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1. Full Text Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death
by Probst, Lukas and Dächert, Jasmin and Schenk, Barbara and Fulda, Simone
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 41 - 52
Ferroptosis has recently been identified as a mode of programmed cell death. However, little is yet known about the signaling mechanism. Here, we report that... 
Acute leukemia | Redox | Ferroptosis | Cell death | ROS | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | NECROPTOSIS | 5-LIPOXYGENASE INHIBITOR | ARACHIDONIC-ACID | PEROXIDATION | ZILEUTON | ANTIOXIDANT | RESISTANCE | PHARMACOLOGY & PHARMACY | Masoprocol - pharmacology | Reactive Oxygen Species - metabolism | Arachidonate 12-Lipoxygenase - metabolism | Glutathione Peroxidase - antagonists & inhibitors | Humans | Arachidonate 12-Lipoxygenase - chemistry | Arachidonate 15-Lipoxygenase - chemistry | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Cyclohexylamines - pharmacology | Lipid Peroxidation - drug effects | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | alpha-Tocopherol - pharmacology | Arachidonate 12-Lipoxygenase - genetics | Fas-Associated Death Domain Protein - genetics | Glutathione Peroxidase - metabolism | Flavanones - pharmacology | Fas-Associated Death Domain Protein - metabolism | Carbolines - antagonists & inhibitors | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Arachidonate 15-Lipoxygenase - metabolism | Glutathione Peroxidase - genetics | Reactive Oxygen Species - antagonists & inhibitors | Arachidonate 15-Lipoxygenase - genetics | Cell Line, Tumor | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Phenylenediamines - pharmacology | Kinetics | Oxidative Stress - drug effects | Lipoxygenase Inhibitors - pharmacology | Carbolines - pharmacology | Biochemistry | Peroxidase | Acute lymphocytic leukemia | Index Medicus
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2. Full Text Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study
by Lamie, Phoebe F and Ali, Waleed A.M and Bazgier, Vaclav and Rárová, Lucie
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Two new series of -substituted indole derivatives and were synthesized. Their chemical structures were confirmed using spectroscopic tools including IR, H NMR,... 
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | DESIGN | CHEMISTRY, MEDICINAL | INDOMETHACIN | CELECOXIB | SELECTIVE COX-2 INHIBITORS | LIPOXYGENASES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INFLAMMATION | ESTERS | AGENTS | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells
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3. Full Text Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines
by Bukhari, Syed Nasir Abbas and Lauro, Gianluigi and Jantan, Ibrahim and Bifulco, Giuseppe and Amjad, Muhammad Wahab
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2014, Volume 22, Issue 15, pp. 4151 - 4161
Arachidonic acid and its metabolites have generated high level of interest among researchers due to their vital role in inflammation. The inhibition of enzymes... 
Tumor necrosis factor alpha | Curcumin | Claisen–Schmidt condensation | Lipopolysaccharides | Claisen-Schmidt condensation | Tumor Necrosis Factor-alpha - metabolism | Interleukin-6 - antagonists & inhibitors | Curcumin - chemistry | Structure-Activity Relationship | Phospholipase A2 Inhibitors - pharmacology | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Prostaglandin-Endoperoxide Synthases - chemistry | Soybeans - enzymology | Phospholipase A2 Inhibitors - chemistry | Phospholipase A2 Inhibitors - chemical synthesis | Binding Sites | Interleukin-6 - metabolism | Protein Structure, Tertiary | Cell Line | Curcumin - pharmacology | Cyclooxygenase Inhibitors - chemistry | Macrophages - cytology | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Macrophages - metabolism | Animals | Phospholipases A2, Secretory - antagonists & inhibitors | Prostaglandin-Endoperoxide Synthases - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Protein Binding | Macrophages - drug effects | Mice | Molecular Docking Simulation | Phospholipases A2, Secretory - metabolism | Lipoxygenase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors
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4. Full Text Recent Advances in the Search for Novel 5‐Lipoxygenase Inhibitors
by Steinhilber, Dieter and Hofmann, Bettina
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 01/2014, Volume 114, Issue 1, pp. 70 - 77
5‐Lipoxygenase (5‐LO) is an important enzyme of the arachidonic acid cascade and catalyses with the help of FLAP, the 5‐LO‐activating protein, the formation of... 
ZILEUTON | EFFICACY | PRODUCTS | INFLAMMATION | ASTHMA | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PROTEIN FLAP | OSTEOARTHRITIS | CYCLOOXYGENASE | POTENT INHIBITORS | LICOFELONE | Leukotrienes - metabolism | Arachidonic Acid - metabolism | Pyrroles - pharmacology | Arachidonate 5-Lipoxygenase - metabolism | Rhinitis, Allergic | Humans | Computational Biology | Drug Design | Lipoxygenase Inhibitors - pharmacology | Rhinitis, Allergic, Perennial - drug therapy | Pharmaceutical industry | Medical research | Asthma | Index Medicus | Allergic rhinitis
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5. Full Text Inhibitors of the Arachidonic Acid Cascade: Interfering with Multiple Pathways
by Meirer, Karin and Steinhilber, Dieter and Proschak, Ewgenij
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 01/2014, Volume 114, Issue 1, pp. 83 - 91
Modulators of the arachidonic acid cascade have been in the focus of research for treatments of inflammation and pain for several decades. Targeting this... 
SOLUBLE EPOXIDE HYDROLASE | BOSWELLIC ACIDS | PROSTAGLANDIN E-2 SYNTHASE-1 | HUMAN-LEUKOCYTES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | 5-LIPOXYGENASE INHIBITORS | THERAPEUTIC TARGET | PHARMACOLOGY & PHARMACY | AIRWAY HYPERRESPONSIVENESS | TOXICOLOGY | DUAL INHIBITORS | THROMBOXANE A SYNTHETASE | Arachidonic Acid - metabolism | Pyrroles - pharmacology | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Inflammation - drug therapy | Pain - drug therapy | Humans | Cytochrome P-450 Enzyme System - metabolism | Epoxide Hydrolases - metabolism | Epoxide Hydrolases - antagonists & inhibitors | Lipoxygenase Inhibitors - pharmacology | Arachidonic acid | Unsaturated fatty acids | Rodents | Index Medicus | Antiinflammatory agents
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6. Full Text Antioxidant capacity and DNA-interaction studies of zinc complexes with a non-steroidal anti-inflammatory drug, mefenamic acid
by Tarushi, Alketa and Karaflou, Zoi and Kljun, Jakob and Turel, Iztok and Psomas, George and Papadopoulos, Athanasios N and Kessissoglou, Dimitris P
Journal of Inorganic Biochemistry, ISSN 0162-0134, 11/2013, Volume 128, pp. 85 - 96
Zinc(II) complexes of a non-steroidal anti-inflammatory drug, mefenamic acid(= Hmef) in the absence or presence of the nitrogen donor heterocyclic ligands... 
Antioxidant capacity | Zinc complexes | Interaction with calf-thymus DNA | Mefenamic acid | Interaction with serum albumins | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTICONVULSANT ACTIVITIES | CRYSTAL-STRUCTURES | STRUCTURAL-CHARACTERIZATION | BINDING PROPERTIES | CHEMISTRY, INORGANIC & NUCLEAR | COPPER(II) COMPLEXES | IN-VITRO | BIOLOGICAL EVALUATION | COBALT(II) COMPLEXES | METAL-COMPLEXES | Free Radical Scavengers - pharmacology | Antioxidants - chemistry | Free Radical Scavengers - chemistry | Antioxidants - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coordination Complexes - metabolism | Crystallography, X-Ray | Zinc - chemistry | Biphenyl Compounds - metabolism | Mefenamic Acid - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Lipoxygenase - metabolism | Zinc Compounds - metabolism | Biphenyl Compounds - antagonists & inhibitors | Lipoxygenase Inhibitors - chemistry | Zinc Compounds - pharmacology | Cattle | Mefenamic Acid - metabolism | Picrates - chemistry | Soybeans - enzymology | Coordination Complexes - pharmacology | Free Radicals - metabolism | Serum Albumin, Bovine - chemistry | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Biphenyl Compounds - chemistry | Serum Albumin - chemistry | Free Radical Scavengers - metabolism | Free Radicals - chemistry | Picrates - metabolism | Antioxidants - pharmacology | DNA - metabolism | Serum Albumin, Bovine - metabolism | Coordination Complexes - chemistry | Spectrophotometry, Ultraviolet | Zinc Compounds - chemistry | DNA - chemistry | Free Radicals - antagonists & inhibitors | Mefenamic Acid - pharmacology | Picrates - antagonists & inhibitors | Animals | Lipoxygenase Inhibitors - metabolism | Kinetics | Lipoxygenase Inhibitors - pharmacology | Serum Albumin - metabolism | Proteins | Antioxidants | Drug interactions | DNA | Genetic research | Nonsteroidal anti-inflammatory drugs | Protein binding
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7. Full Text Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY
by Abdelall, Eman K.A and Lamie, Phoebe F and Ali, Waleed A.M
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2016, Volume 26, Issue 12, pp. 2893 - 2899
Two new series of 1,5-diaryl pyrazoline ( – ) and 1,5-diaryl pyrazole ( and ) were designed as both COX-2 and 15-LOX inhibitors. All the prepared compounds... 
15-Lipoxygenase inhibitors | Diethyl oxalate | Sulfonamide pharmacophores | Cyclooxygenase inhibitors | Antiinflammatory | CHEMISTRY, MEDICINAL | COX-2 | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | 5-LIPOXYGENASE | DERIVATIVES | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cyclooxygenase 2 Inhibitors - pharmacology | Humans | Models, Molecular | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Structure-Activity Relationship | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cyclooxygenase 2 - metabolism | Celecoxib - chemical synthesis | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Lipoxygenase Inhibitors - pharmacology | Pyrazoles - pharmacology | COX-2 inhibitors | Liability (Law)
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8. Full Text Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity
by Detsi, Anastasia and Majdalani, Maya and Kontogiorgis, Christos A and Hadjipavlou-Litina, Dimitra and Kefalas, Panagiotis
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 23, pp. 8073 - 8085
Naturally occurring and synthetic flavonoids belonging to the 2’hydroxy-chalcone and aurone families, have been synthesized and tested for their antioxidant... 
Lipid peroxidation | Aureusidin | Soybean lipoxygenase | Antioxidant | Aurones | 2′-Hydroxy-chalcones | SUBSTITUTED CHALCONES | OXIDATION | ANTIINFLAMMATORY ACTIVITY | DESIGN | CHEMISTRY, MEDICINAL | RAW-264.7 CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | FLAVONOIDS | 2 '-Hydroxy-chalcones | BIOLOGICAL EVALUATION | AGENTS | 5-LIPOXYGENASE | DERIVATIVES | Chalcones - chemistry | Antioxidants - chemistry | Magnetic Resonance Spectroscopy | Linoleic Acid - metabolism | Picrates - metabolism | Benzofurans - chemical synthesis | Benzofurans - pharmacology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Biphenyl Compounds - metabolism | Benzofurans - chemistry | Linoleic Acid - antagonists & inhibitors | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Picrates - antagonists & inhibitors | Biphenyl Compounds - antagonists & inhibitors | Chalcones - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Mass Spectrometry | Chalcones - pharmacology | Lipoxygenase Inhibitors - pharmacology
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9. Full Text Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR
by Abdelall, Eman K.A and Kamel, Gehan M
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
Two new series of 1,5-diaryl pyrazoles ( , , , and ) and 1,5-diaryl pyrazoline ( and were prepared as both Cyclooxygenase-2 and 15-lipoxygenase inhibitors.... 
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | CHEMISTRY, MEDICINAL | COX-2 | LEUKOTRIENES | CYCLOOXYGENASE | PROSTAGLANDINS | INFLAMMATION | BIOLOGICAL EVALUATION | AGENTS | 5-LIPOXYGENASE | MEDIATORS | DERIVATIVES | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law)
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10. Full Text Triblock Conjugates: Identification of a Highly Potent Antiinflammatory Agent
by Singh, Palwinder and Kaur, Jagroop and Singh, Gurjit and Bhatti, Rajbir
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2015, Volume 58, Issue 15, pp. 5989 - 6001
Rationally designed conjugates of chrysin, indole, and barbituric acid were synthesized and screened for their antiinflammatory activities through in vitro and... 
THIOBARBITURIC ACID | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | MECHANISM | INFLAMMATION | DRUGS | INHIBITORS | PAINS | PREDICTION | MOLECULES | TOOL | Analgesics - pharmacology | Anti-Inflammatory Agents - pharmacology | Anti-Inflammatory Agents - toxicity | Cyclooxygenase Inhibitors - chemistry | Analgesics - toxicity | Spectrophotometry, Ultraviolet | Cyclooxygenase Inhibitors - pharmacology | Cyclooxygenase Inhibitors - toxicity | Animals | Anti-Inflammatory Agents - chemistry | Lipoxygenase Inhibitors - chemistry | Inhibitory Concentration 50 | Calorimetry | Female | Lipoxygenase Inhibitors - toxicity | Mice | Molecular Docking Simulation | Lipoxygenase Inhibitors - pharmacology
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11. Full Text Fragment-based design, docking, synthesis, biological evaluation and structure–activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors
by Eleftheriou, Phaedra and Geronikaki, Athina and Hadjipavlou-Litina, Dimitra and Vicini, Paola and Filz, Olga and Filimonov, Dmitry and Poroikov, Vladimir and Chaudhaery, Shailendra S and Roy, Kuldeep K and Saxena, Anil K
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Balanced modulation of several targets is one of the current strategies for the treatment of multi-factorial diseases. Based on the knowledge of inflammation... 
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | ACID | MECHANISM | CRYSTAL-STRUCTURE | DRUG DISCOVERY | CANDIDATE | DUAL INHIBITORS | DERIVATIVES | ANTIMICROBIAL ACTIVITY | LIGAND DESIGN | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes
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12. Full Text Synthesis of Celecoxib Analogues Possessing a N-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity
by Chowdhury, Morshed A and Abdellatif, Khaled R. A and Dong, Ying and Das, Dipankar and Suresh, Mavanur R and Knaus, Edward E
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 6, pp. 1525 - 1529
A novel class of 1-(4-methanesulfonylphenyl and 4-aminosulfonylphenyl)-5-[4-(1-difluoromethyl-1,2-dihydropyrid-2-one)]-3-trifluoromethyl-1H-pyrazole hybrid... 
CHEMISTRY, MEDICINAL | AGENTS | COX-2 INHIBITORS | DERIVATIVES | DRUGS | Magnetic Resonance Spectroscopy | Pyrazoles - chemical synthesis | Humans | Celecoxib | Sulfonamides - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Sulfonamides - chemical synthesis | Lipoxygenase Inhibitors - chemical synthesis | Animals | Spectrophotometry, Infrared | Cyclooxygenase Inhibitors - chemical synthesis | Drug Evaluation, Preclinical | Lipoxygenase Inhibitors - pharmacology | Pyrazoles - pharmacology
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13. Full Text Synthesis and Structure–Activity Relationship Studies of 4‑((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase
by Luci, Diane K and Jameson, J. Brian and Yasgar, Adam and Diaz, Giovanni and Joshi, Netra and Kantz, Auric and Markham, Kate and Perry, Steve and Kuhn, Norine and Yeung, Jennifer and Kerns, Edward H and Schultz, Lena and Holinstat, Michael and Nadler, Jerry L and Taylor-Fishwick, David A and Jadhav, Ajit and Simeonov, Anton and Holman, Theodore R and Maloney, David J
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2014, Volume 57, Issue 2, pp. 495 - 506
Human lipoxygenases (LOXs) are a family of iron-containing enzymes which catalyze the oxidation of polyunsaturated fatty acids to provide the corresponding... 
CHEMISTRY, MEDICINAL | ACID | POSSIBLE INVOLVEMENT | 12-HUMAN | 15-HUMAN | LIPOXYGENASE INHIBITORS | BIOLOGICAL-ACTIVITIES | PLATELET-TYPE 12-LIPOXYGENASE | HUMAN 15-LIPOXYGENASE | DISCOVERY | 12/15-LIPOXYGENASE | Islets of Langerhans - drug effects | Benzene Derivatives - chemical synthesis | Arachidonate 12-Lipoxygenase - metabolism | Sulfonamides - chemistry | Calcium - metabolism | Islets of Langerhans - enzymology | Humans | Biological Availability | Structure-Activity Relationship | Sulfonamides - pharmacology | Sulfonamides - chemical synthesis | Lipoxygenase Inhibitors - chemical synthesis | Animals | Lipoxygenase Inhibitors - chemistry | Blood Platelets - metabolism | Mice | Platelet Aggregation - drug effects | Benzene Derivatives - chemistry | Blood Platelets - drug effects | Lipoxygenase Inhibitors - pharmacology | Benzene Derivatives - pharmacology
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