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Vascular pharmacology, ISSN 1537-1891, 08/2012, Volume 57, Issue 1, pp. 56 - 64
... – exerts atheroprotective effects in vitro , while FTY720, a non-selective S1P mimetic inhibits atherosclerosis in LDL receptor-deficient (LDL-R... 
Cardiovascular | Sphingosine 1-phosphate (S1P) | Inflammation | High density lipoproteins (HDL) | Atherosclerosis | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Spleen - immunology | Spleen - drug effects | Body Weight - immunology | Antigens, CD - metabolism | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Oxadiazoles - pharmacology | Serine Endopeptidases - immunology | CD8-Positive T-Lymphocytes - metabolism | Lymph Nodes - drug effects | Receptors, Lysosphingolipid - metabolism | Interleukin-6 - metabolism | Lymphocytes - metabolism | Propylene Glycols - pharmacology | Atherosclerosis - immunology | CD4-Positive T-Lymphocytes - metabolism | Lymph Nodes - metabolism | Receptors, LDL - metabolism | Lymph Nodes - immunology | Receptors, LDL - immunology | Atherosclerosis - metabolism | Sphingosine - pharmacology | Macrophages - metabolism | Sphingosine - analogs & derivatives | Interleukin-6 - immunology | Receptors, Lysosphingolipid - agonists | Mice | CD8-Positive T-Lymphocytes - immunology | Antigens, CD - immunology | Genes, MHC Class II - immunology | Interleukin-2 - immunology | Lymphocytes - immunology | Female | Propylene Glycols - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Interleukin-2 - metabolism | Atherosclerosis - drug therapy | CD11b Antigen - immunology | Mice, Inbred C57BL | Proprotein Convertases - metabolism | Fingolimod Hydrochloride | Sphingosine - immunology | Proprotein Convertases - immunology | Receptors, Lysosphingolipid - immunology | Animals | Spleen - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | CD8-Positive T-Lymphocytes - drug effects | Lymphocytes - drug effects | Macrophages - drug effects | Serine Endopeptidases - metabolism | CD11b Antigen - metabolism | CD4-Positive T-Lymphocytes - drug effects | Indans - pharmacology | Hypercholesterolemia | Blood lipids | Mitogens | Low density lipoproteins | Sphingosine | Index Medicus
Journal Article
Journal Article
The FEBS journal, ISSN 1742-464X, 05/2017, Volume 284, Issue 9, pp. 1324 - 1337
SIRT6 is a pivotal regulator of lipid metabolism. It is also closely connected to cardiovascular diseases, which are the main cause of death in diabetic patients... 
atherosclerosis | foam cells | SIRT6 | autophagy | cholesterol efflux | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Autophagy-Related Protein 5 - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Foam Cells - ultrastructure | Microtubule-Associated Proteins - metabolism | Humans | MicroRNAs - metabolism | Autophagy-Related Protein 5 - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 1 - metabolism | Autophagy | Foam Cells - cytology | Recombinant Fusion Proteins - metabolism | ATP Binding Cassette Transporter 1 - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | RNA Interference | Gene Expression Regulation, Developmental | Sirtuins - genetics | Foam Cells - metabolism | Macrophages - immunology | Recombinant Proteins - metabolism | Macrophages - ultrastructure | Microscopy, Electron, Transmission | Lysosome-Associated Membrane Glycoproteins - metabolism | Lipoproteins, LDL - adverse effects | Recombinant Proteins - chemistry | Macrophages - cytology | Cholesterol - metabolism | Macrophages - metabolism | Lipoproteins, LDL - antagonists & inhibitors | Autophagy-Related Protein 5 - metabolism | Cell Line, Tumor | Lysosome-Associated Membrane Glycoproteins - genetics | Luminescent Proteins - genetics | Foam Cells - immunology | Mutation | Sirtuins - antagonists & inhibitors | Sirtuins - metabolism | ATP Binding Cassette Transporter 1 - genetics | Amino Acid Substitution | Luminescent Proteins - metabolism | Diabetics | Macrophages | Low density lipoproteins | Cholesterol | Atherosclerosis | Lipoproteins (low density) | Diabetes mellitus | Lipids | Metabolism | Electron microscopy | ABCA1 protein | Transmission electron microscopy | Arteriosclerosis | ATP-binding protein | Lipid metabolism | Cardiovascular diseases | Phagocytosis | Index Medicus
Journal Article
The New England journal of medicine, ISSN 1533-4406, 03/2012, Volume 366, Issue 12, pp. 1108 - 1118
.... In all three groups, the antibody reduced levels of LDL cholesterol. In 2003, Abifadel and colleagues 1 described two families with autosomal dominant hypercholesterolemia... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Proprotein Convertases - antagonists & inhibitors | Injections, Intravenous | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Injections, Subcutaneous | Serine Endopeptidases - immunology | Adult | Cholesterol, LDL - blood | Female | Hyperlipoproteinemia Type II - drug therapy | Drug Therapy, Combination | Pyrroles - therapeutic use | Proprotein Convertases - metabolism | Receptors, LDL - metabolism | Lipoproteins - blood | Anticholesteremic Agents - adverse effects | Proprotein Convertases - immunology | Hyperlipoproteinemia Type II - metabolism | Atorvastatin Calcium | Anticholesteremic Agents - therapeutic use | Antibodies, Monoclonal - administration & dosage | Anticholesteremic Agents - administration & dosage | Least-Squares Analysis | Serine Endopeptidases - metabolism | Receptors, LDL - drug effects | Hypercholesterolemia - metabolism | Proprotein Convertase 9 | Drugs | Dose-response relationship (Biochemistry) | Hypercholesterolemia | Monoclonal antibodies | Cholesterol, LDL | Dosage and administration | Product/Service Evaluations | Research | Drug therapy | Health aspects | Studies | Lipoproteins (low density) | Kexin | Serine | Atorvastatin | Cardiovascular disease | Subtilisin | Low density lipoprotein | Cholesterol | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article