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Gene Therapy, ISSN 0969-7128, 04/2013, Volume 20, Issue 4, pp. 361 - 369
Journal Article
Neuron, ISSN 0896-6273, 2010, Volume 65, Issue 3, pp. 320 - 327
Endocannabinoids are released from postsynaptic neurons and cause retrograde suppression of synaptic transmission. Anandamide and 2-arachidonoylglycerol (2-AG)... 
SYSNEURO | MOLNEURO | SIGNALING | SYSTEM | ENDOGENOUS CANNABINOIDS | DEPOLARIZATION | ACTIVATION | PRESYNAPTIC INHIBITION | GABA RELEASE | METABOTROPIC GLUTAMATE RECEPTORS | CANNABINOID CB1 RECEPTOR | NEUROSCIENCES | BRAIN | HIPPOCAMPAL SYNAPSES | Synaptic Transmission - physiology | Synaptic Transmission - genetics | Calcium - metabolism | Cerebellum - drug effects | Hippocampus - drug effects | Cerebellum - physiology | Corpus Striatum - cytology | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Neural Inhibition - physiology | Arachidonic Acids - metabolism | Inhibitory Postsynaptic Potentials - genetics | Potassium Chloride - pharmacology | Lipoprotein Lipase - classification | Neurons - physiology | Statistics, Nonparametric | Synaptic Transmission - drug effects | Glycerol - analogs & derivatives | Neurons - drug effects | Electric Stimulation - methods | Lipoprotein Lipase - metabolism | Endocannabinoids | Excitatory Postsynaptic Potentials - genetics | Animals, Newborn | Neural Inhibition - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Lipoprotein Lipase - deficiency | Hippocampus - cytology | Polyunsaturated Alkamides - metabolism | Mice, Knockout | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Glycerol - metabolism | Cerebellum - cytology | Corpus Striatum - drug effects | Corpus Striatum - physiology | Mice | Hippocampus - physiology | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Index Medicus
Journal Article
Science, ISSN 0036-8075, 11/2004, Volume 306, Issue 5700, pp. 1383 - 1386
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2006, Volume 103, Issue 46, pp. 17450 - 17455
Lipoprotein lipase (LPL) has a central role in lipoprotein metabolism to maintain normal lipoprotein levels in blood and, through tissue specific regulation of... 
Adipose tissues | Enzymes | Lipoproteins | Messenger RNA | Dimers | Surface plasmon resonance | Heparin | Sensors | Monomers | Food | Protein folding | Chaperone | Heparin affinity | NUTRITIONAL STATE | heparin affinity | MULTIDISCIPLINARY SCIENCES | chaperone I | DOWN-REGULATION | GUINEA-PIG | HEART | OVEREXPRESSION | INHIBITION | METABOLISM | surface plasmon resonance | GENETICS | ANGPTL3 | protein folding | Surface Plasmon Resonance | Heparin - metabolism | Blood Proteins - metabolism | Angiopoietin-like 4 Protein | Blood Proteins - genetics | Blood Proteins - isolation & purification | Protein Structure, Quaternary | Lipoprotein Lipase - chemistry | Dimerization | Lipoprotein Lipase - metabolism | Angiopoietins - metabolism | Gene Expression | RNA, Messenger - genetics | Models, Molecular | Rats | Blood Proteins - chemistry | Protein Folding | Animals | Chromatography, Affinity | Angiopoietins - chemistry | Heparin - analogs & derivatives | Protein Binding | Adipose Tissue - enzymology | Mice | Enzyme Activation | Angiopoietins - genetics | Lipoprotein lipase | Research | Molecular chaperones | Proteins | Ribonucleic acid--RNA | Rodents | Index Medicus | Biological Sciences | chaperone | Models; Molecular | Lipoprotein Lipase/chemistry/metabolism | Heparin/analogs & derivatives/metabolism | Chromatography; Affinity | Angiopoietins/chemistry/genetics/metabolism | Blood Proteins/chemistry/genetics/isolation & purification/metabolism | Adipose Tissue/enzymology | RNA; Messenger/genetics | Protein Structure; Quaternary
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2006, Volume 26, Issue 18, pp. 4740 - 4751
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2007, Volume 92, Issue 6, pp. 2292 - 2299
Aim/Hypothesis: Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is... 
3T3-L1 ADIPOCYTES | SUBCUTANEOUS FAT-CELLS | BETA-ADRENERGIC STIMULATION | WEIGHT-REDUCTION | TISSUE | ENDOCRINOLOGY & METABOLISM | UPPER-BODY OBESITY | PPAR-GAMMA | SKELETAL-MUSCLE METABOLISM | TNF-ALPHA | LIPOPROTEIN-LIPASE | Hyperinsulinism - metabolism | Obesity - diet therapy | Humans | Middle Aged | Sterol Esterase - metabolism | Adipose Tissue - pathology | Male | Lipase - metabolism | RNA, Messenger - metabolism | Diet, Reducing | Obesity - metabolism | Obesity - pathology | Gene Expression Regulation, Enzymologic | Hyperinsulinism - pathology | Regression Analysis | Sterol Esterase - genetics | Biopsy | Insulin Resistance - physiology | Weight Loss - physiology | Adult | Female | Adipose Tissue - enzymology | Hyperinsulinism - diet therapy | Lipase - genetics | Index Medicus | Abridged Index Medicus | Obesity | Sterol Esterase | Biochemistry, Molecular Biology | Insulin Resistance | Lipase | Life Sciences | Weight Loss | Adipose Tissue | RNA, Messenger | Hyperinsulinism | Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is mediated by hormone-sensitive lipase (HSL) and the recently discovered adipose triglyceride lipase (ATGL). The aim of the present study was to examine whether ATGL and HSL mRNA and protein expression are altered in insulin-resistant conditions. In addition | gender | indicating a tight coregulation and transcriptional control. CONCLUSIONS: In obese subjects | Medical and Health Sciences | Medicin och hälsovetenskap | before and just after a 10-wk hypocaloric diet. ATGL and HSL protein and mRNA expression was determined by Western blot and quantitative RT-PCR | and body composition. Both mRNA and protein levels of ATGL and HSL were reduced in insulin-resistant compared with insulin-sensitive subjects (P < 0.05). Weight reduction significantly decreased ATGL and HSL mRNA and protein expression. A positive correlation between the decrease in leptin and the decrease in ATGL protein level after weight reduction was observed. Finally | we investigated whether a possible impaired expression could be reversed by a period of weight reduction. METHODS: Adipose tissue biopsies were taken from obese subjects (n = 44) with a wide range of insulin resistance | respectively. RESULTS: Fasting insulin levels and the degree of insulin resistance (using the homeostasis model assessment index for insulin resistance) were negatively correlated with ATGL and HSL protein expression | Klinisk medicin | independent of fat mass. Data on weight reduction indicated that also other factors (e.g. leptin) relate to ATGL and HSL protein expression | Clinical Medicine | Endokrinologi och diabetes | ATGL and HSL mRNA and protein levels seem to be highly correlated | independent of age | insulin resistance and hyperinsulinemia are strongly associated with ATGL and HSL mRNA and protein expression | fat cell size | Endocrinology and Diabetes
Journal Article