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1. Full Text Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study
by Lamie, Phoebe F and Ali, Waleed A.M and Bazgier, Vaclav and Rárová, Lucie
European journal of medicinal chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
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2. Full Text Fragment-based design, docking, synthesis, biological evaluation and structure–activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors
by Eleftheriou, Phaedra and Geronikaki, Athina and Hadjipavlou-Litina, Dimitra and Vicini, Paola and Filz, Olga and Filimonov, Dmitry and Poroikov, Vladimir and Chaudhaery, Shailendra S and Roy, Kuldeep K and Saxena, Anil K
European journal of medicinal chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes | Index Medicus
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3. Full Text Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity
by Detsi, Anastasia and Majdalani, Maya and Kontogiorgis, Christos A and Hadjipavlou-Litina, Dimitra and Kefalas, Panagiotis
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 23, pp. 8073 - 8085
Lipid peroxidation | Aureusidin | Soybean lipoxygenase | Antioxidant | Aurones | 2′-Hydroxy-chalcones | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Fundamental and applied biological sciences. Psychology | Food industries | Biological and medical sciences | Fruit and vegetable industries | Chalcones - chemistry | Antioxidants - chemistry | Magnetic Resonance Spectroscopy | Linoleic Acid - metabolism | Picrates - metabolism | Benzofurans - chemical synthesis | Benzofurans - pharmacology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Biphenyl Compounds - metabolism | Benzofurans - chemistry | Linoleic Acid - antagonists & inhibitors | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Picrates - antagonists & inhibitors | Biphenyl Compounds - antagonists & inhibitors | Chalcones - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Mass Spectrometry | Chalcones - pharmacology | Lipoxygenase Inhibitors - pharmacology | Index Medicus
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4. Full Text Synthesis of Celecoxib Analogues Possessing a N-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity
by Chowdhury, Morshed A and Abdellatif, Khaled R. A and Dong, Ying and Das, Dipankar and Suresh, Mavanur R and Knaus, Edward E
Journal of medicinal chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 6, pp. 1525 - 1529
Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Magnetic Resonance Spectroscopy | Pyrazoles - chemical synthesis | Humans | Celecoxib | Sulfonamides - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Sulfonamides - chemical synthesis | Lipoxygenase Inhibitors - chemical synthesis | Animals | Spectrophotometry, Infrared | Cyclooxygenase Inhibitors - chemical synthesis | Drug Evaluation, Preclinical | Lipoxygenase Inhibitors - pharmacology | Pyrazoles - pharmacology | Index Medicus
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5. Full Text Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR
by Abdelall, Eman K.A and Kamel, Gehan M
European journal of medicinal chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law) | Index Medicus
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6. Full Text Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors
by Lai, Yisheng and Ma, Lin and Huang, Wenxing and Yu, Xing and Zhang, Yihua and Ji, Hui and Tian, Jide
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2010, Volume 20, Issue 24, pp. 7349 - 7353
Cyclooxygenase | Amino/methylsufonylphenyl | Anti-inflammatory agents | Indolin-2-one derivatives | 5-Lipoxygenase | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Neuropharmacology | Analgesics | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Analgesics - pharmacology | Indoles - chemical synthesis | Male | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Benzylidene Compounds - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Analgesics - chemical synthesis | Arachidonate 5-Lipoxygenase - chemistry | Cyclooxygenase 1 - chemistry | Indoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Benzylidene Compounds - chemical synthesis | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzylidene Compounds - pharmacology | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Mice | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Index Medicus
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7. Full Text Synthesis and Structure–Activity Relationship Studies of 4‑((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase
by Luci, Diane K and Jameson, J. Brian and Yasgar, Adam and Diaz, Giovanni and Joshi, Netra and Kantz, Auric and Markham, Kate and Perry, Steve and Kuhn, Norine and Yeung, Jennifer and Kerns, Edward H and Schultz, Lena and Holinstat, Michael and Nadler, Jerry L and Taylor-Fishwick, David A and Jadhav, Ajit and Simeonov, Anton and Holman, Theodore R and Maloney, David J
Journal of medicinal chemistry, ISSN 0022-2623, 01/2014, Volume 57, Issue 2, pp. 495 - 506
Islets of Langerhans - drug effects | Benzene Derivatives - chemical synthesis | Arachidonate 12-Lipoxygenase - metabolism | Sulfonamides - chemistry | Calcium - metabolism | Islets of Langerhans - enzymology | Humans | Biological Availability | Structure-Activity Relationship | Sulfonamides - pharmacology | Sulfonamides - chemical synthesis | Lipoxygenase Inhibitors - chemical synthesis | Animals | Lipoxygenase Inhibitors - chemistry | Blood Platelets - metabolism | Mice | Platelet Aggregation - drug effects | Benzene Derivatives - chemistry | Blood Platelets - drug effects | Lipoxygenase Inhibitors - pharmacology | Benzene Derivatives - pharmacology | Index Medicus
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8. Full Text Synthesis and Antiinflammatory Activity of Coumarin Derivatives
by Kontogiorgis, Christos A and Hadjipavlou-Litina, Dimitra J
Journal of medicinal chemistry, ISSN 0022-2623, 10/2005, Volume 48, Issue 20, pp. 6400 - 6408
Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Arthritis, Experimental - drug therapy | Free Radical Scavengers - chemistry | Rats, Inbred F344 | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coumarins - chemistry | Male | Structure-Activity Relationship | Immunologic Factors - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Mannich Bases - chemical synthesis | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Free Radical Scavengers - chemical synthesis | Mannich Bases - pharmacology | Female | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Immunologic Factors - chemistry | Superoxides - chemistry | Rats | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Mannich Bases - chemistry | Coumarins - pharmacology | Animals | Coumarins - chemical synthesis | Cyclooxygenase Inhibitors - chemical synthesis | Carrageenan | Edema - chemically induced | Immunologic Factors - pharmacology | Index Medicus
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9. Full Text Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors
by Reddy, M.V. Ramana and Billa, Vinay K and Pallela, Venkat R and Mallireddigari, Muralidhar R and Boominathan, Rengasamy and Gabriel, Jerome L and Reddy, E. Premkumar
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 7, pp. 3907 - 3916
Molecular modelling | COX-2 | LOX | Lipoxygenase inhibitors | anti-inflammation | Enantiomers | Cyclooxygenase-2 inhibitors | Pyrazolines | Pyrazole | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Fluorine Compounds - pharmacology | Sulfur Compounds - pharmacology | Pyrazoles - chemical synthesis | Stereoisomerism | Humans | Blood Platelets - enzymology | Fluorine Compounds - chemical synthesis | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Fluorine Compounds - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Drug Design | Molecular Structure | Sulfur Compounds - chemistry | Blood Platelets - drug effects | Binding Sites | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Cyclooxygenase 2 - chemistry | Models, Molecular | Hydrogen Bonding | Cyclooxygenase 2 - metabolism | Sulfur Compounds - chemical synthesis | Methylation | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Index Medicus
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10. Full Text Synthesis, biological evaluation and docking study of 3-aroyl-1-(4-sulfamoylphenyl)thiourea derivatives as 15-lipoxygenase inhibitors
by Mahdavi, Mohammad and Shirazi, Maryam Shahzad and Taherkhani, Raana and Saeedi, Mina and Alipour, Eskandar and Moghadam, Farshad Homayouni and Moradi, Alireza and Nadri, Hamid and Emami, Saeed and Firoozpour, Loghman and Shafiee, Abbas and Foroumadi, Alireza
European journal of medicinal chemistry, ISSN 0223-5234, 07/2014, Volume 82, pp. 308 - 313
Thiourea | Docking study | Enzyme inhibitors | Sulfonamides | 15-Lipoxygenase | Antioxidant activity | Cell Survival - drug effects | Cells, Cultured | Hydrogen Peroxide - pharmacology | Models, Molecular | Rats | Structure-Activity Relationship | Arachidonate 15-Lipoxygenase - metabolism | PC12 Cells | Dose-Response Relationship, Drug | Lipoxygenase Inhibitors - chemical synthesis | Animals | Lipoxygenase Inhibitors - chemistry | Cell Differentiation - drug effects | Soybeans - enzymology | Molecular Structure | Cell Death - drug effects | Oxidative Stress - drug effects | Hydrogen Peroxide - antagonists & inhibitors | Lipoxygenase Inhibitors - pharmacology | Antioxidants | Drugstores | Iron compounds | Pharmacy | Organic acids | Index Medicus
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11. Full Text Synthesis and Structure–Activity Relationship Studies of Novel Dual Inhibitors of Soluble Epoxide Hydrolase and 5‑Lipoxygenase
by Meirer, Karin and Rödl, Carmen B and Wisniewska, Joanna M and George, Sven and Häfner, Ann-Kathrin and Buscató, Estel·la and Klingler, Franca-Maria and Hahn, Steffen and Berressem, Dirk and Wittmann, Sandra K and Steinhilber, Dieter and Hofmann, Bettina and Proschak, Ewgenij
Journal of medicinal chemistry, ISSN 0022-2623, 02/2013, Volume 56, Issue 4, pp. 1777 - 1781
Pyridines - chemistry | Humans | Imidazoles - chemistry | Pyridines - chemical synthesis | Recombinant Proteins - chemistry | Structure-Activity Relationship | Urea - chemical synthesis | Urea - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Urea - analogs & derivatives | Arachidonate 5-Lipoxygenase - chemistry | Imidazoles - chemical synthesis | Epoxide Hydrolases - antagonists & inhibitors | Epoxide Hydrolases - chemistry | Index Medicus
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12. Full Text Design, Synthesis, and Structure–Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5‑Lipoxygenase
by Hiesinger, Kerstin and Kramer, Jan S and Beyer, Sandra and Eckes, Timon and Brunst, Steffen and Flauaus, Cathrin and Wittmann, Sandra K and Weizel, Lilia and Kaiser, Astrid and Kretschmer, Simon B. M and George, Sven and Angioni, Carlo and Heering, Jan and Geisslinger, Gerd and Schubert-Zsilavecz, Manfred and Schmidtko, Achim and Pogoryelov, Denys and Pfeilschifter, Josef and Hofmann, Bettina and Steinhilber, Dieter and Schwalm, Stephanie and Proschak, Ewgenij
Journal of medicinal chemistry, ISSN 0022-2623, 10/2020, Volume 63, Issue 20, pp. 11498 - 11521
Arachidonate 5-Lipoxygenase - metabolism | Neutrophils - enzymology | Arachidonate 5-Lipoxygenase - genetics | Humans | Neutrophils - drug effects | Cells, Cultured | Rats | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Epoxide Hydrolases - genetics | Lipoxygenase Inhibitors - chemical synthesis | Animals | Lipoxygenase Inhibitors - chemistry | Microsomes, Liver - drug effects | Drug Design | Protein Binding | Microsomes, Liver - enzymology | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Epoxide Hydrolases - antagonists & inhibitors | Lipoxygenase Inhibitors - pharmacology | Index Medicus
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13. Full Text Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities
by Pontiki, Eleni and Hadjipavlou-Litina, Dimitra and Litinas, Konstantinos and Nicolotti, Orazio and Carotti, Angelo
European journal of medicinal chemistry, ISSN 0223-5234, 01/2011, Volume 46, Issue 1, pp. 191 - 200
Substituted acrylic acids | LOX | COX-1 | Cyclooxygenase inhibitors | Lipoxygenase inhibitors | Anti-inflammatory agents | Antioxidant agents | Free Radical Scavengers - pharmacology | Acrylates - therapeutic use | Antioxidants - chemistry | Free Radical Scavengers - chemistry | Male | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Inflammation - drug therapy | Acrylates - pharmacology | Soybeans - enzymology | Drug Design | Anti-Inflammatory Agents - therapeutic use | Cyclooxygenase 1 - chemistry | Free Radical Scavengers - chemical synthesis | Acrylates - chemical synthesis | Female | Free Radical Scavengers - therapeutic use | Binding Sites | Acrylates - chemistry | Anti-Inflammatory Agents - pharmacology | Lipoxygenase Inhibitors - therapeutic use | Models, Molecular | Rats | Cyclooxygenase Inhibitors - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase Inhibitors - chemical synthesis | Protein Conformation | Anti-Inflammatory Agents - chemical synthesis | Cyclooxygenase 1 - metabolism | Lipoxygenase Inhibitors - pharmacology | Cyclooxygenase Inhibitors - therapeutic use | Antioxidants | Boats and boating | Anti-inflammatory drugs | Analysis | Acrylic acid | Index Medicus
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14. Full Text Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-Lipoxygenase-1
by Rai, Ganesha and Kenyon, Victor and Jadhav, Ajit and Schultz, Lena and Armstrong, Michelle and Jameson, J. Brian and Hoobler, Eric and Leister, William and Simeonov, Anton and Holman, Theodore R and Maloney, David J
Journal of medicinal chemistry, ISSN 0022-2623, 10/2010, Volume 53, Issue 20, pp. 7392 - 7404
Naphthalenes - chemical synthesis | Naphthalenes - chemistry | Alkynes - chemical synthesis | Oxadiazoles - chemical synthesis | Reticulocytes - enzymology | Benzoates - chemistry | Humans | Sulfides - chemistry | Models, Molecular | Arachidonate 15-Lipoxygenase - chemistry | Esters | Sulfides - chemical synthesis | Alkynes - chemistry | Benzoates - chemical synthesis | Structure-Activity Relationship | Thiophenes - chemical synthesis | Small Molecule Libraries | Kinetics | Oxadiazoles - chemistry | Thiophenes - chemistry | Binding Sites | Lipoxygenase Inhibitors | Index Medicus | inhibitor | Human 15-lipoxygenase-1 | high-throughput
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15. Full Text Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY
by Abdelall, Eman K.A and Lamie, Phoebe F and Ali, Waleed A.M
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 06/2016, Volume 26, Issue 12, pp. 2893 - 2899
15-Lipoxygenase inhibitors | Diethyl oxalate | Sulfonamide pharmacophores | Cyclooxygenase inhibitors | Antiinflammatory | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Humans | Models, Molecular | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Structure-Activity Relationship | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cyclooxygenase 2 - metabolism | Celecoxib - chemical synthesis | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Lipoxygenase Inhibitors - pharmacology | Pyrazoles - pharmacology | COX-2 inhibitors | Liability (Law) | Index Medicus
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16. Full Text Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines
by Bukhari, Syed Nasir Abbas and Lauro, Gianluigi and Jantan, Ibrahim and Bifulco, Giuseppe and Amjad, Muhammad Wahab
Bioorganic & medicinal chemistry, ISSN 0968-0896, 08/2014, Volume 22, Issue 15, pp. 4151 - 4161
Tumor necrosis factor alpha | Curcumin | Claisen–Schmidt condensation | Lipopolysaccharides | Claisen-Schmidt condensation | Tumor Necrosis Factor-alpha - metabolism | Interleukin-6 - antagonists & inhibitors | Curcumin - chemistry | Structure-Activity Relationship | Phospholipase A2 Inhibitors - pharmacology | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Prostaglandin-Endoperoxide Synthases - chemistry | Soybeans - enzymology | Phospholipase A2 Inhibitors - chemistry | Phospholipase A2 Inhibitors - chemical synthesis | Binding Sites | Interleukin-6 - metabolism | Protein Structure, Tertiary | Cell Line | Curcumin - pharmacology | Cyclooxygenase Inhibitors - chemistry | Macrophages - cytology | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Macrophages - metabolism | Animals | Phospholipases A2, Secretory - antagonists & inhibitors | Prostaglandin-Endoperoxide Synthases - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Protein Binding | Macrophages - drug effects | Mice | Molecular Docking Simulation | Phospholipases A2, Secretory - metabolism | Lipoxygenase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus
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