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1. Full Text Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines
by Bukhari, Syed Nasir Abbas and Lauro, Gianluigi and Jantan, Ibrahim and Bifulco, Giuseppe and Amjad, Muhammad Wahab
Bioorganic & medicinal chemistry, ISSN 0968-0896, 08/2014, Volume 22, Issue 15, pp. 4151 - 4161
Tumor necrosis factor alpha | Curcumin | Claisen–Schmidt condensation | Lipopolysaccharides | Claisen-Schmidt condensation | Tumor Necrosis Factor-alpha - metabolism | Interleukin-6 - antagonists & inhibitors | Curcumin - chemistry | Structure-Activity Relationship | Phospholipase A2 Inhibitors - pharmacology | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Prostaglandin-Endoperoxide Synthases - chemistry | Soybeans - enzymology | Phospholipase A2 Inhibitors - chemistry | Phospholipase A2 Inhibitors - chemical synthesis | Binding Sites | Interleukin-6 - metabolism | Protein Structure, Tertiary | Cell Line | Curcumin - pharmacology | Cyclooxygenase Inhibitors - chemistry | Macrophages - cytology | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Macrophages - metabolism | Animals | Phospholipases A2, Secretory - antagonists & inhibitors | Prostaglandin-Endoperoxide Synthases - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Protein Binding | Macrophages - drug effects | Mice | Molecular Docking Simulation | Phospholipases A2, Secretory - metabolism | Lipoxygenase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus
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2. Full Text Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study
by Lamie, Phoebe F and Ali, Waleed A.M and Bazgier, Vaclav and Rárová, Lucie
European journal of medicinal chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
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3. Full Text Fragment-based design, docking, synthesis, biological evaluation and structure–activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors
by Eleftheriou, Phaedra and Geronikaki, Athina and Hadjipavlou-Litina, Dimitra and Vicini, Paola and Filz, Olga and Filimonov, Dmitry and Poroikov, Vladimir and Chaudhaery, Shailendra S and Roy, Kuldeep K and Saxena, Anil K
European journal of medicinal chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes | Index Medicus
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4. Full Text Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR
by Abdelall, Eman K.A and Kamel, Gehan M
European journal of medicinal chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law) | Index Medicus
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5. Full Text Antioxidant capacity and DNA-interaction studies of zinc complexes with a non-steroidal anti-inflammatory drug, mefenamic acid
by Tarushi, Alketa and Karaflou, Zoi and Kljun, Jakob and Turel, Iztok and Psomas, George and Papadopoulos, Athanasios N and Kessissoglou, Dimitris P
Journal of inorganic biochemistry, ISSN 0162-0134, 11/2013, Volume 128, pp. 85 - 96
Antioxidant capacity | Zinc complexes | Interaction with calf-thymus DNA | Mefenamic acid | Interaction with serum albumins | Biochemistry & Molecular Biology | Physical Sciences | Chemistry, Inorganic & Nuclear | Chemistry | Life Sciences & Biomedicine | Science & Technology | Free Radical Scavengers - pharmacology | Antioxidants - chemistry | Free Radical Scavengers - chemistry | Antioxidants - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coordination Complexes - metabolism | Crystallography, X-Ray | Zinc - chemistry | Biphenyl Compounds - metabolism | Mefenamic Acid - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Lipoxygenase - metabolism | Zinc Compounds - metabolism | Biphenyl Compounds - antagonists & inhibitors | Lipoxygenase Inhibitors - chemistry | Zinc Compounds - pharmacology | Cattle | Mefenamic Acid - metabolism | Picrates - chemistry | Soybeans - enzymology | Coordination Complexes - pharmacology | Free Radicals - metabolism | Serum Albumin, Bovine - chemistry | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Biphenyl Compounds - chemistry | Serum Albumin - chemistry | Free Radical Scavengers - metabolism | Free Radicals - chemistry | Picrates - metabolism | Antioxidants - pharmacology | DNA - metabolism | Serum Albumin, Bovine - metabolism | Coordination Complexes - chemistry | Spectrophotometry, Ultraviolet | Zinc Compounds - chemistry | DNA - chemistry | Free Radicals - antagonists & inhibitors | Mefenamic Acid - pharmacology | Picrates - antagonists & inhibitors | Animals | Lipoxygenase Inhibitors - metabolism | Kinetics | Lipoxygenase Inhibitors - pharmacology | Serum Albumin - metabolism | Proteins | Antioxidants | Drug interactions | DNA | Genetic research | Nonsteroidal anti-inflammatory drugs | Protein binding | Index Medicus
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6. Full Text Identifying Chelators for Metalloprotein Inhibitors Using a Fragment-Based Approach
by Jacobsen, Jennifer A and Fullagar, Jessica L and Miller, Melissa T and Cohen, Seth M
Journal of medicinal chemistry, ISSN 0022-2623, 01/2011, Volume 54, Issue 2, pp. 591 - 602
Hydroxyquinolines - chemistry | Humans | Nitric Oxide Synthase Type II - chemistry | Iron | Monophenol Monooxygenase - antagonists & inhibitors | Structure-Activity Relationship | Bacterial Toxins - antagonists & inhibitors | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Nitric Oxide Synthase Type II - antagonists & inhibitors | Drug Design | Copper | Monophenol Monooxygenase - chemistry | Recombinant Proteins - antagonists & inhibitors | Antigens, Bacterial - chemistry | Sulfonamides - chemistry | Chelating Agents - chemistry | Recombinant Proteins - chemistry | Hydroxyquinolines - chemical synthesis | Bacterial Toxins - chemistry | Zinc | Sulfonamides - chemical synthesis | Small Molecule Libraries | Matrix Metalloproteinases - chemistry | Matrix Metalloproteinase Inhibitors | Ligands | Chelating Agents - chemical synthesis | Index Medicus
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7. Full Text Dynamic Modeling of Human 5-Lipoxygenase–Inhibitor Interactions Helps To Discover Novel Inhibitors
by Wu, Yiran and He, Chong and Gao, Yang and He, Shan and Liu, Ying and Lai, Luhua
Journal of medicinal chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 6, pp. 2597 - 2605
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Recombinant Proteins - antagonists & inhibitors | Arachidonate 5-Lipoxygenase - blood | Humans | Intramolecular Oxidoreductases - antagonists & inhibitors | Recombinant Proteins - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Intramolecular Oxidoreductases - blood | Microsomes - enzymology | Structure-Activity Relationship | Dinoprostone - blood | Molecular Dynamics Simulation | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Leukotriene B4 - blood | Pyrroles - pharmacology | Cell-Free System | Lipoxygenase Inhibitors - chemistry | Prostaglandin-E Synthases | Arachidonate 5-Lipoxygenase - chemistry | Protein Binding | Pyrroles - chemistry | Protein Conformation | Lipoxygenase Inhibitors - pharmacology | Databases, Factual | Index Medicus
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8. Full Text Composition and bioactivity of essential oil from citrus grandis (L.) Osbeck ‘Mato Peiyu’ leaf
by Tsai, Mei-Lin and Lin, Cai-Di and Khoo, Keh Ai and Wang, Mei-Ying and Kuan, Tsang-Kuei and Lin, Wei-Chao and Zhang, Ya-Nan and Wang, Ya-Ying
Molecules (Basel, Switzerland), ISSN 1420-3049, 12/2017, Volume 22, Issue 12, p. 2154
Antimicrobial | Chemical composition | Essential oil | Antityrosinase | Antioxidant | Anti-inflammation | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Anti-Infective Agents - isolation & purification | Antioxidants - chemistry | Oils, Volatile - chemistry | Anti-Infective Agents - pharmacology | Escherichia coli - drug effects | Pseudomonas aeruginosa - growth & development | Citrus - chemistry | Oils, Volatile - pharmacology | Monophenol Monooxygenase - antagonists & inhibitors | Candida albicans - growth & development | beta Carotene - chemistry | Monophenol Monooxygenase - metabolism | Microbial Sensitivity Tests | Monoterpenes - pharmacology | Candida albicans - drug effects | Biphenyl Compounds - antagonists & inhibitors | Aldehydes - pharmacology | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Picrates - chemistry | Aldehydes - isolation & purification | Anti-Inflammatory Agents - isolation & purification | Biphenyl Compounds - chemistry | Escherichia coli - growth & development | Microwaves | Plant Leaves - chemistry | Monoterpenes - isolation & purification | Arachidonate 5-Lipoxygenase - metabolism | Nitric Oxide - chemistry | Anti-Inflammatory Agents - pharmacology | Nitric Oxide - antagonists & inhibitors | beta Carotene - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Antioxidants - pharmacology | Oils, Volatile - isolation & purification | Pseudomonas aeruginosa - drug effects | Enzyme Inhibitors - isolation & purification | Picrates - antagonists & inhibitors | Anti-Inflammatory Agents - chemistry | Antioxidants - isolation & purification | Monoterpenes - chemistry | Liquid-Liquid Extraction - methods | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Aldehydes - chemistry | Distillation - methods | Citronellal | Antimicrobial activity | Essential oils | Steam distillation | Assaying | Antiinfectives and antibacterials | Antioxidants | Leaves | E coli | Arachidonate 5-lipoxygenase | Pruning | Pseudomonas aeruginosa | Inhibition | Distillation | Scavenging | Mass spectroscopy | Antimicrobial agents | Inflammation | Agricultural wastes | Biological activity | Linoleic acid | β-Carotene | Gas chromatography | Citronellol | Nitric oxide | Steam | Oils & fats | Skin | Lipoxygenase | Mass spectrometry | Index Medicus | antimicrobial | antioxidant | anti-inflammation | essential oil | antityrosinase | chemical composition
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9. Full Text Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors
by Lai, Yisheng and Ma, Lin and Huang, Wenxing and Yu, Xing and Zhang, Yihua and Ji, Hui and Tian, Jide
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2010, Volume 20, Issue 24, pp. 7349 - 7353
Cyclooxygenase | Amino/methylsufonylphenyl | Anti-inflammatory agents | Indolin-2-one derivatives | 5-Lipoxygenase | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Neuropharmacology | Analgesics | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Analgesics - pharmacology | Indoles - chemical synthesis | Male | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Benzylidene Compounds - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Analgesics - chemical synthesis | Arachidonate 5-Lipoxygenase - chemistry | Cyclooxygenase 1 - chemistry | Indoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Benzylidene Compounds - chemical synthesis | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzylidene Compounds - pharmacology | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Mice | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Index Medicus
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10. Full Text Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS
by Xie, Linlin and Lee, David Yue-wei and Shang, Ying and Cao, Xiaotong and Wang, Siqi and Liao, Jun and Zhang, Teng and Dai, Ronghua
Phytomedicine (Stuttgart), ISSN 0944-7113, 10/2020, Volume 77, pp. 153284 - 153284
Saponins | AUF-LC-MS | Inflammation | Cyclooxygenase-2 | 5-lipoxygenase | Dual targeted inhibitors | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Spirostans - pharmacology | Arachidonate 5-Lipoxygenase - genetics | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Chromatography, High Pressure Liquid | Cyclooxygenase 2 Inhibitors - chemistry | Saponins - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Ultrafiltration | Anemarrhena - chemistry | Lipoxygenase Inhibitors - chemistry | Rhizome - chemistry | Cyclooxygenase 2 - genetics | Inflammation - drug therapy | Mass Spectrometry | Arachidonate 5-Lipoxygenase - chemistry | Steroids - pharmacology | Spirostans - chemistry | Drug Evaluation, Preclinical | Glycosides - chemistry | Steroids - chemistry | Sterols - pharmacology | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Sterols - chemistry | Cyclooxygenase 2 - chemistry | Rats | Glycosides - pharmacology | Animals | Cyclooxygenase 2 - metabolism | Molecular Docking Simulation | Lipoxygenase Inhibitors - pharmacology | Saponins - pharmacology | Index Medicus
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11. Full Text Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities
by Pontiki, Eleni and Hadjipavlou-Litina, Dimitra and Litinas, Konstantinos and Nicolotti, Orazio and Carotti, Angelo
European journal of medicinal chemistry, ISSN 0223-5234, 01/2011, Volume 46, Issue 1, pp. 191 - 200
Substituted acrylic acids | LOX | COX-1 | Cyclooxygenase inhibitors | Lipoxygenase inhibitors | Anti-inflammatory agents | Antioxidant agents | Free Radical Scavengers - pharmacology | Acrylates - therapeutic use | Antioxidants - chemistry | Free Radical Scavengers - chemistry | Male | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Inflammation - drug therapy | Acrylates - pharmacology | Soybeans - enzymology | Drug Design | Anti-Inflammatory Agents - therapeutic use | Cyclooxygenase 1 - chemistry | Free Radical Scavengers - chemical synthesis | Acrylates - chemical synthesis | Female | Free Radical Scavengers - therapeutic use | Binding Sites | Acrylates - chemistry | Anti-Inflammatory Agents - pharmacology | Lipoxygenase Inhibitors - therapeutic use | Models, Molecular | Rats | Cyclooxygenase Inhibitors - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase Inhibitors - chemical synthesis | Protein Conformation | Anti-Inflammatory Agents - chemical synthesis | Cyclooxygenase 1 - metabolism | Lipoxygenase Inhibitors - pharmacology | Cyclooxygenase Inhibitors - therapeutic use | Antioxidants | Boats and boating | Anti-inflammatory drugs | Analysis | Acrylic acid | Index Medicus
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