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Biochemical pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 41 - 52
Acute leukemia | Redox | Ferroptosis | Cell death | ROS | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Masoprocol - pharmacology | Reactive Oxygen Species - metabolism | Arachidonate 12-Lipoxygenase - metabolism | Glutathione Peroxidase - antagonists & inhibitors | Humans | Arachidonate 12-Lipoxygenase - chemistry | Arachidonate 15-Lipoxygenase - chemistry | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Cyclohexylamines - pharmacology | Lipid Peroxidation - drug effects | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | alpha-Tocopherol - pharmacology | Arachidonate 12-Lipoxygenase - genetics | Fas-Associated Death Domain Protein - genetics | Glutathione Peroxidase - metabolism | Flavanones - pharmacology | Fas-Associated Death Domain Protein - metabolism | Carbolines - antagonists & inhibitors | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Arachidonate 15-Lipoxygenase - metabolism | Glutathione Peroxidase - genetics | Reactive Oxygen Species - antagonists & inhibitors | Arachidonate 15-Lipoxygenase - genetics | Cell Line, Tumor | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Phenylenediamines - pharmacology | Kinetics | Oxidative Stress - drug effects | Lipoxygenase Inhibitors - pharmacology | Carbolines - pharmacology | Biochemistry | Peroxidase | Acute lymphocytic leukemia | Index Medicus
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 08/2014, Volume 22, Issue 15, pp. 4151 - 4161
Tumor necrosis factor alpha | Curcumin | Claisen–Schmidt condensation | Lipopolysaccharides | Claisen-Schmidt condensation | Tumor Necrosis Factor-alpha - metabolism | Interleukin-6 - antagonists & inhibitors | Curcumin - chemistry | Structure-Activity Relationship | Phospholipase A2 Inhibitors - pharmacology | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Prostaglandin-Endoperoxide Synthases - chemistry | Soybeans - enzymology | Phospholipase A2 Inhibitors - chemistry | Phospholipase A2 Inhibitors - chemical synthesis | Binding Sites | Interleukin-6 - metabolism | Protein Structure, Tertiary | Cell Line | Curcumin - pharmacology | Cyclooxygenase Inhibitors - chemistry | Macrophages - cytology | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Macrophages - metabolism | Animals | Phospholipases A2, Secretory - antagonists & inhibitors | Prostaglandin-Endoperoxide Synthases - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Protein Binding | Macrophages - drug effects | Mice | Molecular Docking Simulation | Phospholipases A2, Secretory - metabolism | Lipoxygenase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
Journal Article
Basic & clinical pharmacology & toxicology, ISSN 1742-7835, 01/2014, Volume 114, Issue 1, pp. 83 - 91
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Arachidonic Acid - metabolism | Pyrroles - pharmacology | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Inflammation - drug therapy | Pain - drug therapy | Humans | Cytochrome P-450 Enzyme System - metabolism | Epoxide Hydrolases - metabolism | Epoxide Hydrolases - antagonists & inhibitors | Lipoxygenase Inhibitors - pharmacology | Arachidonic acid | Unsaturated fatty acids | Index Medicus | Antiinflammatory agents
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law) | Index Medicus
Journal Article
Fundamental & clinical pharmacology, ISSN 0767-3981, 10/2019, Volume 33, Issue 5, pp. 535 - 543
liver injury | compensation | aluminum | cyclooxygenase‐2 | 5‐lipoxygenase | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Malondialdehyde - metabolism | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Chemical and Drug Induced Liver Injury, Chronic - metabolism | Liver - metabolism | Aluminum - pharmacology | Rats | Caffeic Acids - pharmacology | Chemical and Drug Induced Liver Injury, Chronic - drug therapy | Rats, Sprague-Dawley | Inflammation - metabolism | Animals | Liver - drug effects | Inflammation - drug therapy | Cyclooxygenase 2 - metabolism | Oxidative Stress - drug effects | Lipoxygenase Inhibitors - pharmacology | Meloxicam | Immunohistochemistry | COX-2 inhibitors | Liver diseases | Liver | Oxidative stress | Aluminum | Caffeic acid | Prostaglandin endoperoxide synthase | Histopathology | Acids | Tumor necrosis factor | Liquid oxygen | Compensation | Lipoxygenase | Injuries | Index Medicus
Journal Article
Basic & clinical pharmacology & toxicology, ISSN 1742-7835, 01/2014, Volume 114, Issue 1, pp. 70 - 77
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Leukotrienes - metabolism | Arachidonic Acid - metabolism | Pyrroles - pharmacology | Arachidonate 5-Lipoxygenase - metabolism | Rhinitis, Allergic | Humans | Computational Biology | Drug Design | Lipoxygenase Inhibitors - pharmacology | Rhinitis, Allergic, Perennial - drug therapy | Pharmaceutical industry | Medical research | Asthma | Index Medicus | Allergic rhinitis
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 6, pp. 2597 - 2605
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Recombinant Proteins - antagonists & inhibitors | Arachidonate 5-Lipoxygenase - blood | Humans | Intramolecular Oxidoreductases - antagonists & inhibitors | Recombinant Proteins - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Intramolecular Oxidoreductases - blood | Microsomes - enzymology | Structure-Activity Relationship | Dinoprostone - blood | Molecular Dynamics Simulation | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Leukotriene B4 - blood | Pyrroles - pharmacology | Cell-Free System | Lipoxygenase Inhibitors - chemistry | Prostaglandin-E Synthases | Arachidonate 5-Lipoxygenase - chemistry | Protein Binding | Pyrroles - chemistry | Protein Conformation | Lipoxygenase Inhibitors - pharmacology | Databases, Factual | Index Medicus
Journal Article
The Journal of neuroscience, ISSN 0270-6474, 12/2008, Volume 28, Issue 51, pp. 13985 - 13994
Peroxisome proliferator-activated receptor | Electrophysiology | Fatty acid amide hydrolase | Patch clamp | Dopamine neurons | Endocannabinoids | Nicotine | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | PPAR alpha - drug effects | Cannabinoid Receptor Antagonists | Protein-Tyrosine Kinases - metabolism | Injections, Intraventricular | Male | Ventral Tegmental Area - cytology | Nicotine - pharmacology | Receptors, Cannabinoid - metabolism | Piperidines - pharmacology | Benzamides - pharmacology | Neurons - metabolism | Oleic Acids - pharmacology | Palmitic Acids - pharmacology | Neurons - drug effects | Dopamine - metabolism | Organ Culture Techniques | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | Ventral Tegmental Area - drug effects | Appetite Depressants - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Amidohydrolases - antagonists & inhibitors | Enzyme Activation - drug effects | Ethanolamines | Nicotine - antagonists & inhibitors | Rats, Sprague-Dawley | Arachidonic Acids - pharmacology | Patch-Clamp Techniques | Animals | Rimonabant | Ventral Tegmental Area - metabolism | PPAR alpha - metabolism | Lipoxygenase Inhibitors - pharmacology | Index Medicus | dopamine neurons | nicotine | patch clamp | fatty acid amide hydrolase | electrophysiology | endocannabinoids | peroxisome proliferator-activated receptor
Journal Article