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Cancer Cell, ISSN 1535-6108, 03/2013, Volume 23, Issue 3, pp. 406 - 420
Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical Ras effectors is still very limited. We show that cell-autonomous... 
RAS ONCOGENE | PI3K | ONCOLOGY | DUCTAL ADENOCARCINOMA | MOUSE MODEL | IN-VIVO | C-RAF | TUMOR-SUPPRESSOR | MICE | TUMORIGENESIS | EGF RECEPTOR | CELL BIOLOGY | Neoplasm Transplantation | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - pathology | Cell Proliferation | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | ras Proteins - metabolism | Transplantation, Heterologous | Phosphatidylinositol 3-Kinases - metabolism | Carcinoma, Pancreatic Ductal - genetics | Lithostathine - metabolism | Adenocarcinoma - metabolism | Cell Transformation, Neoplastic - genetics | Adenocarcinoma - genetics | Tumor Cells, Cultured | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Pancreatic Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Pancreatic Neoplasms - genetics | TNF Receptor-Associated Factor 3 - metabolism | Sulfonamides - pharmacology | Carcinoma, Pancreatic Ductal - pathology | Cell Transformation, Neoplastic - metabolism | Indazoles - pharmacology | Metaplasia | Animals | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mice, Inbred NOD | Mice | Enzyme Activation | Analysis | Genomics | Genetic research | Genetic aspects | Livestock | Lung cancer, Non-small cell | Health aspects | Cancer | Index Medicus
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 09/2004, Volume 3, Issue 5, pp. 1042 - 1055
Proteomic technologies provide an excellent means for analysis of body fluids for cataloging protein constituents and identifying biomarkers for early... 
Functional annotation | Body fluid | Liquid chromatography tandem mass spectrometry (LC-MS/MS) | REACTING ANTIGEN NCA | MAC-2-BINDING PROTEIN | INFLAMMATORY MEDIATOR | GASTROINTESTINAL-TRACT | BIOCHEMICAL RESEARCH METHODS | OVARIAN-CANCER | functional annotation | body fluid | CELL LUNG-CANCER | BREAST-CANCER | MESSENGER-RNA | liquid chromatography tandem mass spectrometry (LC-MS/MS) | GENE-EXPRESSION | FACTOR-BINDING PROTEIN-2 | Proteome - genetics | Pancreatic Neoplasms - metabolism | Gene Expression - genetics | Humans | Phylogeny | RNA, Messenger - metabolism | Membrane Proteins - analysis | Lectins, C-Type - metabolism | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Chromatography, Liquid | Pancreatic Juice - metabolism | Carrier Proteins - analysis | Agglutinins - analysis | Glycoproteins - genetics | Amino Acid Sequence | Membrane Proteins - genetics | Proteome - classification | Proteome - analysis | Trypsin - metabolism | Agglutinins - metabolism | Cell Adhesion Molecules - metabolism | Peptide Fragments - analysis | Cell Adhesion Molecules - analysis | Biomarkers, Tumor - genetics | Calcium-Binding Proteins - genetics | Receptors, Cell Surface - genetics | Cell Adhesion Molecules - genetics | Receptors, Cell Surface - analysis | Molecular Sequence Data | Blood Proteins - metabolism | Lectins, C-Type - genetics | alpha-Defensins - genetics | Mass Spectrometry | alpha-Defensins - analysis | Lectins, C-Type - analysis | alpha-Defensins - metabolism | Membrane Proteins - metabolism | Antigens, Neoplasm - analysis | Pancreatic Juice - chemistry | Pancreatic Neoplasms - secretion | Antigens, Neoplasm - genetics | Biomarkers, Tumor - analysis | Antimicrobial Cationic Peptides | Electrophoresis, Polyacrylamide Gel | RNA, Messenger - genetics | Agglutinins - genetics | Receptors, Cell Surface - metabolism | Pancreatitis-Associated Proteins | Blood Proteins - analysis | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Sequence Alignment | Carrier Proteins - metabolism | Lithostathine | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 08/2016, Volume 311, Issue 2, pp. E380 - E395
Type 1 diabetes (T1D) originates from autoimmune beta-cell destruction. IMT504 is an immunomodulatory oligonucleotide that increases mesenchymal stem cell... 
Insulitis | β-cells | Islet gene expression | Serum cytokines | ACTIVATION | PHYSIOLOGY | DENDRITIC CELLS | serum cytokines | islet gene expression | HGF GENE | REG FAMILY GENES | BETA-CELL REGENERATION | MESENCHYMAL STEM-CELLS | IL-6 | insulitis | CPG OLIGONUCLEOTIDE | ENDOCRINOLOGY & METABOLISM | beta-cells | MICE | PANCREATIC ALPHA-CELLS | Islets of Langerhans - drug effects | Apoptosis - drug effects | Chemokine CXCL1 - drug effects | Diabetes Mellitus, Experimental - genetics | Diabetes Mellitus, Type 1 - metabolism | Male | Chemokine CXCL1 - genetics | RNA, Messenger - metabolism | Nestin - drug effects | Insulin - genetics | Interleukin-6 - metabolism | Disease Models, Animal | Somatostatin - genetics | Lithostathine - drug effects | Blood Glucose - drug effects | Insulin - metabolism | Protein Precursors - drug effects | Tumor Necrosis Factor-alpha - drug effects | Mice | Mice, Inbred BALB C | Proglucagon - genetics | Blood Glucose - metabolism | Oligodeoxyribonucleotides - pharmacology | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Tumor Necrosis Factor-alpha - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - drug effects | Stem Cells - metabolism | Insulin-Secreting Cells - metabolism | Proglucagon - drug effects | Somatostatin - drug effects | Islets of Langerhans - metabolism | Nestin - genetics | Diabetes Mellitus, Experimental - metabolism | RNA, Messenger - drug effects | Glucose Tolerance Test | Protein Precursors - genetics | Cytokines - metabolism | Islets of Langerhans - pathology | Lithostathine - genetics | Diabetes Mellitus, Type 1 - genetics | Transcriptome - drug effects | Pancreatitis-Associated Proteins | Proteins - genetics | Animals | Cytokines - drug effects | Insulin-Secreting Cells - drug effects | Platelet Endothelial Cell Adhesion Molecule-1 - drug effects | Proteins - drug effects | Stem Cells - drug effects | Cell Proliferation - drug effects | Physiological aspects | Models | Diabetes | Oligonucleotides | Molecules | Rodents | Genes | Apoptosis | Index Medicus
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 05/2015, Volume 308, Issue 9, pp. G736 - G744
Regenerating gene (Reg) family proteins, which are classified into four types, commonly act as trophic and/or antiapoptotic factors in gastrointestinal (GI)... 
Gastrointestinal mucosa | Proliferation | Reg | Nonsteroidal anti-inflammatory drug | Apoptosis | CELLS | PHYSIOLOGY | proliferation | ULCERATIVE-COLITIS | I-ALPHA PROTEIN | INJURY | apoptosis | MUCOSAL | KNOCKOUT MICE | INFLAMMATORY-BOWEL-DISEASE | GASTRIC-CANCER | COLORECTAL-CANCER | PANCREATITIS-ASSOCIATED PROTEIN | GASTROENTEROLOGY & HEPATOLOGY | gastrointestinal mucosa | nonsteroidal anti-inflammatory drug | Intestinal Mucosa - metabolism | Intestine, Small - pathology | Apoptosis - drug effects | Colon - drug effects | Gastric Mucosa - pathology | Gastric Mucosa - metabolism | Lectins, C-Type - genetics | Neoplasm Proteins - metabolism | Gastrointestinal Tract - pathology | Intestinal Mucosa - drug effects | Lectins, C-Type - metabolism | Lithostathine - metabolism | Time Factors | Gastric Mucosa - drug effects | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Neoplasm Proteins - genetics | Lithostathine - deficiency | Antigens, Neoplasm - genetics | Colon - pathology | Gene Expression Regulation | Lithostathine - genetics | Gastrointestinal Tract - drug effects | Gene Expression Profiling - methods | Pancreatitis-Associated Proteins | Colon - metabolism | Gastrointestinal Tract - metabolism | Indomethacin - pharmacology | Mice, Inbred ICR | Animals | Intestine, Small - drug effects | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Intestine, Small - metabolism | Intestinal Mucosa - pathology | Physiological aspects | Physiological research | Indomethacin | Research | Regeneration (Biology) | Gastrointestinal system | Proteins | Physiology | Nonsteroidal anti-inflammatory drugs | Gene expression | Drug therapy | Gastrointestinal diseases | Index Medicus
Journal Article
Developmental Biology, ISSN 0012-1606, 03/2014, Volume 387, Issue 2, pp. 191 - 202
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 624 - 15
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 7, pp. 4726 - 4739
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2002, Volume 156, Issue 2, pp. 287 - 297
Members of the ciliary neurotrophic factor (CNTF)/leukemia inhibitory factor (LIF)/cardiotrophin gene family are potent survival factors for embryonic and... 
Receptors | Axotomy | Messenger RNA | Neurons | Cell death | Transgenic animals | Cell lines | Facial nerve | Mice | Lesions | Bcl-xl | CNTF | Lesion | Reg-2 | MOTOR-NEURONS | SYMPATHETIC NEURONS | bcl-xl | axotomy | reg-2 | SENSORY NEURONS | CELL-DEATH | CELL BIOLOGY | MICE LACKING GDNF | CNTF RECEPTOR | NEUROTROPHIC FACTOR PREVENTS | BCL-X | PC12 CELLS | TRANSCRIPTION FACTOR | lesion | Nervous System - metabolism | Facial Nerve Injuries - metabolism | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Viral Proteins - metabolism | Motor Neurons - pathology | DNA-Binding Proteins - metabolism | Neurofilament Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Nervous System - growth & development | Nervous System - pathology | Gene Deletion | Motor Neurons - cytology | Trans-Activators - genetics | Aging | Integrases - metabolism | Cell Death - drug effects | Nervous System - embryology | Ciliary Neurotrophic Factor - pharmacology | Animals, Newborn | Calcium-Binding Proteins - metabolism | bcl-X Protein | Signal Transduction | Cell Survival | Facial Nerve Injuries - genetics | RNA, Messenger - genetics | Cells, Cultured | Viral Proteins - genetics | Nerve Tissue Proteins | DNA-Binding Proteins - genetics | Organ Specificity | Mice, Knockout | Motor Neurons - metabolism | Animals | Lithostathine | Facial Nerve Injuries - pathology | Trans-Activators - metabolism | STAT3 Transcription Factor | Integrases - genetics | Physiological aspects | Cellular signal transduction | Developmental neurology | Research | Genes | Leukemia | Injuries | cardiotrophin | leukemia inhibitory factor | Bcl-xL protein | Reg-2 protein | Index Medicus | CNTF; axotomy; lesion; bcl-xl; reg-2
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 12/2015, Volume 1849, Issue 12, pp. 1411 - 1422
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e90045 - e90045
Regenerating (REG) proteins are associated with islet development, beta-cell damage, diabetes and pancreatitis. Particularly, REG-1 and REG-3-beta are involved... 
ISLET INFLAMMATION | STONE PROTEIN/REGENERATING PROTEIN | OXIDATIVE STRESS | REG3-BETA GENES | MULTIDISCIPLINARY SCIENCES | BETA-CELL | REG GENE | KNOCKOUT MICE | UP-REGULATION | SPONTANEOUS MODEL | FAMILY | Antigens, Neoplasm - genetics | Chemokines - blood | Chemokines - secretion | Rats, Wistar | Diabetes Mellitus, Type 2 - genetics | Gene Expression Regulation | Lithostathine - genetics | Rats | Male | Diabetes Mellitus, Type 2 - metabolism | Lectins, C-Type - genetics | Pancreatitis-Associated Proteins | Lectins, C-Type - metabolism | Lithostathine - metabolism | Diabetes Mellitus, Type 2 - blood | Macrophages - metabolism | Animals | Islets of Langerhans - metabolism | Antigens, Neoplasm - metabolism | Biomarkers, Tumor - metabolism | Biomarkers, Tumor - genetics | Diabetes Mellitus, Type 2 - pathology | Proteins | Immunohistochemistry | Type 2 diabetes | Interleukins | RNA | MHC antibodies | Genes | Pancreatitis | Inflammation | Gene expression | Cell culture | Interleukin | Antibodies | Homeostasis | Paraffin | Macrophages | Experiments | Interleukin 6 | Angiogenesis | Hyperglycemia | Cell growth | Rodents | Tumor necrosis factor-TNF | Pancreas | Localization | Vascular endothelial growth factor | Acinar cells | Medical research | Cell survival | Cytokines | Secretion | Diabetes mellitus | Insulin | Medicine | Polymerase chain reaction | Major histocompatibility complex | Ligands | Infiltration | Islets of Langerhans | Diabetes | Histocompatibility | Chemokines | Index Medicus | Life Sciences | Human health and pathology
Journal Article
Journal Article
Journal Article