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1. Full Text Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death
by Probst, Lukas and Dächert, Jasmin and Schenk, Barbara and Fulda, Simone
Biochemical pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 41 - 52
Acute leukemia | Redox | Ferroptosis | Cell death | ROS | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Masoprocol - pharmacology | Reactive Oxygen Species - metabolism | Arachidonate 12-Lipoxygenase - metabolism | Glutathione Peroxidase - antagonists & inhibitors | Humans | Arachidonate 12-Lipoxygenase - chemistry | Arachidonate 15-Lipoxygenase - chemistry | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Cyclohexylamines - pharmacology | Lipid Peroxidation - drug effects | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | alpha-Tocopherol - pharmacology | Arachidonate 12-Lipoxygenase - genetics | Fas-Associated Death Domain Protein - genetics | Glutathione Peroxidase - metabolism | Flavanones - pharmacology | Fas-Associated Death Domain Protein - metabolism | Carbolines - antagonists & inhibitors | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Arachidonate 15-Lipoxygenase - metabolism | Glutathione Peroxidase - genetics | Reactive Oxygen Species - antagonists & inhibitors | Arachidonate 15-Lipoxygenase - genetics | Cell Line, Tumor | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Phenylenediamines - pharmacology | Kinetics | Oxidative Stress - drug effects | Lipoxygenase Inhibitors - pharmacology | Carbolines - pharmacology | Biochemistry | Peroxidase | Acute lymphocytic leukemia | Index Medicus
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2. Full Text Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines
by Bukhari, Syed Nasir Abbas and Lauro, Gianluigi and Jantan, Ibrahim and Bifulco, Giuseppe and Amjad, Muhammad Wahab
Bioorganic & medicinal chemistry, ISSN 0968-0896, 08/2014, Volume 22, Issue 15, pp. 4151 - 4161
Tumor necrosis factor alpha | Curcumin | Claisen–Schmidt condensation | Lipopolysaccharides | Claisen-Schmidt condensation | Tumor Necrosis Factor-alpha - metabolism | Interleukin-6 - antagonists & inhibitors | Curcumin - chemistry | Structure-Activity Relationship | Phospholipase A2 Inhibitors - pharmacology | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Prostaglandin-Endoperoxide Synthases - chemistry | Soybeans - enzymology | Phospholipase A2 Inhibitors - chemistry | Phospholipase A2 Inhibitors - chemical synthesis | Binding Sites | Interleukin-6 - metabolism | Protein Structure, Tertiary | Cell Line | Curcumin - pharmacology | Cyclooxygenase Inhibitors - chemistry | Macrophages - cytology | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Macrophages - metabolism | Animals | Phospholipases A2, Secretory - antagonists & inhibitors | Prostaglandin-Endoperoxide Synthases - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Protein Binding | Macrophages - drug effects | Mice | Molecular Docking Simulation | Phospholipases A2, Secretory - metabolism | Lipoxygenase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus
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3. Full Text Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study
by Lamie, Phoebe F and Ali, Waleed A.M and Bazgier, Vaclav and Rárová, Lucie
European journal of medicinal chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells | Index Medicus
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4. Full Text Inhibitors of the Arachidonic Acid Cascade: Interfering with Multiple Pathways
by Meirer, Karin and Steinhilber, Dieter and Proschak, Ewgenij
Basic & clinical pharmacology & toxicology, ISSN 1742-7835, 01/2014, Volume 114, Issue 1, pp. 83 - 91
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Arachidonic Acid - metabolism | Pyrroles - pharmacology | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Inflammation - drug therapy | Pain - drug therapy | Humans | Cytochrome P-450 Enzyme System - metabolism | Epoxide Hydrolases - metabolism | Epoxide Hydrolases - antagonists & inhibitors | Lipoxygenase Inhibitors - pharmacology | Arachidonic acid | Unsaturated fatty acids | Index Medicus | Antiinflammatory agents
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5. Full Text Fragment-based design, docking, synthesis, biological evaluation and structure–activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors
by Eleftheriou, Phaedra and Geronikaki, Athina and Hadjipavlou-Litina, Dimitra and Vicini, Paola and Filz, Olga and Filimonov, Dmitry and Poroikov, Vladimir and Chaudhaery, Shailendra S and Roy, Kuldeep K and Saxena, Anil K
European journal of medicinal chemistry, ISSN 0223-5234, 2012, Volume 47, Issue 1, pp. 111 - 124
Multi-target drugs | Benzo/benzisothiazolidinones | Inflammation | Lipoxygenase inhibitors | COX-1/2 inhibitors | Fragment-based drug design | Thiazolidines - chemical synthesis | Thiazolidines - metabolism | Male | Structure-Activity Relationship | Anti-Inflammatory Agents - metabolism | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Drug Design | Cyclooxygenase 1 - chemistry | Female | Thiazolidines - pharmacology | Thiazolidines - chemistry | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Edema - drug therapy | Lipoxygenase - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Mice | Cyclooxygenase 1 - metabolism | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Enzymes | Index Medicus
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6. Full Text Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR
by Abdelall, Eman K.A and Kamel, Gehan M
European journal of medicinal chemistry, ISSN 0223-5234, 08/2016, Volume 118, pp. 250 - 258
15-Lipoxygenase inhibitors | Ethyl trifloroacetate | SO2NH2 pharmacophores | Cyclooxygenase inhibitors | Celecoxib analogues | DMFDMA | Anti-inflammatory | pharmacophores | Stereoisomerism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Cyclooxygenase 2 Inhibitors - chemistry | Celecoxib - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Lipoxygenase Inhibitors - chemical synthesis | Pyrazoles - chemistry | Lipoxygenase Inhibitors - chemistry | Cattle | Celecoxib - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Celecoxib - adverse effects | Cyclooxygenase 2 Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic | Cyclooxygenase 2 Inhibitors - pharmacology | Magnetic Resonance Spectroscopy | Rats | Celecoxib - pharmacology | Arachidonate 15-Lipoxygenase - metabolism | Lipoxygenase Inhibitors - adverse effects | Ulcer - chemically induced | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclization | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Lipoxygenase Inhibitors - pharmacology | COX-2 inhibitors | Carrageenin | Nuclear magnetic resonance | Celecoxib | Angiogenesis inhibitors | Liability (Law) | Index Medicus
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7. Full Text Treatment with either COX‐2 inhibitor or 5‐LOX inhibitor causes no compensation between COX‐2 pathway and 5‐LOX pathway in chronic aluminum overload‐induced liver injury in rats
by Xia, Hui and He, Qin and Wang, Hong and Wang, Yongming and Yang, Yang and Li, Yuke and Zhang, Jiahua and Chen, Zhihao and Yang, Junqing
Fundamental & clinical pharmacology, ISSN 0767-3981, 10/2019, Volume 33, Issue 5, pp. 535 - 543
liver injury | compensation | aluminum | cyclooxygenase‐2 | 5‐lipoxygenase | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Malondialdehyde - metabolism | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Chemical and Drug Induced Liver Injury, Chronic - metabolism | Liver - metabolism | Aluminum - pharmacology | Rats | Caffeic Acids - pharmacology | Chemical and Drug Induced Liver Injury, Chronic - drug therapy | Rats, Sprague-Dawley | Inflammation - metabolism | Animals | Liver - drug effects | Inflammation - drug therapy | Cyclooxygenase 2 - metabolism | Oxidative Stress - drug effects | Lipoxygenase Inhibitors - pharmacology | Meloxicam | Immunohistochemistry | COX-2 inhibitors | Liver diseases | Liver | Oxidative stress | Aluminum | Caffeic acid | Prostaglandin endoperoxide synthase | Histopathology | Acids | Tumor necrosis factor | Liquid oxygen | Compensation | Lipoxygenase | Injuries | Index Medicus
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8. Full Text Recent Advances in the Search for Novel 5‐Lipoxygenase Inhibitors
by Steinhilber, Dieter and Hofmann, Bettina
Basic & clinical pharmacology & toxicology, ISSN 1742-7835, 01/2014, Volume 114, Issue 1, pp. 70 - 77
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Leukotrienes - metabolism | Arachidonic Acid - metabolism | Pyrroles - pharmacology | Arachidonate 5-Lipoxygenase - metabolism | Rhinitis, Allergic | Humans | Computational Biology | Drug Design | Lipoxygenase Inhibitors - pharmacology | Rhinitis, Allergic, Perennial - drug therapy | Pharmaceutical industry | Medical research | Asthma | Index Medicus | Allergic rhinitis
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9. Full Text Dynamic Modeling of Human 5-Lipoxygenase–Inhibitor Interactions Helps To Discover Novel Inhibitors
by Wu, Yiran and He, Chong and Gao, Yang and He, Shan and Liu, Ying and Lai, Luhua
Journal of medicinal chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 6, pp. 2597 - 2605
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Recombinant Proteins - antagonists & inhibitors | Arachidonate 5-Lipoxygenase - blood | Humans | Intramolecular Oxidoreductases - antagonists & inhibitors | Recombinant Proteins - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Intramolecular Oxidoreductases - blood | Microsomes - enzymology | Structure-Activity Relationship | Dinoprostone - blood | Molecular Dynamics Simulation | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Leukotriene B4 - blood | Pyrroles - pharmacology | Cell-Free System | Lipoxygenase Inhibitors - chemistry | Prostaglandin-E Synthases | Arachidonate 5-Lipoxygenase - chemistry | Protein Binding | Pyrroles - chemistry | Protein Conformation | Lipoxygenase Inhibitors - pharmacology | Databases, Factual | Index Medicus
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10. Full Text Endogenous Fatty Acid Ethanolamides Suppress Nicotine-Induced Activation of Mesolimbic Dopamine Neurons through Nuclear Receptors
by Melis, Miriam and Pillolla, Giuliano and Luchicchi, Antonio and Muntoni, Anna Lisa and Yasar, Sevil and Goldberg, Steven R and Pistis, Marco
The Journal of neuroscience, ISSN 0270-6474, 12/2008, Volume 28, Issue 51, pp. 13985 - 13994
Peroxisome proliferator-activated receptor | Electrophysiology | Fatty acid amide hydrolase | Patch clamp | Dopamine neurons | Endocannabinoids | Nicotine | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | PPAR alpha - drug effects | Cannabinoid Receptor Antagonists | Protein-Tyrosine Kinases - metabolism | Injections, Intraventricular | Male | Ventral Tegmental Area - cytology | Nicotine - pharmacology | Receptors, Cannabinoid - metabolism | Piperidines - pharmacology | Benzamides - pharmacology | Neurons - metabolism | Oleic Acids - pharmacology | Palmitic Acids - pharmacology | Neurons - drug effects | Dopamine - metabolism | Organ Culture Techniques | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | Ventral Tegmental Area - drug effects | Appetite Depressants - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Amidohydrolases - antagonists & inhibitors | Enzyme Activation - drug effects | Ethanolamines | Nicotine - antagonists & inhibitors | Rats, Sprague-Dawley | Arachidonic Acids - pharmacology | Patch-Clamp Techniques | Animals | Rimonabant | Ventral Tegmental Area - metabolism | PPAR alpha - metabolism | Lipoxygenase Inhibitors - pharmacology | Index Medicus | dopamine neurons | nicotine | patch clamp | fatty acid amide hydrolase | electrophysiology | endocannabinoids | peroxisome proliferator-activated receptor
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