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2013, Third edition., ISBN 9780123878175, 771
This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors... 
Hepatotoxicology | Other branches of medicine | Drugs | Side effects | Effect of drugs on | Liver
eBook
Cell metabolism, ISSN 1550-4131, 2014, Volume 19, Issue 1, pp. 96 - 108
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and... 
SKELETAL-MUSCLE | PPAR-ALPHA | ACTIVATION | MITOCHONDRIAL UNCOUPLING PROTEIN | PGC-1-ALPHA | IN-VIVO | ENDOCRINOLOGY & METABOLISM | MICE | EXPRESSION | EXERCISE | GENOME-WIDE ASSOCIATION | CELL BIOLOGY | Organ Specificity - drug effects | Transcription, Genetic - drug effects | Metabolic Diseases - pathology | Adipocytes, Brown - metabolism | Humans | Adipose Tissue, White - metabolism | Cardiovascular Diseases - pathology | Organ Specificity - genetics | Adipocytes, White - drug effects | Adipose Tissue, White - cytology | Exercise | Liver - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Oxidation-Reduction - drug effects | Weight Gain - drug effects | Physical Conditioning, Animal | Aminoisobutyric Acids - pharmacology | Induced Pluripotent Stem Cells - metabolism | Adipocytes, Brown - pathology | Glucose Tolerance Test | Cardiovascular Diseases - metabolism | Induced Pluripotent Stem Cells - drug effects | Adipocytes, Brown - drug effects | Liver - metabolism | Risk Factors | Aminoisobutyric Acids - blood | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Adipose Tissue, Brown - cytology | Phenotype | Adipocytes, White - pathology | Animals | Metabolic Diseases - metabolism | Cell Differentiation - drug effects | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | PPAR alpha - metabolism | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 7, pp. 1763 - 1774
Background & Aims The NACHT, LRR, and pyrin domain–containing protein 3 (NLRP3) inflammasome induces inflammation in response to organ injury, but little is... 
Gastroenterology and Hepatology | Innate Immune Response | Immune Regulation | Pancreas | Mouse Model | ACTIVATION | NLRP3 INFLAMMASOME | GPR81 | AGONISTS | GENE | TLR9 | MICE | HEPATOTOXICITY | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | SEVERITY | Liver - pathology | Inflammasomes - metabolism | Receptors, G-Protein-Coupled - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Male | NF-kappa B - metabolism | Monocytes - immunology | Lipopolysaccharides | Liver - immunology | Liver - drug effects | RNA Interference | Interleukin-1beta - metabolism | Toll-Like Receptors - drug effects | Anti-Inflammatory Agents - administration & dosage | Toll-Like Receptors - metabolism | Cytoprotection | Disease Models, Animal | Galactosamine | Chemical and Drug Induced Liver Injury - prevention & control | Anti-Inflammatory Agents - pharmacology | Down-Regulation | Liver - metabolism | Injections, Intraperitoneal | Pancreas - pathology | Pancreas - metabolism | Pancreas - immunology | Toll-Like Receptor 4 - metabolism | Chemical and Drug Induced Liver Injury - immunology | Monocytes - drug effects | Macrophages - metabolism | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Sodium Lactate - pharmacology | beta-Arrestins | Mice | Receptors, G-Protein-Coupled - genetics | RNA, Small Interfering - metabolism | Monocytes - metabolism | Pancreatitis - prevention & control | Arrestins - metabolism | Dose-Response Relationship, Drug | Pancreatitis - genetics | Transfection | Inflammasomes - drug effects | Sodium Lactate - administration & dosage | Pancreatitis - immunology | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Macrophages - immunology | Cell Line | Immunity, Innate - drug effects | Toll-Like Receptor 4 - drug effects | Mice, Inbred C57BL | Pancreas - drug effects | Chemical and Drug Induced Liver Injury - genetics | Pancreatitis - chemically induced | Animals | Carrier Proteins - metabolism | beta-Arrestin 2 | Inflammasomes - immunology | Macrophages - drug effects | Pancreatitis - pathology | Pancreatitis - metabolism | Ceruletide | Lactates | Gastrointestinal diseases | Inflammation
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47792
Despite increased risk of a recurrent stroke following a minor stroke, information is minimal regarding the interaction between injurious mild cerebral... 
CELLS | OXIDATIVE STRESS | DISEASES | MULTIDISCIPLINARY SCIENCES | INJURY | TRANS-RESVERATROL | RAT-BRAIN | MODEL | ISCHEMIA-REPERFUSION | BLOOD-BRAIN-BARRIER | EXPRESSION | Inflammation - pathology | Recurrence | Stilbenes - administration & dosage | Stilbenes - therapeutic use | Body Temperature - drug effects | Endothelium, Vascular - drug effects | Stilbenes - pharmacology | Stroke - physiopathology | Brain - metabolism | Stroke - pathology | Heart Rate - drug effects | Inflammation - complications | Liver - drug effects | Oxidation-Reduction - drug effects | Blood Pressure - drug effects | Stress, Physiological - drug effects | Cell Death - drug effects | Biomarkers - metabolism | Cell Hypoxia - drug effects | Oxygen | Stroke - prevention & control | Administration, Oral | Cerebrovascular Circulation - drug effects | Liver - metabolism | Blood Gas Analysis | Rats | Treatment Outcome | Stroke - drug therapy | Blood-Brain Barrier - drug effects | Brain - drug effects | Blood-Brain Barrier - pathology | Glucose - deficiency | Animals | Nitrosation - drug effects | Brain - pathology | Endothelium, Vascular - pathology | Stilbenes - blood | Endothelial Cells - pathology | Endothelial Cells - drug effects | Stroke (Disease) | Usage | Care and treatment | Health aspects | Resveratrol | Cell culture | Oxidative stress | Neurosciences | Pressure effects | Glucose | Health physics | Toxicology | Ischemia | Blood-brain barrier | Cerebral blood flow | Temperature effects | Rodents | Gangrene | Physiology | Blood pressure | Inhibition | Drug dosages | Informatics | Edema | Deprivation | Stroke | Body temperature | Health risks | Pharmacology | Inflammation | Chromatography | Endothelial cells | Blood flow | Endothelium | Medicine | Cell death | Nitric oxide | Brain damage | In vivo methods and tests | Brain injury | Apoptosis
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 503, Issue 7477, pp. 493 - 499
Adiponectin secreted from adipocytes binds to adiponectin receptors AdipoR1 and AdipoR2, and exerts antidiabetic effects via activation of AMPK and PPAR-alpha pathways, respectively... 
CRUCIAL ROLE | SKELETAL-MUSCLE | ACTIVATED PROTEIN-KINASE | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DISEASE | MECHANISMS | ADIPONECTIN LEVELS | EXPRESSION | Liver - pathology | Obesity - drug therapy | Longevity - drug effects | Adipose Tissue, White - metabolism | Receptors, Adiponectin - metabolism | Diabetes Mellitus, Type 2 - metabolism | Muscle Fibers, Skeletal - drug effects | Obesity - genetics | Glucose Intolerance - drug therapy | Liver - drug effects | Piperidines - pharmacology | Inflammation - drug therapy | Adenylate Kinase - metabolism | Diet, High-Fat | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Receptors, Adiponectin - agonists | Adiponectin - metabolism | Drug Evaluation, Preclinical | Diabetes Mellitus, Type 2 - complications | Adipose Tissue, White - pathology | Adiponectin - pharmacology | Dyslipidemias - drug therapy | Piperidines - administration & dosage | Administration, Oral | Obesity - complications | Piperidines - metabolism | Liver - metabolism | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Obesity - physiopathology | Transcription Factors - biosynthesis | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Triglycerides - metabolism | Small Molecule Libraries - chemistry | Receptors, Adiponectin - deficiency | Animals | Signal Transduction - drug effects | Piperidines - therapeutic use | Muscle Fibers, Skeletal - cytology | Mice | Oxidative Stress - drug effects | PPAR alpha - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Adipose Tissue, White - drug effects | Receptors, Adiponectin - genetics | Muscles - cytology | Obesity | Insulin resistance | Muscular system | Kinases | Rodents
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 1, p. e53745
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2013, Volume 123, Issue 8, pp. 3272 - 3291
Journal Article
Journal of translational medicine, ISSN 1479-5876, 2019, Volume 17, Issue 1, pp. 127 - 14
...) especially in those with HF at baseline. These might indicate a potent direct cardioprotective effect, which is currently incompletely understood... 
Sodium-glucose cotransporter-2 inhibitor | Cardioprotection | Canagliflozin | Myocardial ischemia-reperfusion injury | MEDICINE, RESEARCH & EXPERIMENTAL | SGLT2 INHIBITORS | PHOSPHORYLATION | KINASE | CARDIOMYOCYTES | HEART | PRESSURE | AMPK | ARTERY | Apoptosis - drug effects | Canagliflozin - pharmacology | Myocardial Reperfusion Injury - complications | Systole - drug effects | Male | Aldehydes - metabolism | Liver - physiopathology | Cardiotonic Agents - therapeutic use | Liver - drug effects | Canagliflozin - therapeutic use | Diastole - drug effects | Aorta - physiopathology | Myocardial Reperfusion Injury - drug therapy | Phosphorylation - drug effects | Kidney - physiopathology | Biomarkers - metabolism | Endothelium - pathology | Glycosuria - physiopathology | Kidney - drug effects | Aorta - drug effects | Ventricular Function, Left - drug effects | Cardiotonic Agents - pharmacology | Rats, Sprague-Dawley | Glycosuria - complications | Myocardial Reperfusion Injury - physiopathology | Endothelium - physiopathology | Aorta - pathology | Endothelium - drug effects | Animals | Signal Transduction - drug effects | Oxidative Stress - drug effects | Vasodilation - drug effects | Blood Glucose - metabolism | Myocardial Reperfusion Injury - prevention & control | Nitrosative Stress - drug effects | Heart failure | Diabetics | Rats as laboratory animals | Analysis | Clinical trials | Research | Drug therapy | Health aspects | Occlusion | Myocardial infarction | Heart | Oxidative stress | Phosphorylation | Drug delivery systems | Intravenous administration | Heart attacks | Bax protein | 4-Hydroxynonenal | Bcl-2 protein | AKT protein | Myocardial ischemia | mRNA | Size determination | Kinases | Vasodilation | Proteins | Reperfusion | Ischemia | Rodents | Calcium-binding protein | Aorta | Heart diseases | Injury analysis | Medical research | Adenosine monophosphate | AMP | Diabetes mellitus | Coronary artery | Gene expression | Nitric-oxide synthase | Endothelium | Sodium | Protein kinase | Adenosine kinase | Nitric oxide | Ventricle | Diabetes | Laboratory animals | Apoptosis | Myocardial ischemia–reperfusion injury | Sodium–glucose cotransporter-2 inhibitor
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 488, Issue 7413, pp. 621 - 626