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Journal of Clinical Investigation, ISSN 0021-9738, 03/2015, Volume 125, Issue 3, pp. 1269 - 1285
Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. Despite a global increase in... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | INTRAHEPATIC CHOLANGIOCARCINOMA | THIOACETAMIDE | PORCUPINE | LIVER | BILIARY | BETA-CATENIN | RAT CHOLANGIOCARCINOMA | PROGRESSION | CANCER STEM-CELLS | Anisoles - pharmacology | Humans | Male | Cholangiocarcinoma - metabolism | Bile Ducts, Intrahepatic - metabolism | Keratins - metabolism | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Wnt Signaling Pathway | Bile Duct Neoplasms - drug therapy | Cell Survival - drug effects | Aniline Compounds - pharmacology | Bile Duct Neoplasms - metabolism | Pyrimidines - pharmacology | Rats, Sprague-Dawley | beta Catenin - metabolism | Heterocyclic Compounds, 2-Ring - pharmacology | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Macrophages - metabolism | Animals | Cholangiocarcinoma - drug therapy | Mice, Nude | Tamoxifen - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Cell Proliferation - drug effects | Clodronic Acid - administration & dosage | Pyridines - pharmacology | Liposomes | Physiological aspects | Research | Tumor proteins | Wnt proteins | Oncology, Experimental | Cancer | Heparan sulfate | Medical research | Liver | Gene expression | Cancer therapies | Studies | Councils | Medical prognosis | Cell cycle | Ligands | Mutation | Tumors
Journal Article
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 21, pp. 5591 - 5604
Journal Article
1987, Research in, ISBN 0861961072, Volume 2, 178
Book
International Journal of Pharmaceutics, ISSN 0378-5173, 12/2011, Volume 421, Issue 2, pp. 332 - 340
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2001, Volume 276, Issue 27, pp. 25096 - 25100
Journal Article
Nature Nanotechnology, ISSN 1748-3387, 04/2016, Volume 11, Issue 4, pp. 378 - 387
Nanoscale drug delivery vehicles can facilitate multimodal therapies of cancer by promoting tumour-selective drug release. However, few are effective because... 
NEAR-INFRARED LIGHT | ANTIANGIOGENIC THERAPY | METASTASIS | TARGETED DRUG-DELIVERY | PHOTODYNAMIC THERAPY | MATERIALS SCIENCE, MULTIDISCIPLINARY | IN-VIVO | C-MET | NANOSCIENCE & NANOTECHNOLOGY | OVARIAN-CANCER | ADVANCED PANCREATIC-CANCER | ENDOTHELIAL GROWTH-FACTOR | Index Medicus | Therapy | Drug delivery systems | Pathways | Toxicity | Nanostructure | Derivatives | Tumors | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 38, pp. 26481 - 26491
The B cell lymphoma-2 (BCL-2) family is the key mediator of cellular sensitivity to apoptosis during pharmacological interventions for numerous human... 
POTENT | OLIGOMERIZES BAK | CANCERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | MITOCHONDRIAL-MEMBRANE | INHIBITORS | CYTOCHROME-C RELEASE | DISCOVERY | ADDICTION | MEMBRANE PERMEABILIZATION | bcl-2-Associated X Protein - chemistry | Nitriles - pharmacology | Apoptosis - drug effects | Mitochondria, Liver - metabolism | Humans | Unilamellar Liposomes - chemistry | bcl-2-Associated X Protein - physiology | Piperazines - chemistry | Proto-Oncogene Proteins - chemistry | Sulfones - pharmacology | Nitrophenols - chemistry | Benzopyrans - chemistry | bcl-X Protein - chemistry | Molecular Mimicry | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Membrane Proteins - physiology | Sulfones - chemistry | BH3 Interacting Domain Death Agonist Protein - chemistry | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Benzamides - pharmacology | Protein Interaction Domains and Motifs | Biphenyl Compounds - chemistry | Benzopyrans - pharmacology | Benzamides - chemistry | Aniline Compounds - pharmacology | BH3 Interacting Domain Death Agonist Protein - physiology | Sulfonamides - chemistry | Apoptosis Regulatory Proteins - chemistry | Permeability | Sulfonamides - pharmacology | Piperazines - pharmacology | Mitochondrial Membranes - metabolism | Mitochondria, Liver - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - physiology | Pyrroles - pharmacology | Animals | Membrane Proteins - chemistry | bcl-X Protein - physiology | Nitriles - chemistry | Proto-Oncogene Proteins - physiology | Pyrroles - chemistry | Apoptosis Regulatory Proteins - physiology | Mice | Aniline Compounds - chemistry | HeLa Cells | BH3 Mimetics | MOMP | Mitochondria | Bcl-2 Proteins | Bax | Anticancer Drug | Cell Biology | Apoptosis
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 03/2015, Volume 26, Issue 3, pp. 241 - 258
Journal Article
Biomaterials, ISSN 0142-9612, 2012, Volume 34, Issue 9, pp. 2277 - 2288
Abstract Interstitial fluid pressure (IFP) in tumor is much higher than that in normal tissue and it constitutes a great obstacle for the delivery of... 
Advanced Basic Science | Dentistry | Tumor interstitial fluid pressure | Intratumoral delivery | Imatinib | Combination therapy | Doxorubicin | Sterically stabilized liposome | VASCULAR NORMALIZATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | PHASE-II | CANCER | ANTICANCER THERAPEUTICS | MESYLATE | PDGFR-BETA | MELANOMA | INHIBITION | GENE-EXPRESSION | DRUG-COMBINATION | Immunohistochemistry | NIH 3T3 Cells | Apoptosis - drug effects | Melanoma, Experimental - drug therapy | Drug Delivery Systems | Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors | Doxorubicin - analogs & derivatives | Female | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Drug Therapy, Combination | Fibroblasts - metabolism | Polyethylene Glycols - pharmacology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Extracellular Fluid - drug effects | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | Liposomes - pharmacology | Doxorubicin - pharmacology | Anthracyclines | Chemotherapy | Biological products | Platelet-derived growth factor | Biomimetics | Oncology, Experimental | Melanoma | Physiological aspects | Research | Cancer
Journal Article
The AAPS Journal, ISSN 1550-7416, 3/2009, Volume 11, Issue 1, pp. 13 - 22
Arginine-rich cell-penetrating peptides (AR-CPPs) are very promising tools for the delivery of therapeutic macromolecules such as peptides, proteins, and... 
Biochemistry, general | protein transduction domains | Biotechnology | Biomedicine | membrane-disruptive peptides | Pharmacy | oligoarginine | endosomal escape | Pharmacology/Toxicology | arginine-rich cell-penetrating peptides | Membrane-disruptive peptides | Protein transduction domains | Oligoarginine | Endosomal escape | Arginine-rich cell-penetrating peptides | TAT-FUSION PROTEINS | CATIONIC LIPOSOMES | DNA-TRANSFECTION | INTERNALIZATION MECHANISMS | PHARMACEUTICAL NANOCARRIERS | NUCLEAR DELIVERY | NANO DEVICE | INTRACELLULAR DELIVERY | PHARMACOLOGY & PHARMACY | NONVIRAL GENE DELIVERY | Lipopeptides - pharmacokinetics | Lipopeptides - pharmacology | Humans | Macromolecular Substances - administration & dosage | Peptides - pharmacokinetics | Drug Carriers - pharmacology | Endosomes - metabolism | Arginine - chemistry | Peptides - pharmacology | Photosensitizing Agents - pharmacology | Lysosomes - metabolism | Macromolecular Substances - pharmacokinetics | Polymers - pharmacokinetics | Polymers - pharmacology | Photosensitizing Agents - pharmacokinetics | Cytosol - metabolism | Drug Carriers - pharmacokinetics | Intracellular Membranes - drug effects | Drug Delivery Systems - methods | Cell Membrane - drug effects | Liposomes - pharmacokinetics | Membrane Fusion - drug effects | Photochemistry | Proteins | Lipids | Nucleic acids | Universities and colleges
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 01/2015, Volume 89, Issue C, pp. 74 - 81
Journal Article