulence Factors, Bordetella - pharmacology | Type C Phospholipases - antagonists & inhibitors | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Idazoxan - pharmacology | Arginine - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Agmatine - chemistry | Dexmedetomidine - pharmacology | Molecular Structure | Cell Culture Techniques | Nitric Oxide Synthase Type III - metabolism | Umbilical Veins - cytology | Nitrates - analysis | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Nifedipine - pharmacology | Idazoxan - chemistry | Endothelial Cells - metabolism | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Imidazolines - pharmacology | Calcium Channel Blockers - pharmacology | Enzyme Activation - drug effects | Arginine - chemistry | Xanthenes | Endothelial Cells - cytology | Arginine - pharmacology | Lipopolysaccharides - pharmacology | Second Messenger Systems - physiology | Nitrites - analysis | Endothelial Cells - enzymology | Fluorescent Dyes | Biological Sciences
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2006, Volume 26, Issue 18, pp. 4930 - 4939
Increased expression of glial fibrillary acidic protein (GFAP) represents astroglial activation and gliosis during neurodegeneration. However, the molecular... 
cGMP | Neurotoxins | Astroglial activation | Guanylate cyclase | Nitric oxide | GFAP | VIRUS TYPE-1 HIV-1 | nitric oxide | ACTIVATION | HUMAN ASTROGLIA | neurotoxins | MICROGLIAL CELLS | RAT PRIMARY ASTROCYTES | astroglial activation | NEUROSCIENCES | PEPTIDE | SYNTHASE | guanylate cyclase | LONG-TERM POTENTIATION | NF-KAPPA-B | Free Radical Scavengers - pharmacology | Cyclic GMP - pharmacology | Glial Fibrillary Acidic Protein - genetics | Gene Expression - drug effects | Nitric Oxide - pharmacology | Male | Glial Fibrillary Acidic Protein - metabolism | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Tetrazolium Salts | RNA, Messenger - biosynthesis | Drug Interactions | Cyclic GMP - analogs & derivatives | Time Factors | Cyclic N-Oxides - pharmacology | Reverse Transcriptase Polymerase Chain Reaction - methods | Thiazoles | Animals, Newborn | Astrocytes - drug effects | Cell Survival - drug effects | Lysine - analogs & derivatives | Fluorescent Antibody Technique - methods | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Thionucleotides - pharmacology | Electrophoretic Mobility Shift Assay - methods | Animals | Lysine - pharmacology | HIV Envelope Protein gp120 - pharmacology | Lipopolysaccharides - pharmacology | Corpus Striatum - drug effects | Mice | Cytokines - pharmacology
Journal Article
Nature chemical biology, ISSN 1552-4469, 2014, Volume 10, Issue 8, pp. 656 - 663
Journal Article
Neuroscience, ISSN 0306-4522, 2014, Volume 268, pp. 236 - 246
Highlights • l -NAME, aminoguanidine and sildenafil prevent LPS-induced depressive-like behavior. • l -Arginine, a NO precursor, did not prevent LPS-induced... 
Neurology | nitric oxide | depressive-like behavior | neuroinflammation | BDNF | LPS | oxidative stress | Depressive-like behavior | Oxidative stress | Neuroinflammation | Nitric oxide | ACTIVATION | GUANOSINE-MONOPHOSPHATE PATHWAY | PREPULSE INHIBITION | NITROSATIVE STRESS | MAJOR DEPRESSION | KAPPA-B | NEUROSCIENCES | L-TRYPTOPHAN | ANIMAL-MODEL | ACOUSTIC STARTLE | PITUITARY-ADRENAL AXIS | Oxidative Stress - physiology | Nitric Oxide Synthase - antagonists & inhibitors | Depressive Disorder - drug therapy | Guanidines - pharmacology | Male | Sulfones - pharmacology | Lipopolysaccharides | Brain - metabolism | Sildenafil Citrate | Interleukin-1beta - metabolism | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Behavior, Animal - physiology | Depressive Disorder - metabolism | Piperazines - pharmacology | Brain - drug effects | Animals | Cyclic GMP - metabolism | Signal Transduction - drug effects | Arginine - pharmacology | Depressive Disorder - prevention & control | Signal Transduction - physiology | Mice | Nitric Oxide Synthase - metabolism | Oxidative Stress - drug effects | Imipramine - pharmacology | Nitric Oxide - metabolism | Antidepressants | Mitogens | Depression, Mental | Index Medicus
Journal Article