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1998, Lung biology in health and disease, ISBN 9780824701673, Volume 120., xviii, 493
Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes... 
Chemotherapy | Pathophysiology | Metabolism | Leukotrienes | Asthma
Book
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2014, Volume 22, Issue 15, pp. 4151 - 4161
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Balanced modulation of several targets is one of the current strategies for the treatment of multi-factorial diseases. Based on the knowledge of inflammation... 
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | MECHANISM | CRYSTAL-STRUCTURE | LIPOXYGENASES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | COX-2 INHIBITORS | DUAL INHIBITORS | DERIVATIVES | ANTIMICROBIAL ACTIVITY | LIGAND DESIGN | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
Two new series of 1,5-diaryl pyrazoles ( , , , and ) and 1,5-diaryl pyrazoline ( and were prepared as both Cyclooxygenase-2 and 15-lipoxygenase inhibitors.... 
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | CHEMISTRY, MEDICINAL | COX-2 | LEUKOTRIENES | CYCLOOXYGENASE | PROSTAGLANDINS | INFLAMMATION | BIOLOGICAL EVALUATION | AGENTS | 5-LIPOXYGENASE | MEDIATORS | DERIVATIVES | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law) | Index Medicus
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2011, Volume 46, Issue 1, pp. 191 - 200
A series of novel acrylic acid derivatives bearing at the 3 position thienyl, furfuryl and 3,5-ditert-butyl-4-hydroxyphenyl substituents have been designed,... 
Substituted acrylic acids | LOX | COX-1 | Cyclooxygenase inhibitors | Lipoxygenase inhibitors | Anti-inflammatory agents | Antioxidant agents | CHEMISTRY, MEDICINAL | ESTER PRODRUGS | DI-TERT-BUTYLPHENOLS | 2,6-DI-TERT-BUTYLPHENOL | IN-VIVO EVALUATIONS | ANALGESIC AGENTS | BIOLOGICAL EVALUATION | 7-TERT-BUTYL-2,3-DIHYDRO-3,3-DIMETHYLBENZOFURAN DERIVATIVES | DUAL INHIBITORS | CYCLOOXYGENASE-2/5-LIPOXYGENASE INHIBITORS | 5-LIPOXYGENASE | Free Radical Scavengers - pharmacology | Acrylates - therapeutic use | Antioxidants - chemistry | Free Radical Scavengers - chemistry | Male | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Inflammation - drug therapy | Acrylates - pharmacology | Soybeans - enzymology | Drug Design | Anti-Inflammatory Agents - therapeutic use | Cyclooxygenase 1 - chemistry | Free Radical Scavengers - chemical synthesis | Acrylates - chemical synthesis | Female | Free Radical Scavengers - therapeutic use | Binding Sites | Acrylates - chemistry | Anti-Inflammatory Agents - pharmacology | Lipoxygenase Inhibitors - therapeutic use | Models, Molecular | Rats | Cyclooxygenase Inhibitors - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase Inhibitors - chemical synthesis | Protein Conformation | Anti-Inflammatory Agents - chemical synthesis | Cyclooxygenase 1 - metabolism | Lipoxygenase Inhibitors - pharmacology | Cyclooxygenase Inhibitors - therapeutic use | Antioxidants | Boats and boating | Anti-inflammatory drugs | Analysis | Acrylic acid | Index Medicus
Journal Article
Fundamental & Clinical Pharmacology, ISSN 0767-3981, 10/2019, Volume 33, Issue 5, pp. 535 - 543
This study was designed to observe the compensation between cyclooxygenase‐2 pathway and 5‐lipoxygenase pathway in chronic aluminum overload‐induced liver... 
liver injury | compensation | aluminum | cyclooxygenase‐2 | 5‐lipoxygenase | Meloxicam | Immunohistochemistry | Oxidative stress | Aluminum | Liver | Caffeic acid | Prostaglandin endoperoxide synthase | Histopathology | Inhibitors | Acids | Tumor necrosis factor | Liquid oxygen | Compensation | Lipoxygenase | Injuries
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Two new series of -substituted indole derivatives and were synthesized. Their chemical structures were confirmed using spectroscopic tools including IR, H NMR,... 
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | DESIGN | CHEMISTRY, MEDICINAL | INDOMETHACIN | CELECOXIB | SELECTIVE COX-2 INHIBITORS | LIPOXYGENASES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INFLAMMATION | ESTERS | AGENTS | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 972 - 985
A series of novel quinoline-2-carboxamides – was synthesized and evaluated as dual COXs/LOX inhibitors. Compounds and exhibited the highest potency and... 
COXs | Quinoline-2-carboxamides | Docking | LOX | Anti-inflammatory | DESIGN | CHEMISTRY, MEDICINAL | TEPOXALIN | ENZYMES | SELECTIVE CYCLOOXYGENASE-2 INHIBITORS | DRUGS | AGENTS | COX-2 INHIBITORS | 5-LIPOXYGENASE | DERIVATIVES | 5-LOX | Stomach Ulcer - pathology | Gastric Mucosa - pathology | Male | Quinolines - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Gastric Mucosa - drug effects | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Stomach Ulcer - chemically induced | Catalytic Domain | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Lipoxygenase Inhibitors - adverse effects | Quinolines - chemical synthesis | Quinolines - metabolism | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclooxygenase 2 - metabolism | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Lipoxygenase Inhibitors - pharmacology | Quinolines - adverse effects | Alkaloids | Carrageenin | Anti-inflammatory drugs | Analysis | Pharmacy | Quinoline | Drugstores | Index Medicus
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2012, Volume 83, Issue 2, pp. 228 - 240
Journal Article