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The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 01/2019, Volume 104, Issue 1, pp. 21 - 37
Context: Human obesity is associated with increased circulating TNF-alpha, a proinflammatory cytokine that induces hepatocyte cell death. Objective: The... 
LIPOTOXICITY | ACYLATED GHRELIN | FATTY LIVER-DISEASE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | INJURY | BARIATRIC SURGERY | HMGB1 | ACCUMULATION | PREVALENCE | EPIDEMIOLOGY
Journal Article
Journal of Nutrition, ISSN 0022-3166, 06/2017, Volume 147, Issue 6, pp. 1104 - 1112
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/1998, Volume 95, Issue 5, pp. 2498 - 2502
Like obese humans, Zucker diabetic fatty (ZDF) rats exhibit early β cell compensation for insulin resistance (4-fold β cell hyperplasia) followed by... 
Obesity | Diabetes mellitus | Nonesterified fatty acids | DNA fragmentation | Ceramides | Oxidation | Diabetes | Type 2 diabetes mellitus | Prediabetic state | Apoptosis | LIPOTOXICITY | PATHOGENESIS | METABOLISM | ISLETS | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | RATS | CERAMIDE | CS-045 | Pancreatic beta cells | Genetic aspects | Research | Cell death | Medical research | Rodents | Cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 24, pp. 8452 - 8457
Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used to... 
Obesity | Gels | Nonesterified fatty acids | Palmitates | Type 2 diabetes mellitus | Diabetes | Islets of Langerhans | Insulin | Fatty acids | Apoptosis | Type 2 diabetes | 2D difference gel electrophoresis proteomics | Hyperproinsulinemia | Mechanisms of β-cell lipotoxicity | Free fatty acids | LEVELS PREDICT | HUMAN PANCREATIC-ISLETS | ENZYME-ACTIVITY | MULTIDISCIPLINARY SCIENCES | mechanisms of beta-cell lipotoxicity | INSULIN-SECRETION | free fatty acids | ENDOPLASMIC-RETICULUM STRESS | type 2 diabetes | PYRUVATE-DEHYDROGENASE ACTIVITY | PROHORMONE CONVERTASES | FREE FATTY-ACIDS | LINE INS-1 | TRIGLYCERIDE ACCUMULATION | hyperproinsulinemia | Endoplasmic Reticulum - enzymology | Golgi Apparatus - enzymology | Cell Survival | Diabetes Mellitus, Type 2 - genetics | Humans | Cells, Cultured | Diabetes Mellitus, Type 2 - enzymology | Apoptosis - genetics | Proteome | Hyperglycemia - genetics | Insulin-Secreting Cells - ultrastructure | Animals | Insulin-Secreting Cells - drug effects | Mice, Mutant Strains | Palmitates - pharmacology | Carboxypeptidase H - metabolism | Hyperglycemia - enzymology | Hyperinsulinism - enzymology | Hyperinsulinism - genetics | Mice | Palmitates - metabolism | Carboxypeptidase H - genetics | Insulin-Secreting Cells - enzymology | Biological Sciences | mechanisms of β-cell lipotoxicity
Journal Article
Nephrology Dialysis Transplantation, ISSN 0931-0509, 06/2012, Volume 27, Issue 6, pp. 2213 - 2225
Journal Article
Journal Article
Apoptosis, ISSN 1360-8185, 11/2015, Volume 20, Issue 11, pp. 1420 - 1432
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2017, Volume 138, pp. 140 - 149
Pancreatic β-cell lipotoxicity is a central feature of the pathogenesis of type 2 diabetes. To study the mechanism by which fatty acids cause β-cell death and... 
Beta-cell | Islet | Diabetes | Lipotoxicity | HUMAN PANCREATIC-ISLETS | ELASTIC NET | ACTIVATION | CANCER CELLS | RAT | ENDOPLASMIC-RETICULUM STRESS | PATHWAY | GLUCOSE | PHARMACOLOGY & PHARMACY | MAP4K4 | Islets of Langerhans - drug effects | Insulin-Secreting Cells - secretion | Rats, Wistar | Apoptosis - drug effects | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Islets of Langerhans - secretion | Insulin-Secreting Cells - metabolism | RNA Interference | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Insulin-Secreting Cells - cytology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fatty Acids, Nonesterified - adverse effects | Recombinant Proteins - metabolism | Cell Line | Tissue Culture Techniques | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Cells, Cultured | Computational Biology | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Hypoglycemic Agents - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Animals | Class I Phosphatidylinositol 3-Kinases | High-Throughput Screening Assays | Insulin-Secreting Cells - drug effects | Small Molecule Libraries | Fatty Acids, Nonesterified - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Index Medicus
Journal Article