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Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 41 - 52
Ferroptosis has recently been identified as a mode of programmed cell death. However, little is yet known about the signaling mechanism. Here, we report that... 
Acute leukemia | Redox | Ferroptosis | Cell death | ROS | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | NECROPTOSIS | 5-LIPOXYGENASE INHIBITOR | ARACHIDONIC-ACID | PEROXIDATION | ZILEUTON | ANTIOXIDANT | RESISTANCE | PHARMACOLOGY & PHARMACY | Masoprocol - pharmacology | Reactive Oxygen Species - metabolism | Arachidonate 12-Lipoxygenase - metabolism | Glutathione Peroxidase - antagonists & inhibitors | Humans | Arachidonate 12-Lipoxygenase - chemistry | Arachidonate 15-Lipoxygenase - chemistry | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Cyclohexylamines - pharmacology | Lipid Peroxidation - drug effects | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | alpha-Tocopherol - pharmacology | Arachidonate 12-Lipoxygenase - genetics | Fas-Associated Death Domain Protein - genetics | Glutathione Peroxidase - metabolism | Flavanones - pharmacology | Fas-Associated Death Domain Protein - metabolism | Carbolines - antagonists & inhibitors | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Arachidonate 15-Lipoxygenase - metabolism | Glutathione Peroxidase - genetics | Reactive Oxygen Species - antagonists & inhibitors | Arachidonate 15-Lipoxygenase - genetics | Cell Line, Tumor | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Phenylenediamines - pharmacology | Kinetics | Oxidative Stress - drug effects | Lipoxygenase Inhibitors - pharmacology | Carbolines - pharmacology | Biochemistry | Peroxidase | Acute lymphocytic leukemia | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Two new series of -substituted indole derivatives and were synthesized. Their chemical structures were confirmed using spectroscopic tools including IR, H NMR,... 
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | DESIGN | CHEMISTRY, MEDICINAL | INDOMETHACIN | CELECOXIB | SELECTIVE COX-2 INHIBITORS | LIPOXYGENASES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INFLAMMATION | ESTERS | AGENTS | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2014, Volume 22, Issue 15, pp. 4151 - 4161
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 01/2014, Volume 114, Issue 1, pp. 70 - 77
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 11/2013, Volume 128, pp. 85 - 96
Zinc(II) complexes of a non-steroidal anti-inflammatory drug, mefenamic acid(= Hmef) in the absence or presence of the nitrogen donor heterocyclic ligands... 
Antioxidant capacity | Zinc complexes | Interaction with calf-thymus DNA | Mefenamic acid | Interaction with serum albumins | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTICONVULSANT ACTIVITIES | CRYSTAL-STRUCTURES | STRUCTURAL-CHARACTERIZATION | BINDING PROPERTIES | CHEMISTRY, INORGANIC & NUCLEAR | COPPER(II) COMPLEXES | IN-VITRO | BIOLOGICAL EVALUATION | COBALT(II) COMPLEXES | METAL-COMPLEXES | Free Radical Scavengers - pharmacology | Antioxidants - chemistry | Free Radical Scavengers - chemistry | Antioxidants - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coordination Complexes - metabolism | Crystallography, X-Ray | Zinc - chemistry | Biphenyl Compounds - metabolism | Mefenamic Acid - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Lipoxygenase - metabolism | Zinc Compounds - metabolism | Biphenyl Compounds - antagonists & inhibitors | Lipoxygenase Inhibitors - chemistry | Zinc Compounds - pharmacology | Cattle | Mefenamic Acid - metabolism | Picrates - chemistry | Soybeans - enzymology | Coordination Complexes - pharmacology | Free Radicals - metabolism | Serum Albumin, Bovine - chemistry | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Biphenyl Compounds - chemistry | Serum Albumin - chemistry | Free Radical Scavengers - metabolism | Free Radicals - chemistry | Picrates - metabolism | Antioxidants - pharmacology | DNA - metabolism | Serum Albumin, Bovine - metabolism | Coordination Complexes - chemistry | Spectrophotometry, Ultraviolet | Zinc Compounds - chemistry | DNA - chemistry | Free Radicals - antagonists & inhibitors | Mefenamic Acid - pharmacology | Picrates - antagonists & inhibitors | Animals | Lipoxygenase Inhibitors - metabolism | Kinetics | Lipoxygenase Inhibitors - pharmacology | Serum Albumin - metabolism | Proteins | Antioxidants | Drug interactions | DNA | Genetic research | Nonsteroidal anti-inflammatory drugs | Protein binding
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
Two new series of 1,5-diaryl pyrazoles ( , , , and ) and 1,5-diaryl pyrazoline ( and were prepared as both Cyclooxygenase-2 and 15-lipoxygenase inhibitors.... 
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | CHEMISTRY, MEDICINAL | COX-2 | LEUKOTRIENES | CYCLOOXYGENASE | PROSTAGLANDINS | INFLAMMATION | BIOLOGICAL EVALUATION | AGENTS | 5-LIPOXYGENASE | MEDIATORS | DERIVATIVES | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law)
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Balanced modulation of several targets is one of the current strategies for the treatment of multi-factorial diseases. Based on the knowledge of inflammation... 
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ACID | MECHANISM | CRYSTAL-STRUCTURE | DRUG DISCOVERY | CANDIDATE | DUAL INHIBITORS | DERIVATIVES | ANTIMICROBIAL ACTIVITY | LIGAND DESIGN | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes
Journal Article
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