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Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 3, p. 555
Sauchinone, an active lignan isolated from the aerial parts of Saururus chinensis (Saururaceae), exhibits anti-inflammatory, anti-obesity, anti-hyperglycemic,... 
Saururus chinensis | Herb-drug interaction | CYP450 | Metabolic inhibition | Sauchinone | Human liver microsome | Docking | sauchinone | BIOCHEMISTRY & MOLECULAR BIOLOGY | herb-drug interaction | INTERACTIONS FOCUS | PRESCRIBED DRUGS | HERBAL MEDICINES | CHEMISTRY, MULTIDISCIPLINARY | docking | IN-VITRO | INHIBITION | PHARMACOKINETICS | STRUCTURAL BASIS | human liver microsome | METABOLIC ENZYMES | BINDING | DRUG-DRUG INTERACTIONS | metabolic inhibition | Plant Extracts - pharmacology | Humans | Chlorzoxazone - chemistry | Benzopyrans - chemistry | Cytochrome P-450 CYP3A - chemistry | Dioxoles - pharmacology | Anti-Inflammatory Agents - isolation & purification | Cytochrome P-450 Enzyme Inhibitors - chemistry | Microsomes, Liver - enzymology | Binding Sites | Anti-Inflammatory Agents - pharmacology | Plant Extracts - isolation & purification | Saururaceae - chemistry | Benzopyrans - isolation & purification | Microsomes, Liver - chemistry | Dioxoles - chemistry | Ticlopidine - analogs & derivatives | Hypoglycemic Agents - pharmacology | Hypoglycemic Agents - isolation & purification | Anti-Obesity Agents - chemistry | Cytochrome P-450 CYP3A - metabolism | Mice | Molecular Docking Simulation | Kinetics | Anti-Obesity Agents - pharmacology | Cytochrome P-450 CYP2B6 - chemistry | Cytochrome P-450 Enzyme Inhibitors - isolation & purification | Plant Extracts - chemistry | Ticlopidine - pharmacology | Ticlopidine - chemistry | Cytochrome P-450 CYP2E1 - metabolism | Cytochrome P-450 CYP2B6 - metabolism | Microsomes, Liver - drug effects | Cyclobutanes - pharmacology | Protein Interaction Domains and Motifs | Benzopyrans - pharmacology | Cytochrome P-450 CYP2E1 - chemistry | Catalytic Domain | Dioxoles - isolation & purification | Protein Structure, Secondary | Plant Components, Aerial - chemistry | Cytochrome P-450 CYP2C19 - chemistry | Hypoglycemic Agents - chemistry | Anti-Obesity Agents - isolation & purification | Cytochrome P-450 Enzyme Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Chlorzoxazone - pharmacology | Herb-Drug Interactions | Protein Binding | Clopidogrel | Cytochrome P-450 CYP2C19 - metabolism | Cyclobutanes - chemistry | Cytochrome | Herbs | Drugs | Liver | Drug interactions | Amino acids | Inflammation | Sibutramine | Metabolism | Microsomes | Molecular docking | Steatosis | Chlorzoxazone | Fatty liver | Mouse devices | Computer applications | Cytochromes | In vivo methods and tests | Drug interaction | Inhibition | Enzyme kinetics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 38, pp. 26481 - 26491
The B cell lymphoma-2 (BCL-2) family is the key mediator of cellular sensitivity to apoptosis during pharmacological interventions for numerous human... 
POTENT | OLIGOMERIZES BAK | CANCERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | MITOCHONDRIAL-MEMBRANE | INHIBITORS | CYTOCHROME-C RELEASE | DISCOVERY | ADDICTION | MEMBRANE PERMEABILIZATION | bcl-2-Associated X Protein - chemistry | Nitriles - pharmacology | Apoptosis - drug effects | Mitochondria, Liver - metabolism | Humans | Unilamellar Liposomes - chemistry | bcl-2-Associated X Protein - physiology | Piperazines - chemistry | Proto-Oncogene Proteins - chemistry | Sulfones - pharmacology | Nitrophenols - chemistry | Benzopyrans - chemistry | bcl-X Protein - chemistry | Molecular Mimicry | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Membrane Proteins - physiology | Sulfones - chemistry | BH3 Interacting Domain Death Agonist Protein - chemistry | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Benzamides - pharmacology | Protein Interaction Domains and Motifs | Biphenyl Compounds - chemistry | Benzopyrans - pharmacology | Benzamides - chemistry | Aniline Compounds - pharmacology | BH3 Interacting Domain Death Agonist Protein - physiology | Sulfonamides - chemistry | Apoptosis Regulatory Proteins - chemistry | Permeability | Sulfonamides - pharmacology | Piperazines - pharmacology | Mitochondrial Membranes - metabolism | Mitochondria, Liver - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - physiology | Pyrroles - pharmacology | Animals | Membrane Proteins - chemistry | bcl-X Protein - physiology | Nitriles - chemistry | Proto-Oncogene Proteins - physiology | Pyrroles - chemistry | Apoptosis Regulatory Proteins - physiology | Mice | Aniline Compounds - chemistry | HeLa Cells | BH3 Mimetics | MOMP | Mitochondria | Bcl-2 Proteins | Bax | Anticancer Drug | Cell Biology | Apoptosis
Journal Article
Journal Article
Journal Article
Molecules, ISSN 1420-3049, 09/2017, Volume 22, Issue 9, p. 1489
Journal Article
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2014, Volume 58, Issue 12, pp. 7121 - 7127
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 2, p. 400
Plumeria rubra Linn of the family Apocynaceae is locally known in Malaysia as "Kemboja". It has been used by local traditional medicine practitioners for the... 
Xanthine oxidase | Phenol | Antioxidant | Flavonoid | Plumeria rubra | antioxidant | OXIDATIVE STRESS | PHENOLIC-COMPOUNDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE-LIVER | OXONATE-INDUCED MICE | FACTOR-KAPPA-B | SERUM | CHEMISTRY, MULTIDISCIPLINARY | GENE-EXPRESSION | phenol | flavonoid | xanthine oxidase | MEDICINAL-PLANTS | LUNG INFLAMMATION | URIC-ACID LEVELS | Phenols - isolation & purification | Plant Extracts - chemistry | Antioxidants - chemistry | Hyperuricemia - pathology | Plant Extracts - pharmacology | Male | Flowers - chemistry | Benzopyrans - chemistry | Citric Acid - chemistry | Biphenyl Compounds - antagonists & inhibitors | Cinnamates - isolation & purification | Picrates - chemistry | Kaempferols - isolation & purification | Anti-Inflammatory Agents - isolation & purification | Uric Acid - blood | Biphenyl Compounds - chemistry | Cinnamates - chemistry | Xanthine Oxidase - antagonists & inhibitors | Xanthine Oxidase - metabolism | Anti-Inflammatory Agents - pharmacology | Apocynaceae - chemistry | Kaempferols - chemistry | Nitric Oxide - antagonists & inhibitors | Rats | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Oxonic Acid - administration & dosage | Benzopyrans - isolation & purification | Rats, Sprague-Dawley | Hydrogen Peroxide - metabolism | Hyperuricemia - drug therapy | Hyperuricemia - blood | Picrates - antagonists & inhibitors | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - isolation & purification | Uric Acid - antagonists & inhibitors | Citric Acid - isolation & purification | Phenols - chemistry | Flavonoids - isolation & purification | Liquid-Liquid Extraction - methods | Nitric Oxide - metabolism | Flavonoids - chemistry | Hydrogen Peroxide - antagonists & inhibitors | Hyperuricemia - chemically induced | Oxidative stress | Hydrogen peroxide | Toxicity | Liver | Body weight | Arthritis | Flowers | Antioxidants | Rodents | Chelation | Biocompatibility | Inhibition | Free radicals | Kaempferol | Scavenging | Medical treatment | Chlorogenic acid | Superoxide | Uric acid | Xanthine | Rutin | Citric acid | Acids | Quinic acid | Nitric oxide | Quercetin | Phenols | Index Medicus
Journal Article
Journal Article